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| 1 | Overview of business innovations and research opportunities in blockchain and introduction to the special issue显示文摘Blockchain has become a new frontier of venture capitals that has attracted the attention of banks,governments,and other business corporations.The recent blockchain related attempts included legal blockchains by Fadada.com and Microsoft and pork tracking blockchains by Walmart and IBM.Blockchain is poised to become the most exciting invention after the Internet;while the latter connects the world to enable new business models based on online business processes,the former will help resolve the trust issue more efficiently via network computing.In this paper,we give an overview on blockchain research and development as well as introduce the papers in this special issue.We show that while blockchain has enabled Bitcoin,the most successful digital currency,its widespread adoption in finance and other business sectors will lead to many business innovations as well as many research opportunities. | J.Leon Zhao Shaokun Fan Jiaqi Yan | 2016 | Financial Innovation2016，2，1： | 17 |
| 2 | Factors influencing the concentration of negative air ions during the year in forests and urban green spaces of the Dapeng Peninsula in Shenzhen, China显示文摘Negative air ions(NAIs)benefit the mental and physical health of humans,but rapid urbanization can decrease the abundance of NAIs.Quantifying the spatial and seasonal distribution of NAIs and determining the factors that infl uence the concentration during urbanization is thus essential.In the present study of a typical developing urban district in southern China,negative air ion concentrations(NAICs)in 60 forests sites and 30 urban green spaces were quantifi ed on seven consecutive days in each of the four seasons.Large seasonal variations in NAIC were revealed in forests and urban green spaces with trough values in summer.NAIC progressively decreased from forests to urban green spaces and was infl uenced by local land morphology,vegetation characteristics,and climatic factors.The vast,heavily vegetated northeastern region was the richest area for NAIs,whereas the narrow central region(urbanized area)was the poorest,implying dramatic impacts of urbanization on the spatial distribution of NAIs.The relationship between air temperature and NAIC was better fi tted with a quadratic equation than a linear equation.Moreover,the NAIC was more sensitive to local morphology in urban green spaces than in urban forests,indicating the vulnerability of NAIs in urbanized areas.Therefore,the appropriate design of local urban morphology is critical. | Yafei Wang Zhuobiao Ni Di Wu Chen Fan Jiaqi Lu Beicheng Xia | 2020 | Journal of Forestry Research2020，31，6： | 11 |
| 3 | Human natural killer cells for targeting delivery of gold nanostars and bimodal imaging directed photothermal/photodynamic therapy and immunotherapy显示文摘Objective:To construct a novel nanoplatform GNS@CaCO3/Ce6-NK by loading the CaCO3-coated gold nanostars(GNSs)with Chlorin e6 molecules(Ce6)into human peripheral blood mononuclear cells(PBMCs)-derived NK cells for tumor targeted therapy.Methods:GNS@CaCO3/Ce6 nanoparticles were prepared and characterized by TEM and UV-vis.The cell surface markers and cytokines secretion of NK cells before and after loading the GNS@CaCO3/Ce6 nanoparticles were detected by Flow Cytometry(FCM)and ELISA.Effects of the GNS@CaCO3/Ce6-NK cells on A549 cancer cells was determined by FCM and CCK-8.Intracellular fluorescent signals of GNS@CaCO3/Ce6-NK cells were detected via Confocal laser scanning microscopic(CLSM)and FCM at different time points.Intracellular ROS generation of GNS@CaCO3/Ce6-NK cells under laser irradiation were examined by FCM.The distribution of GNS@CaCO3/Ce6-NK in A549 tumor-bearing mice were observed by fluorescence imaging and PA imaging.The combination therapy of GNS@CaCO3/Ce6-NK under laser irradiation were investigated on tumor-bearing mice.Results:The coated CaC03 shell on the surface of GNSs exhibited prominent delivery and protection effect of Ce6 during the cellular uptake process.The as-prepared multifunctional GNS@CaCO3/Ce6-NK cells possessed bimodal functions of fluorescence imaging and photoacoustic imaging.The as-prepared multifunctional GNS@CaCO3/Ce6-NK cells could actively target tumor tissues