维普期刊资源整合服务平台（V6.5）

93篇 您的检索式：作者名="Schink M"

选中清除导出查看参考文献查看引证文献引用追踪共5页首页上一页第1页下一页末页 /5 跳转

	题名	作者	年代	出处	被引量
1	Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling显示文摘Skeletal health relies on architectural integrity and sufficient bone mass, which are maintained through a tightly regulated equilibrium of bone resorption by osteoclasts and bone formation by osteoblasts. Genetic studies have linked the gene coding for low-density lipoprotein receptor-related protein1(Lrp1) to bone traits but whether these associations are based on a causal molecular relationship is unknown. Here, we show that Lrp1 in osteoblasts is a novel regulator of osteoclast activity and bone mass.Mice lacking Lrp1 specifically in the osteoblast lineage displayed normal osteoblast function but severe osteoporosis due to highly increased osteoclast numbers and bone resorption. Osteoblast Lrp1 limited receptor activator of NF-κB ligand(RANKL) expression in vivo and in vitro through attenuation of platelet-derived growth factor(PDGF-BB) signaling. In co-culture, Lrp1-deficient osteoblasts stimulated osteoclastogenesis in a PDGFRβ-dependent manner and in vivo treatment with the PDGFR tyrosine kinase inhibitor imatinib mesylate limited RANKL production and led to complete remission of the osteoporotic phenotype. These results identify osteoblast Lrp1 as a key regulator of osteoblast-to-osteoclast communication and bone mass through a PDGF–RANKL signaling axis in osteoblasts and open perspectives to further explore the potential of PDGF signaling inhibitors in counteracting bone loss as well as to evaluate the importance of functional LRP1 gene variants in the control of bone mass in humans.	Alexander Bartelt Friederike Behler-Janbeck F.Timo Beil Till Koehne Brigitte Müller Tobias Schmidt Markus Heine Laura Ochs Tayfun Yilmaz Martin Dietrich Jan P.Tuckermann Michael Amling Joachim Herz Thorsten Schinke Joerg Heeren Andreas Niemeier	2018	Bone Research2018，6，1：	5
2	Anaerobic nitrate dependent microbial oxidation of ferrousiron显示文摘	Straub K L Benz M Schink B	1996	Appl Environ Microbiol1996，62，4：	1
3	Phosphite oxidation by sulphate reduction显示文摘	Schink B Friedrich M	2000	Nature2000，406，7：	1
4	Rituximab for the second-and third-line therapy of idiopathic membranous nephropathy:a prospective single center study using a new treatment strategy显示文摘	Busch M Rüster C Schink(o)the C		0，，02：	1
5	Head-tohead comparison of multislice computed tomography and exercise electrocardiography for diagnosis of coronary artery disease显示文摘	Dewey M Dubel H P Schink T		0，，20：	1
6	Cartilage formation and calcification in arteries of mice lacking matrix Gla protein显示文摘	EI Maadawy S Kaartinen M T Schinke T	2003	Connect Tissue Res2003，44，1：	1
7	Bacterial metabolism:phosphite oxidation by sulphate reduction显示文摘	Schink B Friedrech M	2000	Nature2000，406，6791：	1
8	Calcitonin deficiency in mice progressively results in high bone turnover显示文摘	Huebner AK Schinke T Priemel M	2006	J Bone Miner Res2006，21，12：	1
9	Extracellular matrix mineralization is regulated locally; different roles of two gla- containing proteins显示文摘	Murshed M Schinke T Mckee MD	2004	J Cell Biol2004，165，5：	1
10	Phosphite oxidation by sulfate reduction显示文摘	Schink B Friedrich M	2000	Nature2000，406，：	1
11	Evidence for airborne infectious disease transmission in public ground transport-a literature review 显示文摘	Mohr O Askar M Schink S	2012	Euro Surveill2012，17，20：	1
12	Mouse cardiac surgery: o comprehensive techniques for the generation of mouse models of human diseases and their application for genomic studies显示文摘	Tarnavski O McMullen JR Schinke M	2004	Physiol Genomics2004，16，：	1
13	Anaerobic, nitrate dependent microbial oxidation of ferrous iron显示文摘	Straub K L Benz M Schink B	1996	Appl Environ Microbiol1996，62，：	1
14	Reorganization of the femoral cortex due to age, sex, and endoprosthetie related effects emphasized by osteonal dimensions and remodeling显示文摘	Busse B Hahn M Schinke T	2010	J Biomed Mater Res A2010，92，4：	1
15	Mouse cardiac surgery: comprehensive techniques for the generation of mouse models of human diseases and their application for genomic studies显示文摘	TARNAVSKI O MCMULLEN J R SCHINKE M	2004	Physiol Ge nomics2004，16，：	1
16	Phosphite Oxidation by Sulfate Reduction显示文摘	Schink B Friedrich M	2000	Nature2000，406，：	1
17	Humic acid reduction by propionibacterium freudenreichii and other fermenting bacteria显示文摘	Benz M Schink B Brune A	1998	Applied and Environmental Microbiology1998，64，11：	1
18	Frequency of referral of patientswith safety-related contraindications to magnetic resonance imaging 显示文摘	Dewey M Schink T Dewey CF	2007	Eur J Radio12007，63，9：	1
19	Mistletne extract reduces the surgical suppression of natural killer cell activity in cancer patients, a randomized phase Ⅲ trial 显示文摘	Schink M Troger W Dabidian A	2007	Forsch Komplementmed2007，14，1：	1
20	Iron metabolism in anoxic environments at near neutral pH 显示文摘	Straub K L Benz M Schink B	2001	FEMS Microbiology Ecology2001，34，：	1

返回顶部每页显示：

共5页首页上一页第1页下一页末页 /5 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示