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| 1 | Linking uric acid metabolism to diabetic complications显示文摘Hyperuricemia have been thought to be caused by the ingestion of large amounts of purines, and prevention or treatment of hyperuricemia has intended to prevent gout. Xanthine dehydrogenase/xanthine oxidase(XDH/XO) is rate-limiting enzyme of uric acid generation, and allopurinol was developed as a uric acid(UA) generation inhibitor in the 1950 s and has been routinely used for gout prevention since then. Serum UA levels are an important risk factor of disease progression for various diseases, including those related to lifestyle. Recently, other UA generation inhibitors such as febuxostat and topiroxostat were launched. The emergence of these novel medications has promoted new research in the field. Lifestyle-related diseases, such as metabolic syndrome or type 2 diabetes mellitus, often have a common pathological foundation. As such, hyperuricemia is often present among these patients. Many in vitro and animal studies have implicated inflammation and oxidative stress in UA metabolism and vascular injury because XDH/XO act as one of the major source of reactive oxygen species Many studies on UA levels and associated diseases implicate involvement of UA generation in disease onset and/or progression. Interventional studies for UA generation, not UA excretion revealed XDH/XO can be the therapeutic target forvascular injury and renal dysfunction. In this review, the relationship between UA metabolism and diabetic complications is highlighted. | Akifumi Kushiyama Kentaro Tanaka Shigeko Hara Shoji Kawazu | 2014 | World Journal of Diabetes2014，5，6： | 19 |
| 2 | Geomorphological zoning for flood inundation using satellite data显示文摘 | Haruyama Shigeko Ohokura | 1996 | Geomorphologiea Journal1996，383，： | 1 |
| 3 | Incidence of Chronic Obstructive Pulmonary Disease, and the Relationship between Age and Smoking in a Japanese Population 显示文摘 | Shigeko Kojima Hiroki Sakakibara Shinichi Motani | 2007 | Journal of Epidemiolo- gy2007，17，2： | 1 |
| 4 | Subject ellipsis in English显示文摘 | Nariyam Shigeko | | 0，，： | 1 |
| 5 | Leflunomide-induced interstitial pneumonitis might be a representative of disease-modifying antirheumatic drug-induced lung injury显示文摘 | Shigeko Inokuma | 2011 | Expert Opinion on Drug Safety2011，，4： | 1 |
| 6 | Ischemic Time-Dependent Microvascular Changes and Reperfusion Injury in the Rat Small Intestine显示文摘 | Mihály Boros Shigeko Takaichi Kaoru Hatanaka | 1995 | Journal of Surgical Research1995，，2： | 1 |
| 7 | Tickling during adolescence alters fear-related and cognitive behaviors in rats after prolonged isolation显示文摘 | Miyo Hori Kazuo Yamada Junji Ohnishi Shigeko Sakamoto Hiroki Furuie Kazuo Murakami Yukio Ichitani | 2014 | Physiology & Behavior2014，，： | 1 |
| 8 | Cytotoxic Effect of 2-Hydrojuglone, a Metabolite in the Branched Pathway of Biosynthesis in Pyricularia oryzae 显示文摘 | YAMAGUCHI I SHIGEKO S HARUO S | 1983 | Jpn J Pestic Sci1983，8，： | 1 |
| 9 | Higher maximal serum concentration of methotrexate predicts the incidengce of adverse reations in Japanese rheumatoid arthritis patients显示文摘 | Hirofumi S Shigeko I Noriyuki Y | 2007 | Mod Rheumatol2007，17，： | 1 |
| 10 | Durable flame-retardant finished cotton fabrics characterized by thermal degradation behaviors显示文摘 | SHIGEKO NAKANISHI FUMI MASUKO TOSHIMASA HASHIMOTO | 1999 | Journal of Applied Polymer Science1999，71，： | 1 |
| 11 | Develop- ment of a whole headspace injection method for the determi- nation of volatile organic compounds in water 显示文摘 | TAKANOBU H SHIGEKO N TOSHIYUKI H | 1996 | J Chro- matogrA1996，746，1： | 1 |
| 12 | Postmarketing surveillance of safety and effectiveness of etanercept in Japanese patiants with rheumatoid arthritis 显示文摘 | Takao Koike Masayoshi Harigai Shigeko Inokuma etc | 2011 | Mod Rheumatol2011，21，4： | 1 |
| 13 | Geomorphological zoning for flood inundation using satellite data显示文摘 | Haruyama Shigeko Ohokura | 1996 | GeoJournal1996，38，3： | 1 |
| 14 | Postmarketing surveillance of tocilizumab for rheumatoid arthritis in Japan: interim analysis of 3881 patients显示文摘 | Takao Koike Masayoshi Harigai Shigeko Inokuma etc | 2011 | Ann Rheum Dis2011，70，12： | 1 |
| 15 | Clinical characteristics of Pneumocystis carinii pneumonia in patients withconnective tissue diseases显示文摘 | Takeo S Shigeko I Reika M | 2005 | Mod Rheumatol2005，15，： | 1 |
| 16 | Horizontal distribution of steroid estrogens in surface sediments in Tokyo Bay显示文摘 | Tomohiko Isobe Shigeko Serizawa Toshihiro Horiguchi Yasuyuki Shibata Satoshi Managaki Hideshige Takada Masatoshi Morita Hiroaki Shiraishi | 2006 | Environmental Pollution2006，，2： | 1 |
| 17 | Calcium oscillation linked to pacemaking of interstitial cells of Cajal: requirement of calcium influx and localization of TRP4 in caveolae显示文摘 | Torihashi Shigeko Fujimoto Toyoshi Trost Claudia | 2002 | J Biol Chem2002，277，19： | 1 |
| 18 | Percutaneous Transcatheter Hepatic Artery Embolization for Liver Cysts in Autosomal Dominant Polycystic Kidney Disease显示文摘 | Ryoji Takei Yoshifumi Ubara Junichi Hoshino Yasushi Higa Tatsuya Suwabe Yoko Sogawa Kazufumi Nomura Shohei Nakanishi Naoki Sawa Hideyuki Katori Fumi Takemoto Shigeko Hara Kenmei Takaichi | 2007 | American Journal of Kidney Diseases2007，，6： | 1 |
| 19 | Horizontal distribution of steroid estrogens in surface sediments in Tokyo Bay显示文摘 | Tomohiko Isobe Shigeko Serizawa Toshihiro Horiguchi Yasuyuki Shibata Satoshi Managaki Hideshige Takada Masatoshi Morita Hiroaki Shiraishi | 2006 | Environmental Pollution2006，，2： | 1 |
| 20 | Detection of emetic Bacillus cereus by real- time PCR in foods显示文摘 | SHIGEKO UEDA MANAMI YAMAGUCHI MIKI IWASE | 2013 | Biocontrol Science2013，18，4： | 1 |
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