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| 1 | Diagnostic evaluation of acute pancreatitis in two patients with hypertriglyceridemia显示文摘We present two diagnostically challenging cases of acute pancreatitis with hypertriglyceridemia accompanied with chylomicronemia caused with a deficiency of lipoprotein lipase and with the presence of type V hyperlipidemia.Both cases suffered from acute abdomen following the ingestion of fatty food and revealed the increase in parameters of inflammation without significant elevation of serum amylase levels. The imaging examination of ultrasonography could not detect significant findings of acute pancreatitis and a computer tomography scan eventually confirmed the findings of acute pancreatitis. Both cases responded to a low fat diet and administration of a cholecystokinin receptor antagonist, exhibiting a relief of abdominal symptoms. As in the present cases with acute abdomen following the ingestion of fatty food, the identification of serum hypertriglyceridemia and an abdominal computer tomography scan might be useful in establishing the diagnosis of acute pancreatitis and in developing the therapeutic regimen, when hypertriglyceridemia interferes with the evaluation of pancreatic enzyme activities and ultrasound examination provides poor pancreatic visualization. | Yoshifumi Okura KozoHayashi TetsujiShingu GoroKajiyama Yoshiyuki Nakashima Keijiro Saku | 2004 | World Journal of Gastroenterology2004，10，24： | 12 |
| 2 | Condyloma acuminatum of the anal canal,treated with endoscopic submucosal dissection显示文摘Condyloma acuminatum(CA) is a common sexually transmitted disease caused by human papilloma virus infection. Not all individuals develop persistent, progressive disease, but careful follow up is required with moderate-to-severe dysplasia to prevent progression to malignancy. Standard therapies include surgical treatments(trans-anal resection and transanal endoscopic microsurgery) and immunotherapeutic and topical methods(topical imiquimod); however, local recurrence remains a considerable problem. Here, we report a case with superficial CA of the anal canal, treated with endoscopic submucosal dissection(ESD). A 28-year-old man presented with a chief complaint of hematochezia. Digital exam did not detect a tumor. Screening colonoscopy revealed 10-mm long, whitish condyles extending from the anal canal to the lower rectum. The lesion covered almost the whole circumference, and only a small amount of normal mucosa remained. Magnifying endoscopy with narrow band imaging showed brownish hairpin-shaped, coiled capillaries. Although histopathological diagnosis by biopsy revealed CA, accurate histological differentiation between CA, papilloma, and squamous cell carcinoma can be difficult with a small specimen. Therefore, weperformed diagnostic ESD, which provides a complete specimen for precise histopathological evaluation. The pathological diagnosis was CA, with moderate dysplasia(anal intraepithelial neoplasia 2). There was no recurrence at 16 mo after the initial ESD. Compared to surgical treatment, endoscopic diagnosis and resection could be performed simultaneously and the tumor margin observed clearly with a magnifying chromocolonoscopy, resulting in less recurrence. These findings suggest that endoscopic resection may be an alternative method for CA that prevents recurrence. | Akiko Sasaki Takeshi Nakajima Hideto Egashira Kotaro Takeda Shinnosuke Tokoro Chikamasa Ichita Sakue Masuda Haruki Uojima Kazuya Koizumi Takeshi Kinbara Taku Sakamoto Yutaka Saito Makoto Kako | 2016 | World Journal of Gastroenterology2016，22，8： | 11 |
| 3 | High-density lipoprotein and atherosclerosis: Roles of lipid transporters显示文摘Various previous studies have found a negative cor-relation between the risk of cardiovascular events and serum high-density lipoprotein(HDL) cholesterol levels. The reverse cholesterol transport, a pathway of choles-terol from peripheral tissue to liver which has several potent antiatherogenic properties. For instance, the particles of HDL mediate to transport cholesterol from cells in arterial tissues, particularly from atherosclerotic plaques, to the liver. Both ATP-binding cassette trans-porters(ABC) A1 and ABCG1 are membrane cholesterol transporters and have been implicated in mediating cholesterol effluxes from cells in the presence of HDL and apolipoprotein A-I, a major protein constituent of HDL. Previous studies demonstrated that ABCA1 and ABCG1 or the interaction between ABCA1 and ABCG1 exerted antiatherosclerotic effects. As a therapeutic approach for increasing HDL cholesterol levels, much focus has been placed on increasing HDL cholesterol levels as well as enhancing HDL biochemical functions. HDL therapies that use injections of reconstituted HDL, apoA-I mimetics, or full-length apoA-I have shown dramatic effectiveness. In particular, a novel apoA-I mi-metic peptide, Fukuoka University ApoA-I Mimetic Pep-tide, effectively removes cholesterol via specific ABCA1 and other transporters, such as ABCG1, and has an an-tiatherosclerotic effect by enhancing the biological func-tions of HDL without changing circulating HDL choles-terol levels. Thus, HDL-targeting therapy has significant atheroprotective potential, as it uses lipid transporter-targeting agents, and may prove to be a therapeutic tool for atherosclerotic cardiovascular diseases. | Yoshinari Uehara Keijiro Saku | 2014 | World Journal of Cardiology2014，6，10： | 10 |
