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| 1 | Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress显示文摘在细胞的 ubiquitin (Ub ) 的改变动态平衡,作为 Ub 知道强调,展示并且影响处于多重条件的细胞的回答,然而,内在的机制不完全地被理解。这里,我们报导 autophagy 受体 p62/sequestosome-1 与结合酶, UBE2D2 和 UBE2D3 的 E2 Ub 交往。内长的 p62 在 Ub 动态平衡的 upregulation 期间经历 E2 依赖的 ubiquitylation,一个条件作为 Ub + 应力称为,那对由 bortezomib 的 Ub overexpression,热吃惊或延长 proteasomal 抑制内在,化学疗法的药。p62 的 Ubiquitylation 破坏 p62 的 UBA 领域的 dimerization,解放它的能力认出为选择 autophagy 的 polyubiquitylated 货物。我们进一步证明这机制可能为在 Ub + 压力条件之上的 autophagy 激活是批评的。机制的描述和在察觉到 Ub 应力并且控制选择 autophagy 的 p62 的规章的角色能帮助理解并且调制细胞的回答到许多内长、环境的挑战,潜在地对 autophagy 相关的病为治疗学的策略的发展打开一条新大街。 | Hong Peng Jiao Yang Guangyi Li Qing You Wen Han Tianrang Li Darning Gao Xiaoduo Xie Byung-Hoon Lee Juan Du Jian Hou Tao Zhang Hai Rao Ying Huang Qinrun Li Rong Zeng Lijian Hui Hongyan Wang Qin Xia Xuemin Zhang Yongning He Masaaki Komatsu Ivan Dikic Daniel Finley Ronggui Hu | 2017 | Cell Research2017，27，5： | 9 |
| 2 | Microstructure,texture evolution and yield strength symmetry improvement of as-extruded ZK60 Mg alloy via multi-directional impact forging显示文摘Multi-direction impact forging(MDIF)was applied to the as-extruded ZK60 Mg alloy,and the microstructure,texture evolution and yield strength symmetry were investigated in the current study.The results showed that the average grain size of forged piece was greatly refined to 5.3μm after 120 forging passes,which was ascribed to the segmenting effect of{10–12}twins and the subsequent multiple rounds of dynamic recrystallization(DRX).A great deal of{10–12}twins were activated at the beginning of MDIF process,which played an important role in grain refinement.With forging proceeding,continuous and discontinuous DRX were successively activated,resulting in the fully DRXed microstructure.Meanwhile,the forged piece exhibited a unique four-peak texture,and the initial<10-10>//ED fiber texture component gradually evolved into multiple texture components composed of<0001>//FFD(first forging direction)and<11–20>//FFD texture.The special strain path was the key to the formation of the unique four-peak texture.The{10–12}twinning and basal slip were two dominant factors to the evolution of texture during MDIF process.Grain strengthening and dislocation strengthening were two main strengthening mechanisms of the forged piece.Besides,the symmetry of yield strength was greatly improved by MDIF process. | Chao Cui Wencong Zhang Wenzhen Chen Jian He Xuemin Chen Jiabin Hou | 2022 | Journal of Magnesium and Alloys2022，10，10： | 2 |
| 3 | Structural Comparison and Drug Screening of Spike Proteins of Ten SARS-CoV-2 Variants显示文摘SARS-CoV-2(severe acute respiratory syndrome coronavirus 2)has evolved many variants with stronger infectivity and immune evasion than the original strain,including Alpha,Beta,Gamma,Delta,Epsilon,Kappa,lota,Lambda,and 21H strains.Amino acid mutations are enriched in the spike protein of SARS CoV-2.which plays a crucial role in cell infetion.However,the impact of these mutations on protein structure and function is unclear.Understanding the pathophysiology and pandemic feaures of these SARS-CoV-2 variants requires knowledge of the spike protein structures.Here,we obtained the spike protein structures of 10 main globally endemic SARS CoV-2 strains using AlphaFold2.The clustering analysis based on structural similarity revealed the unique features of the mainly pandemic SARS CoV-2 Delta variants.indicating that structural clusters can reflect the current characteristics of the epidemic more accurately than those based on the protein sequence.The analysis of the binding afinities of ACE2-RBD,antibody-NTD,and antibody-RBD complexes in the different variants revealed that the recognition of antibodies against SI NTD and RBD was decreased