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| 1 | Preventive effect of a pectic polysaccharide of the common cranberry Vaccinium oxycoccos L. on acetic acid-induced colitis in mice显示文摘AIM: To study isolation and chemical characterization of pectin derived from the common cranberry Vaccinium oxycoccos L. (oxycoccusan OP) and the testing of its preventive effect on experimental colitis.METHODS: Mice were administrated orally with OP two days prior to a rectal injection of 5% acetic acid and examined for colonic damage 24 h later. Colonic inflammation was characterized by macroscopical injury and enhanced levels of myeloperoxidase activity measured spectrophotometrically with o-phenylene diamine as the substrate. The mucus contents of the colon were determined by the Alcian blue dye binding method. Vascular permeability was estimated using 4% Evans blue passage after i.p. injection of 0.05 mol/L acetic acid. RESULTS: In the mice treated with OP, colonic macroscopic scores (1.1 ± 0.4 vs 2.7, P < 0.01) and the total square area of damage (10 ± 2 vs 21 ± 7, P < 0.01) were significantly reduced when compared with the vehicle-treated colitis group. OP was shown to decrease the tissue myeloperoxidase activity in colons (42 ± 11 vs 112 ± 40, P < 0.01) and enhance the amount of mucus of colitis mice (0.9 ± 0.1 vs 0.4 ± 0.1, P < 0.01). The level of colonic malondialdehyde was noted to decrease in OP-pretreated mice (3.6 ± 0.7 vs 5.1 ± 0.8, P < 0.01). OP was found to decrease the inflammatory status of mice as was determined by reduction of vascular permeability (161 ± 34 vs 241 ± 21, P < 0.01). Adhesionof peritoneal neutrophils and macrophages was also shown to decrease after administration of OP (141 ± 50 vs 235 ± 37, P < 0.05).CONCLUSION: Thus, a preventive effect of pectin from the common cranberry, namely oxycoccusan OP, on acetic acid-induced colitis in mice was detected. A reduction of neutrophil infiltration and antioxidant action may be implicated in the protective effect of oxycoccusan. | Sergey V Popov Pavel A Markov Ida R Nikitina Sergey Petrishev Vasily Smirnov Yury S Ovodov | 2006 | World Journal of Gastroenterology2006，12，41： | 9 |
| 2 | High-fidelity multimode fibre-based endoscopy for deep brain in vivo imaging显示文摘Progress in neuroscience relies on new techniques for investigating the complex dynamics of neuronal networks.An ongoing challenge is to achieve minimally invasive and high-resolution observations of neuronal activity in vivo inside deep brain areas.Recently introduced methods for holographic control of light propagation in complex media enable the use of a hair-thin multimode optical fibre as an ultranarrow imaging tool.Compared to endoscopes based on graded-index lenses or fibre bundles,this new approach offers a footprint reduction exceeding an order of magnitude,combined with a significant enhancement in resolution.We designed a compact and high-speed system for fluorescent imaging at the tip of a fibre,achieving a resolution of 1.18±0.04μm across a 50-μm field of view,yielding 7-kilopixel images at a rate of 3.5 frames/s.Furthermore,we demonstrate in vivo observations of cell bodies and processes of inhibitory neurons within deep layers of the visual cortex and hippocampus of anaesthetised mice.This study paves the way for modern microscopy to be applied deep inside tissues of living animal models while exerting a minimal impact on their structural and functional properties. | Sergey Turtaev Ivo T.Leite Tristan Altwegg-Boussac Janelle M.P.Pakan Nathalie L.Rochefort Tomáš Čižmár | 2018 | Light(Science & Applications)2018，7，1： | 8 |
| 3 | Effect of fluence and ambient environment on the surface and structural modification of femtosecond laser irradiated Ti显示文摘Under certain conditions, ultrafast pulsed laser interaction with matter leads to the formation of self-organized conical as well as periodic surface structures(commonly reffered to as, laser induced periodic surface structures, LIPSS). The purpose of the present investigations is to explore the effect of fsec laser fluence and ambient environments(Vacuum &O_2) on the formation of LIPSS and conical structures on the Ti surface. The surface morphology was investigated by scanning electron microscope(SEM). The ablation threshold with single and multiple(N = 100) shots and the existence of an incubation effect was demonstrated by SEM investigations for both the vacuum and the O_2 environment. The phase analysis and chemical composition of the exposed targets were performed by x-ray diffraction(XRD) and