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| 1 | Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer显示文摘渗入肿瘤的 Tregs 的起源,肿瘤免疫力的抑制的批评调停人,是不清楚的。这里,,我们证明在人的乳癌的渗入肿瘤的天真的 CD4 + T 房间和 Tregs 有重叠 TCR 全部剧目几乎别与传播 Tregs 重叠,建议 intratumoral Tregs 主要在 situ 而非从招募的 Tregs 从天真的 T 房间发展。而且,许多天真的 CD4 + T 房间和 Tregs 密切被相关,两个显示的穷人为乳癌病人的预后。天真的 CD4 + T 房间与许多生产 CCL18 巨噬细胞成比例遵守肿瘤片。而且,采纳地转移的人的天真的 CD4 + T 房间以一种 CCL18 依赖的方式渗入人的乳癌 orthotopic 异种皮移植。在在人性化的鼠标的人的乳癌异种皮移植,由将 PITPNM3 的表达式击倒堵住天真的 CD4 + T 房间的招募进肿瘤, CCL18 受体,显著地减少 intratumoral Tregs 并且禁止肿瘤前进。这些调查结果建议那个乳房渗入肿瘤的 Tregs 从在 situ 区分进 Tregs 的传播天真的 CD4 + T 房间的趋化性产生。由防碍 CCL18 的 PITPNM3 识别禁止天真的 CD4 + T 房间招募进肿瘤可以是为 anticancer 免疫疗法的吸引人的策略。 | Shicheng Su Jianyou Liao Jiang Liu Di Huang Chonghua He Fei Chen LinBing Yang Wei Wu Jianing Chen Ling Lin Yunjie Zeng Nengtai Ouyang Xiuying Cui Herui Yao Fengxi Su Jian-dong Huang Judy Lieberman Qiang Liu Erwei Song | 2017 | Cell Research2017，27，4： | 19 |
| 2 | Clinical Characteristics of Hospitalized Patients with SARS-CoV-2 and Hepatitis B Virus Co-infection显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)is a global pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2).SARS-Co V-2 infection was first detected in Wuhan,China in late December 2019.The virus was spreading rapidly to other cities of China and accumulating cases had been reported(Li et al.2020). | Xiaoping Chen Qunqun Jiang Zhiyong Ma Jiaxin Ling Wenjia Hu Qian Cao Pingzheng Mo Lei Yao Rongrong Yang Shicheng Gao Xien Gui Wei Hou Yong Xiong Jinlin Li Yongxi Zhang | 2020 | Virologica Sinica2020，35，6： | 6 |
| 3 | Generation of tooth-like structures from integration-free human urine induced pluripotent stem cells显示文摘Background:Tooth is vital not only for a good smile,but also good health.Yet,we lose tooth regularly due to accidents or diseases.An ideal solution to this problem is to regenerate tooth with patients’own cells.Here we describe the generation of tooth-like structures from integration-free human urine induced pluripotent stem cells(ifhU-iPSCs).Results:We first differentiated ifhU-iPSCs to epithelial sheets,which were then recombined with E14.5 mouse dental mesenchymes.Tooth-like structures were recovered from these recombinants in 3 weeks with success rate up to 30%for 8 different iPSC lines,comparable to H1 hESC.We further detected that ifhU-iPSC derived epithelial sheets differentiated into enamel-secreting ameloblasts in the tooth-like structures,possessing physical properties such as elastic modulus and hardness found in the regular human tooth.Conclusion:Our results demonstrate that ifhU-iPSCs can be used to regenerate patient specific dental tissues or even tooth for further drug screening or regenerative therapies. | Jinglei Cai Yanmei Zhang Pengfei Liu Shubin Chen Xuan Wu Yuhua Sun Ang Li Ke Huang Rongping Luo Lihui Wang Ying Liu Ting Zhou Shicheng Wei Guangjin Pan Duanqing Pei | 2013 | Cell Regeneration2013，2，1： | 4 |
| 4 | Efficient Extraction of Lithium Ions from High Mg/Li Ratio Brine through the Synergy of TBP and Hydroxyl Functional Ionic Liquids显示文摘of main observation and conclusion The extraction of Li^+from the high Mg/Li ratio brine was performed using hydroxyl functional ionic lic-uids(ILs)as the coextractant and tributyl phosphate(TBP)as the extractant.irsty the extractive system,1-2-hydroxyethyl-3-mnethylimidazolumbis(trifuoromethylsulfonyl)imide([HOEmim][NTf2])+TBP was proved to exhibit the highest extraction efficiency of Li^+(88.15%)from LiCl aqueous solutions among the extractants composed of differents TB P,and ls+TBP.Effects of various extraction parameters on the extraction eficiencies of Li^+and Mg^2+were then investigated.95.01%of Li^+was extracted and the Li^+/Mg^2+separation factor reached 405.76 in a singl-stage at 278.15 Kand O/A of 2:1.The extraction complexes were determined by the slope analysis method and ESI-MS analysis,and the metal complexes in the organic phase were indcated to be mainly[L-2TBP][NTf;J.The striping study showed that 92.86%of i*was stripped with 1.0 mol·L^-1 HCl.98%extraction capacity of the synergyextractants was remained after 5 regeneration cycles.The thermodynamic parameters(△G°,△H°,and△S°),together with the mechanism of the Li^+extraction were further demonstrated finally,According to the results,[HOEmim][NTf2]+TBP extraction system showed promising performance in extracting lithium from salt lake brine with high Mg/Li ratio. | Ruibing Bai Junfeng Wang Li Cui Shicheng Yang Wei Qian Penglei Cui Yanqiang Zhang | 2020 | Chinese Journal of Chemistry2020，38，12： | 4 |