| 4 | Efficacy of combination therapy with natriuretic and aquaretic drugs in cirrhotic ascites patients: A randomized study显示文摘AIM To assess the effects of a combination therapy with natriuretic and aquaretic drugs in cirrhotic ascites patients.METHODS A two-center,randomized,open-label,prospective study was conducted. Japanese patients who met the criteria were randomized to trial group and the combination diuretic group(received 7.5 mg of tolvaptan) or the conventional diuretic group(received 40 mg of furosemide) for 7 d in addition to the natriuretic drug which was used prior to enrolment in this study. The primary endpoint was the change in body weight from the baseline. Vital signs,fluid intake,and laboratory and urinary data were assessed to determine the pharmacological effects after administration of aquaretic and natriuretic drugs.RESULTS A total of 56 patients were randomized to receive either tolvaptan(n = 28) or furosemide(n = 28). In the combination and conventional diuretic groups,the average decrease in body weight from the baseline was 3.21 ± 3.17 kg(P < 0.0001) and 1.75 ± 2.36 kg(P = 0.0006),respectively,when measured on the final dosing day. Following 1 wk of treatment,a significantly greater reduction in body weight was observed in the combination diuretic group compared to that in the conventional diuretic group(P = 0.0412).CONCLUSION Compared to a conventional diuretic therapy with only a natriuretic drug,a combination diuretic therapy with natriuretic and aquaretic drugs is more effective for patients with cirrhotic ascites. | Haruki Uojima Hisashi Hidaka Tsuyoshi Nakayama Ji Hyun Sung Chikamasa Ichita Shinnosuke Tokoro Sakue Masuda Akiko Sasaki Kazuya Koizumi Hideto Egashira Makoto Kako | 2017 | World Journal of Gastroenterology2017，23，45： | 2 |
| 5 | The HMG-CoA reductase inhibitor atorvastatin prevents atrial fibrillation by inhibiting inflammation in a canine sterile pericarditis model显示文摘 | Kumagai K Nakashima H Saku K | 2004 | Cardiovasc Res2004，62，1： | 1 |
| 6 | A feasible method for fractional snow cover mapping in boreal zone based on a reflectance model显示文摘 | SARI J Mets(a)m(a)ki SAKU T Anttila HUTTUNEN J Markus 2005 | 2005 | Remote Sensing of Environment2005，95，： | 1 |
| 7 | The HMG2CoA reduetase inhibitor atorvastatin prevents atrial fibrillation by inhibiting inflammation in a canine sterile pericarditismodel 显示文摘 | Kumagai K Nakashima H Saku K | 2004 | Cadiovasc Res2004，62，1： | 1 |
| 8 | Deposition af oxidized low-&nsity lipoprotein and collagenosis occur coincidentally in human coronary stenosis :an immunohistochemical study of atherectomy 显示文摘 | Jir6 S Saku K Kusaba H | 1998 | Coron Artery Dis1998，9，9： | 1 |
| 9 | The HMG-COA reductase inhibitor atorvastatin revents atrial fibrillation by inhibiting inflammation in a canine sterile eriearditis model显示文摘 | Kumagai K Nakashima H Saku K | 2004 | Cardiovasc Res2004，62，1： | 1 |
| 10 | Transactivation of KDR/Flk-1 by the B2 receptor induces tube formation in hu-man coronary endothelial cells 显示文摘 | Miura S Matsuo Y Saku K | 2003 | Hypertension2003，41，： | 1 |
| 11 | Synthetic studies on selective adenosine A2a receptor antagonists:synthesis and structure-activity relationships of novel benzofnran derivatives 显示文摘 | Saku O Saki M Kurokawa M | 2010 | Bioorganic and Medicinal Chemistry Letters2010，20，3： | 1 |
| 12 | High-density iipoprotein and apolipoprotein A-I deficiency induced by combination therapy with probueol and bezafibrate显示文摘 | Saku K Zhang B Jimi S | 1995 | Eur J Clin Pharmacol1995，48，34： | 1 |
| 13 | Insulin resistance and angiographical characteristics of coronary atherosclerosis显示文摘 | Takezako T Saku K Zhang B | | 0，，： | 1 |
| 14 | Crossed cerebellar hy- poperfusion in hyperacute ischemic stroke显示文摘 | Kamouchi M Fu)ishima M Saku Y | 2004 | J Neurol Sci2004，225，12： | 1 |
| 15 | Levela of soluble adhesion molecules in patiems with angiographically defined coronary atherosclerosis显示文摘 | Saku K Zhang B | 1999 | Jpn Ciec J1999，63，1： | 1 |
| 16 | The HMG-CoA reductase inhibitor atorvaatatin prevents atrial fibrillation by inhibiting inflammation in a canine sterile pericarditis model显示文摘 | Kumagai K Nakashima H Saku K | 2004 | Cardiovasc Res2004，62，1： | 1 |
| 17 | Constitutively active homooligomeric angiotensin II type 2 receptor induces cell signaling independent of receptor conformation and ligand stimulation 显示文摘 | Miura S Karnik S S Saku K | 2005 | J Biol Chem2005，280，18： | 1 |
| 18 | The HMG-CoA reductase inhibitor atorvastatinprevents atrial fibrillation by inhibiting infammation in a canine sterile sterile pericarditis model显示文摘 | Kumagai K Nakasshima H Saku K | 2004 | Cardiovasc Res2004，62，1： | 1 |
| 19 | HDL-associated factors provide additional prognostic information for coronary artery disease as determined by multi-detector row computed tomography显示文摘 | Ryoko Mitsutake Shin-ichiro Miura Bo Zhang Keijiro Saku | 2009 | International Journal of Cardiology2009，，1： | 1 |
| 20 | Randomized head-to-head comparison of pitavastatin,atorvastatin,and rosuvastatin for safety and efficacy(quantity and quality of LDL):the PATROL显示文摘 | Saku K Zhang B Noda K | | 0，，： | 1 |
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