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| 1 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 2 | Synthesis and evaluation of novel analogues of mangiferin as potent antipyretic显示文摘Objective:To screen different analogues of mangiferin pharmacologically for antipyretic activity. Methods:The naturally occurring xanthone glycoside mangiferin was isolated by column chromatography from the elhanolic extract of stem bark of Mangifera indica.Mangiferin was further converted to 5-(N-phenylamino methyleno) mangiferin.5-(N-p-chlorophenylamino methyleno) mangiferin,5-(N-2-methyl phenylamino methyleno) mangiferin.5-(N-p-methoxy phenylamino methyleno) mangiferin.5-(N,N-diphenylamino methyleno) mangiferin,5-(N-α-napthylamino methyleno) mangiferin and 5-(N-4-methyl phenylamino methyleno) mangiferin analogues.The synthesized compounds were further screened for antipyretic activity along with mangiferin at a dose level of 100 and 200 tng/kg.Mangiferin and its analogues were characterized by melting point and R_f value determination and through spectral technique like UV,IR,and NMR spectral analysis.Results:The antipyretic activity of mangiferin as well as all analogues was found to be more significant in at higher dose ie.200 mg/kg which was depicted thmugh a decrease in rectal temperature up to 3 h.Conclusions:The antipyretic activity of mangiferin and its analogues may be attributed to inhibition in synthesis of TNF-αand anti-oxidant activity associated with amelioration of inflammatory actions of cytokines. | Shashi Kant Singh Saurabh K Sinha SK Prasad R Kumar Bhawani S Bithu S Sadish Kumar P Singh | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，11： | 4 |
| 3 | Lysozyme: an important defence molecule of -sh innate immune system显示文摘 | Saurabh S Sahoo P K | 2008 | Aquacult Res2008，39，： | 1 |
| 4 | Lysozyme: an important defence molecule of fish innate immune system 显示文摘 | Saurabh S Sahoo P K | 2008 | Aquac Res2008，39，3： | 1 |
| 5 | Lack of mucosal im mune reconstitution during prolonged treatment of acute and ear- ly HIV-1 infection显示文摘 | Saurabh M Michael A P Klara T R | 2006 | PLoS Medicine2006，3，2： | 1 |
| 6 | Intermediateterm prospective results of radiofrequency-assisted laparoscopic partial nephrectomy:a non-ischaemic coagulative technique显示文摘 | LLIA SZ SAURABH M SANGTAE P | 2007 | BJU2007，14，： | 1 |
| 7 | Locality-preserving dimensionality reduction and classification for hyperspeetral image analysis显示文摘 | WEI L SAURABH P JAMES E F | 2012 | IEEE Transactions on Geoscience and Remote Sensing2012，50，5： | 1 |
| 8 | Inducing toxicity by introducing a leucine-zipper-like motif in frog antimicrobial peptide, magainin 2 显示文摘 | Brijesh K P Saurabh S Manish S | 2011 | Biochemical journal2011，436，3： | 1 |
| 9 | Treatment of orange I1 azo-dye by electrocoagulation (EC) technique in a continuous flow cell using sacrificial iron electrodes 显示文摘 | Mohammad Y A M Saurabh R P Prashanth K P | 2004 | Journal of Hazardous Materials2004，109，123： | 1 |
| 10 | Lack of mucosal immune reconstitution during prolonged treatment of acute and early HIV-1 infection 显示文摘 | Saurabh M Michael A P Klara T R | 2006 | Plos Medicine2006，3，2： | 1 |
| 11 | Wireless Community Networks显示文摘 | Saurabh Jain Dharma P Agrawal | 2003 | IEEE Computer2003，8，： | 1 |
| 12 | Decision fusion of textural features derived from polarimetric data for levee assessment显示文摘 | CUI Minshan SAURABH P MAJID M | 2012 | IEEE Journal of Selected Topic in Applied Earth Observation and Remote Sensing2012，5，3： | 1 |
| 13 | Lysozyme: an important defence molecule of fish innate immune system显示文摘 | Saurabh S Sahoo P | 2008 | Aquaculture Research2008，39，3： | 1 |
| 14 | Treatment of orange Ⅱ azo-dye by electrocoagulation (EC) technique in a continuous flow cell using sacrificial iron electrodes显示文摘 | Mohammad Y A M Saurabh R P Prashanth K P | 2004 | Journal of Hazardous Materials B2004，，109： | 1 |
| 15 | Lysozyme: an important defence molecule of fish innate immune system显示文摘 | Saurabh S Sahoo P K | 2008 | Aquacult Res2008，39，3： | 1 |
| 16 | A process, voltage, and temperature compensated CMOS constant current reference 显示文摘 | S Sengupta K Saurabh P E Allen | 2004 | ISCAS Circuits and Systems2004，1，： | 1 |
| 17 | Effect of SBS content on low temperature imp act strength, ,norphology and theology of PP-co/SBS blends 显示文摘 | VISHAL D SAURABH S G ARVIND K P | 2011 | Polym Plast Technol Eng2011，50，8： | 1 |
| 18 | Surgical patterns in os- teoporotic vertebral compression fractures显示文摘 | Sanganagouda P Saurabh R Deepak S | 2013 | Eur Spine J2013，22，88： | 1 |
| 19 | Lysozyme: an important de- fense molecule of fish innate immune system显示文摘 | Saurabh S Sahoo P K | 2008 | Aq- uaculture Research2008，39，3： | 1 |
| 20 | Stability analysis of fractional-order generalized chaotic susceptible-infected-recovered epidemic model and its synchronization using active control method显示文摘 | Sana P A Saurabh K A Subir D | 2015 | Pramana-Journal of physics2015，84，1： | 1 |
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