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| 1 | Plasma and aqueous humor levels of adiponutrin and pannexin 1 in patients with and without diabetic retinopathy显示文摘AIM: To evaluate plasma and aqueous levels of adiponutrin and pannexin 1 in patients with and without diabetic retinopathy.METHODS: The study included three age and gendermatched groups of 20 cataract patients with no diabetes or additional disease(Group C), 20 cataract patients with diabetes and no retinopathy(Group DM+C), and 20 cataract patients with diabetic retinopathy(Group DR+C).All the patients were examined with respect to body mass index(BMI), fasting plasma glucose, hemoglobin A1c(HbA1c), and lipid profile.Phacoemulsification and intraocular lens(Phaco+IOL) implantation were performed to all patients in all the groups, and aqueous samples were taken during the operation.The plasma and aqueous adiponutrin and pannexin 1 levels were analyzed using enzyme-linked immunosorbent assays.RESULTS: A statistically significant difference was determined between the groups with respect to BMI, fasting plasma glucose, and HbA1c levels(P<0.05 for all parameters tested).The plasma adiponutrin levels of Group DR+C were statistically significantly lower than those of Group C and Group DM+C(P<0.001, P=0.004).No statistically significant difference was determined in the aqueous adiponutrin levels in three groups.The plasma pannexin 1 levels of Groups DM+C and DR+C were statistically significantly lower than those of Group C(both P=0.001).The aqueous pannexin 1 levels of Group DR+C were statistically significantly higher than those of Group C and Group DM+C(P=0.001, P<0.001).CONCLUSION: Adiponutrin and pannexin 1, which play an important role in the pathophysiology of diabetes and obesity, and have a regulatory role in hyperglycemia and insulin resistance.The measurement of adiponutrin and pannexin 1 levels may support clinicians in determining the risk of DR development. | Fatih Cem Gül Sabiha Güngör Kobat FatihÇelik Süleyman Aydin Ramazan Fazil Akkoç | 2022 | International Journal of Ophthalmology(English edition)2022，15，3： | 3 |
| 2 | The effect on wound healing of pazopanib and bevacizumab compared with corticosteroid in experimental glaucoma filtration surgery显示文摘AIM: To compare the effects of bevacizumab and pazopanib with corticosteroids on wound healing after trabeculectomy. METHODS: In the study, 35 New Zealand white rabbits were randomly divided into five groups. Apart from the first group, limbus-based trabeculectomy was performed for the eyes of rabbits. No postoperative treatment was administered for group Ⅰ. Topically administered saline, prednisolone acetate(1%), bevacizumab 5 mg/mL, pazopanib 5 mg/mL for group Ⅱ, Ⅲ, Ⅳ and Ⅴ respectively were applied for groups 6 h daily for 28 d. On day 28 of the experiment, eyes were enucleated and histologically and immunohistochemically analyzed.RESULTS: The fibroblast counts of groups Ⅳ and Ⅴ were determined to be lower than those of groups Ⅱ and Ⅲ(P<0.05). In the mononuclear cell(MNC) count evaluation, no statistically significant difference was determined between the treatment groups(P>0.05). The immunohistochemical staining intensity of fibroblast growth factor β(FGF-β) and vascular endothelial growth factor(VEGF) was determined to be lower in groups Ⅳ and Ⅴ than in groups Ⅱ and Ⅲ(P<0.05). No statistically significant difference was determined between groups Ⅳ and Ⅴ in respect of fibroblast count, MNC count, FGF-β and VEGF staining intensity(P>0.05). The platelet derived growth factor β(PDGF-β) intensity was lower in group Ⅴ than in groups Ⅱ, Ⅲ and Ⅳ(P<0.05). While the PDGF-β staining intensity was significantly lower in group Ⅳ thanin group Ⅱ, the difference compared with group Ⅲ was not statistically significant(P>0.05). CONCLUSION: Bevacizumab and pazopanib might be good alternatives of corticosteroid treatment on delaying wound healing in glaucoma surgery. | Sabiha Gungor Kobat Fatma Ulku Celiker Adile Ferda Dagli Kader Kasar | 2018 | International Journal of Ophthalmology(English edition)2018，11，12： | 2 |
