|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Therapeutic efficacy of the Qing Dai in patients with intractable ulcerative colitis显示文摘Ulcerative colitis (UC) is a chronic inflammatory bowel disease that may become intractable when treated with conventional medications such as aminosalicylates, corticosteroids, and azathioprine. The herbal medicine Qing Dai has traditionally been used in Chinese medicine to treat UC patients, but there is a lack of published data on the efficacy of Qing Dai in UC treatment. We report several cases of patients with intractable UC who take Qing Dai in a retrospective observational study. Furthermore, we explore the mechanisms of action of Qing Dai. Nine patients with active UC who received conventional medications but wished to receive Qing Dai as an alternative medication were included in our analysis. The UC severity level was determined based on the clinical activity index (CAI). Additionally, 5 of the 9 patients were endoscopically evaluated according to the Matts grading system. Each patient received 2 g/d of Qing Dai orally and continued taking other medications for UC as prescribed. Electron spin resonance was applied to explore the mechanisms of action of Qing Dai. After 4 mo of treatment with Qing Dai, the CAI score decreased from 8.3 ± 2.4 to 2.4 ± 3.4 (mean ± SD; P < 0.001). Similarly, the endoscopic Matts grade decreased from 3.4 ± 0.5 to 2.2 ± 0.8 (P = 0.02). Six of 7 patients who were on prednisolone upon enrollment in the study were able to discontinue this corticosteroid. Electron spin resonance revealed that Qing Dai possesses strong hydroxyl radical scavenging activity. Qing Dai showed significant clinical and endoscopic efficacy in patients who failed to respond to conventional medications. Scavenging of hydroxyl radicals appears to be a potential mechanism through which Qing Dai acts, but the significance of the scavenging ability of Qing Dai with respect to the anti-inflammatory effect in UC patients warrants further investigation. | Hideo Suzuki Tsuyoshi Kaneko Yuji Mizokami Toshiaki Narasaka Shinji Endo Hirofumi Matsui Akinori Yanaka Aki Hirayama Ichinosuke Hyodo | 2013 | World Journal of Gastroenterology2013，19，17： | 19 |
| 2 | 查看详情显示文摘 | Minamikawa H Hayakawa S Yamada T Iwasawa N Narasaka K | | 0，，： | 1 |
| 3 | Stereoselective synthesis of meso (or erythro) 1,3-diols from β-hydroxyketones 显示文摘 | Narasaka K Rai H C | 1980 | Chem Lett1980，11，： | 1 |
| 4 | Chiral Lewis acids in catalytic asymmetric reactions显示文摘 | Narasaka K | 1991 | Synthesis1991，，1： | 1 |
| 5 | Beckmann rearrangement of oximes catalyzed with tetrabutylammonium perrhenate and trifluoromethanesulfonic acid显示文摘 | Hiroyuki Kusama Yuko Yabashita Koichi Narasaka | 1995 | Bull Chem Soc JPn1995，68，1： | 1 |
| 6 | FriedeI-Crafts acylation of arenes catalyzed by bromopentacarbonyirhenium(I)显示文摘 | Kusam A H Narasaka K | 1995 | Bull Chem Soc Jpn1995，68，： | 1 |
| 7 | New Aldol type reaction 显示文摘 | Mukaiyam T Narasaka K Banno K | 1973 | Chemistry Letters1973，9，： | 1 |
| 8 | Chiral lewis acids in catalytic asymmetric reactions显示文摘 | Narasaka K | 1991 | Synthesis1991，1，： | 1 |
| 9 | Asymmetric Diels - Alder reaction catalyzed by a chiral titanium reagent 显示文摘 | Narasaka K Iwasawa N Inoue M | 1989 | J Am Chem Soc1989，111，： | 1 |
| 10 | DNA microarray analyses of the effects of dietary proteins 显示文摘 | Kato H Narasaka S Endo Y | 2004 | Biofactors2004，21，14： | 1 |
| 11 | Involvement of Cyclooxygenase-2–Prostaglandin E2 Pathway in Interleukin-8 Production in Gastric Cancer Cells显示文摘 | Hisashi Takehara Jun-Ichi Iwamoto Yuji Mizokami Kimiko Takahashi Toshiya Ootubo Syuuhei Miura Toshiaki Narasaka Hiroki Takeyama Takayuki Omata Koichi Shimokobe Masanori Ito Takeshi Matsuoka | 2006 | Digestive Diseases and Sciences2006，，12： | 1 |
| 12 | Transformation of 1,5-and 1,6-dienes to carbocycles by hydrozirconation and oxidation with cerium(IV) compounds显示文摘 | Azemi T Kitanura M Narasaka K | 2004 | Tetrahedron2004，60，6： | 1 |
| 13 | DNA microarray analyses of the effects of dietary proteins显示文摘 | KATO H NARASAKA S ENDO Y | 2004 | Biofactors2004，21，14： | 1 |
| 14 | DNA microarray analyses of the effects of dietary proteins显示文摘 | Kato H Narasaka S Endo Y | 2004 | Biofactors2004，21，14： | 1 |
| 15 | Expressions of urokinase-type plasminogen activator, its receptor and plasminogen activator inhibitor-1 in gastric cancer cells and effects of Helicobacter pylori显示文摘 | Junichi Iwamoto Yuji Mizokami Kimiko Takahashi Kazuhiko Nakajima Toshiya Ohtsubo Syuhei Miura Toshiaki Narasaka Hiroki Takeyama Takayuki Omata Koichi Shimokobe Masanori Ito Hisashi Takehara Takeshi Matsuoka | 2005 | Scandinavian Journal of Gastroenterology2005，，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员