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| 1 | 乙型肝炎病毒慢性感染者血清中不同类型病毒转录体的检测及其意义显示文摘目的:建立针对乙型肝炎病毒(HBV)全长型(fRNA)和顿挫型转录体(trRNA)的血清学检测方法,并探讨其临床应用价值.方法:自患者血清中提取病毒核酸,经PCR及PRT-PCR进行扩增,琼脂糖电泳显示产物,Southern印迹验证反应的特异性.取代表性产物克隆,测序.结果:在HBV慢性携带者的血清中检测到了在上述不同poly(A)位点成熟的病毒RNA.血清中fRNA的检出与e抗原阳性和较强的病毒DNA信号相对应,与转氨酶活性呈正相关,这一血清学指标反映了病毒复制;而trRNA的检出与e抗原阳性和转氨酶活性无关,不象fRNA那样依赖于血清中病毒DNA的量.二者检出率随年龄有不同变化,前者随年龄增加而进行性减低乃至转阴;而后者在10-20岁期间检出率升至80%,以后维持在较高水平.即使在某些表面抗原阴性血清中,也能检测到trRNA和不在上述两个位点成熟的病毒RNA.这些转录体在某些隐源性肝硬变和丙型肝炎患者血清中也存在.结论:病毒转录体的血清学检测有助于确定目前尚不认识的HBV感染期,可用来更准确地区分复制期和非复制期以及检出隐匿性HBV感染. | 苏勤 张伟 刘节 王淑芳 Kunio Takegoshi Claus H Schrder | 2003 | 世界华人消化杂志2003，11，2： | 16 |
| 2 | Structure, mechanism and regulation of peroxiredoxins 显示文摘 | Wood Z A Schrder E Robin H J | 2003 | Trends in Biochemi- cal Sciences2003，28，1： | 1 |
| 3 | Percutaneous endoscopic gastrostomy in paediatric cancer patients显示文摘 | Barlaug M Kruse A Schrder H | | 0，，23： | 1 |
| 4 | Effects of opioid antagonists and morphine in a hippocampal hypoxia/ hypoglycemiamodel显示文摘 | Ammon-Treiber S Stolze D Schrder H | 2012 | Neuropharmacology2012，55，8： | 1 |
| 5 | Heme oxygenase-1 and cardiovascular disease显示文摘 | Immenschuh S Schrder H | 2006 | Histol Histopathol2006，1，6： | 1 |
| 6 | DnaK, DnaJ, and GrpE from a Cellular Chaperone Machinery Capable of Repairing Heat - induced Protein Damage显示文摘 | Schrder H Langer T Hard F U | 1993 | EMBO J1993，12，11： | 1 |
| 7 | Identificationand elimination of the competing ^-acetyldiaminopentanepathway for improved production of diaminopentane bycorynebacterium glutamicum 显示文摘 | KIND S JEONG W K SCHRDER H | 2010 | Applied and Environ-mental Microbiology2010，76，15： | 1 |
| 8 | Investigation of the laminarturbulent transition of boundary layers disturbed by wakes 显示文摘 | Pfeil H Herbst R Schrder T | 1983 | ASME Journal of Engineering for Power1983，105，2： | 1 |
| 9 | Deposition of Nano- crystalline Silicon Films (nc-Si :H) From a Pure ECWR- Sill4 Plasma显示文摘 | Scheib M Schrder B Oechsner H | 1996 | Journal of Non-Crystalline Solids1996，，： | 1 |
| 10 | The possible roles of food-derived bioactive peptides in reducing therisk of cardiovascular disease 显示文摘 | Erdmann K Cheung B W Y Schrder H | 2008 | The Journal of Nutritional Biochemistry2008，19，10： | 1 |
| 11 | Metabolic engineering of the tricarboxylic acid cycle for improved lysine production by Corynebacterium glutamicum显示文摘 | Becker J Klopprogge C Schrder H | | 0，，24： | 1 |
| 12 | An oscillating and renewing silver electrode for cadmium and lead detection in differential pulse stripping voltammetry显示文摘 | Mikkelsen E Schrder K H | 2001 | Electroanalysis2001，13，89： | 1 |
| 13 | Gout-current diagnosis and treatment显示文摘 | TAUSCHE A K JANSEN T L SCHRDER H E | 2009 | Dtsch Arztebl Int2009，106，3435： | 1 |
| 14 | Field tests of anchors in clay II: predictions and interpretation显示文摘 | ANDERSEN K H DYVIK R SCHRDER K | 1993 | Journal of Geotechnical Engineering ASCE1993，119，10： | 1 |
| 15 | Field tests of anchors in clay II: predictions and interpretation显示文摘 | ANDERSEN K H DYVIK R SCHRDER K | 1993 | ASCE Journal of Geotechnical Engineering1993，119，10： | 1 |
| 16 | Field tests of anchors in clay II: Predictions and Interpretation显示文摘 | ANDERSEN K H DYVIK R SCHRDER K | 1993 | ASCE Journal of Geoteehnical Enineerina1993，19，10： | 1 |
| 17 | Stability of fluorinated surfactants in advanced oxidation proeesses:a follow up of degradation products using flow inject/on- mass spectrometry, liquid chromatography-mass spectrometry and liquid chromatography-multiple stage mass spectrometry 显示文摘 | SCHRDER H F MEESTERS R J W | 2005 | Journal of Chromatography A2005，1082，1： | 1 |
| 18 | Parecoxib and its metabolite valdecoxib directly interact with cannabinoid binding sites in CB1-expressing HEK 293 cells and rat brain tissue 显示文摘 | Schrder H Hllt V Becker A | 2011 | Neurochem Int2011，58，1： | 1 |
| 19 | Chromosome aberration analysis in aircrew members显示文摘 | Schrder H Lengfelder E | 1995 | Radiat Prot Dosim1995，60，2： | 1 |
| 20 | Activation of thromboxane reeeptor modulates interleukin- lfl- induced monocyte adhesion- A novel role of Noxl 显示文摘 | Bayat H Schrder K Pimentel DR | 2012 | Free Radical Biology and Medicine2012，52，9： | 1 |
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