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| 1 | Portal hypertensive colopathy in patients with liver cirrhosis显示文摘AIM: In patients with liver cirrhosis and porlal hypertension, portal hypertensive colopathy is thought to be an important cause of lower gastrointestinal hemorrhage. In this study, we evaluated the prevalence of colonic mucosal changes in patients with liver cirrhosis and its clinical significance. METHODS: We evaluated the colonoscopic findings and liver function of 47 patients with liver cirrhosis over a 6-year period. The main cause of liver cirrhosis was post-viral hepatitis (68%) related to hepatitis B (6%) or C (62%)infection. All patients underwent upper gastrointestinal endoscopy to examine the presence of esophageal varices, cardiac varices, and congestive gastropathy, as well as a full colonoscopy to observe changes in colonic mucosa. Portal hypertensive colopathy was defined endoscopically in patients with vascular ectasia, redness, and blue vein. Vascular ectasia was classified into two types: type 1, solitary vascular ectasia; and type 2, diffuse vascular ectasia.RESULTS: Overall portal hypertensive colopathy was present in 31 patients (66%), including solitary vascular ectasia in 17 patients (36%), diffuse vascular ectasia in 20 patients (42%), redness in 10 patients (21%) and blue vein in 6 patients (12%). As the Child-Pugh class increased in severity, the prevalence of portal hypertensive colopathy rose. Child-Pugh class B and C were significantly associated with portal hypertensive colopathy. Portal hypertensive gastropathy, esophageal varices, ascites and hepatocellular carcinoma were not related to occurrence of portal hypertensive colopathy. Platelet count was significantly associated with portal hypertensive colopathy, but prothrombin time, serum albumin level, total bilirubin level and serum ALT level were not related to occurrence of portal hypertensive colopathy. CONCLUSION: As the Child-Pugh class worsens and platelet count decreases, the prevalence of portal hypertensive colopathy increases in patients with liver cirrhosis. A colonoscopic examination in patients with liver cirrhosis is indicated, especially those with worsening Child-Pugh class and/or decreasing platelet count, to prevent complications such as lower gastrointestinal bleeding. | Keiichi Ito Katsuya Shiraki Takahisa Sakai Hitoshi Yoshimura Takeshi Nakano | 2005 | World Journal of Gastroenterology2005，11，20： | 19 |
| 2 | Prognostic significance of perioperative tumor marker levels in stage Ⅱ/Ⅲ gastric cancer显示文摘AIM To evaluate the prognostic significance of perioperative carcinoembryonic antigen(CEA) and carbohydrate antigen 19-9(CA19-9) levels in stage Ⅱ/Ⅲ gastric cancer.METHODS From a multi-institutional retrospective database compiled by integrating clinical data from nine institutions, data of 998 patients who underwent curative resection for stage Ⅱ/Ⅲ gastric cancer between 2010 and 2014 were retrieved and analyzed. The prognostic impact of the preoperative and postoperative levels and chronological changes in CEA, CA19-9 and their combination were evaluated. To test whether postoperative adjuvant chemotherapy alters the prognostic impact of perioperative CEA and CA19-9 levels, the hazard ratios for mortality were compared between patients who underwent surgery alone and patients who underwent surgery followed by adjuvant chemotherapy.RESULTS The prognostic impact of postoperative CEA and CA19-9 was superior to that of the preoperative levels. Multivariable analysis identified high postoperative CEA and CA19-9 levels as independent prognostic factors for overall survival.Disease-free survival rates clearly decreased in a stepwise manner in association with postoperative CEA and CA19-9 levels, and patients with