with the enhanced photothermal/photodynamic therapy and immunotherapy.Conclusions:The GNS@CaCO3/Ce6-NK shows effective tumor-targeting ability and prominent therapeutic efficacy toward lung cancer A549 tumor-bearing mice.Through fully utilizing the features of GNSs and NK cells,this new nanoplatform provides a new synergistic strategy for enhanced photothermal/photodynamic therapy and immunotherapy in the field of anticancer development in the near future. | Bin Liu Wen Cao Jin Cheng Sisi Fan Shaojun Pan Lirui Wang Jiaqi Niu Yunxiang Pan Yanlei Liu Xiyang Sun Lijun Ma Jie Song Jian Ni Daxiang Cui | 2019 | Cancer Biology & Medicine2019，16，4： | 7 |
| 4 | Recent advances in photodynamic therapy based on emerging two-dimensional layered nanomaterials显示文摘Photodynamic therapy(PDT)is a promising non-invasive therapy approach for various diseases including malignant tumor.The process of PDT involves three interrelated aspects,namely photosensitizer(PS),light source,and oxygen,among which PS is the decisive factor that determines its anticancer efficiency.There exist some defects in currently applied PDT,such as inadequate production of reactive oxygen species(ROS),poor penetration of exciting light,insufficient oxygen supply,and nonselective distribution of PS.With unique physicochemical and optical properties,two-dimensional nanomaterials(2DNMs)have aroused great interest in biomedical fields.2DNMs-based PDT is promising to significantly improve antitumor efficacy compared to conventional PDT.In this review,we will firstly introduce the underlying mechanism of PDT and how 2DNMs are absorbed and distribute inside tumor cells.After that,we will not only illustrate how 2DNMs-based PDT can enhance tumor-killing efficacy and minimize side-effects through conquering the above-mentioned defects of conventional PDT and the preparation process of 2DNMs,but also elaborate recent advances about 2DNMs-based PDT.Lastly,we will summarize the challenges and future prospects of 2DNMs-based PDT. | Xinqiang Wu Xiaofeng Jiang Taojian Fan Zhiwei Zheng Zhaoyuan Liu Yubin Chen Liangqi Cao Zhongjian Xie Dawei Zhang Jiaqi Zhao Qiwen Wang Zhenhui Huang Zhijian Chen Ping Xue Han Zhang | 2020 | Nano Research2020，13，6： | 6 |
| 5 | Attribution analysis based on Budyko hypothesis for land evapotranspiration change in the Loess Plateau, China显示文摘Land evapotranspiration(ET) is an important process connecting soil, vegetation and the atmosphere, especially in regions that experience shortage in precipitation.Since 1999, the implementation of a large-scale vegetation restoration project has significantly improved the ecological environment of the Loess Plateau in China.However, the quantitative assessment of the contribution of vegetation restoration projects to long-term ET is still in its infancy.In this study, we investigated changes in land ET and associated driving factors from 1982 to 2014 in the Loess Plateau using Budyko-based partial differential methods.Overall, annual ET slightly increased by 0.28 mm/a and there were no large fluctuations after project implementation.An attribution analysis showed that precipitation was the driving factor of inter-annual variability of land ET throughout the study period;the average impacts of precipitation, potential evapotranspiration, and vegetation restoration on ET change were 61.5%, 11.5% and 26.9%, respectively.These results provide an improved understanding of the relationship between vegetation condition change and climate variation on terrestrial ET in the study area and can support future decision-making regarding water resource availability. | HE Guohua ZHAO Yong WANG Jianhua GAO Xuerui HE Fan LI Haihong ZHAI Jiaqi WANG Qingming ZHU Yongnan | 2019 | Journal of Arid Land2019，11，6： | 5 |