| 3 | Seroprevalence of hepatitis B surface antigen in pregnant women attending antenatal clinic in Honiara Solomon Islands,2015显示文摘AIM To determine the seroprevalence of hepatitis B surface antigen(HBsAg) among pregnant women attending antenatal clinic in Honiara, Solomon Islands. METHODS This descriptive cross-sectional study was carried out in seven area health centers in Honiara. From March to June 2015, identification of eligible pregnant women in each site was conducted using systematic random sampling technique. A total of 243 pregnant women who gave written informed consent were enrolled. Standardized tool was used to record demographics, obstetric history and serology results. HBsAg and hepatitis B e antigen(HBeAg) were tested using point-of-care rapid diagnostic test. All HBsAg positive samples were verified using enzyme-linked immunosorbent assay. RESULTS The mean age of participants was 26 ± 6 years. The overall hepatitis HBsAg prevalence was 13.8% with higher rate(22%) reported in women between 30-34 years of age. Majority of HBsAg positive participants were Melanesians(29 out for 33). None of the pregnant women in the 15-19 years and ≥ 40 years tested positive for HBsAg. There was no statistically significant difference in HBsAg prevalence by age, ethnicity, education and residential location. The overall HBeAg seroprevalence was 36.7%. Women between 20-24 years of age had the highest rate of 54.5%. Low level of knowledge about hepatitis B vaccination was reputed. Overall, 54.6% of participants were not aware of their hepatitis B vaccination status and only 65.2% of mothers reported their child had been vaccinated. CONCLUSION Hepatitis B is a disease of public health importance in Solomon Islands and emphasize the need for integrated preventative interventions for its control. | Aneley Getahun Margaret Baekalia Nixon Panda Alice Lee Elliot Puiahi Sabiha Khan Donald Tahani Doris Manongi | 2016 | World Journal of Hepatology2016，8，34： | 2 |
| 4 | Genotoxicity of ferric oxide nanoparticles in Raphanus sativus:Deciphering the role of signaling factors,oxidative stress and cell death显示文摘We have studied the genotoxic and apoptotic potential of ferric oxide nanoparticles(Fe_2O_3-NPs) in Raphanus sativus(radish).Fe_2O_3-NPs retarded the root length and seed germination in radish.Ultrathin sections of treated roots showed subcellular localization of Fe_2O_3-NPs,along with the appearance of damaged mitochondria and excessive vacuolization.Flow cytometric analysis of Fe_2O_3-NPs(1.0 mg/m L) treated groups exhibited 219.5%,161%,120.4% and 161.4% increase in intracellular reactive oxygen species(ROS),mitochondrial membrane potential(ΔΨm),nitric oxide(NO) and Ca2+influx in radish protoplasts.A concentration dependent increase in the antioxidative enzymes glutathione(GSH),catalase(CAT),superoxide dismutase(SOD) and lipid peroxidation(LPO) has been recorded.Comet assay showed a concentration dependent increase in deoxyribonucleic acid(DNA) strand breaks in Fe_2O_3-NPs treated groups.Cell cycle analysis revealed 88.4% of cells in sub-G1 apoptotic phase,suggesting cell death in Fe_2O_3-NPs(2.0 mg/m L) treated group.Taking together,the genotoxicity induced by Fe_2O_3-NPs highlights the importance of environmental risk associated with improper disposal of nanoparticles(NPs) and radish can serve as a good indicator for measuring the phytotoxicity of NPs grown in NP-polluted environment. | Quaiser Saquib Mohammad Faisal Abdulrahman A.Alatar Abdulaziz A.Al-Khedhairy Mukhtar Ahmed Sabiha M.Ansari Hend A.Alwathnani Mohammad K.Okla Sourabh Dwivedi Javed Musarrat Shelly Praveen Shams T.Khan Rizwan Wahab Maqsood A.Siddiqui Javed Ahmad | 2016 | Journal of Environmental Sciences2016，28，9： | 2 |
