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| 1 | Hepatic intra-arterial infusion of yttrium-90 microspheres in the treatment of recurrent hepatocellular carcinoma after liver transplantation: A case report显示文摘Hepatocellular carcinoma (HCC) recurs with a reported frequency of 12%-18% after liver transplantation. Recurrence is associated with a mortality rate exceeding 75%. Approximately one-third of recurrences develop in the transplanted liver and are therefore amenable to local therapy. A variety of treatment modalities have been reported including resection, transarterial chemo- embolization (TACE), radiofrequency ablation (RFA), ethanol ablation, cryoablation, and external beam irradiation. Goals of treatment are tumor control and the minimization of toxic effect to functional parenchyma. Efficacy of treatment is mitigated by the need for ongoing immunosuppression. Yttrium-90 microspheres have been used as a treatment modality both for primary HCC and for pre-transplant management of HCC with promising results. Twenty-two months after liver transplantation for hepatitis C cirrhosis complicated by HCC, a 42-year old man developed recurrence of HCC in his transplant allograft. Treatment of multiple right lobe lesions with anatomic resection and adjuvant chemotherapy was unsuccessful. Multifocal recurrence in the remaining liver allograft was treated with hepatic intra-arterial infusion of yttrium-90 microspheres (SIR-Spheres, Sirtex Medica Inc., Lake Forest, IL, USA). Efficacy was demonstrated by tumor necrosis on imaging and a decrease in alpha-fetoprotein (AFP) level. There were no adverse consequences of initial treatment. | Louis Rivera Huan Giap William Miller Jonathan Fisher Donald J Hillebrand Christopher Marsh Randolph L Schaffer | 2006 | World Journal of Gastroenterology2006，12，35： | 6 |
| 2 | Genetic and environmental control of fruit maturation,dry matter and firmness in apple(Malus×domestica Borkh.)显示文摘For any given genotype,the environment in which an apple is grown can influence the properties of the fruit considerably.While there has been extensive research on the mechanism of the genetic control of fruit quality traits,less effort has been made to investigate the way that these genetic mechanisms interact with the environment.To address this issue,we employed a large‘Royal Gala’בBraeburn’population of 572 seedlings replicated over sites in three climatically diverse apple-growing regions in New Zealand.Phenotyping for traits including fruit maturation timing,firmness and dry matter content was performed at each of these three sites for a single growing season(2011),and at two sites(Motueka and Hawke’s Bay)for two seasons(2009 and 2010).The phenotype data collected over 2 years at two sites enabled the detection of 190 quantitative trait loci(QTL)that controlled these traits regardless of year or growing location,as well as some chromosomal loci that influenced the traits in a single given environment or year.For those loci that were environmentally stable over three sites,there was an interdependency of fruit maturation date,dry matter content and storage potential within this population,with two regions on Linkage Groups(LGs)10 and 16 strongly contributing.If these loci were used in a marker-assisted selection programme to select for progeny bearing firmer fruit,this would have the unintentional consequence of selecting,high dry matter content,later maturing apples.In addition,a further 113 new QTLs with a smaller effect were identified,some of which were exhibited only in a single growing environment,demonstrating the underlying complexity of control of traits determining fruit quality,in addition to the need for being aware of environmental effects when developing new apple varieties. | David Chagne Daya Dayatilake Robert Diack Murray Oliver Hilary Ireland Amy Watson Susan E Gardiner Jason W Johnston Robert J Schaffer Stuart Tustin | 2014 | Horticulture Research2014，1，1： | 2 |
| 3 | Gapped BLAST and PSI-BLAST: a new generation of protein database searchprograms显示文摘 | Madden T L Schaffer A A Zhang J Zhang Z Miller W Lipman D J | 1997 | Nucle ic Acids Res1997，25，： | 1 |
| 4 | T lymphocytes can be effectively recruited for ex vivo and in vivo lysis of AML blasts by a novel CD33/CD3-bispecific BiTE antibody construct显示文摘 | Aigner M Feulner J Schaffer S | 2013 | Leukemia2013，27，5： | 1 |
| 5 | Tumor classification using phylogenetic methods on expression data 显示文摘 | Desper R Khan J Schaffer AA | 2004 | J Theor Biol2004，228，： | 1 |
| 6 | Design and Performance Analysis of a Massively Parallel Atmospheric General Circulation Model显示文摘 | Schaffer D S Suarez M J | 2000 | Scientific Programming2000，8，1： | 1 |
| 7 | The influence of collision ener- gy and strain accumulation on the kinetics of mechanical al- loying显示文摘 | Schaffer G B Forrester J S | 1997 | J Mater Sci1997，32，12： | 1 |
| 8 | Biochemistry of metallothionein显示文摘 | Kagi J H Schaffer A | 1988 | Biochemistry1988，27，23： | 1 |
| 9 | PI3K/Akt and CREB regulate adult neural hippoeampal progenitor proliferation and differe-ntiation 显示文摘 | Peltier J O'Neill A Schaffer DV | 2007 | Developmental Neurobiology2007，67，10： | 1 |
| 10 | An improved procedure for synthesis of DL-4-hydroxy-3-ethoxymandelic acid显示文摘 | Alexander J Fatiadi Robert Schaffer | 1974 | Journal of Research of the National Bureau of Standards Section A:Physics and Chemistry1974，78，3： | 1 |
| 11 | Nanophase- separated polymer films as high-performance antireflection coatings显示文摘 | Walheim S Schaffer E Mlynek J | 1999 | Science1999，283，： | 1 |
| 12 | Mechanism underlying theantioxidant activity of taurine: prevention of mitochondrial oxidantproduction显示文摘 | Jong CJ Azuma J Schaffer S | 2012 | Amino Acids2012，42，6： | 1 |
| 13 | Four independent mu- tations in the feline fibroblast growth factor 5 gene determine the long-haired phenotype in domestic cats 显示文摘 | Kehler J S David V A Schaffer AA | 2007 | J Hered2007，98，6： | 1 |
| 14 | Role of mitochondrial permeabilitytransition in taurine deficiency-induced apoptosis 显示文摘 | Jong CJ Azuma J Schaffer SW | 2011 | Exp ClinCardiol2011，16，4： | 1 |
| 15 | Role of antioxidant activity of taurine in diabetes显示文摘 | Schaffer SW Azuma J Mozaffari M | 2009 | Can J Physiol Pharmacol2009，87，： | 1 |
| 16 | Requirement for cellular cyclin-dependent kinases in herpes simplex virus replication and transcription 显示文摘 | Schang LM Phillips J Schaffer PA | 1998 | J Virol1998，72，7： | 1 |
| 17 | Microarray analysis of diurnal and circadian-regulated genes in Arabidopsis显示文摘 | Schaffer R Landgraf J Accerbi M Simon V Larson M Wisman E | | 0，，： | 1 |
| 18 | Mechanism underlying the antioxidant activity of taurine: prevention of mitochondrial oxidant production显示文摘 | Jong CJ Azuma J Schaffer S | 2012 | Amino Acids2012，42，6： | 1 |
| 19 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs 显示文摘 | Altschul S F Madden T L Schaffer A A Zhang J Zhang Z Miller W Lipman D J | 1997 | Nucleic Acids Res1997，25，： | 1 |
| 20 | The effect of ultrafiltered dialysate on the cellular content of interleukin-1 receptor antagonist in patients on chronic hemodialysis显示文摘 | Schindler R Lonnemann G Schaffer J | 1994 | Nephron1994，68，： | 1 |
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