| 5 | A Positive Feedback Loop between Mesenchymal-like Cancer Cells and Macrophages Is Essential to Breast Cancer Metastasis显示文摘 | Shicheng Su Qiang Liu Jingqi Chen Jianing Chen Fei Chen Chonghua He Di Huang Wei Wu Ling Lin Wei Huang Jin Zhang Xiuying Cui Fang Zheng Haiyan Li Herui Yao Fengxi Su Erwei Song | 2014 | Cancer Cell2014，，5： | 3 |
| 6 | Overexpression of PITPNM3 promotes hepatocellular carcinoma cell metastasis显示文摘A previous study indicated that C–C chemokine(C–C motif)ligand 18(CCL18)is capable of inducing tumor cell invasion and metastasis by interacting with receptor membrane-associated phosphatidylinositol transfer protein 3(PITPNM3)in breast cancer cells.The present study aims to investigate the correlation between the PITPNM3 expression and metastasis in hepatocellular carcinoma(HCC).Real-time quantitative polymerase chain reaction and Western blot were performed to detect the expression pattern of PITPNM3 in patient samples and HCC cell lines.Wound-healing and transwell chamber assays were performed to assess the migration and invasiveness of HCC cells,and the activation of the signaling protein downstream of PITPNM3 was also detected by Western blot and immunofluorescence.The results revealed that PITPNM3 was upregulated in HCC tissue compared to matched normal liver tissue.Silencing the expression of PITPNM3 by specific siRNAs markedly attenuated the invasive and metastatic abilities of HCC cells,whereas the upregulation of PITPNM3 significantly increased HCC cell mobility.Furthermore,inhibiting the expression of PITPNM3 suppressed the activation of Pyk2,FAK,and Src,while overexpression of PITPNM3enhanced the phosphorylation of FAK and Src in HCC cells.Besides,suppression of Pyk2 can also impair the clustering of integrin.These results imply that PITPNM3 is a vital determinant of HCC migration and invasion. | Chonghua He Shicheng Su Fei Chen Di Huang Fang Zheng Wei Huang Jianing Chen Xiuying Cui Qiang Liu Erwei Song Herui Yao Yujie Liu | 2014 | Chinese Science Bulletin2014，59，12： | 3 |
| 7 | Research of Electrochemical Noise Technology on Corrosion Resistance显示文摘This paper is focus on the corrosion resistance property analysis on three electric blasting of the coating-FeAl,FeCrAl,FeCrAlRE by electrochemical noise technology,acceleration of copper acetate salt spray accelerated corrosion test.According to a comparative analysis of three tests coated by the Impedance curve,FeCrAlRE coating power spectral density(SPD)curve and Power curve,FeAl,FeCrAlRE coating has two more notable for the corrosion resistance properties than FeAl,FeCrAl coatings. | Wei Shicheng Yi, Liang Yi, Liu Wang Yujing Xu Binshi | 2012 | 稀有金属材料与工程2012，41，S1： | 2 |
| 8 | Effect of heat treatment on microwave absorption properties of Ni-Zn-Mg-La ferrite nanopmlicles 显示文摘 | Yi Liu Shicheng Wei Binshi Xu | 2013 | Journal of Magnetism and Magnetic Materials2013，349，2014： | 1 |
| 9 | Fertilizer recommendation for maize in China based on yield response and agronomic efficiency显示文摘 | Xinpeng Xu Ping He Mirasol F. Pampolino Adrian M. Johnston Shaojun Qiu Shicheng Zhao Limin Chuan Wei Zhou | 2014 | Field Crops Research2014，，： | 1 |
| 10 | Polyetheretherketone/nano-fluorohydroxyapatite composite with antimicrobial activity and osseointegration properties显示文摘 | Lixin Wang Shu He Xiaomian Wu Shanshan Liang Zhonglin Mu Jie Wei Feng Deng Yi Deng Shicheng Wei | 2014 | Biomaterials2014，，25： | 1 |
| 11 | Rare Metal Materials and Engineering显示文摘 | Wang Yujiang Wei Shicheng Liu Yi | 2012 | 2012,41(2): 323 (in Chinese)2012，41，2： | 1 |
