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| 1 | 在结肠和直肠的癌症的淋巴节点收获: 当前的考虑显示文摘 The prognostic significance of identifying lymph node(LN) metastases following surgical resection for colon and rectal cancer is well recognized and is reflected in accurate staging of the disease.An established body of evidence exists,demonstrating an association between a higher total LN count and improved survival,particularly for node negative colon cancer.In node positive disease,however,the lymph node ratios may represent a better prognostic indicator,although the impact of this on clinical treatment has yet to be universally established.By extension,strategies to increase surgical node harvest and/or laboratory methods to increase LN yield seem logical and might improve cancer staging.However,debate prevails as to whether or not these extrapolations are clinically relevant,particularly when very high LN counts are sought.Current guidelines recommend a minimum of 12 nodes harvested as the standard of care,yet the evidence for such is questionable as it is unclear whether an increasing the LN count results in improved survival.Findings from modern treatments,including down-staging in rectal cancer using pre-operative chemoradiotherapy,paradoxically suggest that lower LN count,or indeed complete absence of LNs,are associated with improved survival;implying that using a specific number of LNs harvested as a measure of surgical quality is not always appropriate.The pursuit of a sufficient LN harvest represents good clinical practice;however,recent evidence shows that the exhaustive searching for very high LN yields may be unnecessary and has little in? uence on modern approaches to treatment. | James R McDonald Andrew G Renehan Sarah T O’Dwyer Najib Y Haboubi | 2012 | World Journal of Gastrointestinal Surgery2012，4，1： | 8 |
| 2 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 6 |
| 3 | Facility-based constraints to exchange transfusions for neonatal hyperbilirubinemia in resource-limited settings显示文摘Several clinical guidelines for the management of infants with severe neonatal hyperbilirubinemia recommend immediate exchange transfusion(ET) when the risk or presence of acute bilirubin encephalopathy is established in order to prevent chronic bilirubin encephalopathy or kernicterus. However, the literature is sparse concerning the interval between the time the decision for ET is made and the actual initiation of ET, especially in low- and middle-income countries(LMICs) with significant resource constraints but high rates of ET. This paper explores the various stages and potential delays during this interval in complying with the requirement for immediate ET for the affected infants, based on the available evidence from LMICs. The vital role of intensive phototherapy, efficient laboratory and logistical support, and clinical expertise for ET are highlighted. The challenges in securing informed parental consent, especially on religious grounds, and meeting the financial burden of this emergency procedure to facilitate timely ET are examined. Secondary delays arising from posttreatment bilirubin rebound with intensive phototherapy or ET are also discussed. These potential delays can compromise the effectiveness of ET and should provide additional impetus to curtail avoidable ET in LMICs. | Cecilia A Mabogunje Sarah M Olaifa Bolajoko O Olusanya | 2016 | World Journal of Clinical Pediatrics2016，5，2： | 4 |