energy dispersive x-ray spectroscopy(EDS), respectively. SEM investigations reveal the formation of LIPSS(nano & micro). FFT d-spacing calculations illustrate the dependence of periodicity on the fluence and ambient environment. The periodicity of nano-scale LIPSS is higher in the case of irradiation under vacuum conditions as compared to O_2. Furthermore, the O2 environment reduces the ablation threshold. XRD data reveal that for the O_2 environment, new phases(oxides of Ti) are formed. EDS analysis exhibits that after irradiation under vacuum conditions, the percentage of impurity element(Al) is reduced. The irradiation in the O_2 environment results in 15% atomic diffusion of oxygen. | Umm-i-Kalsoom Shazia Bashir Nisar Ali M Shahid Rafique Wolfgang Husinsky Chandra S R Nathala Sergey V Makarov Narjis Begum | 2016 | Chinese Physics B2016，25，1： | 2 |
| 4 | Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial显示文摘 | Edward B Garon Tudor-Eliade Ciuleanu Oscar Arrieta Kumar Prabhash Konstantinos N Syrigos Tuncay Goksel Keunchil Park Vera Gorbunova Ruben Dario Kowalyszyn Joanna Pikiel Grzegorz Czyzewicz Sergey V Orlov Conrad R Lewanski Michael Thomas Paolo Bidoli Shaker | 2014 | The Lancet2014，，： | 2 |
| 5 | Management of displaced intraarticu lar calcaneal fractures by using external ring fixation,minimally invasive open reduction,and early weight bearing显示文摘 | George R Sergei Y | 2004 | J Foot Ankle Surg2004，43，1： | 1 |
| 6 | Repartition effect of aromatic polyaniline coatings on the separation of bioactive peptides in capillary electrophoresis显示文摘 | ALESSANDRA B SERGEY A P ANTHONY P F T PIER G R | 2002 | Electrophoresis2002，23，2： | 1 |
| 7 | On the syn- thesis of a-zirconium phosphate 显示文摘 | CAMINO T SERGEI A K JOSE R G | 2000 | Chem Mater2000，12，6： | 1 |
| 8 | JPhys Chem B 显示文摘 | Chert J Apparao M R Sergei Lyuksyutov | 2001 | 105(13): 25252001，105，13： | 1 |
| 9 | Infrared luminescence of ytterbium ion in complexes with calixresorcinarenes显示文摘 | Sergey V S Natalia V R Anna M T | 1998 | Journal of Fluorescence1998，8，3： | 1 |
| 10 | Biomedical Appli- cations of Carbon Adsorbents显示文摘 | Sergey V Susan R Carol A Gary J etal | 2012 | Novel Carbon Adsorbents2012，，： | 1 |
| 11 | Output feedback control of current-fed induction motors with unknown rotor resistance显示文摘 | Marino R Sergei P | 1996 | IEEE Trans on Control System Technology1996，4，4： | 1 |
| 12 | Immunity,inflamma-tion and cancer显示文摘 | Sergei I Grivennikov Florian R | 2010 | Cell2010，140，6： | 1 |
| 13 | Struc- tural and Morphological Study of Pulsed Laser Deposited Bioceramic Coatings : Influence of Deposition Conditions, Laser Parameters, and Target Properties 显示文摘 | Haitong Zeng William R Lacefield Sergey Mirov | 2000 | J Biomed Mater2000，50，2： | 1 |
| 14 | Synthetic strategy for Fe - MCM -41 catalyst: A key factor for homogeneous or heterogeneous phenol ox- idation 显示文摘 | SERGEY V S IRINA 1c M BORIS V R | 2011 | Catal Sci Technol2011，1，6： | 1 |
| 15 | Crosstalk between the canonical NF-[kappa]B and Notch signaling pathways inhibits Ppar[gamma] expression and promotes pancreatic cancer progression in mice显示文摘 | Maniati Eleni Bossard Maud Cook Natalie Candido Juliana B Emami-Shahri Nia Nedospasov Sergei A Balkwill Frances R Tuveson David A Hagemann Thorsten | 2011 | Journal of Clinical Investigation2011，，12： | 1 |
| 16 | Analysis of 16S rDNA reveals bacterial shift during in vitro fermentation of fermentable carbohydrate using piglet faeces as inoculum显示文摘 | Wei-Yun Zhu Barbara A Williams Sergey R Konstantinov Seerp Tamminga Willem M De Vos Antoon D.L Akkermans | 2003 | Anaerobe2003，，： | 1 |
| 17 | Slayer protein A of Lactobacillus acidophilus NCFM regulates immature dendritic cell and T cell function显示文摘 | SERGEY R HAUKE S WILLEM M | 2008 | Proceedings of the National Academy of Sciences of the United States of America2008，105，19： | 1 |
| 18 | Localization and Registration Accuracy in Image Guided Neurosurgery:A Clinical Study 显示文摘 | Reuben R S Leo J Sergey S | 2009 | International Journal of Computer Assisted Radiology and Surgery2009，4，1： | 1 |
| 19 | Experimental myocardial infarction triggers canonical Wnt signaling and endothelial- to-mesenchymal transition显示文摘 | Omonigho A Meena R Sergey R | 2011 | Disease Models & Mecha- nisms2011，4，： | 1 |
| 20 | Management of displaced intraarticular calcaneal fractures by using external ringfixation, minimally invasive, open reduction, and early weightbearing显示文摘 | Leonard M George R Sergei Y | 2004 | J Foot Ankle Surg2004，43，1： | 1 |
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