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| 1 | 外用辣椒素治疗慢性疼痛:系统性综述显示文摘评价局部应用辣椒素治疗神经及肌肉骨骼功能失调引起的慢性疼痛的疗效和安全性。 | Lorna Mason R Andrew Moore Sheena Derry Jayne E Edwards Henry J Mcquay 孙静 | 2004 | 英国医学杂志中文版2004，7，5： | 3 |
| 2 | Evidence for the involvement of NOD2 in regulating colonic epithelial cell growth and survival显示文摘AIM: To investigate the function of NOD2 in colonic epithelial cells (CEC). METHODS: A combination of in vivo and in vitro analyses of epithelial cell turnover in the presence and absence of a functional NOD2 protein and, in response to enteric Salmonella typhimurium infection, were used. shRNA interference was also used to investigate the consequences of knocking down NOD2 gene expression on the growth and survival of colorectal carcinoma cell lines. RESULTS:In the colonic mucosa the highest levels of NOD2 expression were in proliferating crypt epithelial cells. Muramyl dipeptide (MDP), that is recognized by NOD2, promoted CEC growth in vitro . By contrast,the growth of NOD2-deficient CECs was impaired. In vivo CEC proliferation was also reduced and apoptosis increased in Nod2-/- mice, which were also evident following enteric Salmonella infection. Furthermore, neutralization of NOD2 mRNA expression in human colonic carcinoma cells by shRNA interference resulted in decreased survival due to increased levels of apoptosis. CONCLUSION: These findings are consistent with the involvement of NOD2 protein in promoting CEC growth and survival. Defects in proliferation by CECs in cases of CD may contribute to the underlying pathology of disrupted intestinal homeostasis and excessive inflammation. | Sheena M Cruickshank Louise Wakenshaw John Cardone Peter D Howdle Peter J Murray Simon R Carding | 2008 | World Journal of Gastroenterology2008，14，38： | 3 |
| 3 | Characterization of colonic dendritic cells in normal and colitic mice显示文摘AIM: Recent studies demonstrating the direct involvement of dendritic cells (DC) in the activation of pathogenic T cells in animal models of inflammatory bowel disease identify DC as important antigen presenting cells in the colon. However, very little is known about the properties of colonic DC.METHODS: Using immunohistochemistry, electron microscopy and flow cytometry we have characterized and compared colonic DC in the colon of healthy animals and interleukin-2-deficient (IL2-/-) mice that develop colitis.RESULTS: In the healthy colon, DC resided within the lamina propria and in close association with the basement membrane of colonic villi. Type 1 myeloid (CD11c+, CD11b+,B220-, CD8α-) DC made up the largest (40-45%) population and all DC expressed low levels of CD80, CD86, and CD40,and had high endocytic activity consistent with an immature phenotype. In colitic IL2-/- mice, colonic DC numbers increased four- to five-fold and were localized within the epithelial layer and within aggregates of T and B cells. They were also many more DC in mesenteric lymph nodes (MLN).The majority (>85%) of DC in the colon and MLN of IL2-/-mice were type 1 myeloid, and expressed high levels of MHC class Ⅱ, CD80, CD86, CD 40, DEC 205, and CCR5molecules and were of low endocytic activity consistent with mature DC.CONCLUSION: These findings demonstrate striking changes in the number, distribution and phenotype of DC in the inflamed colon. Their intimate association with lymphocytes in the colon and draining lymph nodes suggest that they may contribute directly to the ongoing inflammation in the colon. | Sheena M Cruickshank Nicholas R English Peter J Felsburg Simon R Carding | 2005 | World Journal of Gastroenterology2005，11，40： | 3 |
| 4 | Effects of weaning age on the behavioural and neuroendocrinedevelopment of piglets 显示文摘 | Susan J Christine M Sheena K R | 2008 | Appl Ani Behav Sei2008，110，1： | 1 |
| 5 | Specifying Model Transformations at the Metamodel Level显示文摘 | Sheena R Judson Robert B France Doris L Carver | 2003 | Proc of the Workshop in Software Model Engineering2003，，： | 1 |
| 6 | Survey of eye movement record- ing methods 显示文摘 | YOUNG L R SHEENA D | 1975 | Behavior Research Methods and Instru- mentation1975，7，5： | 1 |
| 7 | Incidence of epidural hematoma, infection, and neurologic injury in obstetric patients with epiduml analgesia/anesthesia显示文摘 | Wilhelm R Sheena D Henry MQ | 2006 | Anesthesiology2006，105，2： | 1 |
| 8 | The objective rating of oral-motor functions during feeding 显示文摘 | Sheena R David S | 1995 | Dysphagia1995，10，： | 1 |
| 9 | Oral feeding in low birth weight infants显示文摘 | Lau C Sheena H R Shulman R J | 1997 | J Pediatr1997，130，4： | 1 |
| 10 | Prospective associations of vitamin D with 显示文摘 | Sheena K Ravi R Harris S B | 2011 | Diabetes2011，60，11： | 1 |
| 11 | Association of vitamin D with insulin resistance and β-cell dysfunction in subjects at risk for type 2 diabetes显示文摘 | Sheena K Reinhold V Ravi R | 2010 | Diabetes Care2010，33，6： | 1 |
| 12 | Impact of fungal and bacterial biocides on microbial induced water repellency in arable soil显示文摘 | FEENEY D S HALLETT P D SHEENA R | 2006 | Geodrrma2006，135，3： | 1 |
| 13 | Program ruing the offspring of the pig by prenatal social stress: neuroendocrine activity and behaviour 显示文摘 | Susan J Christine M Sheena K R | 2006 | Hormo Behav2006，49，1： | 1 |
| 14 | Programming the offspring of the pig by prenatal social stress neuro- endocrine activity and behaviour 显示文摘 | Susan J Christine M Sheena K R | 2006 | Horm Behav2006，49，： | 1 |
| 15 | Suppression of hepatocyte nuclear factor-4 alpha by acyl-CoA thioesters of hypolipedemic peroxisome proliferators 显示文摘 | HERTZ R SHEENA V KALDERON B | 2001 | Biol Chem Pharmaco12001，61，9： | 1 |
| 16 | Oral feeding in low birth weight infants显示文摘 | LAU C SHEENA H R SHULMAN R J | 1997 | J Pediatrics1997，130，4： | 1 |
| 17 | The association of crown-rump length discrepancy with birthweight discord- ance in spontaneous versus assisted conception dichori0nic twins显示文摘 | Ben Ami I Sheena L Svirsky R | 2014 | Prenat Diaqn2014，34，8： | 1 |
| 18 | Spectroscopic investigation(FT-IR and FT-Raman),vibrational assignments,HOMO-LUMO analysis and molecular docking study of 1-hydroxy-4,5,8-tris(4-methoxyphenyl)anthraquinone显示文摘 | Renjith R Sheena M Y Hema T V | 2015 | J Phys Chem Solids2015，87，： | 1 |
| 19 | Eye movement measurement techniques显示文摘 | Young L R Sheena D | 1975 | Amer Physiologist1975，30，： | 1 |
| 20 | When Choice is Demotivating: Can One Desire Too Much of a Good Thing 显示文摘 | lyengar Sheena S Mark R Lepper | 2000 | Journal of Personality and Social Psychology2000，79，6： | 1 |
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