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| 1 | Effects and mechanism of adenovirus-mediated phosphatase and tension homologue deleted on chromosome ten gene on collagen deposition in rat liver fibrosis显示文摘AIM To evaluate the effects of phosphatase and tension homologue deleted on chromosome ten(PTEN) gene on collagen metabolism in hepatic fibrosis and the underlying mechanisms.METHODS rat primary hepatic stellate cells(HSCs) and human LX-2 cells were transfected with adenovirus containing c DNA constructs encoding wild-type PTEN(Ad-PTEN), PTEN mutant G129 E gene(Ad-G129E), and r NA interference constructs targeting the PTEN sequence PTEN short hairpin r NA to up-regulate and downregulate the expression of PTEN. HSCs were assayed using fluorescent microscopy, real-time polymerase chain reaction, and western blotting. Moreover, a CCl_4-induced rat hepatic fibrosis model was established to investigate the in vivo effects. Hematoxylin and eosin, and Masson's trichrome were used to assess the histological changes. The expression of collagen Ⅰ and Ⅲ was assessed using immunohistochemistry and western blot analysis.RESULTS Elevated expression of PTEN gene reduced serum levels of alanine transaminase and aspartate transaminase, decreased collagen deposition in the liver, and reduced hepatocyte necrosis. In contrast, knockdown of PTEN expression had an opposite effect, such as increased collagen deposition in the liver, and was molecularly characterized by the increased expression of matrix metalloproteinase(MMP)-13(P < 0.01) and MMP-2(P < 0.01), as well as decreased expression of the tissue inhibitor of metalloproteinase(TIMP)-1(P < 0.01) and TIMP-2(P < 0.01).CONCLUSION These data indicated that gene therapy using recombinant adenovirus encoding PTEN might be a novel way of treating hepatic fibrosis. | Shu-rui Xie Jun-yan An Li-bo Zheng Xiao-Xia Huo Jian Guo David Shih Xiao-Lan Zhang | 2017 | World Journal of Gastroenterology2017，23，32： | 3 |
| 2 | Ten‐Day Quadruple Therapy Comprising Proton‐Pump Inhibitor, Bismuth, Tetracycline, and Levofloxacin Achieves a High Eradication Rate for H elicobacter pylori Infection after Failure of Sequential Therapy显示文摘 | Ping‐I Hsu Wen‐Chi Chen Feng‐Woei Tsay Chih‐An Shih Sung‐Shuo Kao Huay‐Min Wang Hsien‐Chung Yu Kwok‐Hung Lai Hui‐Hwa Tseng Nan‐Jing Peng Angela Chen Chao‐Hung Kuo Deng‐Chyang Wu | 2014 | Helicobacter2014，，1： | 3 |
| 3 | High In- volvement Work System, Work Family Conflict and Expatriate Per- formance Examining Taiwanese Expatriates in China显示文摘 | Hsi - An Shih Yun - Hwa Chiang Chu - Chun Hsu | 2010 | The Inter- national Journal of Human Resource Management2010，21，11： | 1 |
| 4 | A structural approach to synthesizing soft switching PWM converters显示文摘 | Wu Tsai Fu Liang Shih An Chen Yukai | 2003 | IEEE Transactions on Power Electronics2003，18，1： | 1 |
| 5 | Hybrid minimally invasive surgery-a bridge between laparoscopic and translumenal surgery显示文摘 | Shih SP Kantsevoy SV Kalloo AN | 2007 | Surg Endosc2007，21，8： | 1 |
| 6 | The Analytic Net-work Process for Partner Selection Criteria in Strategic Alliances显示文摘 | Wann Yih Wu Hsi - An Shih Hui - Chun Chan | 2009 | Expert Systems with Applications2009，，36： | 1 |
| 7 | Identification of the unbalance distribution in flexible rotors 显示文摘 | Yuan Pin Shih An Chen Lee | 1997 | International Journal of Mechanical Science1997，39，7： | 1 |
| 8 | Notch signaling enhances nestin expression in gliomas显示文摘 | Shih AN Holland EC | 2006 | Neoplasia2006，8，12： | 1 |
| 9 | In- dividual initiative, skill variety, and creativity: the moderating role of knowledge specificity and creative resources显示文摘 | CHUNG - JEN CHEN HSI - AN SHIH YA - CHING YEh | 2011 | The Inter- national Journal of Human Resource Management2011，22，17： | 1 |
