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| 1 | Retrospective epidemiological study of thyroid nodules by ultrasound in asymptomatic subjects显示文摘 | Sharen Gaowa Zhang Bo Zhao Ruina Sun Jie Gai Xiaorong Lou Huiping | 2014 | Chinese Medical Journal2014，，9： | 17 |
| 2 | Application of Shear Wave Elastography and Contrast-Enhanced Ultrasound in Transrectal Prostate Biopsy显示文摘Objective To explore the clinical value of ultrasound shear wave elastography(SWE)and contrast-enhanced ultrasound(CEUS)in transrectal prostate biopsy.Methods A total of 54 patients(average age:67.79±12.01 years)in the experimental group underwent transrectal prostate biopsy under the guidance of SWE,while 46 patients(average age:69.22±11.54 years)in the control group underwent transrectal prostate biopsy guided by CEUS.Results There were a total of 451 needles,with an average of 8.35±1.67 needles per patient in the experimental group,and a total of 462 needles,with an average of 10.04±1.33 needles per patient in the control group.The difference in puncture times between the two groups was statistically significant(P<0.05).There was no significant difference in the positive detection rate,sensitivity or specificity between the two groups(P>0.05),but there was a significant difference in the diagnostic accuracy between the two groups(P<0.05).The E_(mean)and E_(max)of prostate cancer were significantly higher in the experimental group than in benign prostatic hyperplasia(P<0.05).The receiver operating characteristic curve(ROC)analysis showed that the area under the ROC curve(AUC)of E_(mean)was 0.752(S.E.=0.072,95%CI=0.611-0.894,P=0.007),and the best cutoff value was 47.005 kPa.Conclusion In summary,both SWE-and CEUS-guided transrectal prostate biopsy can help find the focus and guide the puncture,and improve the positive detection rate. | Gao-wa SHAREN Jun ZHANG | 2022 | Current Medical Science2022，42，2： | 3 |
| 3 | A rare case of Staphylococcus lugdunensis septicemia associated with myocarditis and atrioventricular block显示文摘Myocarditis is a relatively rare,possibly life-threatening disease characterized by the inflammation of the myocardium.111 The disease pathogenesis is primarily initiated by acute injury and necrosis of cardiomyocytes,leading to an inflammatory response mediated by the immune system that can potentially cause further aggravation of myocardial damage and organ dysfunction.Prognosis in patients with myocarditis depends on the clinical presentation,which ranges from an asymptomatic disease course to the concomitant development of cardiac arrhythmias,heart failure,cardiogenic shock and even the occurrence of death in extreme cases[1]. | Alex Tsz Lai Nganh Sharen Lee Tong LIU Mark Tam Ka Hou Christien Li Michelle Vangi Wong Michael Huen Sum Lam Gary Tse Ishan Lakhani | 2019 | Journal of Geriatric Cardiology2019，16，1： | 2 |
| 4 | A Balanced-Force Algorithm for Contimlous and Sharp Interfacial Surface Tension Models Within a Volume Tracking Framework 显示文摘 | Marianne M Francois Sharen J Cummins Edward D Dendy | 2006 | Journal of Computational Physics2006，213，： | 1 |
| 5 | Survival and prognostic factors of motor neuron disease in a multi-ethnic Asian population显示文摘 | Khean-Jin Goh Sharen Tian Nortina Shahrizaila Chiu-Wan Ng Chong-Tin Tan | 2011 | Amyotrophic Lateral Sclerosis2011，，2： | 1 |
| 6 | A bal- anced-force algorithm for continuous and sharp interfa- cial surface tension models within a volume tracking frame work 显示文摘 | Marianne M F Sharen J C Edward D D | 2006 | Journal of Computational Physics2006，213，1： | 1 |
| 7 | Using distributed contacts in DEM 显示文摘 | Sharen J Cummins Paul W Cleary | 2011 | Applied Mathematical Modeling2011，35，4： | 1 |
| 8 | An investigation of the comparative behaviour of alternative contact force models during inelastic collisions显示文摘 | Colin Thornton Sharen J. Cummins Paul W. Cleary | 2013 | Powder Technology2013，，： | 1 |
| 9 | An investigation of the comparative behaviour of alternative contact force models during elastic collisions显示文摘 | Colin Thornton Sharen J. Cummins Paul W. Cleary | 2011 | Powder Technology2011，，3： | 1 |
| 10 | Ultrasonographic Observation of the Breast in Early Postmenopausal Women during Therapy with Cimicifuga Foetida Extract and Sequential Therapy with Estrogen and Progestin显示文摘 | Sharen Gaowa Ai-Jun Sun Ying Jiang Fa-Wei He Ting-Ping Zheng Ya-Ping Wang | 2015 | Chinese Medical Journal2015，，8： | 1 |
| 11 | Application of multiquadric method for numerical solution of elliptic partial differential equations 显示文摘 | Sharen M Kansa E J Gupta S | 1997 | Appl Math Comp1997，84，： | 1 |
