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| 1 | FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway显示文摘成纤维细胞生长因素 21 (FGF21 ) , FGF 总科的一个最近识别的成员,主要从肝和脂肪质的纸巾被分泌并且在改进新陈代谢的症候群和动态平衡起一个重要作用。这研究的目的是在含酒精的脂肪肝疾病(AFLD ) 评估 FGF21 的角色并且决定它是否在 AFLD 上有治疗学的效果。在这份报纸,我们在长期的乙醇 gavage 和对待白酒的 HepG2 房间的一个鼠科的模型在导致白酒的肝损害上测试了 FGF21 的效果。男千米;公里老鼠每天收到了 5 g/kg 乙醇 gavage 的单个剂量 6 个星期,它导致了重要脂肪肝和肝损害。导致白酒的脂肪肝房间模型被在 75 公里的最后的集中增加乙醇进 HepG2 房间文化的媒介 9 天完成。结果与 recombinant FGF21 显示出那个处理在长期的乙醇 gavage 和对待白酒的 HepG2 房间的一个鼠科的模型的改善含酒精的脂肪肝和肝损害。另外, FGF21 处理下面调整丰满的酸的肝的表示合成的关键酶,激活的肝的 AMPK-SIRT1 小径和显著地下面调整的肝的氧化压力蛋白质。一起拿, FGF21 由 AMPK-SIRT1 小径的激活在 vitro 并且在 vivo 改正 AFLD 的多重新陈代谢的参数。 | Shenglong Zhu Lei Ma Yunzhou Wu Xianlong Ye Tianyuan Zhang Qingyang Zhang Lubna Muhi Rasoul Yunye Liu MO Guo Bing Zhou Guiping Ren Deshan Li | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 11 |
| 2 | Study of severe and rare complications of transarterial chemoembolization (TACE) for liver cancer显示文摘 | Jinglin Xia Zhenggang Ren Shenglong Ye Dilip Sharma Zhiying Lin Yuhong Gan Yi Chen Ninglin Ge Zengchen Ma Zhiquan Wu Jia Fan Lunxiu Qin Xinda Zhou Zhaoyou Tang Binghui Yang | 2006 | European Journal of Radiology2006，，3： | 2 |
| 3 | IMPROVEMENT OF HOT CORROSION RESISTANCE OF Ti_3Al INTERMETALLIC COMPOUND BY显示文摘IMPROVEMENTOFHOTCORROSIONRESISTANCEOFTi_3AlINTERMETALLICCOMPOUNDBYSPUTTEREDNiCrAlYCOATINGZeng;ChaoliuZhang;JianqingWu,;Weitao?.. | Zeng Chaoliu Zhang Jianqing Wu, Weitao Zhu, Shenglong(Corrosion Science Laboratory Institute of Corrosion and Protection of Metals, Academia Sinica , Shenyang 110015) | 1995 | 中国有色金属学会会刊:英文版1995，5，1： | 1 |
| 4 | Genome Wide Analysis of Nucleotide-Binding Site Disease Resistance Genes in Brachypodium distachyon显示文摘 | Shenglong Tan Song Wu Ferenc Olasz | 2012 | Comparative and Functional Genomics2012，，： | 1 |
| 5 | The Effect of Surface Finish on the Scaling Behavior of Stainless Steel in Steam and Supercritical Water显示文摘 | Juntao Yuan Ximao Wu Wen Wang Shenglong Zhu Fuhui Wang | 2013 | Oxidation of Metals2013，，5： | 1 |
| 6 | Effects of berylliumon fatigue crack propagation of A357 alloys containing iron显示文摘 | TAN Yenhung LEE Shenglong WU Homyu | 1996 | International journal of Fatigue1996，18，2： | 1 |
| 7 | The mechanism of scale adhesion on sputtered microcrystallized CoCrAl films显示文摘 | Fuhui Wang Hanyi Lou Shenglong Zhu Weitao Wu | 1996 | Oxidation of Metals (-)1996，，1： | 1 |
| 8 | Genetic variation in exon 10 of the BPI gene is associated with Escherichia coli F18 susceptibility in Sutai piglets显示文摘 | Lu Liu Jing Wang Qiaohui Zhao Chen Zi Zhengchang Wu Xianmin Su Yongjiu Huo Guoqiang Zhu Shenglong Wu Wenbin Bao | 2013 | Gene2013，，1： | 1 |
| 9 | Spatial-Temporal Change of Phytoplankton Biomass in the East China Sea with MODIS Data显示文摘A ten-year chlorophyll-a concentration dataset from Moderate Resolution Imaging Spectro-radiometer(MODIS) were used to analyze the variation of phytoplankton biomass and its potential relation with climate in the East China Sea. The result indicated that the phytoplankton biomass generally had a regular pattern every year, and phytoplankton bloom mainly occurred between May and July. The highest phytoplankton biomass appeared near the Yangtze River Estuary. The lowest phytoplankton biomass located near the Taiwan Strait. In general, the starting bloom time was earlier in the south than in the north, and the span time of the former was also longer. During the recent ten years, the phytoplankton biomass around the Yangtze River Estuary decreased obviously. The change of phytoplankton biomass was found to be related with the Ni?o3.4 Index. The correlation between the intensity of phytoplankton bloom with the number and square of red tide were 0.63 and 0.74, respectively. | WU Yumei ZHU Haopeng DANG Xiaoyan CHENG Tianfei YANG Shenglong WANG Lin HUANG Liangmin CUI Xuesen | 2021 | Journal of Ocean University of China2021，20，2： | 1 |
