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| 1 | Borderline Resectable Pancreatic Cancer: Need for Standardization and Methods for Optimal Clinical Trial Design显示文摘 | Matthew H. G. Katz Robert Marsh Joseph M. Herman Qian Shi Eric Collison Alan P. Venook Hedy L. Kindler Steven R. Alberts Philip Philip Andrew M. Lowy Peter W. T. Pisters Mitchell C. Posner Jordan D. Berlin Syed A. Ahmad | 2013 | Annals of Surgical Oncology2013，，8： | 4 |
| 2 | Quinone oxidoreductase 1 is overexpressed in gastric cancer and associated with outcome of adjuvant chemotherapy and survival显示文摘BACKGROUND Quinine oxidoreductase 1(NQO1)plays a vital role in protecting normal cells against oxidative damage and electrophilic attack.It is highly expressed in many solid tumors,suggesting a role in cancer development and progression.However,the role of NQO1 in gastric cancer and its effect on cancer development and prognosis have not been fully investigated.AIM To investigate the clinical relevance of NQO1 protein expression in gastric cancer and to explore the potential of NQO1 to serve as a prognostic biomarker and therapeutic target.METHODS In this retrospective study,gastric cancer specimens of 175 patients who were treated between 1995 and 2011 were subjected to immunohistochemistry analyses for NQO1.The correlation of NQO1 expression with gastric cancer prognosis and clinical and pathological parameters was investigated.RESULTS NQO1 protein was overexpressed in 59.43%(104/175)of the analyzed samples.Overexpression of NQO1 was associated with a significantly inferior prognosis.In addition,multivariate analysis suggested that NQO1 overexpression,along with tumor stage and patient age,are prominent prognostic biomarkers for gastric cancer.Moreover,NQO1 overexpression was correlated to a better response to 5-fluorouracil(5-FU)-based adjuvant chemotherapy.CONCLUSION NQO1 overexpression is associated with a significantly poor prognosis and better response to 5-FU in patients with gastric cancer.These findings are relevant for improving therapeutic approaches for gastric cancer patients. | Zhi-Nong Jiang Syed Minhaj Uddin Ahmed Qin-Chuan Wang Hong-Fei Shi Xiu-Wen Tang | 2021 | World Journal of Gastroenterology2021，27，22： | 2 |
| 3 | Structural Comparison and Drug Screening of Spike Proteins of Ten SARS-CoV-2 Variants显示文摘SARS-CoV-2(severe acute respiratory syndrome coronavirus 2)has evolved many variants with stronger infectivity and immune evasion than the original strain,including Alpha,Beta,Gamma,Delta,Epsilon,Kappa,lota,Lambda,and 21H strains.Amino acid mutations are enriched in the spike protein of SARS CoV-2.which plays a crucial role in cell infetion.However,the impact of these mutations on protein structure and function is unclear.Understanding the pathophysiology and pandemic feaures of these SARS-CoV-2 variants requires knowledge of the spike protein structures.Here,we obtained the spike protein structures of 10 main globally endemic SARS CoV-2 strains using AlphaFold2.The clustering analysis based on structural similarity revealed the unique features of the mainly pandemic SARS CoV-2 Delta variants.indicating that structural clusters can reflect the current characteristics of the epidemic more accurately than those based on the protein sequence.The analysis of the binding afinities of ACE2-RBD,antibody-NTD,and antibody-RBD complexes in the different variants revealed that the recognition of antibodies against SI NTD and RBD was decreased in the variants,especally the Delta variant compared with the original strain,which may induce the immune evasion of SARS-CoV-2 variants.Furthermore,by virtual screening the ZINC database against a high-accuracy predicted structure of Delta spike protein and experimental validation,we identified multiple compounds that target S1 NTD and RBD,which might contribute towards the development of clinical anti-SARS-CoV-2 medicines.Our findings provided a basic foundation for future in vitro and in vivo investigations that might speed up the development of potential therapies for the SARS-CoV-2 va riants. | Qiangzhen Yang Xuemin Jian Ali Alamdar Shah Syed Aamir Fahira Chenxiang Zheng zijia Zhu Ke Wang Jinmai Zhang Yangin Wen Zhiqiang Li Dun Pan Tingting Lu Zhuo Wang Yongyong Shi | 2022 | Research2022，，2： | 2 |
