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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | 二甲双胍与吡格列酮两种2型糖尿病药物在亲水作用色谱上的保留机理研究(英文)显示文摘二甲双胍和吡格列酮是治疗2型糖尿病的常见药物,经常用于同一复方制剂。制药和临床领域常要求同时测定这两种药物。亲水作用色谱近来在医药分析领域展现出良好的前景。本文通过研究流动相的有机溶剂含量、pH值和缓冲盐浓度等参数对色谱保留的影响,从而尝试揭示两种药物在亲水性硅胶柱上的分离机理。流动相中甲醇的增加会导致二甲双胍的保留因子的增加。流动相pH值比较低时,二甲双胍的保留因子会随着pH值升高而增加,而当pH值>6.09,其反而会随着pH值的升高而下降。吡格列酮的保留因子几乎不受甲醇比例和pH值的影响。缓冲盐浓度对两种药物的保留因子几乎都没有影响。因此,对于二甲双胍,亲水作用是主要的保留机理,静电作用和氢键也起到了重要作用。对于吡格列酮,亲水作用是支配性的。经过优化的亲水作用色谱方法可成功地应用到分离测定两种药物在2型糖尿病复方药物中的含量。 | 鲁肖飞 Caroline Martin 戚忠林 Pari Samani Zemen Berhe Dominic B Siaw Shyam K Pahari 左跃钢 | 2019 | 分析科学学报2019，35，6： | 4 |
| 3 | Nrf2 is required for normal postnatal bone acquisition in mice显示文摘A large body of literature suggests that bone metabolism is susceptible to the ill effects of reactive species that accumulate in the body and cause cellular dysfunction. One of the body's front lines in defense against such damage is the transcription factor, Nrf2. This transcription factor regulates a plethora of antioxidant and cellular defense pathways to protect cells from such damage. Despite the breadth of knowledge of both the function of Nrf2 and the effects of reactive species in bone metabolism, the direct role of Nrf2 in skeletal biology has yet to be thoroughly examined. Thus, in the current study, we have examined the role of Nrf2 in postnatal bone metabolism in mice. Mice lacking Nrf2(Nrf22/2) exhibited a marked deficit in postnatal bone acquisition,which was most severe at 3 weeks of age when osteoblast numbers were 12-fold less than observed in control animals. While primary osteoblasts from Nrf22/2mice functioned normally in vitro, the colony forming capacity of bone marrow stromal cells(BMSCs) from these mice was significantly reduced compared to controls.This defect could be rescued through treatment with the radical scavenger N-acetyl cysteine(NAC), suggesting that increased reactive species stress might impair early osteoblastogenesis in BMSCs and lead to the failure of bone acquisition observed in Nrf22/2animals. Taken together, these studies suggest Nrf2 represents a key pathway in regulating bone metabolism, which may provide future therapeutic targets to treat osteoporosis. | Jung-Hyun Kim Vandana Singhal Shyam Biswal Rajesh K Thimmulappa Douglas J Di Girolamo | 2014 | Bone Research2014，2，4： | 3 |
| 4 | Induction of the differentiation of HL-60 promyelocytic leukemia cells by curcumin in combination with low levels of vitamin D3 显示文摘 | Sokoloski JA Shyam K Sartorelli AC | 1997 | Oncol Res1997，9，1： | 1 |
| 5 | Removal of sulfadiazine,sulfamethizole,sulfamethoxazole,and sulfathiazole from aqueous solution by ozonation显示文摘 | Temesgen Garoma Shyam K Umamaheshwar Alison Mumper | 2010 | Chemosphere2010，79，： | 1 |
| 6 | Ameliorative effect of Koflet formulations against pyridine-induced pharyngitis in rats 显示文摘 | Viswanatha C L Rafiq M Thippeswamy A H M Yuvaraj H C Kavya K J Mirza R B Suryakant A Mohammed A Patki P S Pushpalatha H B Prafulla S C Shyam R | 2014 | Toxicology Reports2014，1，： | 1 |
| 7 | Diversity of the killer cell Ig-like receptors of rhesus monkeys 显示文摘 | Hershberger K L Shyam R Miura A | 2001 | J Immunol2001，166，7： | 1 |
| 8 | 1,2-Bis(methylsulfonyl)-l- ( 2-chloroethyl ) -2- hydrazine : an anticancer agent targeting hypoxic cells 显示文摘 | Seow H A Penketh P G Shyam K | 2005 | PNAS2005，102，26： | 1 |
| 9 | Role of atrial ischaemia in development of atrial fibrillation following coronary artery bypass surgery显示文摘 | Shyam K Anthony D Parvez A | 1997 | Eur J Cardithorac Surg1997，11，： | 1 |
| 10 | St ructure-activity studies of novobiocin analogs as modulators of t he cytotoxicity of etoposide (VP-16)显示文摘 | Rappa G Shyam K Lorico A | 2000 | Oncol Res2000，12，3： | 1 |
| 11 | Statistical Modeling and Analysis of High-resolution Synthetic Aperture Radar images显示文摘 | Shyam K | 2000 | Statistics and Computing2000，10，2： | 1 |
| 12 | Fluorometric Assay for the Determination of DNA-DNA Cross-links Utilizing Hoechst33258at Neutral pH Values显示文摘 | PENKETH G P SHYAM K SARTORELLI A C | 1997 | Anal Biochem1997，252，1： | 1 |
| 13 | Primary hemiarthroplasty for unstable osteoporotic intertrochanteric fractures in the elderly:A retrospective case series显示文摘 | Sancheti K h Sancheti P Shyam A at al | 2010 | Indian J Orthop2010，44，4： | 1 |
| 14 | Crataegus special extract WSR 1442 improves cardiac function and reduces infarct size in a rat model of prolonged coronary ischemia and reperfusion显示文摘 | Maris V Egon K Shyam S C | 2004 | Life Sciences2004，74，： | 1 |
| 15 | Negative Refraction in 1D Photonic Crystals 显示文摘 | Ragini Srivastava Thapa K B Shyam Pati | 2008 | Solid State Communications2008，147，34： | 1 |
| 16 | Strategies to eliminate HBV infection 显示文摘 | RAMA K SHYAM K | 2014 | Future Virol2014，9，6： | 1 |
| 17 | Bamboo housing: market potential for low-income groups 显示文摘 | Shyam K Paudel Maxim Lobovikov | 2003 | Journal of Bamboo and Rattan2003，2，4： | 1 |
| 18 | Rusling electeochemistry of bipyridyl derivatives of cobalt in solution of anionic and cationic micelles显示文摘 | GEOFFREY N K THOMAS L SHYAM S S | 1987 | Electroanal Chem1987，233，： | 1 |
| 19 | A resource granularity framework for estimating opportunity costs 显示文摘 | RAMJI B Sivaramakrishnan K Shyam S | 2004 | Accounting Horizons2004，18，3： | 1 |
| 20 | A comparative study of AI and LiF/AI interfaces with poly(3-hexylthiophene) using bias dependent phototuminescence technique显示文摘 | Vipul S Anil K T Shyam S P | 2008 | Organic Electron- ics2008，，9： | 1 |
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