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| 1 | Uplift, climate and biotic changes at the Eocene-Oligocene transition in south-eastern Tibet显示文摘The uplift history of south-eastern Tibet is crucial to understanding processes driving the tectonic evolution of the Tibetan Plateau and surrounding areas.Underpinning existing palaeoaltimetric studies has been regional mapping based in large part on biostratigraphy that assumes a Neogene modernization of the highly diverse,but threatened,Asian biota.Here,with new radiometric dating and newly collected plant-fossil archives,we quantify the surface height of part of the south-eastern margin of Tibet in the latest Eocene(~34 Ma)to be^3 km and rising,possibly attaining its present elevation(3.9 km)in the early Oligocene.We also find that the Eocene–Oligocene transition in south-eastern Tibet witnessed leaf-size diminution and a floral composition change from sub-tropical/warm temperate to cool temperate,likely reflective of both uplift and secular climate change,and that,by the latest Eocene,floral modernization on Tibet had already taken place,implying modernization was deeply rooted in the Palaeogene. | Tao Su Robert A. Spicer Shi-Hu Li He Xu Jian Huang Sarah Sherlock Yong-Jiang Huang Shu-Feng Li Li Wang Lin-Bo Jia Wei-Yu-Dong Deng Jia Liu Cheng-Long Deng Shi-Tao Zhang Paul J. Valdes Zhe-Kun Zhou | 2019 | National Science Review2019，6，3： | 16 |
| 2 | Data Management Planning:How Requirements and Solutions are Beginning to Converge显示文摘Effective stewardship of data is a critical precursor to making data FAIR.The goal of this paper is to bring an overview of current state of the art of data management and data stewardship planning solutions(DMP).We begin by arguing why data management is an important vehicle supporting adoption and implementation of the FAIR principles,we describe the background,context and historical development,as well as major driving forces,being research initiatives and funders.Then we provide an overview of the current leading DMP tools in the form of a table presenting the key characteristics.Next,we elaborate on emerging common standards for DMPs,especially the topic of machine-actionable DMPs.As sound DMP is not only a precursor of FAIR data stewardship,but also an integral part of it,we discuss its positioning in the emerging FAIR tools ecosystem.Capacity building and training activities are an important ingredient in the whole effort.Although not being the primary goal of this paper,we touch also the topic of research workforce support,as tools can be just as much effective as their users are competent to use them properly.We conclude by discussing the relations of DMP to FAIR principles,as there are other important connections than just being a precursor. | Sarah Jones Robert Pergl Rob Hooft Tomasz Miksa Robert Samors Judit Ungvari Rowena I.Davis Tina Lee | 2020 | Data Intelligence2020，2，1： | 7 |
| 3 | Emotional regulation of pain:the role of noradrenaline in the amygdala显示文摘The perception of pain involves the activation of the spinal pathway as well as the supra-spinal pathway,which targets brain regions involved in affective and cognitive processes.Pain and emotions have the capacity to influence each other reciprocally;negative emotions,such as depression and anxiety,increase the risk for chronic pain,which may lead to anxiety and depression.The amygdala is a key-player in the expression of emotions,receives direct nociceptive information from the parabrachial nucleus,and is densely innervated by noradrenergic brain centers.In recent years,the amygdala has attracted increasing interest for its role in pain perception and modulation.In this review,we will give a short overview of structures involved in the pain pathway,zoom in to afferent and efferent connections to and from the amygdala,with emphasis on the direct parabrachio-amygdaloid pathway and discuss the evidence for amygdala’s role in pain processing and modulation.In addition to the involvement of the amygdala in negative emotions during the perception of pain,this brain structure is also a target site for many neuromodulators to regulate the perception of pain.We will end this article with a short review on the effects of noradrenaline and its role in hypoalgesia and analgesia. | STROBEL Cornelia HUNT Sarah SULLIVAN Robert SUN JianYuan SAH Pankaj | 2014 | Science China(Life Sciences)2014，57，4： | 7 |
