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| 1 | DC-SIGN and Immunoregulation显示文摘树枝状的房间(DC ) 被知道到目前为止是最强大的职业介绍抗原的房间。它能激活主要有免疫力的反应,并且另外 downregulate 免疫者反应。DC 有 immunoregulation 的一个独特人物。DC 签名,指定为 CD209 的一个分子,是 C 类型 lectin 总科的一个成员。它是模式识别受体,但是在 DC 的 immunoregulation 含有不仅。因为它的重要角色, DC 签名在调停成为了最近的研究的热点 DC 粘附,移植,发炎,激活的主要 T 房间,触发有免疫力的反应并且参予病原体和肿瘤的有免疫力的逃跑。涉及主要、第二等的有免疫力的反应和相关机制的 DC 签名上的这些研究将当然在治疗并且阻止某些疾病向我们提供一个新方法。细胞与分子的免疫学。2006; 3 (4 ): 279-283。 | Tong Zhou Yongxi Chen Li Hao Yanyun Zhang | 2006 | Cellular & Molecular Immunology2006，3，4： | 11 |
| 2 | Clinical Characteristics of Hospitalized Patients with SARS-CoV-2 and Hepatitis B Virus Co-infection显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)is a global pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2).SARS-Co V-2 infection was first detected in Wuhan,China in late December 2019.The virus was spreading rapidly to other cities of China and accumulating cases had been reported(Li et al.2020). | Xiaoping Chen Qunqun Jiang Zhiyong Ma Jiaxin Ling Wenjia Hu Qian Cao Pingzheng Mo Lei Yao Rongrong Yang Shicheng Gao Xien Gui Wei Hou Yong Xiong Jinlin Li Yongxi Zhang | 2020 | Virologica Sinica2020，35，6： | 6 |
| 3 | Reverse Genetics for Peste des Petits Ruminants Virus: Current Status and Lessons to Learn from Other Non-segmented Negative-Sense RNA Viruses显示文摘Peste des petits ruminants(PPR) is a highly contagious transboundary animal disease with a severe socio-economic impact on the livestock industry, particularly in poor countries where it is endemic. Full understanding of PPR virus(PPRV)pathobiology and molecular biology is critical for effective control and eradication of the disease. To achieve these goals,establishment of stable reverse genetics systems for PPRV would play a key role. Unfortunately, this powerful technology remains less accessible and poorly documented for PPRV. In this review, we discussed the current status of PPRV reverse genetics as well as the recent innovations and advances in the reverse genetics of other non-segmented negative-sense RNA viruses that could be applicable to PPRV. These strategies may contribute to the improvement of existing techniques and/or the development of new reverse genetics systems for PPRV. | Alfred Niyokwishimira Yongxi Dou Bang Qian Prajapati Meera Zhidong Zhang | 2018 | Virologica Sinica2018，33，6： | 3 |
| 4 | Significant effect of lanthanide doping on the texture and properties of nanoerystalline mesoperous TiO2 显示文摘 | Zhang Yuhong Zhang Huaxing Xu Yongxi | 2004 | J Solid State Chem2004，177，10： | 1 |
| 5 | Screening of Potential Biomarkers for Gastric Cancer with Diagnostic Value Using Label-free Global Proteome Analysis显示文摘Gastric cancer(GC)is known as a top malignant type of tumors worldwide.Despite the recent decrease in mortality rates,the prognosis remains poor.Therefore,it is necessary to find novel biomarkers with early diagnostic value for GC.In this study,we present a large-scale proteomic analysis of 30 GC tissues and 30 matched healthy tissues using label-free global proteome profiling.Our results identified 537 differentially expressed proteins,including 280 upregulated and 257 downregulated proteins.The ingenuity pathway analysis(IPA)results indicated that the sirtuin signaling pathway was the most activated pathway in GC tissues whereas oxidative phosphorylation was the most inhibited.Moreover,the most activated molecular function was cellular movement,including tissue invasion by tumor cell lines.Based on IPA results,15 hub proteins were screened.Using the receiver operating characteristic curve,most of hub proteins showed a high diagnostic power in distinguishing between tumors and healthy controls.A four-protein(ATP5B-ATP5O-NDUFB4-NDUFB8)diagnostic signature was built using a random forest model.The area under the curve(AUC)values of this model were 0.996 and 0.886 for the training and testing sets,respectively,suggesting that the four-protein signature has a high diagnostic power.This signature was further tested with independent datasets using plasma enzyme-linked immune sorbent assays,resulting in an AUC value of 0.778 for distinguishing GC tissues from healthy controls,and using immunohistochemical tissue microarray analysis,resulting in an AUC value of 0.805.In conclusion,this study identifies potential biomarkers and improves our understanding of the pathogenesis,providing novel therapeutic targets for GC. | Yongxi Song Jun Wang Jingxu Sun Xiaowan Chen Jinxin Shi Zhonghua Wu Dehao Yu Fei Zhang Zhenning Wang | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 1 |
