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| 1 | Estimating steatosis and fibrosis: Comparison of acoustic structure quantification with established techniques显示文摘AIM:To compare ultrasound-based acoustic structure quantification(ASQ) with established non-invasive techniques for grading and staging fatty liver disease.METHODS:Type 2 diabetic patients at risk of nonalcoholic fatty liver disease(n = 50) and healthy volunteers(n = 20) were evaluated using laboratory analysis and anthropometric measurements, transient elastography(TE), controlled attenuation parameter(CAP), proton magnetic resonance spectroscopy(1H-MRS; only available for the diabetic cohort), and ASQ.ASQ parameters mode, average and focal disturbance(FD) ratio were compared with:(1) the extent of liver fibrosis estimated from TE and nonalcoholic fatty liver disease(NAFLD) fibrosis scores; and(2) the amount of steatosis, which was classified according to CAP values.RESULTS:Forty-seven diabetic patients(age 67.0±8.6 years;body mass index 29.4±4.5 kg/m2)with reliable CAP measurements and all controls(age 26.5±3.2 years;body mass index 22.0±2.7 kg/m2)were included in the analysis.All ASQ parameters showed differences between healthy controls and diabetic patients(P<0.001,respectively).The ASQ FD ratio(logarithmic)correlated with the CAP(r=-0.81,P<0.001)and 1H-MRS(r=-0.43,P=0.004)results.The FD ratio[CAP<250 d B/m:107(102-109),CAP between 250 and 300 d B/m:106(102-114);CAP between 300 and 350 d B/m:105(100-112),CAP≥350 d B/m:102(99-108)]as well as mode and average parameters,were reduced in cases with advanced steatosis(ANOVA P<0.05).However,none of the ASQ parameters showed a significant difference in patients with advanced fibrosis,as determined by TE and the NAFLD fibrosis score(P>0.08,respectively).CONCLUSION:ASQ parameters correlate with steatosis,but not with fibrosis in fatty liver disease.Steatosis estimation with ASQ should be further evaluated in biopsy-controlled studies. | Thomas Karlas Joachim Berger Nikita Garnov Franziska Lindner Harald Busse Nicolas Linder Alexander Schaudinn Bettina Relke Rima Chakaroun Michael Trltzsch Johannes Wiegand Volker Keim | 2015 | World Journal of Gastroenterology2015，21，16： | 9 |
| 2 | Biofilm removal with a dental water jet显示文摘 | Gorur A Lyle DM Schaudinn C | 2009 | Compend Contin Educ Dent2009，1，： | 1 |
| 3 | Imaging of endodontic biofilms by combined microscopy (FISH/cLSM-SEM)显示文摘 | Schaudinn C Carr G Gorur A | 2009 | J Microsc2009，235，2： | 1 |
| 4 | Detection of a microbial biofilm in intraamniotic infection显示文摘 | Romero R Schaudinn C Kusanovic JP | 2008 | Am J Obstet Gynecol2008，198，1： | 1 |
| 5 | Periodontitis:an archetypical biofilm disease显示文摘 | Schaudinn C Gorur A Keller D | 2009 | J Am Dent Assoc2009，140，8： | 1 |
| 6 | Detection of a microbial biofilm in intraamniotic infection显示文摘 | Romero R Schaudinn C Kusanovic JP | | 0，，01： | 1 |
| 7 | Imaging of endodontic biofilms by combined microscopy ( FISH/cLSM -SEM ) 显示文摘 | Schaudinn C Carr G Gorur A | 2009 | J Microsc2009，235，2： | 1 |
| 8 | Pulsed atmospheric-pressure cold plasma for endodon- tic disinfection 显示文摘 | JIANG C CHEN M T SCHAUDINN C | 2009 | IEEE Transaction on Plasma Sci- ence2009，37，7： | 1 |
| 9 | Characterization of enterocoliticin,a phage tail-like bacteriocin,and its effect on pathogenic Yersinia enterocolitica strains显示文摘 | STRAUCH E KASPAR H SCHAUDINN C | 2001 | Appl Environ Microbiol2001，67，12： | 1 |
| 10 | Detec- tion of a microbial biofilm in intraamniotic infection 显示文摘 | Romero R Schaudinn C Kusanovic JP | 2008 | Am J Obstet Crynecol2008，198，1： | 1 |
| 11 | First-time isolation and characterization of a bacteriophage encoding the Shiga toxin 2c variant,which is globally spread in strains of Escherichia coli O157显示文摘 | Strauch E Schaudinn C Beutin L | 2004 | Infect Immun2004，72，12： | 1 |
| 12 | First-time isolation and characterization of a bacteriophage encoding the Shiga toxin 2c variant,which is globally spread in strains of Escherichia coli O157显示文摘 | STRAUCH E SCHAUDINN C BEUTIN L | 2004 | Infection and Immunity2004，72，12： | 1 |
| 13 | Detection of a microbial biofilm in intraamniotic infection显示文摘 | Romero R Schaudinn C Kusanovic JP | 2008 | Am J Obstet Gynecol2008，198，1： | 1 |
| 14 | Detection of a micro- bial biofilm in intraamniotic infection显示文摘 | Romero R Schaudinn C Kusanovic JP | 2008 | Am J Obstet Gynecol2008，198，1： | 1 |
| 15 | Detection of a microbial biofilm in into-amniotic infection显示文摘 | Romeo R Schaudinn C Kusanovic JP | | 0，，01： | 1 |
| 16 | Detection of a microbial biofilm in intraamniotic infection显示文摘 | Romero R Schaudinn C Kusanovic JP | | 0，，01： | 1 |
| 17 | Imaging of endodontic biofihns by eombined microseopy (FISH/eLSM-SEM) 显示文摘 | Schaudinn C Cart G Gorur A | 2009 | J Mierosc2009，235，： | 1 |
| 18 | Detection of a microbial biofilm in intraamniotic infection 显示文摘 | Romero R Schaudinn C Kusanovic J P | 2008 | Am J Obstet Gynecol2008，198，1： | 1 |
| 19 | Periodon- titis: an archetypical biofilm disease显示文摘 | SCHAUDINN C GORUR A KELLER D | 2009 | Am Dent Assoc2009，140，8： | 1 |
| 20 | Pulsed atmospheric -pressure cold plasma for endodontic disinfection 显示文摘 | C Jiang MT Chen C Schaudinn | 2009 | IEEE Trans Plasma Sei2009，37，： | 1 |
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