| 4 | Gastrointestinal Microbiome Signatures of Pediatric Patients With Irritable Bowel Syndrome显示文摘 | Delphine M. Saulnier Kevin Riehle Toni–Ann Mistretta Maria–Alejandra Diaz Debasmita Mandal Sabeen Raza Erica M. Weidler Xiang Qin Cristian Coarfa Aleksandar Milosavljevic Joseph F. Petrosino Sarah Highlander Richard Gibbs Susan V. Lynch Robert J. Shulman | 2011 | Gastroenterology2011，，5： | 4 |
| 5 | Antifibrogenic effects of vitamin D derivatives on mouse pancreatic stellate cells显示文摘AIM To study the molecular effects of three different D-vitamins, vitamin D2, vitamin D3 and calcipotriol, in pancreatic stellate cells(PSCs).METHODS Quiescent PSCs were isolated from mouse pancreas and activated in vitro by seeding on plastic surfaces. The cells were exposed to D-vitamins as primary cultures(early-activated PSCs) and upon re-culturing(fullyactivated cells). Exhibition of vitamin A-containing lipid droplets was visualized by oil-red staining. Expression of α-smooth muscle actin(α-SMA), a marker of PSC activation, was monitored by immunofluorescence and immunoblot analysis. The rate of DNA synthesis was quantified by 5-bromo-2'-deoxyuridine(Brd U) incorporation assays. Real-time PCR was employed to monitor gene expression, and protein levels of interleukin-6(IL-6) were measured by ELISA. Uptake of proline was determined using 18 F-proline.RESULTS Sustained culture of originally quiescent PSCs inducedcell proliferation, loss of lipid droplets and exhibition of stress fibers, indicating cell activation. When added to PSCs in primary culture, all three D-vitamins diminished expression of α-SMA(to 32%-39% of the level of control cells; P < 0.05) and increased the storage of lipids(scores from 1.97-2.15 on a scale from 0-3; controls: 1.49; P < 0.05). No such effects were observed when D-vitamins were added to fully-activated cells, while incorporation of Brd U remained unaffected under both experimental conditions. Treatment of re-cultured PSCs with D-vitamins was associated with lower expression of IL-6(-42% to-49%; P < 0.05; also confirmed at the protein level) and increased expression of the vitamin D receptor gene(209%-321% vs controls; P < 0.05). There was no effect of D-vitamins on the expression of transforming growth factor-β1 and collagen type 1(chain α1). The lowest uptake of proline, a main component of collagen, was observed in calcipotriol-treated PSCs.CONCLUSION The three D-vitamins inhibit, with similar efficiencies, activation of PSCs in vitro, but cannot reverse the phenotype once the cells are fully activated. | Peter Wallbaum Sarah Rohde Luise Ehlers Falko Lange Alexander Hohn Carina Bergner Sarah Marie Schwarzenbock Bernd Joachim Krause Robert Jaster | 2018 | World Journal of Gastroenterology2018，24，2： | 3 |
| 6 | Hospitalized prevalence and 5-year mortality for IBD:Record linkage study显示文摘AIM:To establish the hospitalized prevalence of severe Crohn's disease(CD) and ulcerative colitis(UC) in Wales from 1999 to 2007;and to investigate long-term mortality after hospitalization and associations with social deprivation and other socio-demographic factors.METHODS:Record linkage of administrative inpatient and mortality data for 1467 and 1482 people hospitalised as emergencies for ≥ 3d for CD and UC,respectively.The main outcome measures were hospitalized prevalence,mortality rates and standardized mortality ratios for up to 5 years follow-up after hospitalization.RESULTS:Hospitalized prevalence was 50.1 per 100 000 population for CD and 50.6 for UC.The hospitalized prevalence of CD was significantly higher(P < 0.05) in females(57.4) than in males(42.2),and was highest in people aged 16-29 years,but the prevalence of UC was similar in males(51.0) and females(50.1),and increased continuously with age.The hospital-ized prevalence of CD was slightly higher in the most deprived areas,but there was no association between social deprivation and hospitalized prevalence of UC.Mortality was 6.8% and 14.6% after 1 and 5 years follow-up for CD,and 9.2% and 20.8% after 1 and 5 years for UC.For both CD and UC,there was little discernible association between mortality and social deprivation,distance from hospital,urban/rural residence and geography.CONCLUSION:CD and UC have distinct demographic profiles.The higher prevalence of hospitalized CD in more deprived areas may reflect higher prevalence and higher hospital dependency. | Lori A Button Stephen E Roberts Michael J Goldacre Ashley Akbari Sarah E Rodgers John G Williams | 2010 | World Journal of Gastroenterology2010，16，4： | 3 |
