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| 1 | Overall expression of beta-catenin outperforms its nuclear accumulation in predicting outcomes of colorectal cancers显示文摘AIM: To examine the expression of beta-catenin in colorectal cancer and look for association with other clinico-pathological parameters. METHODS: Tumor samples from 163 cases of colorectal cancer (CRC) who had undergone primary colectomy between May,1998 and November,2002 with complete follow-up data for either 5 years or until death were recruited for a beta-catenin immunohistochemical study. The percentage of immunoreacted tumor cells was defined as overall staining density (OSD) and percentage of cells having nuclear localization was counted as nuclear staining density (NSD). Univariate exploration used log-rank test and multivariate survival analysis used Cox's hazard regression model. RESULTS: Beta-catenin immunoreactivity was detected in 161 samples (98.8%),of which 131 cases had nuclear staining. High OSD (≥ 75%),detected in 123 cases (75.5%),was significantly associated with earlier clinical staging (P < 0.01),lower nodal status (P = 0.02),non-metastatic status (P < 0.01) and better differentiation (P = 0.02). Multivariate analysis found that high OSD was independently associated with better survival [Cox's hazard ratio 0.51,95% confidence interval (CI) 0.31-0.83]. Although high NSD (≥ 75%) was correlated with high pre-operative serum CEA (P = 0.03),well differentiation (P < 0.01),and increased staining intensity (P < 0.01),the parameter was not significantly associated with survival. CONCLUSION: Unlike previous reports,the study did not find a predictive value of nuclear beta-catenin in CRC. Instead,the overall expression of beta-catenin in CRC showed an association with better differentiation and earlier staging. Moreover,the parameter also independently predicted superior survival. | Worrawit Wanitsuwan Samornmas Kanngurn Teeranut Boonpipattanapong Rassamee Sangthong Surasak Sangkhathat | 2008 | World Journal of Gastroenterology2008，14，39： | 10 |
| 2 | Whole body imaging in blunt rnultisystern trauma patients without obvious signs of injury: results of a prospective study显示文摘 | Salim A Sangthong B Martin M el al | 2006 | Arch Surg2006，141，5： | 1 |
| 3 | Universal screening of gesta-tional diabetes mellitus:prevalence and diagnostic value of clinicalrisk factors显示文摘 | Arora D Arora R Sangthong S | 2013 | J Med Assoc Thai2013，96，3： | 1 |
| 4 | Whole body imaging inblunt multisystem trauma patients without obvious signs of injury :results of a prospective study显示文摘 | Salim A Sangthong B Martin M | 2006 | Arch Sui^2006，141，5： | 1 |
| 5 | Development of quality indicators for sterilization practices of the cen-tral sterile supply department显示文摘 | Sangthong K Soparat P Moongtui W | 2005 | J Med Assoc Thai2005，8810，： | 1 |
| 6 | Universal screening of gestational diabetes mellitus:prevalence and diagnostic value of clinical risk factors显示文摘 | Arora D Arora R Sangthong S | 2013 | J Med Assoc Thai2013，96，3： | 1 |
| 7 | Workplace violence directed at nursing staff at a general hospital in southern Thailand显示文摘 | Kamchuchat C Chongsuvivatwong V 0ncheunjit S Yip TW Sangthong R | 2008 | J Occup Health2008，50，2： | 1 |
| 8 | Multiple substance use among heroin - dependent patients before and during attend- ance at methadone maintenance treatment program, Yunnan, China 显示文摘 | Li L Sangthong R Chongsuvivatwong V | 2011 | Drug Alcohol Depend2011，29，10： | 1 |
| 9 | Results of Gastric Pull-up Reconstruction for Pharyngolaryngo-oesophagectomy in Advanced Head and Neck Cancer and Cervical Oesophageal Squamous Cell Carcinoma显示文摘 | Puttisak Puttawibul Chuchart Pornpatanarak Burapat Sangthong Teeranut Boonpipattanapong | 2004 | Asian Journal of Surgery2004，，3： | 1 |
| 10 | Mechanical property improvement of unsatu-rated polyester composite reinforced with admicellar-treatedsisal fibers显示文摘 | SUPRANEE Sangthong THIRAWUDH Pongprayoon NAN-TAYA Yanumet | 2009 | Composites Part A2009，40，： | 1 |
| 11 | Effect of gamma - irradiation frozen shrimps for decontamination of pathogenic bacteria 显示文摘 | Hitoshi Ito Harun Or Rashid Naruemon Sangthong Takasaki | 2002 | Radiation Chemistry Research Establelishment2002，28，8： | 1 |
| 12 | 显示文摘 | Supranee Sangthong Thirawudh Pongprayoon | 2009 | Compos ites:Part A2009，40，： | 1 |
| 13 | Characteristics of the tetraploid plant derived as a so-maclonal variation in Lilium longiflorum 显示文摘 | Sangthong R Mii M Soonthornchainaksaeng P | 2005 | Acta Horticulturae2005，673，： | 1 |
| 14 | Whole body imaging in blunt multisystem trauma patients without obvious signs of injury:resuits of a prospective study显示文摘 | Salim A Sangthong B Martin M | 2006 | Arch Surg2006，141，： | 1 |
| 15 | Universal screening of gestational diabetes mellitus:prevalence and diagnostic value of clinical risk factors显示文摘 | Arora D Arora R Sangthong S | 2013 | J Med Assoc Thai2013，96，3： | 1 |
| 16 | Whole body imagine in blunt multisystem trauma patients without obvious signs of injury results of a prospective study显示文摘 | Slim A Sangthong B Marin M | 2006 | Arch Surg2006，141，5： | 1 |
| 17 | Whole body imaging in blunt multisystem trauma patients without obvious signs of injury: results of a prospective study 显示文摘 | Salim A Sangthong B Martin M | 2006 | Arch Surg2006，141，5： | 1 |
| 18 | Whole body imaging in blunt multisystem trauma patients without obvious signs of injury: results of a prospective study 显示文摘 | Salim A Sangthong B Martin M | 2006 | Arch Surg2006，141，5： | 1 |
| 19 | Use of computed tomography in anterior abdominal stab wounds: results of a prospective study 显示文摘 | Salim A Sangthong B Martin M | 2006 | Arch Surg2006，141，8： | 1 |
| 20 | HIV vaccine acceptability among immigrant Thai residents in Los Angeles: a mixed-method approach显示文摘 | Sung-Jae Lee Ronald A. Brooks Peter A. Newman Danielle Seiden Rassamee Sangthong Naihua Duan | | AIDS Care0，，： | 1 |
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