| 10 | A structural approach to synthesizing soft switching PWM converters显示文摘 | Wu Tsai Fu Liang Shih An Chen Yu Kai | 2003 | IEEE Transactions on Power Electronics2003，18，1： | 1 |
| 11 | The Impact of Team - member Exchange, Differentiation, Team Commitment, and Knowledge Sharing on R&D Project Team Performance显示文摘 | Yuwen Liu Robert T Keller Hsi -An Shih | 2011 | R&D Management2011，41，3： | 1 |
| 12 | Preparation and characterization of water soluble and crosslinkable cellulose acrylate显示文摘 | Mu Shih Lin An Jong Chen | 1993 | Polymer1993，34，2： | 1 |
| 13 | A LAN fault diagnosis system 显示文摘 | Chi shih Chao Don ling Yang An chi Liu | 2001 | Computer Communications2001，，24： | 1 |
| 14 | Can High Performance Work Systems Really Lead to Better Performance 显示文摘 | Hsi - An Shih Yun - Hwa Chiang Chu - Chun Hsu | 2006 | International Journal of Manpower2006，，： | 1 |
| 15 | EGCG ‐rich green tea extract stimulates s RAGE secretion to inhibit S 100 A 12‐ RAGE axis through ADAM 10‐mediated ectodomain shedding of extracellular RAGE in type 2 diabetes显示文摘 | Shang‐Ming Huang Yin‐Hsuan Chang Ya‐Chan Chao Jer‐An Lin Chi‐Hao Wu Ching‐Yi Lai Kung‐Chi Chan Shih‐Ting Tseng Gow‐Chin Yen | 2013 | Mol Nutr Food Res2013，，12： | 1 |
| 16 | Self-Efficacy Triggers Psychological Appraisal Mechanism for Mindset Shift显示文摘This paper talks about how to insist staying in changed mindset based on the assigned cognitive reframing principles,andfinally the changed mindset become a forever psychological status by PSI model proposed by this study.P is the cognitive reframing principle of positive psychology,happiness in this case;S is self-efficacy,which plays the important role in maintaining the stress taker to psychologically stay in the changed mindset in the long run.I represent of insisting power,the mental toughness to against the adverse negative emotions.Improving university students’stress coping skills through the psychological dynamics formed by cognitive reframing principles of positive psychology,self-efficacy,and mental toughness will help them effectively deal with stressful events.This study aims to reduce university students’stress level by increasing their ability to cope with stress,and improving their life satisfaction by understanding the mechanism for mindset-shift of university students and proposal of the new PSI reframing model for creating a new path to let students view stressors as challenge,not hindrance.Theories adopted in this study include cognitive reframing principles,appraisal theory,hindrance-challenge theory,cognitive reframing the schema.In the introduction section,the authors will clearly depict the logics for utilization of these theories in supporting the proposed PSI model.This research was divided into two studies.Study 1 postulated that cognitive reframing principles of positive psychology,self-efficacy,and mental toughness have a positive mediating effect in the causal relationship between university students’stress level and life satisfaction.Findings revealed that stressful life events negatively predict the level of LS.Also,PP,SE,and MT exert a positive and significant impact on the relationship between stressful life events and LS.PP strengthens individuals’perception of stressful life events as chal-lenges instead of hindrances.This study showed that individuals need to think positively and develop self-efficacy in order to generate mental toughness when confronted with challenges from stressful life events,and needs to have self-efficacy and confidence towards cognitive reframing principles of positive psychology in their mind,andfinally form a mental toughness competence to protect the newly changed mindset in the long run. | Song Ching Fan Hui-Chuan Shih Hui-Chu Tseng Kuei-Feng Chang Wei-Chin Li An Shin Shia | 2021 | International Journal of Mental Health Promotion2021，23，1： | 0 |
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