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| 1 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 2 | Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn’s disease: an open randomised trial显示文摘 | Geert D’Haens Filip Baert Gert van Assche Philip Caenepeel Philippe Vergauwe Hans Tuynman Martine De Vos Sander van Deventer Larry Stitt Allan Donner Severine Vermeire Frank J Van De Mierop Jean-Charles R Coche Janneke van der Woude Thomas Ochsenkühn Ad A | 2008 | The Lancet2008，，9613： | 5 |
| 3 | 阿尔茨海默病患者脑血流的动态调节显示文摘脑自动调节和压力反射敏感性是维持脑血流量的关键机制。该研究评估了这些调控机制在阿尔茨海默病导致的痴呆和轻度认知障碍患者中是否受到影响,因为这会增加降压治疗的风险。 | 刘青 叶鹏 de Heus RAA de Jong DLK Sanders ML van Spijker GJ Oudegeest-Sander MH Hopman MT Lawlor BA Olde Rikkert MGM Claassen JAHR | 2018 | 中华高血压杂志2018，26，8： | 4 |
| 4 | Enteric neuropathology of congenital intestinal obstruction:A case report显示文摘试验性的证据显示肠的长期的机械亚吸藏可以损坏伤寒神经系统(ENS ) ,尽管在人的数据正在缺乏。我们这里描述伤寒的第一诉讼与内脏的先天的阻塞有关的退化神经病。3 年的 A 和老女孩开始抱怨了呕吐的 9 瞬间,腹的扩张,有空气液体的便秘在飞机铺平腹的辐射学。她的随后的病历被 3 操作描绘:首先显示出的扩大 duodeno-jejunal 当闭塞的损害不在时循环;第二(2 年以后) 被执行获得扩大的肠的环的完整厚度的活体检视并且在组织病理学说揭示了 hyperganglionosis;第三(在 hyperganglionosis 以后的 9 年被识别) 揭示了 Ladd 被移开的乐队,联系内脏旋转不良被改正。完整厚度的活体检视显示出的重复 intraoperative 与 Cajal 的减少的空隙的房间一起的退化神经病在 Ladd 的乐队下面在阻塞和正常的神经与肌的层上面在扩大的环联网的伤寒。病人容忍了的在最近的外科以后的一年口头的喂并且很好,建议那先天(部分) 在人的小肠的机械阻塞能唤起类似于在肠的机械吸藏的动物模型发现的那些的 ENS 的进步适应变化。如此的 ENS 变化模仿在肠的伪阻塞观察的神经元畸形。 | Giovanni Di Nardo Vincenzo Stanghellini Salvatore Cucchiara Giovanni Barbara Gianandrea Pasquinelli Donatella Santini Cristina Felicani Gianluca Grazi Antonio D Pinna Rosanna Cogliandro Cesare Cremon Alessandra Gori Roberto Corinaldesi Kenton M Sanders Roberto De Giorgio | 2006 | World Journal of Gastroenterology2006，12，32： | 4 |
| 5 | Changes in the global value of ecosystem services显示文摘 | Robert Costanza Rudolf de Groot Paul Sutton Sander van der Ploeg Sharolyn J. Anderson Ida Kubiszewski Stephen Farber R. Kerry Turner | 2014 | Global Environmental Change2014，，： | 2 |
| 6 | Immunity:研究开发出最优的HIV疫苗递送模式显示文摘HIV已不再占据头条新闻。这主要是因为抗逆转录病毒药物的成功开发已将HIV病毒感染导致的艾滋病(AIDS)转化为一种慢性的可控制的疾病。然而。当前在全世界大约0.367亿名HIV感染者中,仅约一半的人能够获得控制这种病毒所需的药物。与此同时。新的HIV感染率持续保持在非常高的水平,这突出强调了需要开发一种预防性疫苗。然而,几十年来。 | Matthias Pauthner Colin Havenar-Daughton Devin Sok Joseph P. Nkolola Raiza Bastidas Archana V. Boopathy Diane G. Carnathan Abishek Chandrashekar Kimberly M. Cirelli Christopher A. Cottrell Alexey M. Eroshkin Javier Guenaga Kirti Kaushik Daniel W. Kulp Jinyan Liu Laura E. McCoy Aaron L. Oom Gabriel Ozorowski Kai W. Post Shailendra K. Sharma Jon M. Steichen Steven W. de Taeye Talar Tokatlian Alba Torrents de la Peña Salvatore T. Butera Celia C. LaBranche David C. Montefiori Guido Silvestri Ian A. Wilson Darrell J. Irvine Rogier W. Sanders William R. Schief Andrew B. Ward Richard T. Wyatt Dan H. Barouch Shane Crotty Dennis R. Burton | 2017 | 现代生物医学进展2017，17，27： | 2 |
