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| 1 | A pilot study of antioxidant potential of endophytic fungi from some Sudanese medicinal plants显示文摘Objective: To evaluate the total phenolic content and total antioxidant capacity of ethyl acetate extracts of 21 endophytic fungi isolated from five Sudanese medicinal plants: Calotropis procera, Catharanthus roseus, Euphorbia prostrate, Vernonia amygdalina and Trigonella foenumgraecum. Methods: Crude extracts of endophytic fungi and their host plants were tested by classical Folin-Ciocalteu colorimetric method to determine the total phenolic content, also total antioxidant capacity was estimated using 1,1-diphenyl-2-picrylhydrazyl free radical scavenging in vitro method. Results: Among the endophytes, endophytic fungus Aspergillus sp. from Trigonella foenum-graecum seeds demonstrated the highest both total phenolic content in term of gallic acid equivalent(GAE) [(89.9±7.1 mg GAE/g)] and antioxidant activity for 1,1-diphenyl-2-picrylhydrazyl radical scavenging assay [IC50:(18.0±0.1 μg/m L)]. A high positive linear correlation(R2=0.999 1) was found between total antioxidant capacity and total phenolic content of endophytic fungi isolated from Vernonia amygdalina. Conclusions: The present study revealed that some endophytic fungi from the five Sudanese medicinal plants could be a potential source of novel natural antioxidant compounds. | Afra Khiralla Ietidal Mohamed Justinne Thomas Beno t Mignard Rosella Spina Sakina Yagi Dominique Laurain-Mattar | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，9： | 9 |
| 2 | Pancreatic enzymes and abdominal adipose tissue distribution in new-onset prediabetes/diabetes after acute pancreatitis显示文摘BACKGROUND New-onset prediabetes/diabetes after acute pancreatitis(NODAP)is the most common sequela of pancreatitis,and it differs from type 2 prediabetes/diabetes mellitus(T2DM).AIM To study the associations between circulating levels of pancreatic amylase,pancreatic lipase,chymotrypsin and fat phenotypes in NODAP,T2DM,and health.METHODS Individuals with NODAP(n=30),T2DM(n=30),and sex-matched healthy individuals(n=30)were included.Five fat phenotypes(intra-pancreatic fat,liver fat,skeletal muscle fat,visceral fat,and subcutaneous fat)were determined using the same magnetic resonance imaging protocol and scanner magnet strength for all participants.One-way analysis of covariance,linear regression analysis,and relative importance analysis were conducted.RESULTS Intra-pancreatic fat deposition(IPFD)was higher in NODAP(9.4%±1.8%)and T2DM(9.8%±1.1%)compared with healthy controls(7.8%±1.9%)after adjusting for covariates(P=0.003).Similar findings were observed in regards to visceral fat volume(P=0.005),but not subcutaneous fat volume,liver fat,or skeletal muscle fat.Both IPFD(β=-2.201,P=0.023)and visceral fat volume(β=-0.004,P=0.028)were significantly associated with circulating levels of pancreatic amylase in NODAP,but not in T2DM or healthy individuals.Of the five fat phenotypes,IPFD explained the highest amount of variance in pancreatic amylase concentration(R2=15.3%out of 41.2%).None of the phenotypes contributed meaningfully to the variance in pancreatic lipase or chymotrypsin.CONCLUSION Both NODAP and T2DM are characterized by increased IPFD and visceral fat volume.However,only NODAP is characterized by significant inverse associations between the two fat phenotypes and pancreatic amylase. | Juyeon Ko Loren Skudder-Hill Jaelim Cho Sakina H Bharmal Maxim S Petrov | 2021 | World Journal of Gastroenterology2021，27，23： | 5 |
| 3 | Lipofuscins prepared by modification of photoreceptor cells via glycation or lipid peroxidation show the similar phototoxicity显示文摘AIM To investigate the effect of two ways of lipofuscin production(lipid peroxidation and glycation) on lipofuscin fluorescence characteristics and phototoxicity and to compare them with the properties of natural lipofuscin.METHODS Model lipofuscins were prepared on the basis of bovine photoreceptor outer segments(POS) with bisretinoid A2 E addition. One set of samples was prepared from POS modified by lipid peroxidation,while another set from POS modified by glycation with fructose. Fluorescent properties and kinetics of photoinduced superoxide generation of model lipofuscins and human retinal pigment epithelium(RPE) lipofuscin were compared. The fluorescence spectra of samples were measured at 365 nm excitation wavelength and 380-650 emission wavelength. RESULTS The fluorescence