| 6 | Aboveground biomass and its spatial distribution pattern of herbaceous marsh vegetation in China显示文摘Herbaceous marsh is the most widely distributed type of marsh wetland ecosystem,and has important ecological functions such as water conservation,climate regulation,carbon storage and fixation,and sheltering rare species.The carbon sequestration function of herbaceous marsh plays a key role in slowing climate warming and maintaining regional environmental stability.Vegetation biomass is an important index reflecting the carbon sequestration capacity of wetlands.Investigating the biomass of marsh vegetation can provide a scientific basis for estimating the carbon storage and carbon sequestration capacity of marshes.Based on field survey data of aboveground biomass of herbaceous marsh vegetation and the distribution data set of marsh in China,we analyzed the aboveground biomass and its spatial distribution pattern of herbaceous marsh on a national scale for the first time.The results showed that in China the total area of herbaceous marsh was 9.7×10^(4) km^(2),the average density of aboveground biomass of herbaceous marsh vegetation was 227.5±23.0 g C m-2(95%confidence interval,the same below),and the total aboveground biomass was 22.2±2.2 Tg C(1 Tg=1012 g).The aboveground biomass density of herbaceous marsh vegetation is generally low in Northeast China and the Tibetan Plateau,and high in central North China and coastal regions in China.In different marsh distribution regions of China,the average biomass density of herbaceous marsh vegetation from small to large was as follows:temperate humid and semi-humid marsh region(182.3±49.3 g C m^(-2)) | Xiangjin SHEN Ming JIANG Xianguo LU Xingtu LIU Bo LIU Jiaqi ZHANG Xianwei WANG Shouzheng TONG Guangchun LEI Shengzhong WANG Chuan TONG Hangqing FAN Kun TIAN Xiaolong WANG Yuanman HU Yonghong XIE Muyuan MA Shuwen ZHANG Chunxiang CAO Zhichen WANG | 2021 | Science China Earth Sciences2021，64，7： | 4 |
| 7 | Growth of Carbon Nanocoils by Porous α-Fe2O3/SnO2 Catalyst and Its Buckypaper for High Efficient Adsorption显示文摘High-purity(99%)carbon nanocoils(CNCs)have been synthesized by using porousα-Fe2O3/SnO2 catalyst.The yield of CNCs reaches 9,098%after a 6 h growth.This value is much higher than the previously reported data,indicating that this method is promising to synthesize high-purity CNCs on a large scale.It is considered that an appropriate proportion of Fe and Sn,proper particle size distribution,and a loose-porous aggregate structure of the catalyst are the key points to the high-purity growth of CNCs.Benefiting from the high-purity preparation,a CNC Buckypaper was successfully prepared and the electrical,mechanical,and electrochemical properties were investigated comprehensively.Furthermore,as one of the practical applications,the CNC Buckypaper was successfully utilized as an efficient adsorbent for the removal of methylene blue dye from wastewater with an adsorption efficiency of 90.9%.This study provides a facile and economical route for preparing high-purity CNCs,which is suitable for large-quantity production.Furthermore,the fabrication of macroscopic CNC Buckypaper provides promising alternative of adsorbent or other practical applications. | Yongpeng Zhao Jianzhen Wang Hui Huang Tianze Cong Shuaitao Yang Huan Chen Jiaqi Qin Muhammad Usman Zeng Fan Lujun Pan | 2020 | Nano-Micro Letters2020，12，2： | 3 |
| 8 | Performance improvement of optimization solutions by POD-based data mining显示文摘The performance of an optimized aerodynamic shape is further improved by a second-step optimization using the design knowledge discovered by a data mining technique based on Proper Orthogonal Decomposition(POD) in the present study. Data generated in the first-step optimization by using evolution algorithms is saved as the source data, among which the superior data with improved objectives and maintained constraints is chosen. Only the geometry components of the superior data are picked out and used for constructing the snapshots of POD. Geometry characteristics of the superior data illustrated by POD bases are the design knowledge, by which the second-step optimization can be rapidly achieved. The optimization methods are demonstrated by redesigning a transonic compressor rotor blade, NASA Rotor 37, in the study to maximize the peak adiabatic efficiency, while maintaining the total pressure ratio and mass flow rate.Firstly, the blade is redesigned by using a particle swarm optimization method, and the adiabatic efficiency is increased by 1.29%. Then, the second-step optimization is performed by using the design knowledge, and a 0.25% gain on the adiabatic efficiency is obtained. The results are presented and addressed in detail, demonstrating that geometry variations significantly change the pattern and strength of the shock wave in the blade passage. The former reduces the separation loss,while the latter reduces the shock loss, and both favor an increase of the adiabatic efficiency. | Yanhui DUAN Wenhua WU Peihong ZHANG Fulin TONG Zhaolin FAN Guiyu ZHOU Jiaqi LUO | 2019 | Chinese Journal of Aeronautics2019，32，4： | 3 |
