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| 1 | Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population显示文摘● AIM: To assess if the included vascular endothelial growth factor(VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus(T2DM).● METHODS: A case-control study was conducted in adult individuals with T2 DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2 DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study(ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by q PCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts.● RESULTS: In total 142 individuals were enrolled, 71 individuals with T2 DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021[OR(95% CI)=0.44(0.08-2.2); P=0.25] and rs2010963 [OR(95% CI)=0.63(0.25-1.6); P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r^2=0.1043, P≤0.0001; rs3025021 vs rs2010963: D'=0.442, r^2=0.0446, P=0.149; rs3025035 vs rs2010963: D'=0.505, r^2=0.0214, P=0.142.● CONCLUSION: This is the first analysis involving VEGFA polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations have different associations for the same polymorphisms. | Roberto Gonzalez-Salinas Maria C Garcia-Gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga Pablo Garcia-Solis David G Garcia-Gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 2 | Antimicrobial activity and phytochemical studies of some lichens from south of Spain显示文摘 | SAENZ M T GARCIA M D ROWE J G | 2006 | Fitoterapia2006，77，： | 1 |
| 3 | Mod- eling and control of a wind turbine driven doubly fed induction generator 显示文摘 | TAPIA A TAPIA G OSTOLAZA J X SAENZ J R | 2003 | IEEE Transactions on Energy Conversion2003，18，2： | 1 |
| 4 | 18S rRNA gene sequences and supraordinal classification of the Erysiphales显示文摘 | Saenz G S Taylor J W Gargas A | 1994 | Mycologia1994，86，： | 1 |
| 5 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 6 | Effects of tadalafil on erectile dysfunction in men with diabetes显示文摘 | Saenz de Tejada I Anglin G Knight JR | 2002 | Diabetes Care2002，25，12： | 1 |
| 7 | Safety and efficacy of colistin in Acinetobacter and Pseudomonas infections: a prospective cohort study 显示文摘 | Reina R Estenssoro E Saenz G | 2005 | Intensive Care Med2005，31，8： | 1 |
| 8 | 18s rRNA gene sequences and supraordinal classification of the Erysiphales显示文摘 | Saenz G S Taylor J W Gargas A | 1994 | Mycologia1994，86，： | 1 |
| 9 | Modeling and control of a wind turbine driven doubly fed induction generator显示文摘 | TAPIA A G OSTOLAZA J X Saenz J R | 2003 | IEEE ransactions on Energy Conversion2003，8，2： | 1 |
| 10 | Advanced nanovehicles for cancer management 显示文摘 | Saenz del Burgo L Pedraz JL Orive G | 2014 | Drug Discov Today2014，19，10： | 1 |
| 11 | Self-assembly of Spider Silk Proteins is Controlled by a pH-Sensitive Relay 显示文摘 | Askarieh G Nordling K Saenz A | 2010 | Nature2010，465，7295： | 1 |
| 12 | Susce - ptibility of Helicohacter pylori to mupirocin, oxazohdinones,quinupristin/dalfopristin and new quinolones 显示文摘 | SANCHZ J E SAENZ N G RINCON M R | 2000 | J Antimicrob Chemother2000，46，： | 1 |
| 13 | Cialis(TM) (IC351) asa treatment of erectile dysfunction in diabetic men 显示文摘 | Saenz TI Fredlund P Anglin G | 2001 | Diabetes2001，50，： | 1 |
| 14 | Analyzing the impact of renewable electricity support schemes on power prices:the case of wind electricity in Spain显示文摘 | Saenz de Miera G Del Rio G P Vizcaino I | | 0，，09： | 1 |
| 15 | Safety and efficacy of colistin in Acinetobacter and Pseudomonas infections: a prospective cohort study显示文摘 | Raeina R Estenssoro E Saenz G | 2005 | Intensive Care Med2005，31，8： | 1 |
| 16 | Modeling and Control of a Wind Turbine Driven Doubly Fed Induction Generator显示文摘 | Tapia A Tapia G Ostolaza J X Saenz J R | 2003 | IEEE Transactions on Energy Conversion2003，18，2： | 1 |
| 17 | The behaviour of second phase particles during anodizing of aluminium alloys显示文摘 | SAENZ DE MIERA M CURIONI M SKELDON P THOMPSON G E | 2010 | Corrosion Science2010，52，7： | 1 |
| 18 | Macroscopic and local filming behavior of AA2024 T3 aluminum alloy during anodizing in sulfuric acid electrolyte显示文摘 | CURIONI M SAENZ DE MIERA M SKELDON P THOMPSON G E FERGUSON J | 2008 | Journal of the Electrochemical Society2008，155，8： | 1 |
| 19 | Laparoscopic unilateral and bilateral adrenalectomy for Cushing's syndrome:transperitoneal and retroperitoneal approaches显示文摘 | Fernandez-Gruz L Saenz A Benarroch G | 1996 | Ann Surg1996，224，： | 1 |
| 20 | Antihistaminic and antieicosanoid effects of oleanolic and ursolic acid fraction from Helichrysum picardii 显示文摘 | Santos R C Garca G M D Saenz R M T | 2007 | Pharmazie2007，62，6： | 1 |
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