| 4 | Prognostic value of pre-treatment F-18-FDG PET-CT in patients with hepatocellular carcinoma undergoing radioembolization显示文摘AIM To evaluate the value of pre-treatment 18F-FDG PET/CT in patients with HCC following liver radioembolization.METHODS We identified 34 patients with HCC who underwent an FDG PET/CT scan prior to hepatic radioembolization at our institution between 2009 and 2013. Patients wereseen in clinic one month after radioembolization and then at 2-3 mo intervals. We assessed the influence of FDG tumor uptake on outcomes including local liver control(LLC), distant liver control(DLC), time to distant metastases(DM), progression free survival(PFS) and overall survival(OS).RESULTS The majority of patients were males(n = 25, 74%), and had Child Pugh Class A(n = 31, 91%), with a median age of 68 years(46-84 years). FDG-avid disease was found in 19(56%) patients with SUVmax ranging from 3 to 20. Female patients were more likely to have an FDG-avid HCC(P = 0.02). Median follow up of patients following radioembolization was 12 months(1.2-62.8 mo). FDG-avid disease was associated with a decreased 1 year LLC, DLC, DM and PFS(P < 0.05). Using multivariate analysis, FDG avidity predicted for LLC, DLC, and PFS(all P < 0.05).CONCLUSION In this retrospective study, pre-treatment HCC FDGavidity was found to be associated with worse LLC, DLC, and PFS following radioembolization. Larger studies are needed to validate our initial findings to assess the role of F-18-FDG PET/CT scans as biomarker for patients with HCC following radioembolization. | Yazan Abuodeh Arash O Naghavi Kamran A Ahmed Puja S Venkat Youngchul Kim Bela Kis Junsung Choi Benjamin Biebel Jennifer Sweeney Daniel A Anaya Richard Kim Mokenge Malafa Jessica M Frakes Sarah E Hoffe Ghassan El-Haddad | 2016 | World Journal of Gastroenterology2016，22，47： | 3 |
| 5 | Blockade of PD1 and TIM3 Restores Innate and Adaptive Immunity in Patients with Acute Alcoholic Hepatitis显示文摘 | Lee J.L. Markwick Antonio Riva Jennifer M. Ryan Helen Cooksley Elena Palma Tom H. Tranah Godhev K. Manakkat Vijay Nikhil Vergis Mark Thursz Alex Evans Gavin Wright Sarah Tarff John O’Grady Roger Williams Debbie L. Shawcross Shilpa Chokshi | 2014 | Gastroenterology2014，，： | 2 |
| 6 | Paediatric retinal detachment:aetiology,characteristics and outcomes显示文摘AIM: To provide contemporary data on the aetiology, clinical features and outcomes of paediatric retinal detachment.METHODS: A retrospective review of all those under 16 y who underwent surgical repair for retinal detachment at a single centre between the years 2008 and 2015 inclusive was performed. In each case the cause of retinal detachment, the type of detachment, the presence or absence of macular involvement, the number and form of reparative surgeries undertaken, and the surgical outcome achieved was recorded.RESULTS: Twenty-eight eyes of 24 patients, 15(62.5%) of whom were male and 9(37.5%) of whom were female, their mean age being 11.6 y and range 2-16y developed retinal detachment over the eight year period studied. Trauma featured in the development of retinal detachment in 14(50.0%) cases. Retinal detachment was associated with other ocular and/or systemic conditions in 11(39.3%) cases. A mean of 3.0 procedures with a range of 1-9 procedures per patient were undertaken in the management of retinal detachment. Complex vitrectomy combined with scleral buckling or complex vitrectomy alone were those most frequently performed. Mean postoperative visual acuity was 1.2 log MAR with range 0.0-3.0 log MAR. In 22 of 26(84.6%) cases which underwent surgical repair the retina was attached at last follow-up.CONCLUSION: Aggressive management of paediatric retinal detachment including re-operation increases the likelihood of anatomical success. In cases where the retinal detachment can be repaired by an external approach alone there is a more favourable visual outcome. | Elizabeth McElnea Kirk Stephenson Sarah Gilmore Michael O'Keefe David Keegan | 2018 | International Journal of Ophthalmology(English edition)2018，11，2： | 2 |