| 7 | Burden of onchocerciasis-associated epilepsy:first estimates and research priorities显示文摘Background:Since the 1990s,evidence has accumulated of an increased prevalence of epilepsy in onchocerciasisendemic areas in Africa as compared to onchocerciasis-free areas.Although the causal relationship between onchocerciasis and epilepsy has yet to be proven,there is likely an association.Here we discuss the need for disease burden estimates of onchocerciasis-associated epilepsy(OAE),provide them,detail how such estimates should be refined,and discuss the socioeconomic impact of OAE,including a cost-estimate for anti-epileptic drugs.Main body:Providing OAE burden estimates may aid prevention of epilepsy in onchocerciasis-endemic areas by inciting and informing collaboration between onchocerciasis control programmes and mental health services.Epilepsy not only massively impacts the health of those affected,but it also carries a high socioeconomic burden for the households and communities involved.We used previously published geospatial estimates of onchocerciasis in Africa and a separately published logistic regression model quantifying the association between onchocerciasis and epilepsy to estimate the number of OAE cases.We then applied disability weights for epilepsy to quantify the burden in terms of years of life lived with disability(YLD)and estimate the cost of treatment.We estimate that in 2015 roughly 117000 people were affected by OAE across onchocerciasis-endemic areas previously under the African Programme for Onchocerciases control(APOC)mandate where OAE has ever been reported or suspected,and another 264000 persons in onchocerciasis-endemic areas where OAE has never been investigated before.The total number of YLDs due to OAE was 39300 and 88700 in these areas respectively,based on a weighted mean disability weight of 0.336.The burden of OAE is approximately 13%of the total YLDs attributable to onchocerciasis and 10%of total YLDs attributable to epilepsy.We estimated that by 2015 the total costs of treatment with antiepileptic drug for OAE cases would have been a minimum of 12.4 million US$.Conclusions:These estimates suggest a considerable health,social and economic burden of OAE in Africa.The treatment and care for people with epilepsy,especially in hyperendemic onchocerciasis areas with high epilepsy prevalence thus requires more financial and human resources. | Natalie V.S.Vinkeles Melchers Sarah Mollenkopf Robert Colebunders Michael Edlinger Luc E.Coffeng Julia Irani Tresor Zola Joseph N.Siewe Sake Jde Vlas Andrea S.Winkler Wilma A.Stolk | 2018 | Infectious Diseases of Poverty2018，7，1： | 3 |
| 8 | Drug-drug interactions with oral anti-HCV agents and idiosyncratic hepatotoxicity in the liver transplant setting显示文摘 | Sarah Tischer Robert J. Fontana | 2013 | Journal of Hepatology2013，，： | 3 |
| 9 | Diverse Tumorigenic Pathways in Ovarian Serous Carcinoma显示文摘 | Gad Singer Robert J. Kurman Hsueh-Wei Chang Sarah K.R. Cho Ie-Ming Shih | 2002 | The American Journal of Pathology2002，，4： | 2 |
| 10 | Perioperative glucose management and outcomes in liver transplant recipients: A qualitative systematic review显示文摘AIM To investigate the relationship between post-liver transplantation(LT) glycemic control and LT outcomes. METHODS A qualitative systematic review on relevant prospective interventions designed to control glucose levels including insulin protocols. Studies investigating an association between glycemic control and post-LT outcomes such as mortality, graft rejection, and infection rate were reviewed. Pub Med, EMBASE, and other databases were searched through October 2016. RESULTS Three thousands, six hundreds and ninety-two patients from 14 studies were included. Higher mortality rate was seen when blood glucose(BG) ≥ 150 mg/dL(P = 0.05). BG ≥ 150 mg/dL also led to higher rates of infection. Higher rates of graft rejection were seen at BG > 200 mg/dL(P < 0.001). Mean BG ≥ 200 mg/dL was associated with more infections(P = 0.002).Nurse-initiated protocols and early screening strategies have shown a reduction in negative post-LT outcomes.CONCLUSION Hyperglycemia in the perioperative period is associated with poor post-LT outcomes. Only a few prospective studies have designed interventions aimed at managing post-LT hyperglycemia, post-transplant diabetes mellitus(PTDM) and their impact on post-LT outcomes. | Prani Paka Sarah R Lieber Ruth-Ann Lee Chirag S Desai Robert E Dupuis Alfred Sidney Barritt | 2018 | World Journal of Transplantation2018，8，3： | 2 |
