|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Catalytic transfer hydrogenation of levulinate ester intoγ-valerolactone over ternary Cu/ZnO/Al2O3 catalyst显示文摘An effective catalytic transfer hydrogenation (CTH) process of bio-based levulinate esters into γ-valerolactone (GVL) was explored over ternary Cu/ZnO/Al2O3 catalyst which was prepared by coprecipitation method and could be sustainably used. As a result, quantitative conversion of ethyl levulinate (EL) and 99.0% yield of GVL were obtained in the CTH process using i-PrOH as hydrogen donor. The Cu/ZnO/Al2O3 catalyst with high-surface-area could be reused at least four times without the loss of catalytic activity. Furthermore, the structure and properties of Cu/ZnO/Al2O3 catalyst was characterized through XRD, BET, SEM, TEM and H2-TPR. Also, the influence of different support oxides and calcination temperatures was investigated. | Chuntao Zhang Zhibao Huo Dezhang Ren Zhiyuan Song Yunjie Liu Fangming Jin Wanning Zhou | 2019 | Journal of Energy Chemistry2019，28，5： | 2 |
| 2 | Managerial incentives, CEO characteristics and corporate innovation in China’s private sector显示文摘 | Chen Lin Ping Lin Frank M. Song Chuntao Li | 2010 | Journal of Comparative Economics2010，，2： | 1 |
| 3 | Managerial incentives, CEO characteristics and corporate innovation in China’s private sector显示文摘 | Chen Lin Ping Lin Frank M. Song Chuntao Li | 2010 | Journal of Comparative Economics2010，，2： | 1 |
| 4 | Preoperative ultrasound combined with routine blood tests in predicting the malignant risk of pancreatic cystic neoplasms显示文摘Objective:Accurate preoperative identification of benign or malignant pancreatic cystic neoplasms(PCN)may help clinicians make better intervention choices and will be essential for individualized treatment.Methods:Preoperative ultrasound and laboratory examination findings,and demographic characteristics were collected from patients.Multiple logistic regression was used to identify independent risk factors associated with malignant PCN,which were then included in the nomogram and validated with an external cohort.The Net Reclassification Index(NRI)and Integrated Discrimination Improvement(IDI)were calculated to evaluate the improvement in the predictive power of the new model with respect to that of a combined imaging and tumor marker prediction model.Results:Malignant PCN were found in 83(40.7%)and 33(38.7%)of the model and validation cohorts,respectively.Multivariate analysis identified age,tumor location,imaging of tumor boundary,blood type,mean hemoglobin concentration,neutrophil-tolymphocyte ratio,carbohydrate antigen 19-9,and carcinoembryonic antigen as independent risk factors for malignant PCN.The calibration curve indicated that the predictions based on the nomogram were in excellent agreement with the actual observations.A nomogram score cutoff of 192.5 classified patients as having low vs.high risk of malignant PCN.The model achieved good C-statistics of 0.929(95%CI 0.890–0.968,P<0.05)and 0.951(95%CI 0.903–0.998,P<0.05)in predicting malignancy in the development and validation cohorts,respectively.NRI=0.268;IDI=0.271(P<0.001 for improvement).The DCA curve indicated that our model yielded greater clinical benefits than the comparator model.Conclusions:The nomogram showed excellent performance in predicting malignant PCN and may help surgeons select patients for detailed examination and surgery.The nomogram is freely available at https://wangjunjinnomogram.shinyapps.io/DynNomapp/. | Xiuchao Wang Junjin Wang Xi Wei Lihui Zhao Bo Ni Zekun Li Chuntao Gao Song Gao Tiansuo Zhao Jian Wang Weidong Ma Xiao Hu Jihui Hao | 2022 | Cancer Biology & Medicine2022，19，10： | 1 |
| 5 | Genotypic and Phenotypic Characterization of HIV-1 CRF01_AE env Molecular Clones From Infections in China显示文摘 | Jianhui Nie Chuntao Zhang Wei Liu Xueling Wu Feng Li Suting Wang Fuxiong Liang Aijing Song Youchun Wang | 2010 | JAIDS Journal of Acquired Immune Deficiency Syndromes2010，，4： | 1 |
