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231篇 您的检索式：作者名="Shen SH"

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	题名	作者	年代	出处	被引量
1	Establishment of an orthotopic transplantation tumor model of hepatocellular carcinoma in mice显示文摘AIM:To improve the outcome of orthotopic transplantation in a mouse model,we used an absorbable gelatin sponge(AGS) in nude mice to establish an orthotopic implantation tumor model.METHODS:MHCC-97L hepatocellular carcinoma(HCC)cells stably expressing the luciferase gene were injected into the subcutaneous region of nude mice.One week later,the ectopic tumors were harvested and transplanted into the left liver lobe of nude mice.The AGS was used to establish the nude mouse orthotopic implantation tumor model.The tumor suppressor gene,paired box gene 5(PAX5),which is a tumor suppressor in HCC,was transfected into HCC cells to validate the model.Tumor growth was measured by bioluminescence imaging technology.Semi-quantitative reverse transcription polymerase chain reaction(RT-PCR) and histopathology were used to confirm the tumorigenicity of the implanted tumor from the MHCC-97L cell line.RESULTS:We successfully developed an orthotopic transplantation tumor model in nude mice with the use of an AGS.The success rate of tumor transplantation was improved from 60% in the control group to 100% in the experimental group using AGS.The detection of fluorescent signals showed that tumors grew in all live nude mice.The mice were divided into 3 groups:AGS-,AGS+/PAX5-and AGS+/PAX5 +.Tumor size was significantly smaller in PAX5 transfected nude mice compared to control mice(P < 0.0001).These fluorescent signal results were consistent with observations made during surgery.Pathologic examination further confirmed that the tissues from the ectopic tumor were HCC.Results from RT-PCR proved that the HCC originated from MHCC-97L cells.CONCLUSION:Using an AGS is a convenient and efficient way of establishing an indirect orthotopic liver transplantation tumor model with a high success rate.	Gui-Jun Zhao Li-Xia Xu Eagle SH Chu Ning Zhang Jia-Yun Shen Alatangaole Damirin Xiao-Xing Li	2012	World Journal of Gastroenterology2012，18，47：	4
2	Bilateral xanthogranu-lomatous pyelonephritis显示文摘	Tsai KH Lai MY Shen SH	2008	J Chin Med Assoc2008，71，6：	1
3	Over-expression of interleukin-6 in human basel cell lines increases anti-apoptotic activity and tumoergenic potency 显示文摘	Jee SH Shen SC Chiu HC	2001	Oncogene2001，20，2：	1
4	Role of interleukin- 18 in acute lung inflammation induced by gut ischemia reperfusion 显示文摘	Yang YJ Shen Y Chen SH	2005	World J Gastroenterol2005，11，29：	1
5	MRI findings of prostatic synovial sarcoma显示文摘	Cheng YC WangJ H Shen SH	2007	Br J Radiol2007，80，：	1
6	Char-acteristics and biocompatibility of a biodegradable genipin-crosslinked gelatin/β-tricalcium phosphate reinforced nerve guide conduit显示文摘	Yang YC Shen CC Huang TB Chang SH Cheng HC Liu BS		0，，：	1
7	Curcumin induces a p53 de pendent apoptosis in human basal cell carcinoma cells显示文摘	Jee SH Shen SC Tseng CR	1998	J In vest Dermatol1998，111，4：	1
8	in- telligent identification of childhood musical murmurs 显示文摘	CHEN Y R WANG SH Y SHEN CH H	2012	Journal of Heahhcare Engineering2012，，3：	1
9	MRI findings of prostatic synovial sarcoma显示文摘	Cheng YC Wang JH Shen SH	2007	Br J Radiol2007，80，949：	1
10	Use of serum procalcitonin to detect bacterial infection in patients with autoimmune diseases 显示文摘	Wu JY Lee SH Shen CJ	2012	Arthritis Rheum2012，64，：	1
11	Ascending migration of endophytic rhizobia,from roots to leaves,inside rice plants and assessment of benefits to rice growth physiology显示文摘	Chi F Shen SH Cheng HP Jing YX Yanni YG Dazzo FB		0，，11：	1
12	Partial trachelectomy: A new treatment choice for persistent or recurrent high grade cervical intraepithelial neoplasia 显示文摘	Jeng C J Shen J Huang SH	2006	Gynecol Oncol2006，100，：	1
13	Diffusion-weighted singleshot echo-planar imaging with parallel technique in assessment of endometrial cancer显示文摘	Shen SH Chiou YY Wang JH	2008	AJR2008，190，2：	1
14	High-level apoptosis is persistent in myocardio-cytes of sinoaortic-denervated rats显示文摘	Tao X Zhang SH Shen FM	2004	Hypertension2004，22，：	1
15	Partial trachelectomy:a new treatment choice for persistent or recurrent high grade cervical intraepithelial neoplasia显示文摘	Jeng CJ Shen J Huang SH	2006	Gynecol Oncol2006，100，：	1
16	Delta-aminolevulinate dehydratase polymorphism and blood lead levels in Chinese children 显示文摘	Shen XM Wu SH Yan CH	2001	Environ Res Sec2001，85，：	1
17	Partial trachelectomy a new treatment choice for persistent or recurrent high grade cervical intraepithelial neoplasia 显示文摘	Jeng C J Shen J Huang SH	2006	Gynecol Oncol2006，100，2：	1
18	Partial trachelectomy:a new treatment choice for persistent or recurrent high grade cerical intraepithelial neoplasia显示文摘	Jeng C J Shen J Huang SH	2006	Gyneeal Oneol2006，100，：	1
19	Movement of rhizobia inside tobacco and lifestyle alternation from endophytes to free-living rhizobia on leaves显示文摘	Ji KX Chi F Yang MF Shen SH Jing YX Dazzo FB Cheng HP		0，，：	1
20	p90 ribosomal S6 kinase 2 is associated with and dephosphorylated by protein phosphatase 2Cδ显示文摘	Doehn U Gammeltoft S Shen SH	2004	Biochem J2004，382，22：	1

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