in the variants,especally the Delta variant compared with the original strain,which may induce the immune evasion of SARS-CoV-2 variants.Furthermore,by virtual screening the ZINC database against a high-accuracy predicted structure of Delta spike protein and experimental validation,we identified multiple compounds that target S1 NTD and RBD,which might contribute towards the development of clinical anti-SARS-CoV-2 medicines.Our findings provided a basic foundation for future in vitro and in vivo investigations that might speed up the development of potential therapies for the SARS-CoV-2 va riants. | Qiangzhen Yang Xuemin Jian Ali Alamdar Shah Syed Aamir Fahira Chenxiang Zheng zijia Zhu Ke Wang Jinmai Zhang Yangin Wen Zhiqiang Li Dun Pan Tingting Lu Zhuo Wang Yongyong Shi | 2022 | Research2022，，2： | 2 |
| 4 | Clustering uncertain data based on probability distribution similarity显示文摘 | Jiang Bin Pei Jian Tao Yufei Lin Xuemin | | 0，，： | 1 |
| 5 | A Sequential Rank-Based Nonparametric Adaptive EWMA Control Chart显示文摘 | Liu Liu Xuemin Zi Jian Zhang Zhaojun Wang | 2013 | Communications in Statistics - Simulation and Computation2013，，4： | 1 |
| 6 | Deciphering of advantageous electrocatalytic water oxidation behavior of metal-organic framework in alkaline media显示文摘Carboxylic acid-based metal-organic frameworks(MOFs)are normally passed for the“pre-catalysts”for oxygen evolution reaction(OER)due to the hydroxides constructed in-situ during its alkaline hydrolysis process(AHP)in lye.Whereas,it remains a mystery that they show advantageous activity over prototypical hydroxides when they are directly acted as OER catalysts.Herein,we propose for the first time that the steric hindrance effect of Nafion can induce enhanced catalytic activity of such MOFs.Different from conventional catalysts without AHP,the Nafion with 3D structure weakens the AHP of Co-MOF nanoribbons,thus forming small size and low crystallinity species(cobalt hydroxide)with more active sites.And the existence of Nafion also optimizes its electronic structure,which is confirmed by transmission electron microscopy(TEM),in-situ UV absorption spectra,in-situ Raman spectroscopy and so on.Compared with Co-MOF-K obtained by directly immersing the Co-MOF nanoribbons in 1.0 M KOH,the Co-MOF-NK obtained by AHP of Co-MOF mixed with Nafion shows better catalytic activity.Based on the above inspiration,we realized the low overpotential of 268 mV at 10 mA·cm^(−2) by preparing CoFe-MOF-NK.This work provides a new understanding of the structural reconstruction of MOFs in the field of electrocatalysis. | Ming Liu Lingjun Kong Xuemin Wang Jie He Jijie Zhang Jian Zhu Xian-He Bu | 2021 | Nano Research2021，14，12： | 0 |
| 7 | The Nucleation Process in the Preparation of Graphene Films by Pulsed Laser Deposition显示文摘The nucleation process of graphene films prepared by pulsed laser deposition has been investigated in detail. It is found that graphene nucleates at the steps on the substrate surface firstly, from aggregation of nuclei into particles. High pulsed laser energy offers large incident energy for carbon particles deposited on the surface of the substrate, which is beneficial to the nucleation of graphene. A lot of steps are formed on the copper substrate due to the high temperature, so that the high incident energetic carbon species are able to form a stable nucleus at the steps. As the incident particles increases, the graphene nuclei are combined to grow together. Further, it is found that graphene tends to form few layer graphene particles instead of large graphene sheets. | 王进 WANG Xuemin YU Jian XIAO Tingting PENG Liping XIONG Zhengwei CAO Linhong WANG Chuanbin 沈强 | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，2： | 0 |
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