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| 1 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 2 | The cultural shaping of depression:Somatic symptoms in China,psychological symptoms in north American显示文摘 | Ryder AG Yang J Zhu XZ | | 0，，02： | 1 |
| 3 | CXCR4 knockdown by small interfering RNA abrogates breast tumor growth in vivo显示文摘 | Lapteva N Yang AG Strube RW et aI | 2005 | Cancer Gene Ther2005，12，1： | 1 |
| 4 | Corretation among the dysphonia severity index (DSI), the RBH voice perceptual evaluation, and minimum glottal area in female patients with vocal fold nodules 显示文摘 | Hussein Gaber AG Liang FY Yang JS et at | 2014 | Journal of Voice2014，28，1： | 1 |
| 5 | Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells显示文摘 | Luis AG Yang CC Zhao TL | 2011 | J Clin Invest2011，121，2： | 1 |
| 6 | Familial risk of lung cancer among nonsmokers and their relatives 显示文摘 | Schwartz AG Yang P Swanson GM | 1996 | Am J Epidemiol1996，144，： | 1 |
| 7 | Long-term visual outcomes of laser- treated threshold retinopathy of prematurity: a study of refractive status at 7 years显示文摘 | Yang CS Wang AG Sung CS | 2010 | Eye (Lond)2010，24，1： | 1 |
| 8 | Gene alteration of intestinal intraepithelial lymphocytes in response to massive small bowel resection显示文摘 | Wildhaber BE Yang H Coran AG | 2003 | Pediatr Surg Int2003，19，： | 1 |
| 9 | Alpha4 integrins regulate the proliferation/differentiation balance of multi- lineage hematopoietic progenitors in vivo显示文摘 | Arroyo AG Yang JT Rayburn H | 1999 | Immunity1999，11，5： | 1 |
| 10 | Hyperactivation of p21ras and PI3K cooperate to alter murine and human neu- rofibromatosis type 1 -haploinsufficient osteoclast functions 显示文摘 | Yang FC Chen S Robling AG | 2006 | J Clin Invest2006，116，11： | 1 |
| 11 | A combination of iron and retinolsupplementation benefits iron status,IL-2 level and lymphocyteproliferation in anemic pregnant women显示文摘 | Sun YY Ma AG Yang F | 2010 | Asia Pac J Clin Nutr2010，19，4： | 1 |
| 12 | Chemokines MCP-1 and RANTES in isolated rat pancreatic acinar cells treated with CCK and ethanol in vitro显示文摘 | YANG BM DEMAINE AG KINGSNORTH A | 2000 | Pancreas2000，21，1： | 1 |
| 13 | The struc- tural basis for homotropic and heterotropic cooper- ativity of midazolam metabolism by human cyto- chrome P450 3A4 显示文摘 | Roberts AG Yang J Halpert JR | 2011 | Biochemistry2011，50，10： | 1 |
| 14 | Potent antitumour activity of a new class of turnout-specific killer cells显示文摘 | Chen SY Yang AG Chen JD | 1997 | Nature1997，385，： | 1 |
| 15 | Potent antitumour activity of a new class of tumour-specific killer cells显示文摘 | Chen SY Yang AG Chen JD | 1997 | Nature1997，385，2： | 1 |
| 16 | CXCR4 knockdown by small interfering RNA abrogates breast tumor growth in vivo 显示文摘 | Lapteva N Yang AG Sanders DE | 2005 | Cancer Gene Ther2005，12，1： | 1 |
| 17 | Plasmacytoid dendritic cells mediate the regulation of inflammatory type T cell response for optimal immunity against respiratory Chlamydia pneumoniae infection显示文摘 | Joyee AG Yang X | 2013 | PLo S One2013，8，83： | 1 |
| 18 | Cancer gene therapy targe- ting cellular apoptosis machinery 显示文摘 | Jia LT Chert SY Yang AG | 2012 | Cancer Treat Rev2012，38，7： | 1 |
| 19 | Transforming growth factor-beta signaling in prostate stromal cells supports prostate carcinoma growth by up-regulating stromal genes related to tissue remodeling 显示文摘 | Verona EV Elkahloun AG Yang J | 2007 | Cancer Res2007，67，12： | 1 |
| 20 | Exploring off-targets and off-systems for adverse drug reactions via chemical-protein interactome-clozapine-induced agranulocytosis as a case study显示文摘 | Yang L Wang K Chen J Jegga AG Luo H Shi L | | 0，，03： | 1 |
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