spectra of model lipofuscins are almost the same as the spectrum of natural lipofuscin. Visible light irradiation of both model lipofuscins and natural lipofuscin isolated from RPE cells leads to decrease of a fluorescence maximum at 550 nm and to appearance of a distinct,new maximum at 445-460 nm. The rate of photogeneration of reactive oxygen forms by both model lipofuscins was almost the same and approximately two times less than that of RPE lipofuscin granules.CONCLUSION These data suggest that fluorescent characteristics and phototoxicity of lipofuscin granules depend only to an insignificant degree on the oxidative modification of POS proteins and lipids,and generally are defined by the bisretinoid fluorophores contained in them. | Alexander Dontsov Anna Koromyslova Mikhail Ostrovsky Natalia Sakina | 2016 | World Journal of Experimental Medicine2016，6，4： | 3 |
| 4 | A framework for analysing supply chain performance evaluationmodels显示文摘 | Dominique Estampe Samir Lamouri Jean-Luc Paris Sakina Brahim-Djelloul | 2010 | International Journal of Production Economics2010，，11： | 1 |
| 5 | Use of Ethnomedicinal Plants by the People Living around Indus River显示文摘 | Sakina Mussarat Nasser M. AbdEl-Salam Akash Tariq Sultan Mehmood Wazir Riaz Ullah Muhammad Adnan John R. S. Tabuti | 2014 | Evidence-Based Complementary and Alternative Medicine2014，，： | 1 |
| 6 | Preliminary psychopharmacological evaluation of Ocimum sanctumleaf extract显示文摘 | Dandiya P C Hamdard M E | 1990 | Journal of Ethnopharmacology1990，28，： | 1 |
| 7 | A mathematical proof of physical optics equivalent edge currents based upon the path of most rap- id phase variation 显示文摘 | Cui S M Sakina K Ando M | 2000 | IEICE Transactions on Electronics2000，83，4： | 1 |
| 8 | Molecular pathway involved in the neurotoxicity of 6-OHDA,dopamine and MPTP:contribution to the apoptotic theory in Parkinsons disease显示文摘 | David B Sakina T Nathalie L | 2001 | Prog Neurobiol2001，65，： | 1 |
| 9 | A mathematical proof of physical optics equivalent edge currents based upon the path of most rapid phase variation 显示文摘 | Cui S M Sakina K Ando M | 2000 | IEICE Transactions on Electronics2000，83，4： | 1 |
| 10 | Frequency and associ- ated factors for care giving among elderly patients visiting a teaching hospital in Karachi,Pakistan显示文摘 | Qidwai W Abdul Rauf MU Sakina S etal | 2011 | Plos One2011，6，11： | 1 |
| 11 | Detection of Achromobacter xylosoxidans in Hospital, Domestic, and Outdoor Environmental Samples and Comparison with Human Clinical Isolates显示文摘 | Lucie Amoureux Julien Bador Sakina Fardeheb Cédric Mabille Charlyne Couchot Clémence Massip Anne-Lise Salignon Guillaume Berlie Véronique Varin Catherine Neuwirth | 2013 | Applied and Environmental Microbiology2013，，23： | 1 |
| 12 | Molecular pathways involved in the neurotoxieity of 6-OHDA, dopamine and MPTP :contribution to the apoptotic theory in Parkinson's disease 显示文摘 | David B Sakina T Nathalie L | 2001 | Prog Neurobiol2001，65，： | 1 |
| 13 | Behavior of Centrally Loaded Concrete Filled Steel Tube Short Columns显示文摘 | SAKINA K NAKAHARA H MORINO S | 2004 | Journal of Structural Engineering2004，13，2： | 1 |
| 14 | In-ternal auditory canal stenosis in congenital sensorineu-ral hearing loss显示文摘 | SAKINA M S GOH B S ABDULLAH A | 2006 | Int J Pediatr Otorhinolaryngol2006，70，： | 1 |
| 15 | 显示文摘 | Fiona Frehill Johannes G Vos Sakina Benrezzak | 2002 | JACS2002，124，13： | 1 |
| 16 | Molecular pathway involved in the neurotoxicity of 6 - OHDA, dopamine and MPTP: contribution to the ap- optotic theory in Parkinson 's disease 显示文摘 | David B Sakina T Nathalie L | 2001 | Prog Neurobiol2001，65，11： | 1 |
| 17 | Agomelatine in the treatment o{ maior depressive Disorder显示文摘 | Sidney H Kennedy Sakina J Rizvi | 2010 | CNS Drugs2010，24，6： | 1 |
| 18 | Study on the composition office bran oil and its higher free fatty acids value 显示文摘 | Gopala Krishna A G Hemakumar K H Sakina K | 2006 | Journal of American Oil Chemists Society2006，83，2： | 1 |
| 19 | Water degumming of rice bran oil:a response surface approach显示文摘 | T N Indira J Hemavathy Sakina Khatoon | 2000 | Journal of Food Engineering2000，43，2： | 1 |
| 20 | Pharmacokinetic characterization of mangosteen ( Garcinia mangostana ) fruit extract standardized to α-mangostin in C57BL/6 mice显示文摘 | Sakina M. Petiwala Gongbo Li Atulkumar Ramaiya Anoop Kumar Ravinder K. Gill Seema Saksena Jeremy J. Johnson | 2014 | Nutrition Research2014，，： | 1 |
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