|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Altered vasoactive intestinal peptides expression in irritable bowel syndrome patients and rats with trinitrobenzene sulfonic acid-induced colitis显示文摘AIM: To investigate the vasoactive intestinal peptides(VIP) expression in irritable bowel syndrome(IBS) and trinitrobenzene sulfonic acid(TNBS) induced colitis.METHODS: The VIP gene expression and protein plasma levels were measured in adult participants(45.8% male) who met Rome Ⅲ criteria for IBS for longer than 6 mo and in a rat model of colitis as induced by TNBS.Plasma and colons were collected from naive and inflamed rats.Markers assessing inflammation(i.e.,weight changes and myeloperoxidase levels) were assessed on days 2,7,14 and 28 and compared to controls.Visceral hypersensitivity of the rats was assessed with colo-rectal distension and mechanical threshold testing on hind paws.IBS patients(n = 12) were age,gender,race,and BMI-matched with healthy controls(n = 12).Peripheral whole blood and plasma from fasting participants was collected and VIP plasma levels were assayed using a VIP peptide-enzyme immunoassay.Human gene expression of VIP was analyzed using a custom PCR array.RESULTS: TNBS induced colitis in the rats was confirmed with weight loss(13.7 ± 3.2 g) and increased myeloperoxidase activity.Visceral hypersensitivity tocolo-rectal distension was increased in TNBS treated rats up to 21 d and resolved by day 28.Somatic hypersensitivity was also increased up to 14 d post TNBS induction of colitis.The expression of an inflammatory marker myeloperoxidase was significantly elevated in the intracellular granules of neutrophils in rat models following TNBS treatment compared to naive rats.This confirmed the induction of inflammation in rats following TNBS treatment.VIP plasma concentration was significantly increased in rats following TNBS treatment as compared to naive animals(P < 0.05).Likewise,the VIP gene expression from peripheral whole blood was significantly upregulated by 2.91-fold in IBS patients when compared to controls(P < 0.00001; 95%CI).VIP plasma protein was not significantly different when compared with controls(P = 0.193).CONCLUSION: Alterations in VIP expression may play a role in IBS.Therefore,a better understanding of the physiology of VIP could lead to new therapeutics. | Arseima Y Del Valle-Pinero LeeAnne B Sherwin Ethan M Anderson Robert M Caudle Wendy A Henderson | 2015 | World Journal of Gastroenterology2015，21，1： | 7 |
| 2 | Solution properties of high solids intermediate显示文摘 | Sherwin M A | 1981 | Journal of Coatings Technology1981，53，683： | 1 |
| 3 | Unsteady Navier-Stokes solvers using hybrid spectral/hp element methods显示文摘 | SHERWIN S J AINSWORTH M | 2000 | Applied Numerical Mathematics2000，33，14： | 1 |
| 4 | Terahertz power 显示文摘 | Sherwin M | 2002 | Nature2002，420，： | 1 |
| 5 | Delivery of antisense oligonucleotides to leukemia cells by RNA bacteriophage capsids显示文摘 | Wu M Sherwin T Brown W L | 2005 | Nanomedicine2005，1，： | 1 |
| 6 | Differential effects of estrogen and micronized progesterone or medroxyprogesterone acetate on cognition in postmenopausal women显示文摘 | Sherwin BB Grigorova M | 2011 | Fertil Steril2011，96，2： | 1 |
| 7 | The endometrial response to chorionic gonadotropin is blunted in a baboon model of endometriosis 显示文摘 | Sherwin J R A Hastings J M Jackson K S | 2010 | Endocrinology2010，151，： | 1 |
| 8 | The effect of fertilizers on germination and seedling growth显示文摘 | SHERWIN M E | 1923 | J Amer Soc Agron1923，23，： | 1 |
| 9 | Effects of environmental enrichment,fluorescent and intermittent lighting on injurious pecking amongst male turkey poults 显示文摘 | Sherwin C M Lewis P D Perry G C | 1999 | British Poultry Science1999，40，： | 1 |
| 10 | Domestic turkeys are not averse to compact fluorescent lighting 显示文摘 | Sherwin C M | 1999 | Applied Animal Behaviour Science1999，64，： | 1 |
| 11 | Experimental transplantation of the pancreas into the stomach显示文摘 | Tripodi A M Charles F Sherwin M D | | 0，，02： | 1 |
| 12 | Cave air and hydrological controls on priorcalcite precipitation and stalagmite growth rates : Implications forpalaeoclimate reconstructions using speleothems显示文摘 | Sherwin C M Baldini JUL | 2011 | Geochimica etCosmochimicaActa2011，75，14： | 1 |
| 13 | Fluid dynamic loading on curved riser pipes 显示文摘 | Miliou A Sherwin S J Graham J M R | 2003 | Journal of Offshore Mechanics and Arctic Engineering2003，125，3： | 1 |
| 14 | Solution properties of high solids intermediate显示文摘 | Sherwin M A | 1981 | J Coat Tech1981，53，683： | 1 |
| 15 | Identification of novel genesregulated by chorionic gonadotropin in baboon endometrium during the window of implantation显示文摘 | Sherwin J R Sharkey A M Cameo P | | 0，，2： | 1 |
| 16 | Studies on the motivation for burrowing by laboratory mice显示文摘 | Sherwin C M Haug E Terkelsen N | | 0，，3： | 1 |
| 17 | Effect of anticonvulsants on sleep 显示文摘 | Sammaritano M Sherwin A | 2000 | Neurology2000，54，51： | 1 |
| 18 | Altered responsiveness to cortisol, eipinephrine and glucagons in insulin-indused juvenile onset diabetes 显示文摘 | Shamoon M Hendler R Sherwin R | 1980 | Diabetes1980，29，4： | 1 |
| 19 | Ubiquitin-independent proteolytic functions of the proteasome显示文摘 | Orlowski M Sherwin W | 2003 | Arch of Biochem Biophys2003，415，1： | 1 |
| 20 | Vanadium dioxide films grownfrom vanadium tetra-isopropoxide by the sol-gel process显示文摘 | Speck K R Sherwin M E | 1988 | Thin Solid Films1988，165，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员