| 6 | Significant effect of lanthanide doping on the texture and properties of nanocrystalline mesoporous TiO2 显示文摘 | Zhang Yuhong Hang Huaxing Xu Yongxi | 2004 | Journal of Solid State Chemistry2004，177，10： | 1 |
| 7 | Significant effect of lanthanide doping on the texture and proper- ties of nanocrystaUine mesoporous TiO2 显示文摘 | Zhang Yuhong Zhang Huaxing Xu Yongxi Wang Yanguang | 2004 | Journal of Solid State Chemistry2004，177，： | 1 |
| 8 | Significant effect of lanthanide doping on the texture and properties of nano-crystalline mesoporous TiO2 显示文摘 | Yuhong Zhang Huaxing Zhang Yongxi Xu | 2004 | Journal of Solid Chemistry2004，，177： | 1 |
| 9 | Nucleic acids analysis显示文摘Nucleic acids are natural biopolymers of nucleotides that store, encode, transmit and express genetic information, which play central roles in diverse cellular events and diseases in living things. The analysis of nucleic acids and nucleic acids-based analysis have been widely applied in biological studies, clinical diagnosis, environmental analysis, food safety and forensic analysis.During the past decades, the field of nucleic acids analysis has been rapidly advancing with many technological breakthroughs.In this review, we focus on the methods developed for analyzing nucleic acids, nucleic acids-based analysis, device for nucleic acids analysis, and applications of nucleic acids analysis. The representative strategies for the development of new nucleic acids analysis in this field are summarized, and key advantages and possible limitations are discussed. Finally, a brief perspective on existing challenges and further research development is provided. | Yongxi Zhao Xiaolei Zuo Qian Li Feng Chen Yan-Ru Chen Jinqi Deng Da Han Changlong Hao Fujian Huang Yanyi Huang Guoliang Ke Hua Kuang Fan Li Jiang Li Min Li Na Li Zhenyu Lin Dingbin Liu Juewen Liu Libing Liu Xiaoguo Liu Chunhua Lu Fang Luo Xiuhai Mao Jiashu Sun Bo Tang Fei Wang Jianbin Wang Lihua Wang Shu Wang Lingling Wu Zai-Sheng Wu Fan Xia Chuanlai Xu Yang Yang Bi-Feng Yuan Quan Yuan Chao Zhang Zhi Zhu Chaoyong Yang Xiao-Bing Zhang Huanghao Yang Weihong Tan Chunhai Fan | 2021 | Science China Chemistry2021，64，2： | 1 |
| 10 | Genetic polymorphism of interleukin-6 influences susceptibility to HBV-related hepatocellular carcinoma in a male Chinese Han population显示文摘 | Shengli Tang Yufeng Yuan Yueming He Dingyu Pan Yongxi Zhang Yuanyuan Liu Quanyan Liu Zhonglin Zhang Zhisu Liu | 2014 | Human Immunology2014，，4： | 1 |
| 11 | 显示文摘 | Zhang Yuhong Zhang Huaxing Xu Yongxi | 2004 | Journal of Solid State Chemistry2004，177，10： | 1 |
| 12 | Endogenous chitinase might lead to differences in growth performance and intestinal health of piglets fed different levels of black soldier fly larva meal显示文摘This study aimed to investigate the effects of different levels of black soldier fly(BSF)replacing soybean meal(SBM)in diets on the performance and health condition of piglets.A total of 180 weaned piglets were allocated into 5 treatments:BSF0(corn-soybean meal basal diet),BSF25(BSF replacing 25%SBM),BSF50(BSF replacing 50%SBM),BSF75(BSF replacing 75%SBM)and BSF100(BSF replacing 100%SBM).During the whole period,in comparison with BSF0,average daily gain(ADG)and average daily feed intake increased in the BSF25 and BSF50 groups,whereas ADG decreased in the BSF75 and BSF100groups(P<0.05).The result of quadratic fitting curve showed that piglets exhibited the highest ADG when BSF replaced around 20%SBM.Compared with BSF0,organic matter and dry matter digestibility improved in the BSF25 group,whereas ether extract digestibility decreased in the BSF100 group(P<0.05).In comparison with BSF0,piglets from the BSF25 group showed a higher duodenal ratio of villus height to crypt depth,increased jejunal sucrase activity,serum neuropeptide Y and ghrelin levels,elevated ileal immunoglobulin(Ig)A,Ig G and Ig M contents and a lower leptin level,and piglets from the BSF100 group exhibited an increased relative weight of kidney(P<0.05).However,no significant differences were observed in the expression level of tight junction proteins and chitin-degrading enzyme.Additionally,compared with BSF0,the abundance of short chain fatty acid producing bacteria such as Ruminococcaceae,Faecalibacterium and Butyricicoccus increased,and potential pathogenic bacteria decreased in piglets from the BSF25 group,whereas piglets from the BSF100 group had a greater abundance of harmful bacteria.In conclusion,BSF replacing 25%SBM in diets could improve digestive parameters,immune function and intestinal microbiota,and thus improved growth performance of piglets.However,BSF replacing 100%SBM showed an adverse effect on piglet performance,and the reason might be related to the limited amount of chitin-degrading enzyme. | Sujie Liu Jian Wang Longxian Li Yonggai Duan Xiaolin Zhang Tenghao Wang Jianjun Zang Xiangshu Piao Yongxi Ma Defa Li | 2023 | Animal Nutrition2023，，3： | 0 |
