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| 1 | Long-term outcomes of interventions for radiation-induced xerostomia:A review显示文摘Xerostomia, or dry mouth, is a significant problem affecting quality of life in patients treated with radiation therapy for head and neck cancer. Strategies for reduction of xerostomia burden vary widely, with options including: sialagogue medications, saliva substitutes, acupuncture, vitamins, hyperbaric oxygen,submandibular gland transfer, and acupuncture or associated treatments. In this review, we sought to evaluate long-term outcomes of patients treated with various interventions for radiation-induced xerostomia. A literature search was performed using the terms 'xerostomia' and 'radiation' or 'radiotherapy'; all prospective clinical trials were evaluated, and only studies that reported 1 year follow up were included. The search results yielded 2193 studies, 1977 of which were in English. Of those, 304 were clinical trials or clinical studies. After abstract review, 23 trials were included in the review evaluating the following treatment modalities: pilocarpine(three); cevimeline(one); amifostine(eleven);submandibular gland transfer(five); acupuncture like transcutaneous electrical nerve stimulation(ALTENS)(one); hyperbaric oxygen(one); and acupuncture(one). Pilocarpine, cevimeline, and amifostine have been shown in some studies to improve xerostomia outcomes, at the cost of toxicity. ALTENS has similar efficacy with fewer side effects. Submandibular gland transfer is effective but requires an elective surgery, and thus may not always be appropriate or practical.The use of intensity-modulated radiation therapy, in addition to dose deescalation in select patients, may result in fewer patients with late xerostomia,reducing the need for additional interventions. | Sung Jun Ma Charlotte I Rivers Lucas M Serra Anurag K Singh | 2019 | World Journal of Clinical Oncology2019，10，1： | 4 |
| 2 | Membrane Damage by an α-Helical Pore-forming Protein, Equinatoxin II, Proceeds through a Succession of Ordered Steps显示文摘 | Nejc Rojko Katarina ?. Kristan Gabriella Viero Eva ?erovnik Peter Ma?ek Mauro Dalla Serra Gregor Anderluh | 2013 | Journal of Biological Chemistry2013，，33： | 1 |
| 3 | Antiepileptic drug withdrawal in childhood: Does the duration of tapering off matter for seizure recurrence? 显示文摘 | Serra JG Montenegro MA Guerreiro MM | 2005 | J Child Neurol2005，20，： | 1 |
| 4 | The impact of avoidable mortality on life expectancy at birth in Spain: changes between three periods, from 1987 to 2001显示文摘 | Gispert R Serra I Bar6s MA | 2008 | J Epidemiol Commun Health2008，62，9： | 1 |
| 5 | Structural theory of thermoeconomics,AES(ASME Book H00874)显示文摘 | Valero A Serra L Lozano MA | 1993 | ASME1993，30，： | 1 |
| 6 | Clinical value of increased serum creatinine concentration as predictor of short-term outcome in decompensated cirrhosis 显示文摘 | Serra MA Puchades M J Rodriguez F | 2004 | Scand J Gastroenterol2004，39，11： | 1 |
| 7 | Small molecule in- tegrin antagonists in cancer therapy显示文摘 | Paolillo M Russo MA Serra M | 2009 | Mini Rev Med Chem2009，9，12： | 1 |
| 8 | Effectiveness of a preoperative autologous blood donation programin total knee replacement显示文摘 | Camarasa MA Olle G Serra PM | 2006 | Med C1in2006，21，7： | 1 |
| 9 | IL-6 and IL-18 in blood may diseriminate eirrhotic patients with and without minimal hepatic encephalopathy 显示文摘 | Montoliu C Piedrafita B Serra MA | 2009 | J Clin Gastroenterol2009，43，3： | 1 |
| 10 | Small molocule intogrin antagonists in cancer therapy 显示文摘 | Paolillo M Russo MA Serra M | 2009 | Mini Roy Mod Chore2009，9，12： | 1 |
| 11 | Antiepileptic drug withdrawal in childhood:does the duration of tapering off matter for seizure recurrence显示文摘 | Serra JG Montenegro MA Guerreiro MM | | 0，，： | 1 |
| 12 | Color change of fresh-cut apples coated with whey protein concentrate-based deible coatings显示文摘 | Perez-Gago M B M Serra MA | 2007 | Postharvest Biology and Technology2007，39，： | 1 |
| 13 | Antagonistic effects of TGFbe-tal and BMP-6 on skin keratinocyte differentiation 显示文摘 | McDonnell MA Law BK Serra R | 2001 | Exp Cell Res2001，263，2： | 1 |
| 14 | Antiepileptic drug withdrawal in childhood: does the duration of tapering off matter for seizure recurrence? 显示文摘 | Serra JG Montenegro MA Guerreiro MM | 2005 | J Child Neurol2005，20，7： | 1 |
| 15 | Antiepileptic drugwithdrawal in childhood : does the duration of tapering off mat-ter for seizure recurrence 显示文摘 | Serra JG Montenegro MA Guerreiro MM | 2005 | J Child Neurol2005，20，7： | 1 |
| 16 | Efficacy of aminocap- roic, tranexamic acids in the control of bleeding during total knee re- placement : a randomized clinical trial 显示文摘 | Camarasa MA Olle G Serra - Prat M | 2006 | Br J Anaesth2006，96，： | 1 |
| 17 | Effect of a sardinesupplement on C-reactive protein in patients receiving hemodi-alysis显示文摘 | Moreira AC Gaspar A Serra MA | 2007 | J Ren Nutr2007，17，3： | 1 |
| 18 | Im- pact of exacerbations on the clinical course of chronic obstructive pulmonary disease显示文摘 | Soler-Cataluna JJ Martinez-Garcia MA Catalan Serra P | 2013 | Revista clinica espanola2013，2112，： | 1 |
| 19 | Effectiveness of a preoper- ative autologous blood donation program in total knee replacement 显示文摘 | Camarasa MA One G Serra Prat M etal | 2006 | Med Clin2006，21，7： | 1 |
| 20 | Antiepileptics drugwithdrawal in childhood:Does the duration of tapering off matterfor seizure recurrence? 显示文摘 | Serra JG Montenegro MA Guerreiro MM | 2005 | J Child Neurol2005，20，7： | 1 |
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