| 5 | Vasculitis with renal involvement in essential mixed cryoglobulinemia:Case report and mini-review显示文摘The discovery of a strong association between hepatitis C virus(HCV) infection and mixed cryoglobulinemia(MC) has led to an increasingly rare diagnosis of idiopathic essential MC(EMC).The incidence of EMC is high in regions where there is a comparatively low HCV infection burden and low in areas of high infection prevalence,including HCV.The diagnosis of EMC requires an extensive laboratory investigation to exclude all possible causes of cryoglobulin formation.In addition,although cryoglobulin testing is simple,improper testing conditions will result in false negative results.Here,we present a 46-year-old female patient with a case of EMC with dermatological and renal manifestations,highlighting the importance of extensive investigation to reacha proper diagnosis.We review the need for appropriate laboratory testing,which is often neglected in clinical practice and which can result in false negative results.This review also emphasizes the significance of an extended testing repertoire necessary for better patient management.Despite a strong association of MC with HCV infection and other causes that lead to cryoglobulin formation,EMC remains a separate entity.Correct diagnosis requires proper temperature regulation during sample handling,as well as characterization and quantification of the cryoprecipitate.Inclusion of rheumatoid factor activity and complement levels in the cryoglobulin test-panel promotes better patient management and monitoring.Consensus guidelines should be developed and implemented for cryoglobulin detection and the diagnosis of cryoglobulinemic syndrome,which will reduce variability in inter-laboratory reporting. | Sabiha Anis Khawar Abbas Mohammad Mubarak Ejaz Ahmed Sajid Bhatti Rana Muzaffar | 2014 | World Journal of Clinical Cases2014，2，5： | 2 |
| 6 | Phytochemical screening and evaluation of cytotoxic and hypoglycemic properties of Mangifera indica peels显示文摘Objective: To investigate the presence of different phytoconstituents in Mangifera indica(M. indica) peel and evaluate its cytotoxicity to Artemia salina and hypoglycemic potential in Swiss albino mice.Methods: The methanolic extract of M. indica peel was used to determine the presence of phytoconstituents. Brine shrimp lethality bioassay method was followed to determine the cytotoxic potential of plant extract. In the case of hypoglycemic activity, oral administration of extract at 200 and 400 mg/kg and standard glibenclamide at 10 mg/kg was done, followed by determining the percentage of reduction of plasma glucose from the initial level.Results: The methanolic extract of M. indica peel showed the presence of flavonoid,saponin, steroid, tannins, terpenoids, glycosides and alkaloids. In brine shrimp lethality bioassay, the LC_(50) of the extract and standard vincristine sulfate was found to be 2.04 and0.41 mg/mL, respectively. After 90 and 150 min, the methanolic extract at 200 and 400 mg/kg showed prominent plasma glucose reduction of 13.95%, 22.48% and 14.16%,26.18% respectively compared to standard glibenclamide showing 14.90% and 20.67% plasma glucose reduction.Conclusions: This current research affirms prominent cytotoxic and moderate hypoglycemic potential of M. indica peel. Further bioactivity guided isolation of phytoconstituents and investigation on higher animals can lead to development of new drug molecules. | Sabiha Chowdhury Saikat Kumar Poddar Sarah Zaheen Farah Ashrafi Noor Najneen Ahmed Sanjana Haque Abhijit Sukul Sauda Binte Sunjida MdMahabob Ullah Mazumder Nusrat Akbar | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，1： | 2 |