| 6 | Big Data Based Mobile Terminal Performance Evaluation 显示文摘 | SONG CHUNTAO JIA YUWEI | 2015 | ICSINC2015，2015，12： | 1 |
| 7 | Nuclear PLD1 combined with NPM1 induces gemcitabine resistance through tumorigenic IL7R in pancreatic adenocarcinoma显示文摘Objective:Pancreatic ductal adenocarcinoma(PDAC)is a highly malignant gastrointestinal cancer with a 5-year survival rate of only 9%.Of PDAC patients,15%-20%are eligible for radical surgery.Gemcitabine is an important chemotherapeutic agent for patients with PDAC;however,the efficacy of gemcitabine is limited due to resistance.Therefore,reducing gemcitabine resistance is essential for improving survival of patients with PDAC.Identifying the key target that determines gemcitabine resistance in PDAC and reversing gemcitabine resistance using target inhibitors in combination with gemcitabine are crucial steps in the quest to improve survival prognosis in patients with PDAC.Methods:We constructed a human genome-wide CRISPRa/dCas 9 overexpression library in PDAC cell lines to screen key targets of drug resistance based on sgRNA abundance and enrichment.Then,co-IP,ChIP,ChIP-seq,transcriptome sequencing,and qPCR were used to determine the specific mechanism by which phospholipase D1(PLD1)confers resistance to gemcitabine.Results:PLD1 combines with nucleophosmin 1(NPM1)and triggers NPM1 nuclear translocation,where NPM1 acts as a transcription factor to upregulate interleukin 7 receptor(IL7R)expression.Upon interleukin 7(IL-7)binding,IL7R activates the JAK1/STAT5 signaling pathway to increase the expression of the anti-apoptotic protein,BCL-2,and induce gemcitabine resistance.The PLD1 inhibitor,Vu0155069,targets PLD1 to induce apoptosis in gemcitabine-resistant PDAC cells.Conclusions:PLD1 is an enzyme that has a critical role in PDAC-associated gemcitabine resistance through a non-enzymatic interaction with NPM1,further promoting the downstream JAK1/STAT5/Bcl-2 pathway.Inhibiting any of the participants of this pathway can increase gemcitabine sensitivity. | Danqi Fu Jingrui Yan Zhaoyu Zhang Yang Liu Xiaoqing Ma Jinsheng Ding Shengyu Yang Ran Zhao Antao Chang Chuntao Gao Jing Liu Tiansuo Zhao Xiuchao Wang Chongbiao Huang Song Gao Ying Ma Bo Tang Yukuan Feng Hongwei Wang Jihui Hao | 2023 | Cancer Biology & Medicine2023，20，8： | 0 |
| 8 | Effect of 5-hydroxytryptamine Receptor in the Lower Esophageal Sphincter Regulation Mechanism显示文摘As a neurotransmitter and avascular active substance,the 5-hydroxytryptamine(5-HT,serotonin)is widely distributed in the central nervous system and surrounding tissues.The 5-HT can play its role by acting on its corresponding 5-HT receptor.Nowadays,the 5-HT receptor can be classified into seven,according to different signal transduction method of receptors,the 5-HT3 receptor belongs to the ligandgated ion channels,while other six 5-HT receptors are involved into the G protein-coupled receptors and play the biological role by binding to specific G protein-coupled receptors(GPCRs)on the surface of the cell membrane.The 5-HT plays an important role in the brain-gut information transmission and studies showed that the physiological stimulations like having meals,and pathological stimulations like ischemia and stress could promote the release of the 5-HT.In the gastrointestinal tract,the 5-HT is closely related to gastrointestinal sensitivity,gastrointestinal movement and secretion regulation,as well as many gastrointestinal dysfunction disorders,such as gastrointestinal power and visceral sensitivity abnormality and abnormalities of brain-gut axis. | Hefei Li Junfeng Liu Xixuan Zhang Zhiwei Lai Zhen Gao Chuntao Song | 2019 | Proceedings of Anticancer Research2019，3，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员