| 7 | The Effects of Enhanced Milieu Teaching and a Voice Output Communication Aid on the Requesting of Three Children with Autism显示文摘 | Melissa L. Olive Berenice Cruz Tonya N. Davis Jeffrey M. Chan Russell B. Lang Mark F. O’Reilly Sarah M. Dickson | 2007 | Journal of Autism and Developmental Disorders2007，，8： | 1 |
| 8 | ASSOCIATION OF FIBROBLAST GROWTH FACTOR (FGF)-23 LEVELS WITH RISK OF CARDIOVASCULAR EVENTS IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE显示文摘 | Jacob A. Udell Thomas O'Donnell David Morrow Petr Jarolim Torbjorn Omland Sarah Sloan Marc Pfeffer Eugene Braunwald Marc Sabatine | 2012 | Journal of the American College of Cardiology2012，，13： | 1 |
| 9 | Microbes Central to Human Reproduction显示文摘 | Gregor Reid Patrizia Brigidi Jeremy P. Burton Nikhat Contractor Sylvia Duncan Emilie Fargier Colin Hill Sarah Lebeer Rocio Martín Andrew J. McBain Gil Mor Catherine O’Neill Juan Miguel Rodríguez Jonathan Swann Saskia Hemert Juliett Ansell | 2015 | Am J Reprod Immunol2015，，1： | 1 |
| 10 | When Outgroups Fail; Phylogenomics of Rooting the Emerging Pathogen, Coxiella burnetii显示文摘 | Talima Pearson Heidie M. Hornstra Jason W. Sahl Sarah Schaack James M. Schupp Stephen M. Beckstrom-Sternberg Matthew W. O’Neill Rachael A. Priestley Mia D. Champion James S. Beckstrom-Sternberg Gilbert J. Kersh James E. Samuel Robert F. Massung Paul Keim | 2013 | Systematic Biology2013，，5： | 1 |
| 11 | Schools as a Communily Resource for Physical Activity: Legal Considerations for Decision Makers显示文摘 | John O Spengler Sarah J Young | 2007 | A merican Journal of Health Promotion2007，21，4： | 1 |
| 12 | Aldosterone signaling through transient receptor potential melastatin 7 cation channel (TRPM7) and its α-kinase domain显示文摘 | Alvaro Yogi Glaucia E. Callera Sarah O’Connor Tayze T. Antunes William Valinsky Perrine Miquel Augusto C.I. Montezano Anne-Laure Perraud Carsten Schmitz Alvin Shrier Rhian M. Touyz | 2013 | Cellular Signalling2013，，： | 1 |
| 13 | A Detailed Comparative Study of High-Resolu- tion Ultrasound and Micro-Computed Tomography for Detection of Ar- thritic Bone Erosions 显示文摘 | Stephanie F Sarah O | 2011 | Arthritis & Rheumatism2011，63，5： | 1 |
| 14 | The Dark Side of Flow: A Qualitative Study of Dependence in Big Wave Surfing 显示文摘 | SARAH P ELIZABETH P STEVE O | 2009 | The Sport Psychologist2009，23，2： | 1 |
| 15 | Guillain-Barre syndrome and preceding infection with campylobacter,influenza and Epstein-Barr virus in the general practice research database显示文摘 | Clarence C Tam Sarah J O'Brien Irene Petersen | 2007 | Plos One2007，2，4： | 1 |
| 16 | The use of C oban<sup>TM</sup> compression bandage following below‐knee free‐flap surgery显示文摘 | Toby O Smith Sarah Hazelden Laura Parker Bhavana Jha Margaret Youatt Richard Haywood | 2012 | Int J Nurs Pract2012，，6： | 1 |
| 17 | Comparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart显示文摘 | Ellen T. Roche Conn L. Hastings Sarah A. Lewin Dmitry E. Shvartsman Yevgeny Brudno Nikolay V. Vasilyev Fergal J. O’Brien Conor J. Walsh Garry P. Duffy David J. Mooney | 2014 | Biomaterials2014，，25： | 1 |
| 18 | Analysis of changes in hepatic gene expression in a murine model of tolerance to acetaminophen hepatotoxicity (autoprotection)显示文摘 | Meeghan A. O’Connor Petra Koza-Taylor Sarah N. Campion Lauren M. Aleksunes Xinsheng Gu Ahmed E. Enayetallah Michael P. Lawton José E. Manautou | 2014 | Toxicology and Applied Pharmacology2014，，1： | 1 |
| 19 | Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis显示文摘 | Andrew G Renehan Marcel Zwahlen Christoph Minder Sarah T O’Dwyer Stephen M Shalet Matthias Egger | 2004 | The Lancet2004，，9418： | 1 |
| 20 | Host, viral, and vaccine factors that determine protective efficacy induced by rotavirus and virus-like particles (VLPs) 显示文摘 | Sarah E B Kelly L W Christine M O'Neal | 2006 | Vaccine2006，24，： | 1 |
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