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| 1 | Antagonism of Protease-Activated Receptor 4 Protects Against Traumatic Brain Injury by Suppressing Neuroinflammation via Inhibition of Tab2/NF-κB Signaling显示文摘Traumatic brain injury(TBI)triggers the activation of the endogenous coagulation mechanism,and a large amount of thrombin is released to curb uncontrollable bleeding through thrombin receptors,also known as protease-activated receptors(PARs).However,thrombin is one of the most critical factors in secondary brain injury.Thus,the PARs may be effective targets against hemorrhagic brain injury.Since the PAR1 antagonist has an increased bleeding risk in clinical practice,PAR4 blockade has been suggested as a more promising treatment.Here,we explored the expression pattern of PAR4 in the brain of mice after TBI,and explored the effect and possible mechanism of BMS-986120(BMS),a novel selective and reversible PAR4 antagonist on secondary brain injury.Treatment with BMS protected against TBI in mice.mRNA-seq analysis,Western blot,and qRT-PCR verification in vitro showed that BMS significantly inhibited thrombin-induced inflammation in astrocytes,and suggested that the Tab2/ERK/NF-κB signaling pathway plays a key role in this process.Our findings provide reliable evidence that blocking PAR4 is a safe and effective intervention for TBI,and suggest that BMS has a potential clinical application in the management of TBI. | Jianing Luo Xun Wu Haixiao Liu Wenxing Cui Wei Guo Kang Guo Hao Guo Kai Tao Fei Li Yingwu Shi Dayun Feng Hao Yan Guodong Gao Yan Qu | 2021 | Neuroscience Bulletin2021，37，2： | 5 |
| 2 | Source of ore-forming material for the Huangtuliang gold deposit,Hebei Province and ore prospecting in the deep periphery显示文摘The Huangtuliang gold deposit is characterized by its wide and large ore belt,stable extension and closely spaced orebodies.Unfortunately,no orebody was found by deep drilling.As a result,ore prospecting in this region was once put into dilemma.Detailed analysis of ore-forming and ore-controlling structures in the mining district by the authors has revealed that the ore-forming and ore-controlling structure in this mining district is a steeply dipping(85°-110°/∠70°-85° N-NNE),spade-shaped ductile shear zone,and the ore-controlling structures are a series of nearly erected second-ordered faults which are developed in the upper part of the ductile shear zone,intersecting with the ductile shear zone.Deep cutting of the ductile shear zone made it possible the ascending of ore fluids from the mantle plume at depth and these ore fluids would migrate upwards along the ductile shear zone under certain temperature and pressure conditions.Along their ascending path,the ore fluids would extract ore-forming elements from the country rocks and the extracted ore-forming elements would be deposited as ores in the hanging-wall second-ordered faults.The reason why no orebody was found in early prospecting at depth is that northward-dipping drilling in the southern part of the shear zone extended so deeply as to be beneath the shear zone.Only shallow-level orebodies could be found by southward-dipping drilling practice in the northern part of the shear zone.The location where deep-seated orebodies occurred shifted northwards and the orebodies occurred at greater depth.Therefore,it is natural that no orebody could be found when drill core passed through the shear zone.After the ore-forming and ore-controlling structures were well understood,the focus of ore prospecting was placed on the deep-level,northward-penetrating veins.In this way a number of new blind orebodies of great thickness have been found.On the basis of research development in the mining district,a prospecting plan has been made for ore prospecting in the periphery of eastern mining district.Prospecting practice has shown that there occur generally continuous engineering orebodies at large intervals.So,the Huangtuliang gold deposit has turned at one stroke from a medium sized to a large-sized,even a super-large gold deposit between prospecting lines 30-98. | NIU Shuyin SUN Aiqun WANG Baode HAN Yuchou WEI Minghui ZHANG Hai ZHANG Ge SHI Ping WANG Wenxing | 2008 | Chinese Journal Of Geochemistry2008，27，3： | 4 |
