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| 1 | Polychlorinatedbiphenyls (PCBs)in the British environment:Sinks,sources and temporal trends显示文摘 | Harrad S J Sewart A P Alcock R Boumphrey R Burnett V Davidson R D Halsall C Sanders G Waterhouse K | 1994 | Environmental Pollution1994，85，： | 1 |
| 2 | Clavulanate induces expression of the Pseudomonas aerugintosa AmpC cephalosporinase at phiologically relevant concentrations and antagonizes the antibacterial activity of ticarcillin显示文摘 | Gardner V M Sanders C C | 1999 | Antimicrob agents chemother1999，43，4： | 1 |
| 3 | A humic acid improves growth of tomato seedling in solution culture显示文摘 | David P P Nelson P V Sanders D C | 1994 | J Plant Nutr1994，17，1： | 1 |
| 4 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 5 | CD4 + T, but not CD8 + or B, lymphocytes mediate facial motoneuron strrvival after facial nerve transaction显示文摘 | Serpe C J Coers S Sanders V M | 2003 | Brain Behav Immun2003，17，5： | 1 |
| 6 | Sand culture of vegetables using recirculated aquacultural effluents显示文摘 | McMurtry M R Nelson P V Sanders D C | 1990 | Applied-agricultural-research1990，5，4： | 1 |
| 7 | Resource use efficiency and environmental performance of nine major biofuel crops,processed by first-generation conversion techniques显示文摘 | Sander C V Gerrie W J Martin K I | 2010 | Biomass and Bioenergy2010，34，5： | 1 |
| 8 | Sand culture of vegetables using recirculated aquacultural effluents显示文摘 | McMurtry M R Nelson P V Sanders D C | 1990 | Applied agricultural research1990，5，4： | 1 |
| 9 | Morphology and activity of MoS2 on various supports: Genesis of the active phase显示文摘 | Partt K C Sanders J V Christov V | 1990 | J Catal1990，124，： | 1 |
| 10 | Laughing out loud:control for modeling anatomically inspired laughter using audio显示文摘 | DILORENZO P C ZORDAN V B SANDERS B L | | 0，，05： | 1 |
| 11 | A humic acid improves growth of tomato seedling in solution culture显示文摘 | David P P Nelson P V Sanders D C | 1994 | J Plant Nutr1994，17，1： | 1 |
| 12 | Clavulanate induces expression of the Pseudomonas aeruginosa AmpC cephalosporinase at phiologically rele-vant concentrations and antago-nizes the antibacterial activity of ticarci-llin显示文摘 | Lister P D Gardner V M Sanders C C | 1999 | Antimicrob Agents and Chemother1999，43，4： | 1 |
| 13 | Achieving cultural appropri- ateness in health promotion programs: targeted and tai- lored approaches 显示文摘 | Kreuter M W Lukwago S N Bucholtz D C Clark E M Sanders -Thompson V | 2003 | Health Education and Behavior2003，30，2： | 1 |
| 14 | Morphology and activity of MoS2 on various supports:Genesis of the active phase显示文摘 | PRATT K C SANDERS J V CHRISTOV V | 1990 | J Catal1990，124，2： | 1 |
| 15 | Stress -inducedsuppression of in vivo splenic cytokine production in the ratby neural and hormonal mechanisms显示文摘 | Meltzer J C MacNeil B J Sanders V | 2004 | Brain Behavior and Immunity2004，18，3： | 1 |
| 16 | Unusual manifestations of invasive pneumococcal infection显示文摘 | TAYLOR S N SANDERS C V | 1999 | Am J Med1999，107，1： | 1 |
| 17 | Increased interleukin45 after cardiac surgery predicts infection 显示文摘 | Sander M von-Heymann C von-Dossow V | 2006 | Anesth Analg2006，102，6： | 1 |
| 18 | The genome of Laccaria bicolor provides insights into mycorrhizal symbiosis 显示文摘 | Martin F Aerts A Ahrén D Brun A Danchin EGJ Duchaussoy F Gibon J Kohler A Lindquist E Pereda V Salamov A Shapiro HJ Wuyts J Blaudez D Buée M Brokstein P Canb?ck B Cohen D Courty PE Coutinho PM Delaruelle C Detter JC Deveau A Difazio S Duplessis S Fraissinet-Tachet L Lucic E Frey-Klett P Fourrey C Feussner I Gay G Grimwood J Hoegger PJ Jain P Kilaru S Labbé J Lin YC Legué V Le Tacon F Marmeisse R Melayah D Montanini B Muratet M Nehls U Niculita-Hirzel H Secq MPOudot-Le Peter M Quesneville H Rajashekar B Reich M Rouhier N Schmutz J Yin T Chalot M Henrissat B Kües U Lucas S van de Peer Y Podila GK Polle A Pukkila PJ Richardson PM Rouzé P Sanders IR Stajich JE Tunlid A Tuskan G Grigoriev IV | 2008 | Nature2008，452，： | 1 |
| 19 | EGRET excess of diffuse galactic gamma rays as tracer of dark matter 显示文摘 | DE BOER W SANDER C ZHUKOV V | 2005 | Astronomy and Astrophysics2005，44，45： | 1 |
| 20 | Mortality associated with administration of high - dose tranexamic acid and aprotinin in primary open -heart procedures:a retrospective analysis 显示文摘 | SANDER M SPIES C D MARTINY V | 2010 | Crit Care2010，14，4： | 1 |
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