high levels of both markers showed significantly poorer prognosis than other patient groups. When we analyzed perioperative changes in serum CEA and CA19-9 levels, patients with high levels before and after surgery had the worst disease-free survival rates among all patient groups. Patients with normalized CEA levels after surgery had a significantly lower disease-free survival rate than those with normal perioperative levels, whereas patients with normalized CA19-9 levels after surgery had equivalent survival to those with normal perioperative levels. The prognostic impact of high CEA levels was observably smaller in patients who underwent adjuvant chemotherapy than in patients who underwent surgery alone, whereas that of high CA19-9 was greater in patients who underwent adjuvant chemotherapy. High postoperative CEA levels were significantly associated with an increased prevalence of liver, lung and bone recurrences, and high postoperative CA19-9 levels were significantly associated with increased frequencies of lymph node and liver recurrences.CONCLUSION The evaluation of serum CEA and CA 19-9 levels both before and after surgery provides useful information for precise risk stratification after curative gastrectomy. | Yasuhito Suenaga Mitsuro Kanda Seiji Ito Yoshinari Mochizuki Hitoshi Teramoto Kiyoshi Ishigure Toshifumi Murai Takahiro Asada Akiharu Ishiyama Hidenobu Matsushita Chie Tanaka Daisuke Kobayashi Michitaka Fujiwara Kenta Murotani Yasuhiro Kodera | 2019 | World Journal of Gastrointestinal Oncology2019，11，1： | 7 |
| 3 | Development of ulcerative colitis during the course of rheumatoid arthritis: Association with selective IgA deficiency显示文摘有风湿性关节炎(RA ) 的 29 年的历史的一个 56 岁的女人进入医院,抱怨高发烧,腹的疼痛和严重流血腹泻。结肠镜检查与从直肠延长到远侧的横向的冒号的自发的流血、弥漫的侵蚀和溃疡揭示了脆、水肿的粘膜。直肠的活体检视的组织病理学说的调查结果与 ulcerative (UC ) 兼容。作为有严重活跃左边的 UC 被诊断,她成功地被对待,静脉内的甲基氢化尼松由氢化尼松和 leukocytapheresis 列在后面。实验室测试揭示了低浆液和口水 IgA 层次,它可能在 UC 的发展起一个作用。到我们的知识,这是发生在 RA 的功课期间的 UC 的第一个盒子,由选择 IgA 缺乏伴随了。 | Yuki Asada Hajime Isomoto Saburo Shikuwa Chun Yang Wen Eiichiro Fukuda Masaru Miyazato, Kenta Okamoto Takashi Nakamura Hitoshi Nishiyama Yohei Mizuta Kiyoshi Migita Masahiro Ito Shigeru Kohno | 2006 | World Journal of Gastroenterology2006，12，32： | 2 |
| 4 | Phase II Study of Oral S-1 and Concurrent Radiotherapy in Patients With Unresectable Locally Advanced Pancreatic Cancer显示文摘 | Kentaro Sudo Taketo Yamaguchi Takeshi Ishihara Kazuyoshi Nakamura Taro Hara Tadamichi Denda Katsunobu Tawada Toshiyuki Imagumbai Hitoshi Araki Mitsuhiro Sakai Kazuo Hatano Hiroyuki Kawakami Takashi Uno Hisao Ito Osamu Yokosuka | 2011 | International Journal of Radiation Oncology Biology Physics2011，，1： | 2 |
| 5 | Malignant Transformation Arising From Mature Cystic Teratoma of the Ovary: A Retrospective Study of 20 Cases显示文摘 | Michiko Sakuma Takeo Otsuki Kosuke Yoshinaga Hiroki Utsunomiya Satoru Nagase Tadao Takano Hitoshi Niikura Kiyoshi Ito Keiko Otomo Toru Tase Yoh Watanabe Nobuo Yaegashi | 2010 | International Journal of Gynecological Cancer2010，，5： | 2 |
| 6 | Characteristics of rat bone marrow cells differentiated into a liver cell lineage and dynamics of the transplanted cells in the injured liver显示文摘 | Kazuo Okumoto Takafumi Saito Hiroaki Haga Etsuko Hattori Rika Ishii Tetsuru Karasawa Akihiko Suzuki Keiko Misawa Mai Sanjo Jun-itsu Ito Kazuhiko Sugahara Koji Saito Hitoshi Togashi Sumio Kawata | 2006 | Journal of Gastroenterology2006，，1： | 1 |
| 7 | Investigation of Musashi-1 Expressing Cells in the Murine Model of Dextran Sodium Sulfate-Induced Colitis显示文摘 | Tadahisa Fukui MD Hiroaki Takeda MD Hong-Jin Shu MD Katsuyoshi Ishihama MD Sayaka Otake MD Yasukuni Suzuki MD Shoichi Nishise MD Nanami Ito MD Takeshi Sato MD Hitoshi Togashi MD Sumio Kawata MD | 2006 | Digestive Diseases and Sciences2006，，7： | 1 |