| 10 | Computer simulation of reactive sputtering 显示文摘 | ZHU SHENGLONG WANG HUFUI WU WEITAO | 2001 | International Journal of Materials and Product Technology2001，1，： | 1 |
| 11 | Oxidation Behaviour of Laser Remelted Cr-containing Steels显示文摘Laser surface remelting of steels with different Cr contents has been performed by using a CO2 laser.The results of oxidation tests showed that the effects of laser remelting on the oxidation resistance ofCr-containing steels have close relation to the Cr contents and microstructures of the steels. The re-sistance to high temperature oxidation of 18-8 and HK40 at 1273 K can be obviously improved bylaser remelting, whereas laser remelting showed little effect on the oxidation resistance of Fe-6Crand Cr30 at 1173-1273 K. | Guanyan FU Weitao WU Maocai WANG Shenglong ZHU Corrosion science Lab,Institute of Corrosion and Protection of Metals,Academia Sinica,Shenyang 110015,China | 1993 | Journal of Materials Science & Technology1993，9，4： | 1 |
| 12 | The Potential Vertical Distribution of Bigeye Tuna (Thunnus obesus) and Its Influence on the Spatial Distribution of CPUEs in the Tropical Atlantic Ocean显示文摘Understanding the potential vertical distribution of bigeye tuna(Thunnus obesus) is necessary to understand the catch rate fluctuations and the stock assessment of bigeye tuna. To characterize the potential vertical distribution of this fish while foraging and determine the influences of the distribution on longline efficiency in the tropical Atlantic Ocean, the catch per unit effort(CPUE) data were compiled from the International Commission for the Conservation of Atlantic Tunas and the Argo buoy data were downloaded from the Argo data center. The raw Argo buoy data were processed by data mining methods. The CPUE was standardized by support vector machine before analysis. We assumed the depths with the upper and lower limits of the optimum water temperatures of 15℃ and 9℃ as the preferred swimming depth, while the lower limit of the temperature(12℃) associated with the highest hooking rate as the preferred foraging depth(D12) of bigeye tuna during the daytime in the Atlantic Ocean. The preferred swimming depth and foraging depth range in the daytime were assessed by plotting the isobath based on Argo buoy data. The preferred swimming depth and vertical structure of the water column were identified to investigate the spatial effects on the CPUE by using a generalized additive model(GAM). The empirical cumulative distribution function was used to assess the relationship between the spatial distribution of CPUE and the depth of 12℃ isolines and thermocline. The results indicate that 1) the preferred swimming depth of bigeye tuna in the tropical Atlantic is from 100 m to 400 m and displays spatial variation;2) the preferred foraging depth of bigeye tuna is between 190 and 300 m and below the thermocline;3) the number of CPUEs peaks at a relative depth of 30 –50 m(difference between the 12℃ isolines and the lower boundary of the thermocline);and 4) most CPUEs are within the lower depth boundary of the thermocline levels(LDBT) which is from 160 m to 230 m. GAM analysis indicates that the general relationship between the nominal CPUE and LDBT is characterized by a dome shape and peaks at approximately 190 m. The oceanographic features influence the habitat of tropical pelagic fish and fisheries. Argo buoy data can be an important tool to describe the habitat of oceanic fish. Our results provide new insights into how oceanographic features influence the habitat of tropical pelagic fish and fisheries and how fisheries exploit these fish using a new tool(Argo profile data). | YANG Shenglong SONG Liming ZHANG Yu FAN Wei ZHANG Bianbian DAI Yang ZHANG Heng ZHANG Shengmao WU Yumei | 2020 | Journal of Ocean University of China2020，19，3： | 1 |