| 7 | Bismuth based photoelectrodes for solar water splitting显示文摘Photoelectrochemical water splitting is a sustainable path to generate valuable hydrogen using sunlight and water as the only inputs.Despite significant efforts to date,it is still a challenge to achieve photoelectrode with superior performance and long-term stability.Many bismuth-based semiconductor materials have demonstrated excellent visible light harvesting capability and suitable band edge for water splitting.Herein,we summarized the latest studies conducted on bismuth-based photoelectrodes for photoelectrochemical water splitting.Specifically,photoelectrochemical properties of copper bismuth oxide(CuBi_(2)O_(4)),bismuth ferrites(BiFeO_(3),Bi_(2)Fe_(4)O_(9)),bismuth vanadate(BiVO_(4)),bismuth tungstate(Bi_(2)WO_(6)),bismuth molybdate(Bi_(2)MoO_(6))and bismuth oxyhalids(BiOX,X=I,Cl,Br)are presented.Strategies to achieve high stability and photolectrochemical performance were discussed in the aspects of nanostructure formation,heterostructure assembly,practical defect engineering,preferential facet growth and oxygen evolution catalyst incorporation. | Sabiha Akter Monny Zhiliang Wang Muxina Konarova Lianzhou Wang | 2021 | Journal of Energy Chemistry2021，30，10： | 1 |
| 8 | Seedling Growth of Cassia tora, Cassia occidentalis and Cassia sophera in Relation to Salinity and pH显示文摘 | Sabiha Sultana A.K.M. Nazrul Islam | 2015 | Journal of Agricultural Science and Technology(A)2015，5，7： | 1 |
| 9 | Contact Angle Measurements at the Colemanite and Realgar Surfaces 显示文摘 | Sabiha Koca Mehmet Savas | 2004 | Applied Surface Science2004，225，： | 1 |
| 10 | Bacterial contamination of computer keyboards in a teaching hospital 显示文摘 | Maureen Schuhz Janet Gill Sabiha Zubairi | 2003 | Infection Control and Hospital Epidemiology2003，24，4： | 1 |
| 11 | 基于过渡金属氧化物半导体上光电催化生产过氧化氢显示文摘作为一种有价值的化学品,过氧化氢广泛应用于工业领域.不仅如此,过氧化氢还具有比氢气更高的能量密度及优于传统化石燃料的环保优势,因此,其作为太阳能储能介质的应用也吸引了越来越多研究者的关注.传统蒽醌法生产过氧化氢存在需要贵金属催化剂、能耗大、碳排放高、过程繁琐、产物不纯、产生大量固液气废物等问题,因此,开发简便、环保、节能和安全的方法生产过氧化氢具有十分重要的意义.光电催化法结合了光催化和电催化方法的优势,可以有效提高能量转换效率并降低电能消耗,是具有潜力的生产过氧化氢新方法.同时,过渡金属氧化物半导体是光电催化法生产过氧化氢最有希望的催化剂材料.本综述简要介绍了光电催化法合成过氧化氢的基本原理,概述了光电催化反应合成过氧化氢的两种不同路径(水分子氧化和氧气还原)、相应的中间产物以及制备过氧化氢的三个主要过程(光吸收、光生电荷分离和表面反应),并总结了文献中各种测定过氧化氢浓度的方法.归纳了用于光电催化法生产过氧化氢的过渡金属氧化物半导体光电催化剂的最新进展,主要包括基于钒酸铋、二氧化钛、三氧化钨、氧化镍以及其他过渡金属氧化物的催化剂材料和反应体系,从理论计算和实验测定两个角度揭示了过渡金属氧化物催化剂材料在过氧化氢生产中的巨大潜力,总结了过渡金属氧化物的改性策略以进一步提高其活性和效率.本文还介绍了光电催化生产过氧化氢燃料电池的研究进展,展示了过氧化氢作为储存太阳能的可再生燃料的巨大潜力.最后,着重从催化剂光生电荷分离、活性位点、反应选择性、过氧化氢稳定性、电解质溶液和反应标准化测试六个方面讨论了光电催化法生产过氧化氢所面临的挑战和未来前景.综上,本文旨在为光电催化法生产可再生太阳能燃料过氧化氢提供启发. | 卢海娇 李显龙 Sabiha Akter Monny 王志亮 王连洲 | 2022 | Chinese Journal of Catalysis2022，43，5： | 1 |
| 12 | Weight gain associated with valproate in children显示文摘 | Sabiha A | 2000 | Pediatric neurologe2000，22，： | 1 |
| 13 | Tumor necrosis factor-α inhibits pre-osteoblast differentiation through its type- 1 receptor显示文摘 | Sabiha Abbas Yan-Hong Zhang John C | 2003 | 22(1-2) :33-412003，22，12： | 1 |
| 14 | Imaging of unusual diffuse lung diseases显示文摘 | Raoof Sabiha a Suhail b | 2004 | Current Opinion in Pulmonary Medicine2004，10，5： | 1 |
| 15 | Performance enhancement of a flat plate solar collector using titanium dioxide nanofluid and polyethylene glycol dispersant 显示文摘 | SAID Z SABIHA M SAIDUR R | 2015 | Journal of Cleaner Production2015，92，2015： | 1 |