| 4 | In vitro propagation of spermatogonial stem cells from KM mice 显示文摘 | Shi YQ Wang QZ Liao SY | 2006 | Front Biosci2006，11，： | 1 |
| 5 | Relativity of hippocampal-HPA- PTSD显示文摘 | Chen SY He W Shi YX | 2010 | Chin Foreign Med Treat2010，25，： | 1 |
| 6 | Natriuretic peptide receptor A mediates renal sodium excretory responses to blood volume expansion显示文摘 | Vellaichamy E Chin SY | 2003 | Am J Physiol Renal Physiol2003，285，： | 1 |
| 7 | Clinical application of intraperitoneal chemotherapy before surgery for ovarian cancer and its evaluation显示文摘 | Shi DY Xiao M Chen SY | | 0，，： | 1 |
| 8 | Increased activity and expression of Ca(2+)-dependent NOS in renal cortex of ANG II-infused hypertensive rats显示文摘 | Chin SY Pandey KN Shi SJ | 1999 | Am J Physiol1999，277，52： | 1 |
| 9 | Discovery of xanthine oxidase inhibitors and/or α - glucosidase inhibitors by carboxyalkyl derivatization based on the flavonoid of apigenin显示文摘 | Su ZR Fan SY Shi WG | 2015 | Bioorg Med Chem Lett2015，25，14： | 1 |
| 10 | Fabrication and optimization of the multiplex PCR-based oligonucleotide microarray for detection of Neisseria gonorrhoeae,Chlamydia trachomatis and Ureaplasma urealyticum显示文摘 | Shi G Wen SY Chen SH | 2005 | J Microbiol Methods2005，62，2： | 1 |
| 11 | Difference in receptor usage be- tween severe acute respiratory syndrome (SARS) coronavir- us and SARS-like coronavirus of bat origin显示文摘 | Ren W Qu X Li W Han Z Yu M Zhou P Zhang SY Wang LF Deng H Shi Z | 2008 | J Virol2008，82，4： | 1 |
| 12 | Combination of preparative HPLC and HSCCC methods to separate phosphodiesterase inhibitors from Eucommia ulmoides bark guided by ultrafiltration-based ligand screening 显示文摘 | Shi SY Peng MJ Zhang YP | 2013 | Anal Bioanal Chem2013，405，12： | 1 |
| 13 | Antiepileptic drug-induced skin reactions:a retrospective study and analysis in 3793 Chi- nese patients with epilepsy显示文摘 | Wang XQ Lang SY Shi XB | 2012 | Clin Neurol Neurosurg2012，114，7： | 1 |
| 14 | Transcription factor Nrf 2 activation by deltamethrin in PC12 cells: involvement of ROS 显示文摘 | Li HY Wu SY Shi N | 2007 | Toxicol Lett2007，171，12： | 1 |
| 15 | Antiepileptic drug-induced skin re- actions: a retrospective study and analysis in 3793 Chinese patients with epilepsy 显示文摘 | Wang XQ Lang SY Shi XB | 2012 | Clin Neurol Neurosurg2012，114，7： | 1 |
| 16 | Chemical Chatacteristic of Polysaecharldes Isola- ted from Omithogalum eaudatum Air 显示文摘 | Shi L Liu ZQ Liu SY | 2003 | Chum Res Chin Uni2003，19，： | 1 |
| 17 | Kinetics and mechanism on the epoxidation of cis-l-propenylphosphonic acid in H20 catalyzed by tungstate (VI) or molybdate (VI) 显示文摘 | Wang XY Shi HC Xu SY | 2003 | J Mol CatA: Chemical2003，206，12： | 1 |
| 18 | Mosquitoes and mosquito- borne arboviruses in the Qinghai-Tibet Plateau--focused on the Qinghai area, China 显示文摘 | Li WJ Wang JL Li MH Fu SH Wang HY Wang ZY Jiang SY Wang XW Guo P Zhao SC Shi Y Lu NN Nasci RS Tang Q Liang GD | 2010 | Am J Trop Med Hyg2010，82，4： | 1 |
| 19 | Neither single-marker nor haplotype analyses support an association between monoamine oxidase A gene and bipolar disorder显示文摘 | Huang SY Lin MT Shy MJ | 2008 | Eur Arch Psychiatry Clin Neurosci2008，258，6： | 1 |
| 20 | Initial HRCT findings of novel influenza A (H 1N 1) infection显示文摘 | Yuan Y Tao XF Shi YX Liu SY Chen JQ | | 0，，： | 1 |
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