| 13 | 生物多样性和环境因素对亚热带森林树木生物量和生物量生长的解耦影响显示文摘生物多样性与生态系统功能之间的关系已成为森林生态系统研究的核心问题。然而,在具有不同人类干扰历史的亚热带森林群落中,关于环境因子对生物多样性与生态系统功能关系影响的研究仍然较少。在本研究中,选择位于中国东部浙江省的34个亚热带森林样地,在考虑样方中的环境因子的基础上,利用线性模型,分析样地中木本植物多样性(物种、功能和谱系多样性)与样方内木本植物生物量或生物量变化量之间的关系。物种多样性和功能多样性,并非谱系多样性,与生物量和生物量的变化量之间存在显着相关性。生物量或生物量变化量与年平均温度和海拔高度之间存在显著的正相关关系。此外,在考虑环境因子和森林群落的演替阶段时,生物量变化量与功能多样性的关系显著强于生物量变化量与谱系多样性或物种多样性之间的关系。这些研究结果表明,生物多样性与生态系统功能之间的关系可能取决于生物多样性指数的选择和环境条件。 | Ravi Mohan Tiwari Jinliang Liu Yuchu Xie Shenhao Yao Shenglong Liu Sumei Wu Julian Liu Haiyuan Qian Zupei Lei Hongwei Zhang Lei Zhong Boliang Wei Mingjian Yu | 2023 | Journal of Plant Ecology2023，16，1： | 0 |
| 14 | Identification of cross-reactive CD8^(+)T cell receptors with high functional avidity to a SARS-CoV-2 immunodominant epitope and its natural mutant variants显示文摘Despite the growing knowledge of T cell responses in COVID-19 patients,there is a lack of detailed characterizations for T cell-antigen interactions and T cell functions.Here,with a predicted peptide library from SARS-CoV-2 S and N proteins,we found that specific CD8+T cell responses were identified in over 75%of COVID-19 convalescent patients(15/20)and an epitope from the N protein,N361-369(KTFPPTEPK),was the most dominant epitope from our selected peptide library.Importantly,we discovered 2 N361-369-specific T cell receptors(TCRs)with high functional avidity that were independent of the CD8 co-receptor.These TCRs exhibited complementary cross-reactivity to several presently reported N361-369 mutant variants,as to the wild-type epitope.Further,the natural functions of these TCRs in the cytotoxic immunity against SARS-CoV-2 were determined with dendritic cells(DCs)and the lung organoid model.We found that the N361-369 epitope could be normally processed and endogenously presented by these different types of antigen presenting cells,to elicit successful activation and effective cytotoxicity of CD8+T cells ex vivo.Our study evidenced potential mechanisms of cellular immunity to SARS-CoV-2,and illuminated potential ways of viral clearance in COVID-19 patients.These results indicate that utilizing CD8-independent TCRs against SARS-CoV-2-associated antigens may provide functional superiority that is beneficial for the adoptive cell immunotherapies based on natural or genetically engineered T cells.Additionally,this information is highly relevant for the development of the next-generation vaccines with protections against continuously emerged SARS-CoV-2 mutant strains. | Chao Hu Meiying Shen Xiaojian Han Qian Chen Luo Li Siyin Chen Jing Zhang Fengxia Gao Wang Wang Yingming Wang Tingting Li Shenglong Li Jingjing Huang Jianwei Wang Ju Zhu Dan Chen Qingchen Wu Kun Tao Da Pang Aishun Jin | 2022 | Genes & Diseases2022，9，1： | 0 |
| 15 | HOT CORROSION PERFORMANCE OF AMORPHOUS Al_2O_3 COATING显示文摘The amorphous Al2O3 coatings were prepared on superalloy GH30 by dc reactive sputtering. Hot corrosion behaviors of the coated and uncoated specimens were studied in 75%Na2SO4+25%K2SO4 melt at I 123 K by either immersing the samples half in sulphate or applying sulphate deposit. The Al2O3 coatings reduced the hot corrosion rates by about one magnitude, and the internal sulphidation was not observed in the Al2O3 coated specimens. | Zhu, Shenglong Wang, Fuhui Lou, Hanyi Wu, Weitao Institute of Corrosion and Protection of Metals, Academia Sinica, Shenyang 110015, China | 1993 | 中国有色金属学会会刊:英文版1993，3，3： | 0 |
| 16 | Distance measurement between two flexible sites in proteins in high viscosity medium at physiological temperature using continuous wave EPR显示文摘 | Lu Yu Wei Wang Shenglong Ling Yao He Liang Xiao Kaiqi Wu Longhua Zhang Changlin Tian | 2014 | Protein & Cell2014，5，5： | 0 |
