|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Saposin C stimulates growth and invasion,activates p42/44 and SAPK/JNK signaling pathways of MAPK and upregulates uPA/uPAR expression in prostate cancer and stromal cells显示文摘Aim: To determine the effect of saposin C (a known trophic domain of prosaposin) on proliferation, migration and invasion, as well as its effect on the expression of urokinase plasmonogen activator (uPA), its receptor (uPAR) and matrix metalloproteinases (MMP)-2 and -9 in normal and malignant prostate cells. In addition, we tested whether saposin C can activate p42/44 and stress-activated protein kinase/c-Jun NH2-terminal kinase (SAPK/JNK) signal transduction pathways of the mitogen-activated protein kinase (MAPK) superfamily. Methods: We employed Western blot analysis, phospho-specific antibodies, cell proliferation assay, reverse transcriptase-polymerase chain reaction,in vitro kinase assays and migration and invasion to determine the effect of saposin C on various biological behaviors of prostate stromal and cancer cells. Results: Saposin C, in a cell type-specific manner, upregulates uPA/uPAR and immediate early gene c-Jun expression, stimulates cell proliferation, migration and invasion and activates p42/44 and SAPK/JNK MAPK pathways in prostate stromal and cancer cells. Normal prostate epithelial cells were not responsive to saposin C treatment in the above studies. Conclusion: Saposin C functions as a multipotential modulator of diverse biological activities in prostate cancer and stromal cells. These results strongly suggest that saposin C functions as a potent growth factor for prostatic cells and may contribute to prostate carcinogenesis and/or the development of hormone-refractory prostate cancer. | Shahriar Koochekpour Oliver Sartor Masao Hiraiwa Tae-Jin Lee Walter Rayford Natascha Remmel Konrad Sandhoff ArdalanMinokadeh DavidY.Patten | 2005 | Asian Journal of Andrology2005，7，2： | 7 |
| 2 | Microbial Influences in Inflammatory Bowel Diseases显示文摘 | R. Balfour Sartor | 2008 | Gastroenterology2008，，2： | 5 |
| 3 | 会阴侧切术对阴道分娩后骨盆底组织功能的影响 | Sartore A. De Seta F. Maso G. 李跃萍 | 2005 | 世界核心医学期刊文摘(妇产科学分册)2005，0，8： | 5 |
| 4 | Loss of IKB kinase βpromotes myofibroblast transformation and senescence through activation of the ROS-TGFβ autocrine loop显示文摘 | Liang Chen Zhimin Peng Qinghang Meng Maureen Mongan Jingcai Wang Maureen Sartor Jing-Chen Liang Niu Mario Medvedovic Winston Kao Ying Xia | 2016 | Protein & Cell2016，7，5： | 4 |
| 5 | 可卡因暴露通过miR-30C-5P/苹果酸酶1/活性氧通路升高血压和加强主动脉僵硬度显示文摘滥用可卡因可增加心血管病死亡和发病风险,然而,其中潜在的分子机制仍然未知。通过可卡因滥用小鼠模型,Zhu等发现重复注射可卡因可导致小鼠血压升高和主动脉僵硬度增加(主动脉中活性氧水平同时升高),这种现象类似于人类高血压中观察到的现象。 | 刘莉 叶鹏 Zhu W Wang H Wei J Sartor GC Bao MM Pierce CT Wahlestedt CR Dykxhoorn DM Dong C | 2018 | 中华高血压杂志2018，26，4： | 4 |
| 6 | Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: Summary of a symposium显示文摘 | Vishnudutt Purohit J. Christian Bode Christiane Bode David A. Brenner Mashkoor A. Choudhry Frank Hamilton Y. James Kang Ali Keshavarzian Radhakrishna Rao R. Balfour Sartor Christine Swanson Jerrold R. Turner | 2008 | Alcohol2008，，5： | 3 |