| 13 | Risk-based Two-stage Optimal Scheduling of Energy Storage System with Second-life Battery Units显示文摘With the growing adoption of Electrical Vehicles(EVs),it is expected that a large number of on-board Li-ion batteries will be retired from EVs in the near future.Retired batteries will typically retain 80%of their initial capacities and can be recycled as second life batteries(SLBs).Although the capital costs of SLBs are much cheaper,their operational reliability is an important concern since used batteries may suffer from a higher failure rate.This paper aggregates brand new batteries and SLBs together to improve power system’s operating performance with renewable energy resources.In the context of a day-ahead and intra-day dispatch framework,a two-stage coordinated optimal scheduling method is proposed.Specifically,the energy cost of brand-new batteries and SLBs is calculated based on detailed battery degradation model,and the reliability of batteries is modeled based on the Weibull distribution.Moreover,Conditional value at risk(CVaR)criterion is applied to evaluate the risk induced by intermittent renewable power output,load demand variation and SLBs failure probability.Simulation tests demonstrate the effectiveness of the proposed method. | Yongxi Zhang Jiahua Zhu Yan Xu Renjun Zhou Zhao Yang Dong | 2023 | CSEE Journal of Power and Energy Systems2023，9，2： | 0 |
| 14 | Combining methylated SEPTIN9 and RNF180 plasma markers for diagnosis and early detection of gastric cancer显示文摘Dear Editor,Early diagnosis is critical for successful treatment of gastric adenocarcinoma(GA).However,the sensitivities of tumor markers carcinoembryonic antigen(CEA),cancer antigen 19-9(CA19-9)and CA72-4 for GA detection are approximately 20%[1],and the sensitivities of all markers combined for early gastric cancer detection is still very low[2].DNA methylation plays a major role in tumorigenesis and therefore has obvious potential as a non-invasive biomarker for cancer detection[3].Through genome-wide methylation analysis and histological verification,we previously identified ring finger protein 180(RNF180)as a novel preferentially methylated gene in GA[4,5]. | Yongzhan Nie Xianchun Gao Xiqiang Cai Zhen Wu Qiaoyi Liang Guobing Xu Na Liu Peng Gao Jingyu Deng Hongzhi Xu Zhanlong Shen Changqi Cao Fenrong Chen Nannan Zhang Yongxi Song Mingjun Sun Chengyin Liu Guangpeng Zhou Weili Han Jianhua Dou Huahong Xie Liping Yao Zhiguo Liu Gang Ji Xin Wang Qingchuan Zhao Lei Shang Daiming Fan Xiaoliang Han Jianlin Ren Han Liang Zhenning Wang Jinhai Wang Qi Wu Jun Yu Kaichun Wu the MAGIS Study Group | 2023 | Cancer Communications2023，43，11： | 0 |
| 15 | Short-axis substitution approach on ladder-type benzodithiophene- based electron acceptor toward highly efficient organic solar cells显示文摘Short-axis substitution, as an effective way to change the optical and electronic properties of the organic semiconductors for organic photovoltaics(OPVs), is a readily approach to modify non-fullerene acceptors, especially for the linear fused rings system. Here, two new fused-ring electron acceptors(CBT-IC and SBT-IC) were designed and developed by short-axis modification based on the dithienyl[1,2-b:4,5-b′]benzodithiophene(BDCPDT) system. Combined with a medium bandgap polymer donor J71, both of the OPV devices exhibit high power conversion efficiency(PCE) over 11%, and ~70% external quantum efficiencies. To better understand how this kind of substitution affects the BDCPDT based acceptors, a comparative analysis is also made with the the plain acceptor BDT-IC without this modification. We believe this work could disclose the great potential and the versatility of BDCPDT block and also enlighten other ladder-type series for further optimization. | Jiu-Dong Lin Lian Zhong Fu-Peng Wu Yongxi Li Yi Yuan Haijun Bin Zhanjun Zhang Feng Liu Jian Fan Zhi-Guo Zhang Liang-Sheng Liao Zuo-Quan Jiang Yongfang Li | 2018 | Science China Chemistry2018，61，11： | 0 |