| 12 | An SPH Projection Method显示文摘 | Sharen J Cummins Murray Rudman | 1999 | Journal of Computational Physics1999，，2： | 1 |
| 13 | A Patient with Atezolizumab-Induced Autoimmune Diabetes Mellitus Presenting with Diabetic Ketoacidosis显示文摘Background:Atezolizumab,an immune checkpoint inhibitor,is a humanized monoclonal,anti-programmed death ligand 1(PD-L1)antibody used for the treatment of metastatic urothelial carcinoma that has progressed after chemo-therapy.Case Presentation:We describe a patient with a known history of urothelial carcinoma who presented with dia-betic ketoacidosis 6 weeks following his second cycle of atezolizumab.His serum lactate level was slightly elevated(2 mM)and hisβ-hydroxybutyrate level was elevated(3.9 mM).High anion gap metabolic acidosis secondary to dia-betic ketoacidosis was diagnosed.Subsequent testing demonstrated hemoglobin A 1c level of 9.9%,positivity for anti-glutamic acid decarboxylase antibody(0.03 nM,reference range<0.02 nM),and suppressed C-peptide level(0.1μg/L,reference range 0.9-7.1μg/L)in the absence of detectable anti-islet antigen 2(IA-2)or anti-insulin antibodies.His initial management included cessation of atezolizumab treatment,intravenous sodium chloride administration,and insulin pump infusion,after which metabolic acidosis gradually resolved.The insulin pump was subsequently switched to Protaphane at 18 units before breakfast and 8 units before dinner,together with metformin at 1000 mg twice daily.Four weeks later his medication was changed to human isophane insulin plus neutral insulin(70%/30%;Mixtard 30 HM;26 units/4 units).Linagliptin at 5 mg was added 1 month later.His hemoglobin A 1c level declined to 8.1%1 year later.Conclusions:PD-L1 inhibitors can induce type 1 diabetes,and patients can present with diabetic ketoacidosis.Blood glucose levels should be regularly monitored in patients who are prescribed these medications. | Sharen Lee Gary Tse | 2021 | Cardiovascular Innovations and Applications2021，，3： | 0 |
| 14 | 最棒的妈妈显示文摘你曾经抱怨过自己的妈妈不如别人的妈妈好吗?也许事实并非如此。 | Liddell Sharen 雷起凤(译) | 2010 | 新东方英语.中学生(中英文版)2010，，5： | 0 |
| 15 | The impact of post-operative atrial fibrillation on outcomes in coronary artery bypass graft and combined procedures显示文摘BACKGROUND Postoperative atrial fibrillation(POAF)is a common yet understudied clinical issue after coronary artery bypass graft(CABG)leading to higher mortality rates and stroke.This systematic review and metaanalysis evaluated the rates of adverse outcomes between patients with and without POAF in patients treated with CABG or combined procedures.METHODS The search period was from the beginning of PubMed and Embase to May 18th,2020 with no language restrictions.The inclusion criteria were:(1)studies comparing new onset atrial fibrillation before or after revascularization vs.no new onset AF before or after revascularization.The outcomes assessed included allcause mortality,cardiac death,cerebral vascular accident(CVA),myocardial infarction(MI),repeated revascularization,major adverse cardiac event(MACE),and major adverse cardiac and cerebrovascular events(MACCEs).RESULTS Of the 7,279 entries screened,11 studies comprising of 57,384 patients were included.Compared to nonPOAF,POAF was significantly associated with higher risk of allcause mortality(Risk Ratio(RR)=1.58;95%Confidence Interval(CI):1.42−1.76,P<0.00001)with accompanying high level of heterogeneity(I^(2)=62%).Conclusions Patients with POAF after CABG or combined procedures are at an increased risk of allcause mortality or CVAs.Therefore,POAF after such procedures should be closely monitored and treated judiciously to minimize risk of further complications.While there are studies on POAF versus no POAF on outcomes,the heterogeneity suggests that further studies are needed. | Yau-Lam Alex Chau Ji Won Yoo Ho Chuen Yuen Khalid Bin Waleed Dong Chang Tong Liu Fang Zhou Liu Gary Tse Sharen Lee Ka Hou Christien Li | 2021 | Journal of Geriatric Cardiology2021，18，5： | 0 |