| 3 | Acrolein Induces Systemic Coagulopathy via Autophagy-dependent Secretion of von Willebrand Factor in Mice after Traumatic Brain Injury显示文摘Traumatic brain injury(TBI)-induced coagulopathy has increasingly been recognized as a significant risk factor for poor outcomes,but the pathogenesis remains poorly understood.In this study,we aimed to investigate the causal role of acrolein,a typical lipid peroxidation product,in TBI-induced coagulopathy,and further explore the underlying molecular mechanisms.We found that the level of plasma acrolein in TBI patients suffering from coagulopathy was higher than that in those without coagulopathy.Using a controlled cortical impact mouse model,we demonstrated that the acrolein scavenger phenelzine prevented TBI-induced coagulopathy and recombinant ADAMTS-13 prevented acrolein-induced coagulopathy by cleaving von Willebrand factor(VWF).Our results showed that acrolein may contribute to an early hypercoagulable state after TBI by regulating VWF secretion.mRNA sequencing(mRNA-seq)and transcriptome analysis indicated that acrolein over-activated autophagy,and subsequent experiments revealed that acrolein activated autophagy partly by regulating the Akt/mTOR pathway.In addition,we demonstrated that acrolein was produced in the perilesional cortex,affected endothelial cell integrity,and disrupted the blood-brain barrier.In conclusion,in this study we uncovered a novel pro-coagulant effect of acrolein that may contribute to TBI-induced coagulopathy and vascular leakage,providing an alternative therapeutic target. | Wenxing Cui Xun Wu Dayun Feng Jianing Luo Yingwu Shi Wei Guo Haixiao Liu Qiang Wang Liang Wang Shunnan Ge Yan Qu | 2021 | Neuroscience Bulletin2021，37，8： | 3 |
| 4 | Performance representation of variable-speed compressor for inverter air conditioners based on experimental data显示文摘 | Shuangquan Shao Wenxing Shi Xianting Li Huajun Chen | 2004 | International Journal of Refrigeration2004，，8： | 2 |
| 5 | Performance representation of variable-speed compressor for inverter air conditioners based on experimental data显示文摘 | Shao Shuangquan Shi Wenxing Li Xianting | 2004 | International Journal of Refrigeration2004，27，： | 1 |
| 6 | Per- formance representation of variable-speed compressor for inverter air conditioners based on experimental data 显示文摘 | Shao Shuangquan Shi Wenxing Li Xianting | 2004 | International Journal of Refrigeration2004，27，8： | 1 |
| 7 | Numerical analysis on the effects of refrigerant injection on the scroll compressor显示文摘 | WANG Baolong SHI Wenxing LI Xianting | 2009 | Applied Thermal Engineering2009，29，1： | 1 |
| 8 | A general geometrical model of scroll compressors based on discretional initial angles of involute显示文摘 | Wang Baolong Li Xianting Shi Wenxing | 2005 | International Journal of Refrigeration2005，28，6： | 1 |
| 9 | Modula- tion method of scroll compressor based on suction gas by- pass显示文摘 | Baolong Wang Linjun Han Wenxing Shi | 2012 | Applied Thermal Engineering2012，37，： | 1 |
| 10 | Numerical Anal- ysis on the Effects of Refrigerant Injection on the Scroll Compressor显示文摘 | Wang Baolong Shi Wenxing Li Xianting | 2009 | Applied Thermal Engineering2009，29，1： | 1 |
| 11 | De- velopment of an integrated air conditioner with thermo- syphon and the application in mobile phone base station 显示文摘 | Han Linjun Shi Wenxing Wang Baolong | 2013 | International Journal of Refrigeration2013，36，1： | 1 |
| 12 | Performance representation of variable-speed compressor for inverter air conditioners based on experimental data显示文摘 | Shao Shuangquan Shi Wenxing Li Xianting | 2004 | International Journal of Refrigeration2004，27，8： | 1 |
| 13 | Design of experimental bench and internal pressure measurement of scroll compressor with refrigerant injection 显示文摘 | Baolong Wang Xianting Li Wenxing Shi | 2007 | Interna- tional Journal of Refrigeration2007，30，1： | 1 |
| 14 | Ener- gy consumption model of integrated air conditioner with thermosyphon in mobile phone base station 显示文摘 | Han Linjun Shi Wenxing Wang Baolong | 2014 | Inter- national Journal of Refrigeration2014，40，： | 1 |
| 15 | Optimi- zation of refrigeration system with gas-injected scroll com- pressor显示文摘 | Baolong Wang Wenxing Shi Linjun Han | 2009 | International Journal of Refrigeration2009，32，7： | 1 |
| 16 | Performance representation of variable-speed compressor for inverter air conditioners based on experimental data显示文摘 | Shuangquan Shao Wenxing Shi Xianting Li | 2004 | International Journal of Refrigeration2004，，27： | 1 |
| 17 | A measurement method of ice layer thickness based on resistance-capacitance circuit for closed loop external melt ice storage tank显示文摘 | Shi Wenxing Wang Baolong Li Xianting | 2005 | Applied Thermal Engineering2005，25，1112： | 1 |
| 18 | Numerical analysis on the effects of refrigerant injection on the scroll compressor显示文摘 | Baolong Wang Wenxing Shi Xianting Li | 2008 | Applied Thermal Engineering2008，，1： | 1 |
| 19 | Perfor- mance Representation of Variable-speed Compressor for Inverter Air Conditioners Dased on Experimental Data显示文摘 | Shuangquan Shao Wenxing Shi Xianting Li | 2004 | International Journal of Refrigeration2004，，27： | 1 |
| 20 | Simulation on complex refrigeration system, Part 1: model development显示文摘 | Shao Shuangquan Shi Wenxing Li Xianting | 2008 | International Journal of Refrigeration2008，31，3： | 1 |
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