| 17 | Cold-Resistant Rubbers Based on Flexible Polymer Chains显示文摘Comprehensive Summary,As one of the three types of polymeric materials,rubber has played an irreplaceable role in various fields such as industrial production,aerospace,military,and national defense.Improving the cold resistance of rubbers and extending their service temperature range have always been one of the main focuses in rubber research.However,there have been few detailed public reports or literatures on the progress or summary of cold-resistant rubbers,creating an invisible barrier for new researchers wishing to enter this field of research.Therefore,starting from the basis of polymer physics,this review introduces the research difficulties in this field and systematically summarizes the research progress in constructing cold-resistant rubbers based on three different types of flexible polymer chains in recent years.In addition,several important properties of cold-resistant rubbers including mechanical performance,oil resistance,and self-healing ability are also discussed along with the summary of recent progresses.Finally,the future challenges and prospects of cold-resistant rubbers are discussed. | Lianfeng Wu Shenglong Liao Yapei Wang | 2023 | Chinese Journal of Chemistry2023，41，17： | 0 |
| 18 | A high-quality Bougainvillea genome provides new insights into evolutionary history and pigment biosynthetic pathways in the Caryophyllales显示文摘Bougainvillea is a perennial ornamental shrub that is highly regarded in ornamental horticulture around the world.However,the absence of genome data limits our understanding of the pathways involved in bract coloration and breeding.Here,we report a chromosome-level assembly of the giga-genome of Bougainvillea×buttiana‘Mrs Butt’,a cultivar thought to be the origin of many other Bougainvillea cultivars.The assembled genome is∼5 Gb with a scaffold N50 of 151756278 bp and contains 86572 genes which have undergone recent whole-genome duplication.We confirmed that multiple rounds of whole-genome multiplication have occurred in the evolutionary history of the Caryophyllales,reconstructed the relationship in the Caryophyllales at whole genome level,and found discordance between species and gene trees as the result of complex introgression events.We investigated betalain and anthocyanin biosynthetic pathways and found instances of independent evolutionary innovations in the nine different Caryophyllales species.To explore the potential formation mechanism of diverse bract colors in Bougainvillea,we analyzed the genes involved in betalain and anthocyanin biosynthesis and found extremely low expression of ANS and DFR genes in all cultivars,which may limit anthocyanin biosynthesis.Our findings indicate that the expression pattern of the betalain biosynthetic pathway did not directly correlate with bract color,and a higher expression level in the betalain biosynthetic pathway is required for colored bracts.This improved understanding of the correlation between gene expression and bract color allows plant breeding outcomes to be predicted with greater certainty. | Lan Lan Huiqi Zhao Suxia Xu Shenglong Kan Xiaoni Zhang Weichao Liu Xuezhu Liao Luke RTembrock Yonglin Ren Wayne Reeve Jun Yang Zhiqiang Wu | 2023 | Horticulture Research2023，10，8： | 0 |
| 19 | Sodium butyrate alleviates deoxynivalenol-induced hepatic cholesterol metabolic dysfunction via RORγ-mediated histone acetylation modification in weaning piglets显示文摘Background:Cholesterol is an essential component of lipid rafts in cell plasma membrane,which exerts a hepatoprotective role against mycotoxin exposure in pigs,and cholesterol metabolism is vulnerable to epigenetic histone acetylation.Therefore,our present study aimed to investigate whether a histone deacetylase inhibitor(sodium butyrate [NaBu]) could protect the porcine liver from deoxynivalenol(DON) exposure by modulating cholesterol metabolism.Herein,we randomly divided 28 pigs into four groups,which were fed an uncontaminated basal diet,contaminated diet(4 mg DON/kg),uncontaminated diet supplemented with 0.2% NaBu or 4 mg/kg DON contaminated diet(4 mg DON/kg) supplemented with 0.2% NaBu for 28 d.Results:We found that the serum alanine transaminase(ALT),aspartate