| 7 | Functional Dyspepsia: Not All Roads Seem to Lead to Rome显示文摘 | Lieke A. S. van Kerkhoven Robert J. F. Laheij Villy Meineche-Schmidt Sander J. Veldhuyzen-van Zanten Niek J. de Wit Jan B. M. J. Jansen | 2009 | Journal of Clinical Gastroenterology2009，，2： | 1 |
| 8 | High prevalence of diabetes and intermediate hyperglycemia - The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)显示文摘 | Schmidt MI Hoffmann JF de F6tima Sander Diniz M | 2014 | Diabetol Metab Syndr2014，，6： | 1 |
| 9 | Contribution of the multidrug efflux pump LfrA to innate mycobacterial drug resistance显示文摘 | Sander P De Rossi E Boddinghaus B | 2000 | FEMS Microbiology Letters2000，193，： | 1 |
| 10 | The industry employabil- ity index : Taking account of supply and demand character- istics显示文摘 | De Grip A Van Loo J Sanders J | 2004 | International Labour Review2004，143，3： | 1 |
| 11 | pathophysiology of teth- ered cord syndrome 显示文摘 | Yamada S Zinke DE Sanders D | 1981 | J Neurosurg1981，54，： | 1 |
| 12 | Pathophysiology of tethered cord syndrome显示文摘 | Yanatda S Zinke DE Sanders D | 1981 | J Neurosurg1981，54，： | 1 |
| 13 | Effects of environmental anoxia and different periods of reoxygenation on oxidative balance in gills of the estuarine crab Chasmagnathus granulata显示文摘 | Ubirajara O. de Oliveira Alex Sander da Rosa Araújo Adriane Belló-Klein Roselis S.M. da Silva Luiz Carlos Kucharski | 2004 | Comparative Biochemistry and Physiology Part B2004，，1： | 1 |
| 14 | CXCR4 knockdown by small interfering RNA abrogates breast tumor growth in vivo 显示文摘 | Lapteva N Yang AG Sanders DE | 2005 | Cancer Gene Ther2005，12，1： | 1 |
| 15 | Plasmapheresis rescue therapy in progressive systemic ANCA- associated vasculitis: single -center results of stepwise escalation of immunosuppression显示文摘 | de Joode AA Sanders JS Staid WM | 2014 | J Clin Apher2014，29，5： | 1 |
| 16 | The long-term outcome of adult epilepsy surgery, patterns of seizure remission, and relapse: a cohort study显示文摘 | Jane de Tisi Gail S Bell Janet L Peacock Andrew W McEvoy William FJ Harkness Josemir W Sander John S Duncan | 2011 | The Lancet2011，，9800： | 1 |
| 17 | Paroxysmal Lone Atrial Fibrillation Is Associated With an Abnormal Atrial Substrate显示文摘 | Martin K. Stiles Bobby John Christopher X. Wong Pawel Kuklik Anthony G. Brooks Dennis H. Lau Hany Dimitri Kurt C. Roberts-Thomson Lauren Wilson Paolo De Sciscio Glenn D. Young Prashanthan Sanders | 2009 | Journal of the American College of Cardiology2009，，： | 1 |
| 18 | Quantum encodings in spin systems and harmonic oseillators显示文摘 | Bartlett S D de Guise H Sanders J B C | 2002 | Phys Rev Lett2002，65，05： | 1 |
| 19 | Release mechanisms for polyeleetrolyte capsules 显示文摘 | De Geest B G Sanders N N Sukhorukov G B Demeestera J De Smedt S C | 2007 | Chem Soc Rev2007，36，： | 1 |
| 20 | Pulmonary atelectasis and other respiratory complications after cardiopulmonary bypass and investigation of aetiological factors显示文摘 | Gale GD Teasdale SJ Sanders DE | 1979 | Can Anaesth Soc J1979，26，： | 1 |
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