| 9 | Influence of hydraulic retention time on behavior of antibiotics and antibiotic resistance genes in aerobic granular reactor treating biogas slurry显示文摘The behavior of antibiotics and the corresponding resistance genes in aerobic granular reactors for treating biogas slurry under different hydraulic retention times (10.7 h, Rl;8 h, R2) was investigated in this study. The results indicated that the hydraulic retention time could affect the effluent concentrations and removal efficiencies of sulfonamides. The average removal rates of tetracyclines, fluoroquinolones, and sulfonamides were 63%, 46%, and 90% in Rl, and 62%, 46%, and 86% in R2, respectively. Although the removal efficiencies of tetracyclines and fluoroquinolones were similar in both reactors, the respective accumulated concentrations of tetracyclines and fluoroquinolones in R1 were 7.00 and 11.15μg/g SS, which were lower than those in R2 (8.92 and 13.37μg/g SS, respectively). The difference in the relative abundance of target antibiotic resistance genes between both reactors was not significant, yet the average relative abundances of all target resistance genes in R1 were higher than those in R2 after 45 days of operation. The results of this study suggested that a longer hydraulic retention time could enhance the antibiotic removal ability of aerobic granular sludge, yet it may also increase the risk of surplus sludge utilization from a resistance genes point of view. | Jie Liao Chaoxiang Liu Lin Liu Jie Li Hongyong Fan Jiaqi Ye Zhichao Zeng | 2019 | Frontiers of Environmental Science & Engineering2019，13，3： | 2 |
| 10 | The origin of invasion of an alien frog species in Tibet, China显示文摘 | Supen WANG Liqing FAN Conghui LIU Jiaqi LI Xu GAO Wei ZHU Yiming LI | 2017 | Current Zoology2017，63，6： | 2 |
| 11 | In situ construction of ligand nano-network to integrin αvβ3 for angiogenesis inhibition显示文摘Angiogenesis occurs during the process of tumor growth,invasion and metastasis,and is essential for the survival of solid tumors.As an integrin significantly ove rexpressed in human tumor vascular endothelial cells,αvβ3 is a suitable targeting site for anti-angiogenesis of tumor.We designed and prepared a selfassembling peptide(SAP)with the ability to targeting αvβ3 and self-assembly.SAP formed nanoparticles in solution and transformed into nanofibrous network once specifically binding to integrin αvβ3 on the surface of human umbilical vein endothelial cells(HUVECs).The SAP network stably anchored on HUVECs over 24h,which consequently resulted in high-efficient inhibition of vascularization.In vitro anti-angiogenesis experiment displayed that the inhibition rate of tube-formation reached 94.9%.In vivo anti-angiogenesis array based on chick chorioallantoic membrane(CAM)model exhibited that the SAP had an inhibition rate up to 63.1%.These results indicated the outstanding anti-angiogenic ability of SAP,potentially for tumor therapy. | Ziming Chen Kuo Zhang Jiaqi Fan Yu Fan Chao Yang Wen Tian Yuan Li Wenliang Li Jingping Zhang Hao Wang Lei Wang | 2020 | Chinese Chemical Letters2020，31，12： | 2 |
| 12 | SEM study of a polystyrene/clay nanocomposite 显示文摘 | Fan Jiaqi Liu Suhui Chen Guangming | 2002 | J Appl Polym Sci2002，83，1： | 1 |
| 13 | Enhancement of Graft Yield and Control of Degradation During Polypropylene Maleation in the Presence of Polyfunctional Monomer显示文摘 | Ni Qinglin Fan Jiaqi Niu Hui | 2011 | J Appl Polym Sci2011，121，5： | 1 |
| 14 | Regulated Tran- sient Pool Boiling of Water During Quenching on Nanos- tructured Surfaces With Modified W'ettability from Super- hydrophilic to Superhydrophobic 显示文摘 | FAN Liwu LI Jiaqi LI Danyang | 2014 | International Jour- hal of Heat and Mass Transfer2014，76，： | 1 |