| 11 | Stoichiometry of soil enzyme activity at global scale显示文摘 | Robert L.Sinsabaugh Christian L.Lauber Michael N.Weintraub BonyAhmed Steven D.Allison ChelseaCrenshaw Alexandra R.Contosta DanielaCusack SeritaFrey Marcy E.Gallo Tracy B.Gartner Sarah E.Hobbie KeriHolland Bonnie L.Keeler Jennifer S.Powers MartinaStursova | 2008 | Ecology Letters2008，，11： | 2 |
| 12 | Mutifactorial analysis of risk factors for reduced bone mineral density in patients with Crohn’s disease显示文摘AIM: To determine the prevalence of osteoporosis in a cohort of patients with Crohn’s disease (CD) and to identify the relative significance of risk factors for osteoporosis. METHODS: Two hundred and fifty-eight unselected patients (92 M, 166 F) with CD were studied. Bone mineral density (BMD) was measured at the lumbar spine and hip by dual X-ray absorptiometry. Bone formation was assessed by measuring bone specific alkaline phosphatase (BSAP) and bone resorption by measuring urinary excretion of deoxypyridinoline (DPD) and N-telopeptide (NTX). RESULTS: Between 11.6%-13.6% patients were osteoporotic (T score < -2.5) at the lumbar spine and/or hip. NTX levels were significantly higher in the patients with osteoporosis (P < 0.05) but BSAP and DPD levels were not significantly different. Independent risk factors for osteoporosis at either the lumbar spine or hip were a low body mass index (P < 0.001), increasing corticosteroid use (P < 0.005), and male sex (P < 0.01). These factors combined accounted for 23% and 37% of the reduction in BMD at the lumbar spine and hip respectively. CONCLUSION: Our results confirm that osteoporosis is common in patients with CD and suggest that increased bone resorption is the mechanism responsible for thebone loss. However, less than half of the reduction in BMD can be attributed to risk factors such as corticosteroid use and low BMI and therefore remains unexplained. | Sarah A Bartram Robert T Peaston David J Rawlings David Walshaw Roger M Francis Nick P Thompson | 2006 | World Journal of Gastroenterology2006，12，35： | 2 |
| 13 | Effects of B-vitamins on plasma homocysteine concentrations and on risk of cardiovascular disease and dementia 显示文摘 | Robert C Sarah L Paul S | 2007 | Curt Opin Clin Nutr Metab Care2007，10，1： | 1 |
| 14 | The miR-17-92 Cluster is Over Expressed in and Has an Oncogenic Effect on Renal Cell Carcinoma显示文摘 | Tsz-fung F. Chow Marina Mankaruos Andreas Scorilas Youssef Youssef Andrew Girgis Sarah Mossad Shereen Metias Yostina Rofael R. John Honey Robert Stewart Kenneth T. Pace George M. Yousef | 2010 | The Journal of Urology2010，，2： | 1 |
| 15 | When Outgroups Fail; Phylogenomics of Rooting the Emerging Pathogen, Coxiella burnetii显示文摘 | Talima Pearson Heidie M. Hornstra Jason W. Sahl Sarah Schaack James M. Schupp Stephen M. Beckstrom-Sternberg Matthew W. O’Neill Rachael A. Priestley Mia D. Champion James S. Beckstrom-Sternberg Gilbert J. Kersh James E. Samuel Robert F. Massung Paul Keim | 2013 | Systematic Biology2013，，5： | 1 |
| 16 | Hollow silica and silica-boron nano/microparticles for contrast-enhanced ultrasound to detect small tumors显示文摘 | Alexander Liberman H. Paul Martinez Casey N. Ta Christopher V. Barback Robert F. Mattrey Yuko Kono Sarah L. Blair William C. Trogler Andrew C. Kummel Zhe Wu | 2012 | Biomaterials2012，，20： | 1 |
| 17 | A framework for incorporating the prevention of Lyme disease transmission into the landscape planning and design process显示文摘 | Sarah E Robert D | 2004 | Landscape and Urban Planning2004，66，： | 1 |
| 18 | Differential Sensitivity to JAK Inhibitory Drugs by Isogenic Human Erythroblasts and Hematopoietic Progenitors Generated from Patient‐Specific Induced Pluripotent Stem Cells显示文摘 | Zhaohui Ye Cyndi F. L iu Lucie Lanikova Sarah N. Dowey Chaoxia He Xiaosong Huang Robert A. Brodsky Jerry L. Spivak Josef T. Prchal Linzhao Cheng | 2014 | Stem Cells2014，，1： | 1 |
| 19 | Cholesterol fractions and apolipoproteins as risk factors for heart disease mortality in older men 显示文摘 | Robert C Jonathan RE Sarah P | 2007 | Arch Intern Med2007，167，： | 1 |
| 20 | Pilot study of mutant ras peptide-based vaccine as an adjuvant treatment in pancreatic and colorectal cancers显示文摘 | Antoun Toubaji Moujahed Achtar Maurizio Provenzano Vincent E. Herrin Robert Behrens Michael Hamilton Sarah Bernstein David Venzon Barry Gause Francesco Marincola Samir N. Khleif | 2008 | Cancer Immunology Immunotherapy2008，，9： | 1 |
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