| 7 | Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics显示文摘 | R.Balfour Sartor | 2004 | Gastroenterology2004，，6： | 3 |
| 8 | Microbial Influences in Inflammatory Bowel Diseases显示文摘 | R. Balfour Sartor | 2008 | Gastroenterology2008，，2： | 2 |
| 9 | Enterococcus faecalis Metalloprotease Compromises Epithelial Barrier and Contributes to Intestinal Inflammation显示文摘 | Natalie Steck Micha Hoffmann Irina G. Sava Sandra C. Kim Hannes Hahne Susan L. Tonkonogy Katrin Mair Dagmar Krueger Mihaela Pruteanu Fergus Shanahan Roger Vogelmann Michael Schemann Bernhard Kuster R. Balfor Sartor Dirk Haller | 2011 | Gastroenterology2011，，3： | 2 |
| 10 | 雄激素抵抗型前列腺癌的新观念与治疗新方案显示文摘 | SARTOR Oliver PATTEN David Y NG San San 贺大林 吴开杰 吴开杰(译) | 2009 | 现代泌尿外科杂志2009，14，4： | 2 |
| 11 | Association between glucose variability as assessed by continuous glucose monitoring (CGM) and diabetic retinopathy in type 1 and type 2 diabetes显示文摘 | Giovanni Sartore Nino Cristiano Chilelli Silvia Burlina Annunziata Lapolla | 2013 | Acta Diabetologica2013，，3： | 2 |
| 12 | Future directions in inflammatory bowel disease management显示文摘 | Geert R. D’Haens R. Balfour Sartor Mark S. Silverberg Joel Petersson Paul Rutgeerts | 2014 | Journal of Crohn’s and Colitis2014，，： | 2 |
| 13 | The Hedgehog Signalling Pathway in the Gastrointestinal Tract: Implications for Development, Homeostasis, and Disease显示文摘 | Charlie Lees Sarah Howie R. Balfour Sartor Jack Satsangi | 2005 | Gastroenterology2005，，5： | 2 |
| 14 | Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4显示文摘 | Dianne H. Dapito Ali Mencin Geum-Youn Gwak Jean-Philippe Pradere Myoung-Kuk Jang Ingmar Mederacke Jorge M. Caviglia Hossein Khiabanian Adebowale Adeyemi Ramon Bataller Jay H. Lefkowitch Maureen Bower Richard Friedman R. Balfour Sartor Raul Rabadan Robert | 2012 | Cancer Cell2012，，4： | 2 |
| 15 | Current paradigms and evolving concepts in metastatic castration-resistant prostate cancer显示文摘直到最近,基于 docetaxel 的治疗代表了显示出与变形阉割抵抗的前列腺癌症(mCRPC ) 在病人延长幸存的唯一的治疗。过去的年和一半被崭新的进步为这疾病在治疗标记。三积极阶段 III 临床的试用出现了,有行动的不同机制的每个评估代理人(sipuleucel-T, cabazitaxel 和 abiraterone ) 。此处,三枢轴的试用在被描述过去和当前的大阶段 III 研究在这进行了 mCRPC。为有在当前的临床的试用对待的 mCRPC 的病人的全面幸存比在过去注意更加长。我们注意有更旧的代理人的更最近的试用也显示出改进幸存并且讨论影响结果的这项批评措施的潜在的非治疗学的偏爱。必要性因为当评估新治疗学被强调时,利用使随机化的试用在这 mCRPC 给变化预后。 | Sumanta Kumar Pal Oliver Sartor | 2011 | Asian Journal of Andrology2011，13，5： | 2 |
| 16 | Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria显示文摘 | Sandra C. Kim Susan L. Tonkonogy Carol A. Albright Julia Tsang Edward J. Balish Jonathon Braun Mark M. Huycke R. Balfour Sartor | 2005 | Gastroenterology2005，，4： | 2 |
| 17 | Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells 显示文摘 | Sartor CI Zhou H Kozlowska E | 2001 | Mol Cell Biol2001，21，18： | 1 |
| 18 | 显示文摘 | Sartore A Grimaldi E Guaschino S | 2003 | Am J Obstet Gynecol2003，189，3： | 1 |
| 19 | Indights into the pathogenesis of inflammatory bowel diseases provided by new rodent models of spontaneous coliris显示文摘 | Sartor R B | 1995 | Inflammatory Bowels Dis1995，1，： | 1 |
| 20 | Effect of prednisone on prostate-specific antigen in patients with hormone-refractory prostate cancer显示文摘 | Sartor O Weinberger M Moore A | 1998 | Urology1998，52，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员