| 15 | Transformable peptide nanoparticles inhibit the migration of N-cadherin overexpressed cancer cells显示文摘About 90%cancer-related mortality results from the cancer metastasis,which generally undergoes after epithelial-mesenchymal transition(EMT)process.N-Cadherin,overexpressed on cancer cell surface during EMT,can enhance the migration of cancer cells.He rein,we design and synthesize a transformable peptide BP-KLVFF-SWTLYTPSGQSK(BFS)that can block N-cadherin for inhibiting cancer migration and metastasis.The peptide BFS consists of three modules including(1)the hydrophobic bis-pyrene(BP)unit for forming and locating nanoparticles,(2)the KLVFF peptide sequence for forming and stabilizing fibrous structures and(3)the targeting peptide sequence SWTLYTPSGQSK that can specifically bind to Ncadherin.The peptide BFS can form nanoparticles in PBS,which can transform to nanofibers when targeting and binding to N-cadherin.The nanofibers inhibit the migration of N-cadherin overexpressed MDA-MB-436 cancer cells.The peptide BFS shows 83.6%inhibiting rate in cells wound healing assay.In addition,the inhibition rate is 67.9%when the BFS applied in transwell migration assay.These results indicate that the BFS has excellent ability to inhibit migration of cancer cells.This self-assembly strategy could be potentially utilized to regulate the key protein during EMT for inhibiting the tumor metastasis. | Jiaqi Fan Yu Fan Zijin Wei Yijing Li Xiangdan Li Lei Wang Hao Wang | 2020 | Chinese Chemical Letters2020，31，7： | 1 |
| 16 | Enhancement of graft yield and control of degradation during polypropylene maleation in the presence of polyfunctional monomer显示文摘 | Ni Qinglin Fan Jiaqi Niu Hui | 2011 | Applied Polymer Science2011，121，5： | 1 |
| 17 | A self-assembling peptide targeting VEGF receptors to inhibit angiogenesis显示文摘Vascular endothelial growth factor(VEGF)-vascular endothelial growth factor receptor(VEGFR)pathways are essential in tumor angiogenesis,growth and metastasis.Studies on anti-angiogenic therapy have been mostly focused on the blockage of VEGF-VEGFR pathways.We report an extracellularly transformable peptide-based nanomaterial to develop artificial extracellular matrix(ECM)-like networks for high-efficient blockage of natural VEGF-VEGFR interactions.The transformable peptide-based nanomaterial transforms from nanoparticles into nanofibers upon binding to VEGFR in solution.In addition,the transformable peptide-based nanomate rial forms ECM-like fibrous netwo rks on VEGFR overexpressed cells,inhibiting the VEGF-VEGFR interactions and the subsequent angiogenesis.The tube formation is reduced by nearly 85.1% after treatment.This strategy shows excellent potential for anti-angiogenesis,and inhibition of tumor invasion and metastasis. | Shifang Wen Kuo Zhang Yuan Li Jiaqi Fan Ziming Chen Jjingping Zhang Hao Wang Lei Wang | 2020 | Chinese Chemical Letters2020，31，12： | 1 |
| 18 | General Design and Thermodynamic Analysis of a Supercritical Carbon Dioxide Cannon显示文摘This paper presents a new supercritical carbon dioxide(SCO_(2))cannon based on the carbon dioxide(CO_(2))’s thermodynamic cycle under constant volume.First,Virial equation and NIST database are applied to formulate SCO_(2)’s property and analyze the thermodynamic cycle,which is aimed to get the optimization equation using the cannon’s exit velocity as objective function.Then the cannon’s structural parameters,such as diaphragm thickness and barrel length,and CO_(2)’s filling mass,are optimized.Finally,the flow field and velocity’s change during the launch process is performed with FLUENT.In field test,the ultra-high pressure sensor and ultra-high speed camera are used to measure the pressure distribution along the barrel’s axial direction and the projectile’s exit velocity under different conditions.The results show that all the performance indexes meet the design requirement.The innovative SCO_(2)cannon in this paper has obvious advantages such as high safety,low cost and fast loading,which can be applied in many situations such as disaster relief,peacekeeping and anti-terrorism.Moreover,the unique energy storage method and thermodynamic design ensure its subsequent development. | ZHANG Fan LIU Hongrui WU You LI Jiaqi YU Huazhang WANG Xiaoliang GUO Baoting YUAN Yixiang | 2021 | Journal of Thermal Science2021，30，1： | 1 |
| 19 | Crystallization Behav- ior and Crystallization Kinetic Studies of Isotactic Polypropyl- ene Modified by Long-Chain Branching Polypropylene 显示文摘 | Ni Qinglin Fan Jiaqi Dong Jinyong | 2009 | J ApplPolymSci2009，114，4： | 1 |
| 20 | Enhancement of Graft Yield and Control of Degradation During Polypropylene Ma- leation in the Presence of Polyfunctional Monomer 显示文摘 | Ni Qinglin Fan Jiaqi Niu Hui | 2011 | J Appl PolymSci2011，121，5： | 1 |
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