| 8 | Inhibitory action of a ( 1 - 6) - β - D - Glucan - protein Complex(F Ⅲ - 2- b) isolated from Agaricus blazei Murill (Himenmatsutake) on Meth A Fibrosarcoma-Bearing mice and its antitumor mechanism 显示文摘 | HIROKO ITOH HITOSHI ITO | 1994 | Jpn J Pharmacol1994，66，： | 1 |
| 9 | β‐amyloid in lewy body disease is related to Alzheimer’s disease‐like atrophy显示文摘 | Hitoshi Shimada Hitoshi Shinotoh Shigeki Hirano Michie Miyoshi Koichi Sato Noriko Tanaka Tsuneyoshi Ota Kiyoshi Fukushi Toshiaki Irie Hiroshi Ito Makoto Higuchi Satoshi Kuwabara Tetsuya Suhara | 2012 | Mov Disord2012，，： | 1 |
| 10 | Proteolytic Cleavage of High Mobility Group Box 1 Protein by Thrombin–Thrombomodulin Complexes显示文摘 | Takashi Ito Ko-ichi Kawahara Kohji Okamoto Shingo Yamada Minetsugu Yasuda Hitoshi Imaizumi Yuko Nawa Xiaojie Meng Binita Shrestha Teruto Hashiguchi Ikuro Maruyama | 2008 | Arteriosclerosis, Thrombosis, and Vascular Biology2008，，10： | 1 |
| 11 | Antitumor effects of a new polysaccharide-protein complex (ATOM) prepared from Agaricus blazei (Iwade strain 101)'Himematsutake' and its mechanisms in tumor-bearing mice显示文摘 | | 1997 | Anticancer Research1997，17，： | 1 |
| 12 | Lymphadenectomy for endometrial cancer: is paraaortic lymphadenectomy necessary?显示文摘 | Nobuo Yaegashi Kiyoshi Ito Hitoshi Niikura | 2007 | International Journal of Clinical Oncology2007，，3： | 1 |
| 13 | Clinical effects of fish type i collagen hydrolysate on skin properties显示文摘 | Matsumoto Hitoshi Ohara Hiroki Ito Kyoko | | 0，，3： | 1 |
| 14 | Multicenter Study of Short- and Long-Term Outcomes of Laparoscopic Palliative Resection for Incurable, Symptomatic Stage IV Colorectal Cancer in Japan显示文摘 | Tomonori Akagi Masafumi Inomata Seigo Kitano Koya Hida Yoshiharu Sakai Suguru Hasegawa Yousuke Kinjo Kenichi Yoshimura Masaaki Ito Yosuke Fukunaga Akiyoshi Kanazawa Hitoshi Idani Masahiko Watanabe | 2013 | Journal of Gastrointestinal Surgery2013，，4： | 1 |
| 15 | Phase II trial of S-1 as third-line or further chemotherapy in patients with advanced non-small-cell lung cancer显示文摘 | Seigo Miyoshi Ryoji Ito Hitoshi Katayama Toru Kadowaki Shuichi Yano Akira Watanabe Masahiro Abe Hironobu Hamada Takafumi Okura Jitsuo Higaki | 2014 | International Journal of Clinical Oncology2014，，6： | 1 |
| 16 | Transmission of hepatitis C virus quasispecies between human adults显示文摘 | Takafumi Saito Hisayoshi Watanabe Li Shao Kazuo Okumoto Etsuko Hattori Mai Sanjo Keiko Misawa Akihiko Suzuki Tadashi Takeda Kazuhiko Sugahara Jun-itsu Ito Koji Saito Hitoshi Togashi Sumio Kawata | 2004 | Hepatology Research2004，，2： | 1 |
| 17 | Application of low-pressure negative pressure wound therapy to ischaemic wounds显示文摘 | Yoshiaki Kasai Hitoshi Nemoto Naohiro Kimura Yoshinori Ito Noriyoshi Sumiya | 2011 | Journal of Plastic Reconstructive & Aesthetic Surgery2011，，3： | 1 |
| 18 | In vivo time course of morphological changes and DNA degradation during the degeneration of castration-induced apoptotic prostate cells显示文摘 | Zhongting Hu Takao Ito Kazunari Yuri Cangxia Xie Hitoshi Ozawa M. Kawata | 1998 | Cell & Tissue Research1998，，1： | 1 |
| 19 | Genetic variations in humans associated with differences in the course of hepatitis C显示文摘 | Takafumi Saito Guijin Ji Haruhide Shinzawa Kazuo Okumoto Etsuko Hattori Tohru Adachi Tadashi Takeda Kazuhiko Sugahara Jun-itsu Ito Hisayoshi Watanabe Koji Saito Hitoshi Togashi Keisuke Ishii Tadashi Matsuura Kiyoshi Inageda Masaaki Muramatsu Sumio Kawata | 2004 | Biochemical and Biophysical Research Communications2004，，2： | 1 |
| 20 | Effect of gamma - irradiation frozen shrimps for decontamination of pathogenic bacteria 显示文摘 | Hitoshi Ito Harun Or Rashid Naruemon Sangthong Takasaki | 2002 | Radiation Chemistry Research Establelishment2002，28，8： | 1 |
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