| 12 | Nutrient requirements for maize in China based on QUEFTS analysis显示文摘 | Xinpeng Xu Ping He Mirasol F. Pampolino Limin Chuan Adrian M. Johnston Shaojun Qiu Shicheng Zhao Wei Zhou | 2013 | Field Crops Research2013，，： | 1 |
| 13 | Estimating nutrient uptake requirements for wheat in China显示文摘 | Limin Chuan Ping He Jiyun Jin Shutian Li Cynthia Grant Xinpeng Xu Shaojun Qiu Shicheng Zhao Wei Zhou | 2013 | Field Crops Research2013，，： | 1 |
| 14 | Molecular cloning of a new laccase from the edible straw mushroom Volvariella volvacea:Possible involvement in fruit body development显示文摘 | Shicheng Chen Wei Ge John A Buswell | 2004 | FEMS Microbiology Letters2004，230，： | 1 |
| 15 | Recycled low-temperature direct bonding of Si/glass and glass/glass chips for detachable micro/nanofluidic devices显示文摘Silicon and glass are two of the most ideal materials for micro/nanofluidic devices,which have been widely used for research in multidisciplinary fields.However,many micro/nanofluidic devices enable only single use due to the irreversible bonding between Si/glass or glass/glass chips.If the silicon-and glass-based devices are fabricated to be detachable,the substrates can be reused and bonded again without repeating expensive micro/nanofabrication processes.Herein,we present a recycled direct bonding method for Si/glass and glass/glass chips based on oxygen plasma activation and low-temperature annealing processes.Strong bonding strength and void-free bonding interface are obtained after annealing at 150℃.The surfaces and the bonding interfaces are characterized to elucidate the bonding mechanisms.Moreover,immersion tests are carried out to investigate the interfacial corrosion resistance in various chemical and biological solutions as well as explore a detachable method.The bonding strengths are controlled to meet the demand for micro/nanofluidic devices and the bonding interfaces can be separated in ethanol.As a result,we succeed in the experiment of bonding and detaching of glass substrates without fracturing,which is repeated for three times. | Chenxi Wang Hui Fang Shicheng Zhou Xiaoyun Qi Fanfan Niu Wei Zhang Yanhong Tian Tadatomo Suga | 2020 | Journal of Materials Science & Technology2020，42，11： | 1 |
| 16 | Fretting Corrosion Behavior of Zn-Al-Mg-RE Coating under Dry Friction and NaCl Solution显示文摘The fretting behavior of Zn-Al-Mg-RE coating prepared by high velocity arc spraying was studied for the first time in this paper.All specimens were fretted in air and 3.5%NaCl solution independently.The worn surfaces of the coating were investigated by scanning electron microscopy and X-ray energy dispersive spectroscopy.Fretting tests have shown that friction coefficient in 3.5%NaCl solution was similar to dry condition for Zn-Al-Mg-RE coating.Study of worn surfaces revealed the main mechanism in dry friction was the oxidative wear;while in 3.5%NaCl solution,the main mechanisms were delamination process and abrasive wear. | Yi, Liu Xu Binshi Wei Shicheng Wang Yujiang Yi, Liang | 2012 | 稀有金属材料与工程2012，41，S1： | 1 |
| 17 | Comparative study on corrosion resistance and in vitro biocompatibility of bulk nanoerystalline and micrecrystalline biomedical 304 stainless steel显示文摘 | Nie Feilong Wang Shenggang Wei Shicheng | 2011 | Dental materials2011，，27： | 1 |
| 18 | Nutrient requirements for maize in China based on QUEFTS analysis显示文摘 | Xinpeng Xu Ping He Mirasol F. Pampolino Limin Chuan Adrian M. Johnston Shaojun Qiu Shicheng Zhao Wei Zhou | 2013 | Field Crops Research2013，，： | 1 |
| 19 | Estimating nutrient uptake requirements for wheat in China显示文摘 | Limin Chuan Ping He Jiyun Jin Shutian Li Cynthia Grant Xinpeng Xu Shaojun Qiu Shicheng Zhao Wei Zhou | 2013 | Field Crops Research2013，，： | 1 |
| 20 | Comparison on performance of electro-thermal explosion plasma spraying FeAl-based coatings 显示文摘 | Wei Shicheng Xu Binshi Wang Haidou | 2007 | Surface and Coatings Technology2007，210，911： | 1 |
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