transaminase(AST),and alkaline phosphatase(ALP) were all increased in pigs exposed to DON,indicative of significant liver injury.Furthermore,the cholesterol content in the serum of DON-exposed pigs was significantly reduced,compared to the healthy Vehicle group.Transcriptome analysis of porcine liver tissues revealed that the cholesterol homeostasis pathway was highly enriched due to DON exposure.In which we validated by qRT-PCR and western blotting that the cholesterol program was markedly activated.Importantly,NaBu effectively restored parameters associated with liver injury,along with the cholesterol content and the expression of key genes involved in the cholesterol biosynthesis pathway.Mechanistically,we performed a ChIP-seq analysis of H3K27ac and showed that NaBu strongly diminished DON-increased H3K27ac genome-wide enrichment.We further validated that the elevated H3K27ac and H3K9ac occupancies on cholesterol biosynthesis genes were both decreased by NaBu,as determined by ChIP-qPCR analysis.Notably,nuclear receptor RORγ,a novel regulator of cholesterol biosynthesis,was found in the hyperacetylated regions.Again,a remarkable increase of RORγ at both mRNA and protein levels in DON-exposed porcine livers was drastically reduced by NaBu.Consistent with RORγ expression,NaBu also hindered RORγ transcriptional binding enrichments on these activated cholesterol biosynthesis genes like HMGCR,SQLE,and DHCR24.Furthermore,we conducted an in vitro luciferase reporter assay to verify that porcine RORγ directly bonds to the promoters of the above target genes.Conclusions:Collectively,our results demonstrate the utility of the natural product Na Bu as a potential anti-mycotoxin nutritional strategy for regulating cholesterol metabolism via RORγ-mediated histone acetylation modification. | Qiufang Zong Huan Qu Yahui Zhao Haoyu Liu Shenglong Wu Shuai Wang Wenbin Bao Demin Cai | 2023 | Journal of Animal Science and Biotechnology2023，14，2： | 0 |
| 20 | Exercise precision medicine for type 2 diabetes:Targeted benefit or risk?显示文摘Concurrent exercise and metformin administration may reduce the acute and chronic effects of exercise on glucose metabolism in the patients with type 2 diabetes(T2D).However,several studies suggest that combing metformin and exercise treatment may have neither additive effect nor even cause adverse effects in T2D patients.This case report aimed to highlight the challenges associated with prescribing exercise to type 2 diabetes patients undergoing metformin treatment.A 67-years old woman was followed-up for five months,including assessment of the acute and chronic glucose and lactate metabolism induced by concomitant exercise and metformin.The findings were four-fold:1)During a high-intensity interval training bout,blood glucose systematically decreased,while blood lactate concentrations fluctuated randomly;2)Basal blood lactate levels were well above 2 mmol/L on days with medication only;3)Combined exercise and metformin administration induced additive effects on the normalization of glucose and 4)high levels of physical activity had a positive impact on the continuous glucose fluctuations,while decreased levels of physical activity induced a large fluctuation of glucose due to home confinement of an infectious disease caused by the SARS-CoV-2 virus.Our findings showed that when combined with exercise and metformin treatment for T2D patients,exercise may contribute to improving glycemic control while metformin may elevate lactate levels in the long term.The observed results underline the need to prescribe exercise and monitor lactate levels for reducing possible risks associated with metformin treatment and reinforce the importance of tailoring exercise therapy. | Shenglong Le Moritz Schumann Siman Lei Wu Yao Sulin Cheng | 2023 | Sports Medicine and Health Science2023，5，2： | 0 |
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