| 16 | Association of electrocardiographic markers with myocardial fibrosis as assessed by cardiac magnetic resonance in different clinical settings显示文摘BACKGROUND Cardiac magnetic resonance(CMR)is a unique tool for non-invasive tissue characterization,especially for identifying fibrosis.AIM To present the existing data regarding the association of electrocardiographic(ECG)markers with myocardial fibrosis identified by CMR-late gadolinium enhancement(LGE).METHODS A systematic search was performed for identifying the relevant studies in Medline and Cochrane databases through February 2021.In addition,we conducted a relevant search by Reference Citation Analysis(RCA)(https://www.referencecitationanalysis.com).RESULTS A total of 32 studies were included.In hypertrophic cardiomyopathy(HCM),fragmented QRS(fQRS)is related to the presence and extent of myocardial fibrosis.fQRS and abnormal Q waves are associated with LGE in ischemic cardiomyopathy patients,while fQRS has also been related to fibrosis in myocarditis.Selvester score,abnormal Q waves,and notched QRS have also been associated with LGE.Repolarization abnormalities as reflected by increased Tp-Te,negative Twaves,and higher QT dispersion are related to myocardial fibrosis in HCM patients.In patients with Duchenne muscular dystrophy,a significant correlation between fQRS and the amount of myocardial fibrosis as assessed by LGE-CMR was observed.In atrial fibrillation patients,advanced inter-atrial block is defined as P-wave duration≥120 ms,and biphasic morphology in inferior leads is related to left atrial fibrosis.CONCLUSION Myocardial fibrosis,a reliable marker of prognosis in a broad spectrum of cardiovascular diseases,can be easily understood with an easily applicable ECG.However,more data is needed on a specific disease basis to study the association of ECG markers and myocardial fibrosis as depicted by CMR. | George Bazoukis Sebastian Garcia-Zamora GökselÇinier Sharen Lee Enes Elvin Gul JesúsÁlvarez-García Gabi Miana Mertİlker Hayıroğlu Gary Tse Tong Liu Adrian Baranchuk | 2022 | World Journal of Cardiology2022，14，9： | 0 |
| 17 | ST-Segment Depression in Leads I and aVL: Artifactual or Pathophysiological Findings ?显示文摘The 12-lead electrocardiogram(ECG)is a routinely performed test but is susceptible to misinterpretation even by experienced physicians.We report a case of a 72-year-old lady with no prior cardiac history presented to our hospital with atypical chest pain.Her initial electrocardiogram shows an initial ST depression followed by positive defl ections leads I and aVL.Non-physiological ST segment and T-wave changes are also observed in the precordial leads V2 to V6.By contrast,these abnormalities are notably absent in lead II.A repeat of the ECG taken 30 minutes later reveals the resolution of most abnormalities seen in the initial ECG on a background of high-frequency noise in the limb leads.She was referred to the cardiology department for further management.An urgent echocardiogram revealed no regional wall motion abnormalities with preserved ejection fraction,and her coronary angiogram revealed no signifi cant coro-nary stenosis.This case illustrates the importance of understanding different factors that can cause ST segment abnor-malities,notably artifactual changes that can mimic ST segment myocardial infarction. | Sharen Lee Gary Tse Xin Wang Adrian Baranchuk Tong Liu | 2021 | Cardiovascular Innovations and Applications2021，，4： | 0 |
| 18 | An Open Invitation to Join the International Brugada Electrocardiographic Indices Registry显示文摘Background:The Brugada Electrocardiographic Indices Registry is a comprehensive data registry composed of patients with Brugada patterns on the electrocardiogram(ECG).The aim is to test the hypotheses that(i)ECG indices combining both depolarization and repolarization abnormalities can better predict spontaneous ventricular arrhythmias than existing ECG markers in Brugada syndrome and(ii)that serial ECG measurements will provide additional information for risk stratifi cation,especially in asymptomatic patients.Methods:Patients with both Brugada pattern ECGs and Brugada syndrome are eligible for inclusion in this registry.Baseline characteristics and ECG variables refl ecting depolarization and repolarization will be determined.The primary outcome is spontaneous ventricular tachycardia/ventricular fi brillation or sudden cardiac death.Secondary outcomes are inducible ventricular tachycardia/ventricular fi brillation and syncope.Results:As of November 15,2019,39 investigators from 32 cities in 18 countries had joined this registry.As of December 15,2019,1383 cases had been enrolled.Conclusions:The Brugada Electrocardiographic Indices Registry will evaluate the disease life course,risk factors,and prognosis in a large series of Brugada patients.It will therefore provide insights for improving risk stratification. | Gary Tse Sharen Lee Xuan Jiang Dong Chang Yunfei Gu Zhengrong Huang Xintao Li Qunshan Wang Shaoying Zeng Guoliang Li Dan Hu Jiandong Zhou Qingpeng Zhang Gan-Xin Yan Yunlong Xia Fang Zhou Liu Tong Liu | 2020 | Cardiovascular Innovations and Applications2020，，1： | 0 |
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