| 16 | A microfluidic surface-enhanced Raman scattering(SERS) sensor for microRNA in extracellular vesicles with nucleic acid-tyramine cascade amplification显示文摘Exosomal micro RNA(mi RNA) is an ideal candidate of noninvasive biomarker for the early diagnosis of cancer. Sensitive and accurate sensing of abnormal exosomal mi RNA plays essential role for clinical promotion due to its close correlation with tumor proliferation and progression. Herein, a microfluidic surface-enhanced Raman scattering(SERS) sensor was proposed for an on-line detection of exosomal mi RNA based on rolling circle amplification(RCA) and tyramine signal amplification(TSA) strategy. The microfluidic chip consists of a magnetic enrichment chamber, a serpentine fluidic mixer and a plasmonic SERS substrate functionalized with capture probes. The released mi RNA activates the capture probe, triggers RCA reaction, and generates a large number of single-stranded DNA products to drive the catalysis of nanotags deposition via TSA, producing numerous “hot spots” to enhance the SERS signals. In merit of the microfluidics chip and nucleic acid-tyramine cascade amplification, the developed SERS sensor significantly improves the sensitivity for the exosomal mi RNA assay, resulting in a limit of detection(LOD) as low as 1 pmol/L and can be successfully applied in the analysis of exosomes secreted from breast tumor cells, which demonstrates the potential utility in practical applications. | Yue Zhao Xiaoxing Fang Min Bai Jin Zhang Huahang Yu Feng Chen Yongxi Zhao | 2022 | Chinese Chemical Letters2022，33，4： | 0 |
| 17 | The evolution of central environmental protection inspection policy attention in China: An investigation based on inspection reports显示文摘The central environmental protection inspection (CEPI) system in China is a significant institutional innova‐tion in national environmental governance. The CEPI applies a joint supervision strategy to address salient en‐vironmental issues and strictly enforce the environmental responsibilities of local governments. This study col‐lects and organizes CEPI inspection reports covering three stages that encompass the first round, the “look back”, and the second round, applying text analysis to obtain sample data and conduct statistical quantifica‐tion of word frequency in inspection reports and identify notable changes. The study explores the allocation of CEPI attention between policy objectives and the intensity of policy instruments. We determine that in con‐junction with public opinion feedback, the CEPI conducts targeted inspections and focuses more on pollutant governance, which has high severity and can be addressed quickly. The CEPI fills the gap of normalized gover‐nance with a campaign-style governance approach. Regarding the intensity of policy measures, the CEPI pri‐marily uses economic incentive policy instruments, supplemented by command-and-control and public guid‐ance approaches, advancing the sustainability of regulatory effectiveness through economic, social, and politi‐cal activities. This study extends knowledge in the field of CEPI policy priorities and implementation, expand‐ing the literature related to outcomes of environmental policy in developing countries. | Zhenhua Zhang Qianyu Liu Yongxi Chen Shuai Shao Yating Tang | 2023 | Chinese Journal of Population,Resources and Environment2023，21，4： | 0 |
| 18 | Optimization of LTE Network Coverage显示文摘The trend of mobile,broadband and IP is becoming more and more prominent.Mobile communication technology is now in a critical period in the evolution of network technology.As such,LTE(Long Term Evolution)comes to light.LTE serves as a unified standard for the new generation of mobile communications,equipped with high spectral efficiency,high peak rate,high mobility,flat network architecture and other advantages.Huawei has played a very important role in the commercialization of LTE.As a sponsor of NGMN,Huawei has been actively involved in the research of some key projects of NGMN,such as network self-optimization,system architecture and Network performance evaluation and so on.This paper mainly introduces the problems encountered in the optimization of LTE network coverage,the practical problems encountered by the LTE project team in Qingdao and the analysis and solutions to the problems.At the same time,this paper discusses in detail on the LTE network optimization process. | Yanbo Fu Na Qu Haibin Hou Yongxi Zhang | 2017 | Wireless Communication Technology2017，1，1： | 0 |
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