2篇
您的检索式：作者名="Shifang Wen"
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| 1 | A self-assembling peptide targeting VEGF receptors to inhibit angiogenesis显示文摘Vascular endothelial growth factor(VEGF)-vascular endothelial growth factor receptor(VEGFR)pathways are essential in tumor angiogenesis,growth and metastasis.Studies on anti-angiogenic therapy have been mostly focused on the blockage of VEGF-VEGFR pathways.We report an extracellularly transformable peptide-based nanomaterial to develop artificial extracellular matrix(ECM)-like networks for high-efficient blockage of natural VEGF-VEGFR interactions.The transformable peptide-based nanomaterial transforms from nanoparticles into nanofibers upon binding to VEGFR in solution.In addition,the transformable peptide-based nanomate rial forms ECM-like fibrous netwo rks on VEGFR overexpressed cells,inhibiting the VEGF-VEGFR interactions and the subsequent angiogenesis.The tube formation is reduced by nearly 85.1% after treatment.This strategy shows excellent potential for anti-angiogenesis,and inhibition of tumor invasion and metastasis. | Shifang Wen Kuo Zhang Yuan Li Jiaqi Fan Ziming Chen Jjingping Zhang Hao Wang Lei Wang | 2020 | Chinese Chemical Letters2020，31，12： | 1 |
| 2 | Experiences and Lessons of Combating COVID-19 that Chinese Experts Shared with the World显示文摘At the end of 2019,a novel viral pneumonia was detected in Wuhan City(1)and has spread rapidly throughout 215 countries,areas,and territories with more than 3.8 million cases and over 260,000 deaths as of May 8,2020.This pneumonia,later named coronavirus disease 2019(COVID-19),has become a global public security challenge. | Tao Liu Jiufeng Sun Miaoyun Wen Youping Zhang Xiaodan Luo Xiangxin Liu Shifang Yang Jun Li | 2020 | China CDC weekly2020，2，43： | 1 |
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