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| 1 | Synthesis, insecticidal activities and SAR studies of novel anthranilic diamides containing trifluoroethoxyl substituent and chiral amino acid moieties显示文摘Ryanodine receptors(RyRs) activator has become one class of popular insecticide because of its unique mode of action. In order to find more new RyRs activators as insecticidal agents, a series of 18 novel chiral anthranilic diamides were designed by introducing the D-alanine acid and D-serine acid esters as well as trifluoroethoxyl group into the anthranilic diamide skeleton and synthesized successfully based on anthranilic diamide and FKI-1033 structures. The structures of the title compounds Ia–i and IIa–i were confirmed by melting points,~1H NMR,^(13)C NMR, elemental analysis and specific optical rotation analysis.The preliminary bioassay results indicated that most of the title compounds exhibited considerable larvicidal activities against oriental armyworm at 10 mg/L, especially Ib, Ie and IIh showed remarkable insecticidal activities at 0.5 mg/L. The larvicidal activity against diamondback moth of Ia and IId were 80%and 90% respectively at 0.0001 mg/L, which was similar to that of chlorantraniliprole. The relationship between structure and insecticidal activity was analyzed to reveal a possible co-regulated effect of the chiral amino acid ester, halogen atom or cyano group, and trifluoroethyloxyl group of the skeleton structures of the title compounds, which will provide useful information for guiding the design and discovery of new RyRs activators and insecticidal agrochemicals. | Shaa Zhou Sha Zhou Yongtao Xie Xiangde Meng Baolei Wang Lixia Xiong Na Yang Zhengming Li | 2018 | Chinese Chemical Letters2018，29，8： | 3 |
| 2 | Design, Synthesis and Insecticidal Evaluation of Anthranilic Diamides Containing Optically Pure Amino Acid Moiety显示文摘N-pyridylpyrazolecarboxamide 衍生物的二个系列被介绍 D 丙氨酸酸酉旨和 D 丝氨酸酸酉旨进 chlorantraniliprole 的骨骼设计并且综合。获得的结构被 1 H NMR, 13 C NMR,元素的分析和特定的光旋转分析。初步的生物鉴定显示一些混合物与 chlorantraniliprole 比较对分开的 Mythimna 和 Plutella xylostella 显示了优秀杀虫的活动。特别地, IIq 在 0.01 mg·L −1 与 90% 的死亡率对 Plutella xylostella 显示出优秀杀虫的活动。A 3D-QSAR (CoMSIA ) 学习被执行以便揭示杀虫的结构活动关系并且显示未来工作。CoMSIA 学习证明在 pyrazole 的 3 位置的缺乏的组打电话找的大候补选手和电子是有利的,与氨基酸的酉旨组附近的一个小组一样。 | Shaa Zhou Sha Zhou Xuewen Hua Wei Wei Yongtao Xie Minggui Chen Xiangde Meng Ming Liu Lixia Xiong Na Yang Baolei Wang Zhengming Li | 2016 | Chinese Journal of Chemistry2016，34，12： | 2 |
| 3 | Research on controllable alkaline soil degradation of 5-substituted chlorsulfuron显示文摘Sulfonylurea(SU) has become one class of the most important herbicides worldwide due to their ultralow application rate and mammalian toxicity. Recently application licenses of 3 classical SU herbicides chlorsulfuron, metsulfuron-methyl and ethametsulfuron were suspended due to their undesirable long persistence which is incompatible with the particular rotation planting system in China. Our previous study has discovered that electron-donating groups, especially dimethylamino and diethylamino substituents, on the 5 th position of the benzene ring in chlorsulfuron, greatly accelerated its degradation rate in an acidic soil(p H 5.41). Owing to the natural slower degradation of SUs in alkaline soil,dimethylamino and diethylamino substituted chlorsulfuron Ia and Ib were further studied in an alkaline soil(p H 8.46) with chlorsulfuron as a control. The experimental data indicated that the half-life of degradation(DT_(50)) of Ia was 3.36 days while Ib was 6.25 days which amounted to 30 and 15 folds faster than chlorsulfuron(DT_(50)84.53 days), respectively. The research confirmed that our newly-designed structures Ia and Ib can hasten their degradation rate in alkaline soil as well as in acidic soil. This structural modification of the classical SU provided an opportunity to control the degradation rate to reduce their impact on relevant environment and ecology. | Shaa Zhou Xuewen Hua Wei Wei Minggui Chen Yucheng Gu Sha Zhou Haibin Song Zhengming Li | 2018 | Chinese Chemical Letters2018，29，6： | 2 |
| 4 | Controllable Effect of Structural Modification of Sulfonylurea Herbicides on Soil Degradation显示文摘在与他们的不同结构的属性的关系的 sulfonylurea 除草剂的土壤降级行为的学习是为我们重要的最大可能理解新 eco 友好的除草剂的发展。化学结构的结构的修正能在土壤影响他们的降级率,这被要求。九设计结构被综合分别地学习他们的 herbicidal 活动以及他们的土壤降级行为。新奇混合物 I-3-I-7 被描绘由紫外, 1 H NMR 和 13 C NMR, MS 和 EA。生物鉴定显示大多数目标混合物与 Chlorsulfuron 比较显示了优异 herbicidal 活动。土壤降级结果进一步证实了我们以前的假设在 5 苯戒指的 th 位置清楚地增加了他们的降级率, dimethylamino 和 diethylamino 组能以更有利的地位在之中调整降级率。 | Xuewen Hua Shaa Zhou Minggui Chen Wei Wei Ming Liu Kang Lei Sha Zhou Yonghong Li Baolei Wang Zhengming Li | 2016 | Chinese Journal of Chemistry2016，34，11： | 2 |
| 5 | The exploration of chiral N-cyano sulfiliminyl dicarboxamides on insecticidal activities显示文摘Due to new mechanism of action and ecofriendly characteristics,dicarboxamide insecticides have attracted more and more attentions in modern pest management.A series of 20 dual chiral N-cyano sulfilimines containing two centers(carbon and sulfur) were designed and synthesized.All title compounds were determined by ~1H NMR,high-resolution mass spectrometry(HRMS) and optical polarimeter.The preliminary results indicated that some of them exhibited favourable insecticidal activities against oriental armyworm(Pseudaletia separata Walker).These isomers exhibited different impact on activity following the sequence as(Sc,Ss) >(Sc,Rs),and the rule of title compounds' activity against oriental armyworm was 3-CF_3≥2—CH_3—4—Cl>2,3,4-trifluro in the anilide moiety.The results indicated that these groups such as 3-CF_3,2—CH_3—4—Cl or 2,3,4-trifluro were inefficient to replace heptafluoroisopropyl group for high larvicidal activity,which provided some guidance for the further modifications of sulfiliminyl dicarboxamides. | Sha Zhou Shaa Zhou Yong-Tao Xie Ru-Yi Jin Xiang-De Meng Dong-Kai Zhang Xue-Wen Hua Ming Liu Chang-Chun Wu Li-Xia Xiong Yu Zhao Zheng-Ming Li | 2017 | Chinese Chemical Letters2017，28，7： | 1 |
| 6 | Design, Synthesis, Biological Evaluation and SARs of Novel N-Substituted Sulfoximfnes as Potential Ryanodine Receptor Modulators显示文摘 | Yongtao Xie Sha Zhou Yuxin Li Shaa Zhou Minggui Chen Baolei Wang Lixia Xiong Na Yang Zhengming Li | 2018 | Chinese Journal of Chemistry2018，36，2： | 0 |
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