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| 1 | Immunomodulatory activity of butanol fraction of Gentiana olivieri Griseb. on Balb/C mice显示文摘Objective:To explore the immunomodulatory properties of 80% ethanol extract and butanol fraction of Gentiana olivieri(G. olivieri) Griseb on Balb/C mice.Methods:The study was performed with basic models of immunomodulation such as the humoral antibody response(hemoglutination antibody titres), cell mediated immune response(delayed type hypersensitivity and in vivocarbon clearance or phagocytosis). Ethanol(80%) extract of flowering aerial parts of G.olivieriand its butanol fraction were administered p.o.(orally) to the mice. Levamisole, 2.5 mg/kg was used as standard drug.Results:There was a potentiation of immune response to sheep red blood cells by cellular and humoral mediated mechanisms comparable to levamisole(2.5 mg/kg) by both 80% ethanol extract and the butanol fraction at doses of 50-200 mg/kg in male Balb/C mice. Both significantly(P<0.01) potentiated the humoral immune response in cyclophosphamide(250 mg/kg)immunosupressed mice at 100 and 200 mg/kg of each extract and fraction as compared to control.The potentiation of delayed type hypersensitivity response was statistically significant(P<0.01) at200 mg/kg of ethanol extract and 100, 200 mg/kg of butanol fraction as compared to control. The phagocytosis was significant at 200 mg/kg with butanol fraction ofG. olivieri.Conclusions:The results reveal the immunostimulant effects of plantG. olivieriin mice by acting through cellular and humoral immunity in experimental models of immunity in mice. Butanol fraction is the most effective at a dose level of 200 mg/kg. | Satnam Singh Yadav CPS Malleshappa N Noolvi | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，6： | 2 |
| 2 | Muhidrug Resistant Childhood Tuberculosis显示文摘 | Varinder Singh Satnam Kaur | 2011 | Indian J Pediatr2011，78，4： | 1 |
| 3 | Chitosan inhibits growth of spoilage micro-organisms in chilled pork products显示文摘 | SATNAM SAGOO RON BOARD SIBEL ROLLER | 2002 | Food Microbiology2002，，19： | 1 |
| 4 | SiO2-coated pure anatase TiO2 catalysts for enhanced photo-oxidation of naphthalene and anthracene显示文摘 | Inderpreet Singh Grover Roop Chand Prajapat Satnam Singh Bonamali Pal | 2017 | Particuology2017，15，5： | 1 |
| 5 | Chitosan in hibits growth of spoilage micro-organisms in chilled pork products显示文摘 | Satnam S Ron B Sibel R | | 0，，2： | 1 |
| 6 | A methodology for intelligent sensor measurement,validation,fusion,and fault detection for equipment monitoring and diagnostics显示文摘 | Satnam A Alice M A Mahesh M | 2001 | Artificial Intelligence for Engineering Design Analysis and Manufacturing2001，15，4： | 1 |
| 7 | Chitosan Inhibits Growth of Spoilage Micro - organisms in Chilled Pork Products 显示文摘 | Satnam Sagoo Ron Board and Sibel Roller | 2002 | Food Microbiology2002，19，： | 1 |
| 8 | Biodiesel from mutton fat using KOH impregnated MgO as heterogeneous catalysts 显示文摘 | Vishal Mutreja Satnam Singh Amjad Ali | 2011 | Renewable Energy2011，36，8： | 1 |
| 9 | Chitosan inhibits growth of spoilage micro-organisms in chilled pork products 显示文摘 | Satnam S Ron B Sibel R | 2002 | Food Microbiology2002，19，2： | 1 |
| 10 | Biodiesel from mutton fat using KOH impregnated MgO as heterogeneous catalysts显示文摘 | Vishal Mutreja Satnam Singh Amjad Ali | 2011 | Renewable Energy2011，36，8： | 1 |
| 11 | Improvements to the finite-difference time-domain method for calculating the radar cross section of a perfectly conducting target显示文摘 | Furse Cynthia M Mathur Satnam | 2006 | IEEE Transactions on Microwave Theory and Techniques2006，，7： | 1 |
| 12 | RhNF-κB can trigger theNotch signaling pathway by inducing the expression of Jagged1,a lig-and for Notch receptors显示文摘 | Judy B Wei xing Z Satnam B | 1999 | The EMBO Journal1999，18，10： | 1 |
| 13 | Health monitoring of electronic products based on Mahalanobis distance and Weibull decision metrics显示文摘 | Gang Niu Satnam Singh Steven W Holland | 2011 | Microelectronics Reliability2011，51，： | 1 |
| 14 | The effect of temperature on PAHs emission from incineration of acrylic waste 显示文摘 | Satnam Singh Vinit Prakash | 2007 | Environ Monit Assess2007，127，： | 1 |
| 15 | Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate‐nitrite‐nitric oxide pathway显示文摘 | Satnam Lidder Andrew J. Webb | 2013 | Br J Clin Pharmacol2013，，3： | 1 |
| 16 | BMP signalling: Agony and Antagony in the family显示文摘 | Derek P. Brazil Rachel H. Church Satnam Surae Catherine Godson Finian Martin | 2014 | Trends in Cell Biology2014，，： | 1 |
| 17 | Health Monitoring of Electronic Products Based on Mahalanobis Distanace and Weibull Decision Metrics 显示文摘 | Gang Niu Satnam Singh Steven W Holland | 2011 | Mieroelectron-ics Reliability2011，51，： | 1 |
| 18 | Fabrication of core-shell PLGA/PLA-pNIPAM nanocomposites for improved entrapment and release kinetics of antihypertensive drugs显示文摘Polylactic acid (PLA)and poly(lactic-co-glycolic)acid (PLGA)are two commonly applied biodegrad- able polymers for the preparation of nanocomposites used in drug-delivery systems.However,these polymers lack desirable attributes such as resistance to aggregation during long-term storage due to lyophilisation.To improve their efficacy,in this work,PLA and PLGA were encapsulated within a shell of poly(N-isopropylacrylamide)(pNIPAM)using a single emulsion technique followed by an aqueous free radical precipitation polymerisation process,yielding core-shell PLA/PLGA-pNIPAM nanocomposites. The nanocomposites were cbaracterised using zeta potential,dynamic light scattering,and transmission electron microscopy analyses and were further applied as a delivery system for ramipril,an antihypertensive drug.The drug-loaded PLGA-pNIPAM core-shell nanoparticles exhibited a higher drug content (91%)and entrapment efficiency (78%)than their PLA counterparts.An in vitro release study of the formulations at pH 7.3in phosphate-buffered saline indicated that PLGA was more efficient than PLA with a sustained release of 86% of ramipril from the polymer matrix within 24h.Furthermore,to determine the release kinetics,the data were fitted to Korsmeyer-Peppas and Higuchi models;the release of ramipril from the polymer matrix followed zero-order rate kinetics and an anomalous (non-Fickian)diffusion mechanism. | Tanushree Basu Bonamali Pal Satnam Singh | 2018 | Particuology2018，16，5： | 1 |
| 19 | Chitosan inhibits growth of spoilage micro-organisms in chilled pork products显示文摘 | Satnam S Ron B Sibel R | 2002 | Food Microbiology2002，19，2： | 1 |
| 20 | Chitosan Inhibits Growth of Spoilage Micro - organisms in Chilled Pork Products显示文摘 | Satnam Sagoo Ron Sibel Roller | 2002 | Food Microbiology2002，19，： | 1 |
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