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| 1 | Acute effects of rotavirus and malnutrition on intestinal barrier function in neonatal piglets显示文摘AIM: To investigate the effect of protein-energy malnutrition on intestinal barrier function during rotavirus enteritis in a piglet model.METHODS: Newborn piglets were allotted at day 4 of age to the following treatments:(1) full-strength formula(FSF)/noninfected;(2) FSF/rotavirus infected;(3) half-strength formula(HSF)/noninfected;or(4) HSF/rotavirus infected.After one day of adjustment to the feeding rates,pigs were infected with rotavirus and acute effects on growth and diarrhea were monitored for 3 d and jejunal samples were collected for Ussingchamber analyses.RESULTS: Piglets that were malnourished or infected had lower body weights on days 2 and 3 post-infection(P < 0.05).Three days post-infection,marked diarrhea and weight loss were accompanied by sharp reductions in villus height(59%) and lactase activity(91%) and increased crypt depth(21%) in infected compared with non-infected pigs(P < 0.05).Malnutrition also increased crypt depth(21%) compared to full-fed piglets.Villus:crypt ratio was reduced(67%) with viral infection.There was a trend for reduction in transepithelial electrical resistance with rotavirus infection and malnutrition(P = 0.1).3H-mannitol flux was significantly increased(50%;P < 0.001) in rotavirus-infected piglets compared to non-infected piglets,but there was no effect of nutritional status.Furthermore,rotavirus infection reduced localization of the tight junction protein,occludin,in the cell membrane and increased localization in the cytosol.CONCLUSION: Overall,malnutrition had no additive effects to rotavirus infection on intestinal barrier function at day 3 post-infection in a neonatal piglet model. | Sheila K Jacobi Adam J Moeser Anthony T Blikslager J Marc Rhoads Benjamin A Corl Robert J Harrell Jack Odle | 2013 | World Journal of Gastroenterology2013，19，31： | 4 |
| 2 | An analysis of mass casualty incidents in the setting of mass gatherings and special events 显示文摘 | Sheila A T Adam L Ronald R B | 2014 | Disaster Med Public Health Prep2014，7，1： | 1 |
| 3 | Evaluation of waist circumference, waist-to-hip ratio, and the conicity index as screening tools for high trunk fat mass ,as measured by dual-energy X-ray absorptiometry in ehildren aged 3-19 y显示文摘 | Rachael W T Ianthe E J Sheila M W | 2000 | Am J Clin Nutr2000，72，： | 1 |
| 4 | Lossless Image Compression with Projectiong-Based and Adaptive Reversible Integer Wavelet Transforms显示文摘 | Aaron T Deever Sheila S Hemami | 2003 | IEEE Transactions On Image Processing2003，12，5： | 1 |
| 5 | Relationship of plasma amphetamine levels to physiological,subjective,cognitive and biochemical measures in healthy volunteers显示文摘 | Sheila J A Veronique A M I T Glen B B | 2003 | Hum Psychopharmacol Clin Exp2003，18，： | 1 |
| 6 | The Value of Scarce Water: Measuring The Inefficiency of Municipal Regulations 显示文摘 | Mansur Erin T Olmstead Sheila M | 2012 | Journal of Urban Economics2012，71，3： | 1 |
| 7 | Learning object identification rules for information integration 显示文摘 | Sheila T Craig A K Steven M | 2001 | Information Systems2001，26，8： | 1 |
| 8 | An analysis of mass casualty incidents in the setting of mass gatherings and special events显示文摘 | Sheila A T Adam L Ronald R B | 2014 | Disaster Med Public Health Prep2014，8，2： | 1 |
| 9 | Determinants of particiFation restric- tion among community dwelling stroke survivors : a path analysis 显示文摘 | Janita PC David R Sheila T | 2009 | Neurology2009，49，9： | 1 |
| 10 | Transcriptional and posttranscriptional processes regulate gene expression in oxygendeprived roots of maize 显示文摘 | Sheila L Fennoy T N Bailey-Serres J | 1998 | Plant J1998，15，6： | 1 |
| 11 | Platelet verification under microscope calculated by the patient's hemoglobin factor显示文摘 | Sheila Lopez T Eliud Lopez V | 2004 | Lab Med2004，7，： | 1 |
| 12 | Inhibition of telomerase limits the growth of human cancer cells显示文摘 | WILLIAM C H SHEILA A STEWAR T | 1999 | Nature Med1999，5，10： | 1 |
| 13 | Comparison of Serologic Assays and PCR for Diagnosis of Human Herpesvirus 8 Infection显示文摘 | Spira T J Dollard L La Sheila C | 2000 | Journal of Clinical Micro- biology2000，38，6： | 1 |
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