| 16 | Numerical Study of Natural Convection in an Inclined Porous Cavity显示文摘Two-dimensional transient laminar natural convection in a square cavity containing a porous medium and inclined at an angle of 30°is investigated numerically.The vertical walls are differentially heated,and the horizontal walls are adiabatic.The effect of Rayleigh number on heat transfer and on the road to chaos is analyzed.The natural heat transfer and the Darcy Brinkman equations are solved by using a finite volume method and a Tri Diagonal Matrix Algorithm(TDMA).The results are obtained for a porosity equal to 0.45,a Darcy number and a Prandtl respectively equal to 10^(-3)and 0.71;they are analyzed in terms of streamlines,isotherms,phase portrait,attractors,and spectra amplitude as a function of the Rayleigh number.It is found that,as Rayleigh number increases,the natural convection changes from a steady state to a time-periodic state and finally to a chaotic condition. | Saad Adjal Sabiha Aklouche-Benouaguef Belkacem Zeghmati | 2022 | Fluid Dynamics & Materials Processing2022，18，5： | 1 |
| 17 | Dynamic Analysis of Train - bridge System and Riding Comfort of Trains with Rail Irregularities 显示文摘 | Youcef K Sabiha T El Mostafa D etc | 2013 | Journal of Mechanical Science and Technology2013，，4： | 1 |
| 18 | Early detection and classification of live bacteria using time-lapse coherent imaging and deep learning显示文摘Early identification of pathogenic bacteria in food,water,and bodily fluids is very important and yet challenging,owing to sample complexities and large sample volumes that need to be rapidly screened.Existing screening methods based on plate counting or molecular analysis present various tradeoffs with regard to the detection time,accuracy/sensitivity,cost,and sample preparation complexity.Here,we present a computational live bacteria detection system that periodically captures coherent microscopy images of bacterial growth inside a 60-mm-diameter agar plate and analyses these time-lapsed holograms using deep neural networks for the rapid detection of bacterial growth and the classification of the corresponding species.The performance of our system was demonstrated by the rapid detection of Escherichia coli and total coliform bacteria(i.e.,Klebsiella aerogenes and Klebsiella pneumoniae subsp.pneumoniae)in water samples,shortening the detection time by >12 h compared to the Environmental Protection Agency(EPA)-approved methods.Using the preincubation of samples in growth media,our system achieved a limit of detection(LOD)of ~1 colony forming unit(CFU)/L in≤9 h of total test time.This platform is highly cost-effective(~$0.6/test)and has high-throughput with a scanning speed of 24 cm2/min over the entire plate surface,making it highly suitable for integration with the existing methods currently used for bacteria detection on agar plates.Powered by deep learning,this automated and cost-effective live bacteria detection platform can be transformative for a wide range of applications in microbiology by significantly reducing the detection time and automating the identification of colonies without labelling or the need for an expert. | Hongda Wang Hatice Ceylan Koydemir Yunzhe Qiu Bijie Bai Yibo Zhang Yiyin Jin Sabiha Tok Enis Cagatay Yilmaz Esin Gumustekin Yair Rivenson Aydogan Ozcan | 2020 | Light(Science & Applications)2020，9，1： | 1 |
| 19 | The association of oxidative stress markers with conventional risk factors in the metabolic syndrome显示文摘 | Gulcan G. Korkmaz Esma Alt?noglu Sabiha Civelek Volkan Sozer Füsun Erdenen Omur Tabak Hafize Uzun | 2013 | Metabolism2013，，6： | 1 |
| 20 | Kinetic study of dowex 50 Wx8-catalyzed esterification and hydrolysis of benzyl acetate 显示文摘 | Sami H A Sabiha Q M | 2009 | Ind Eng Chem Res2009，48，： | 1 |
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