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| 1 | Small-bowel mucosal injuries in low-dose aspirin users with obscure gastrointestinal bleeding显示文摘AIM: To investigate the clinical differences between small intestinal injuries in low-dose aspirin(LDA) users and in non-steroidal anti-inflammatory drug(NSAID) users who were examined by capsule endoscopy(CE) for obscure gastrointestinal bleeding(OGIB). METHODS: A total of 181 patients who underwent CE for OGIB were included in this study. Based on clinical records, laboratory data such as hemoglobin levels, major symptoms, underlying diseases, the types and duration of LDA and NSAID use, and endoscopic characteristics of CE were reviewed.RESULTS: Out of a total of 45 cases of erosive lesions, 27 cases were taking LDA or NSAIDs(7 were on NSAIDs, 9 were on LDA alone, 9 were on LDA and thienopyridine, and 2 were on LDA and warfarin).The prevalence of ulcers or erosion during chronic use of LDA, LDA and the anti-platelet drug thienopyridine (clopidogrel or ticlopidine), and NSAIDs were 64.3%, 80.0%, and 75.0%, respectively. Erosive lesions were observed predominantly in chronic LDA users, while ulcerative lesions were detected mainly in NSAID users. However, concomitant use of thienopyridine such as clopidogrel with LDA increased the proportion of ulcers. The erosive lesions were located in the whole of the small intestine(jejunum and ileum), whereas ulcerative lesions were mainly observed in the ileum(P < 0.05). CONCLUSION: Our CE findings indicate that chronic LDA users and NSAID users show different types and locations of small-bowel mucosal injuries. The concomitant use of anti-platelet drugs with LDA tends to exacerbate the injuries from LDA-type to NSAID-type injuries. | Junichi Iwamoto Yuji Mizokami Yoshifumi Saito Koichi Shimokobe Akira Honda Tadashi Ikegami Yasushi Matsuzaki | 2014 | World Journal of Gastroenterology2014，20，36： | 9 |
| 2 | Therapeutic barium enema for bleeding colonic diverticula:Four case series and review of the literature显示文摘The prevalence of diverticular diseases of the colon, including severe and persistent bleeding in Eastern countries, has increased in the last decades. The bleeding from colonic diverticula is the most common cause of acute lower gastrointestinal bleeding. Herein, we report four cases of severe and persistent bleeding of colonic diverticular disease that could be treated with a high concentration barium enema. These four cases showed a similar pattern of bleeding whose source could not be identified. Colonoscopy revealed fresh blood in the entire colon and many diverticula were noted throughout the colon. No active bleeding source was identified, but large adherent clots in some diverticula were noted. After endoscopic and angiographic therapies failed, therapeutic barium enema stopped the severe bleeding. These patients remained free of re-bleeding in the follow-up period (range 17-35 mo) after the therapy. We report the four case series of therapeutic barium enema and reviewed the literature pertinent to this procedure. | Jun-ichi Iwamoto Yuji Mizokami Koichi Shimokobe Takeshi Matsuoka Yasushi Matsuzaki | 2008 | World Journal of Gastroenterology2008，14，41： | 2 |
| 3 | Caries - preventive effect of glass ionomer reapplication: study presents three - year results 显示文摘 | Komatsu H Shimokobe H Kawakami S | 1996 | JADA1996，125，： | 1 |
| 4 | Caries-preventive effect of glass ionomer reapplication: study presents three -years results显示文摘 | Komatsu H Shimokobe H Kawakami S | 1996 | J Am Dent Assoc1996，125，5： | 1 |
| 5 | The effect of metoclopramide in capsule endoscopy显示文摘 | Iwamoto J Mizokami Y Shimokobe K | 2010 | Hepatogastroenterology2010，57，： | 1 |
| 6 | Clinical Features of Gastroduodenal Ulcer in Japanese Patients Taking Low-Dose Aspirin显示文摘 | Junichi Iwamoto Yuji Mizokami Koichi Shimokobe Masanori Ito Takeshi Hirayama Yoshifumi Saito Tadashi Ikegami Akira Honda Yasushi Matsuzaki | 2010 | Digestive Diseases and Sciences2010，，8： | 1 |
| 7 | Involvement of Cyclooxygenase-2–Prostaglandin E2 Pathway in Interleukin-8 Production in Gastric Cancer Cells显示文摘 | Hisashi Takehara Jun-Ichi Iwamoto Yuji Mizokami Kimiko Takahashi Toshiya Ootubo Syuuhei Miura Toshiaki Narasaka Hiroki Takeyama Takayuki Omata Koichi Shimokobe Masanori Ito Takeshi Matsuoka | 2006 | Digestive Diseases and Sciences2006，，12： | 1 |
| 8 | Clinical fea- tures of gastroduodenal ulcer in Japanese patients taking low-dose aspirin显示文摘 | Iwamoto J Mizokami Y Shimokobe K | 2010 | Dig Dis Sci2010，55，8： | 1 |
| 9 | Expressions of urokinase-type plasminogen activator, its receptor and plasminogen activator inhibitor-1 in gastric cancer cells and effects of Helicobacter pylori显示文摘 | Junichi Iwamoto Yuji Mizokami Kimiko Takahashi Kazuhiko Nakajima Toshiya Ohtsubo Syuhei Miura Toshiaki Narasaka Hiroki Takeyama Takayuki Omata Koichi Shimokobe Masanori Ito Hisashi Takehara Takeshi Matsuoka | 2005 | Scandinavian Journal of Gastroenterology2005，，7： | 1 |
| 10 | Successful treatment of cervical spinal epidural abscess by combined hyperbaric oxygenation Mt Sinai J Med 显示文摘 | Kohshi K Abe H Mizoguchi Y Shimokobe M | 2005 | Mt Sinai J Med2005，72，6： | 1 |
| 11 | Recent advances in operational tropical cyclone genesis forecast显示文摘Tropical cyclone(TC)genesis prediction is a major scientific challenge to the TC operation and research community.This report surveys the current status of TC genesis forecasts by a number of major operational centers covering the key ocean basins across both hemispheres.Since IWTC-9,we see an emergence of probabilistic TC genesis forecast products by operational centers,typically supported by the statistical processing of a combination of ensemble prediction and satellite analysis,covering time periods of couple of days to weeks ahead.The prevalence of multi-center grand ensemble approach highlights the uncertainties involved and the forecast challenges in quantitative genesis prediction.While operational practice might differ across agencies,verification efforts generally report a steady or slightly improving skill level in terms of reliability,which likely results from the continual improvement in global numerical weather prediction capability. | K.K.Hon Robert Ballard Eric Blake Steph Bond Robb Gile Daniel Halperin Charles Helms Hoang Lam Xinyan Lyu Mrutyunjay Mohapatra Monica Sharma Akira Shimokobe Ralf Toumi Seonghee Won | 2023 | Tropical Cyclone Research and Review2023，12，4： | 0 |
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