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251篇 您的检索式：作者名="Sharon S"

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	题名	作者	年代	出处	被引量
1	Chemical conjugation of a novel antibody interleukin 2 immunoconjugate against c erbB 2 product显示文摘Objective To develop a new chemical method to produce a monoclonal antibody (MoAb) 520C9/recombinant human interleukin 2 (rhIL 2) conjugate Methods MoAb 520C9 reactive with the protooncogene c erbB 2 product P185 was chemically conjugated with rhIL 2 by using a simple two step method First, the rhIL 2 was activated by Sulfosuccinimidyl 4 [N maleimidomethyl] cyclohexane 1 carboxylate, a heterobifunctional linker, and N succinimidyl s acetylthioacetate was introduced onto 520C9 Then SATA on the 520C9 was reacted with the maleimide group on the activated rhIL 2 to generate 520C9 rhIL 2 immunoconjugate Results The immunoconjugate retained the antigen binding activity compared to the respective native antibody as determined by an indirect live cell binding assay The immunoconjugate also possessed IL 2 activity as measured by the standard CTLL 2 cells proliferation assay and the stimulation of human peripheral blood mononuclear cells (PBMCs) into lymphokine activated killer cells Conclusion Our method of conjugation of rhIL 2 to 520C9 preserves the binding activity of the antibody and the cytokine function of IL 2 This simple and efficient method of conjugation should be applicable to other types of MoAbs and recombinant	李君 Sharon E Lee Marie Belciug David B Ring Cheuk S Kwok	2000	Chinese Medical Journal2000，，2：	3
2	Pharmacokinetics of melamine in pigs following intravenous administration显示文摘	RONALD E B GEOF S SHARON E M	2008	Food and Chemical Toxicology2008，46，：	1
3	Regulatory challenges for new drugs to treat obesity and eomorbid metabolic disorders 显示文摘	David J H Jane G Sharon L S	2009	Br J ClinPharmaeol2009，68，6：	1
4	Breast cancer in men显示文摘	Sharon H	2002	Annals of Internal Medicine2002，137，8：	1
5	Estimating the prevalence, incidence and cessation of injecting drug use in Glasgow 1960 - 2000 : Combining expert opinion with capture - recapture prevalence data显示文摘	SHARON J HUTCHINSON S M BIRD A T	2006	J Drug Policy2006，17，：	1
6	Fuzzy c-means clustering with spatial information for image segmenta- tion显示文摘	KEH S C HONG L T SHARON C	2006	Computerized Medical Imaging and Graphics2006，30，1：	1
7	Preventing the Sex-ual Transmission of HIV-1 with Topical Microbicides:Another Piece of the Equation显示文摘	Lisa C R Sharon L H Charlene S D	2007	EDITORIAL COM-MENTARY2007，96，：	1
8	A Randomized Controlled Trim of the Efficacy and Respiratory Effects of Patient-Controlld Intravenous Remifentanil Analgesia and Patient-Controlled Epidural Analgesia in Laboring Women 显示文摘	DANIEL S ID1T M SHARON E	2014	Anesth Analg2014，118，3：	1
9	Serum bactericidal activities of moxifloxacin and lcvofloxacin against aerobic and anaerobic intraabdominal pathogens显示文摘	Gary ES Sharon S Kerin LT	2008	Anaerobe2008，14，1：	1
10	Mixed dentition analysis for Asian - Americans 显示文摘	Sharon LC Lee-Chan S Jacobson BN	1998	Am J Orthod Dentofacial Orthop1998，113，3：	1
11	Vitamin D metabolites and analogs induce lipoxygenase mRNA expression and activity as well as reactive oxygen species (ROS) production in human bone cell line显示文摘	Somjen D Katzburg S Grafi-Cohen M Knoll E Sharon O Posner GH	2011	J Steroid Biochem Mol Biol2011，123，12：	1
12	Effects of a Pomegranate Fruit Extract rich in punicalagin on oxidation-sensitive genes and eNOS activity at sites of perturbed shear stress and atherogenesis显示文摘	Filomena N Sharon W I Vincenzo S	2007	Cardiovascular Research2007，73，：	1
13	Exploring Stakeholders' Expectations of the Benefits and Barriers of E-government Knowledge Sharing显示文摘	Jing Zhang Sharon S Dawes Joseph Sarkis	2005	The Journal of Enterprise Information Management2005，，5：	1
14	Vitamin D analogs induce lipoxygenase mRNA expression and activity as well as reactive oxygen species (ROS) production in human bone cells显示文摘	Somjen D Katzburg S Knoll E Sharon O Posner GH Stern N	2010	J Steroid Biochem Mol Biol2010，121，12：	1
15	Constructing LDPC codes by errorminimization progressive edge growth显示文摘	Sharon E Litsyn S	2008	IEEE Transac-tions on Communications2008，56，3：	1
16	Taguchi optimization ofthe carbon anode for Li-ion battery from natural precursors显示文摘	Bhardwaj S Sharon M Ishihara T	2008	Curr Appl Phys2008，8，：	1
17	Isolation and identification of thiohomosildenafil and thiosildenafil in health supplements 显示文摘	ZOU P HOU P L SHARON S Y	2008	J Pharm Biomed Anal2008，47，2：	1
18	Mecha- nisms of macrophage migration inhibitory factor ( MIF )-dependent tumor microenvironmental adaptation 显示文摘	Rendon Beatriz E Willer Sharon S Zundel Wayne	2009	Exp Mol Pathol2009，86，：	1
19	Development of monoclonal antibodies for an assay of cardiac troponin-I and preliminary results in suspected cases of myocardial infarction显示文摘	Geza S B Sharon P Yvonne L	1992	Clin Chem1992，38，11：	1
20	Contracting and Patterns of Nonprofit Governance显示文摘	SHARON L H	1998	Nonprofit management & leadership1998，8，3：	1

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