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| 1 | Optimal three-dimensional impact time guidance with seeker’s field-of-view constraint显示文摘This paper proposes a new three-dimensional optimal guidance law for impact time control with seeker’s Field-of-View(FOV) constraint to intercept a stationary target. The proposed guidance law is devised in conjunction with the concept of biased Proportional Navigation Guidance(PNG). The guidance law developed leverages a nonlinear function to ensure the boundedness of velocity lead angle to cater to the seeker’s FOV limit. It is proven that the impact time error is nullified in a finite-time under the proposed method. Additionally, the optimality of the biased command is theoretically analyzed. Numerical simulations confirm the superiority of the proposed method and validate the analytic findings. | Shaoming HE Chang-Hun LEE Hyo-Sang SHIN Antonios TSOURDOS | 2021 | Chinese Journal of Aeronautics2021,34,2: | 6 |
| 2 | Effect of Laser Power on Microstructure and Wear Resistance of WC_P/Ni Cermet Coating显示文摘Laser cladding nickel-based alloy coating (Ni60) and nickel-based composite coating doped with WC par-ticles by 35 %( WCP/Ni) were produced onthelow-carbon steel substrate by CO2continuous wavelaser with pow-er of 5 kWusing theinjected powder technique . The effect of laser power on microstructure and wear resistance oflaser cladding WCP/Ni cermet coating was investigated . The WC_P/Ni alloy coating with evenly distributed WCce-ramic phases and the better bond with the substrate alloy was obtained at a power of 2·2 kW. Diffusion solutionreaction happened between WC particles and the substrate alloy during laser cladding ,and led to the formation ofblock rich-tungsten carbide on the edges of the WC particles ,especially at higher power . The WC_P/Ni alloy coat-ing consists of the undissolved WC particles ,the block or dendritic rich-tungsten carbide ,the bar-like rich-chromi-umcarbide ,and dendrite solid solution and eutectic structure among the carbides . Microhardness and wear resist-ance of the WC_P/Ni coating at different powers were much higher or better than those of Ni60 alloy coating ,andthe best results were obtained at power of 2·2 kW. | SI Song-hua YUAN Xiao-min LIU Yue-long HE Yi-zhu Keesam Shin | 2006 | Journal of Iron and Steel Research(International)2006,13,3: | 6 |
| 3 | Nose-to-brain delivery of macromolecules mediated by cell-penetrating peptides显示文摘Brain delivery of macromolecular therapeutics(e.g., proteins) remains an unsolved problem because of the formidable blood–brain barrier(BBB). Although a direct pathway of nose-to-brain transfer provides an answer to circumventing the BBB and has already been intensively investigated for brain delivery of small drugs,new challenges arise for intranasal delivery of proteins because of their larger size and hydrophilicity. In order to overcome the barriers and take advantage of available pathways(e.g., epithelial tight junctions, uptake by olfactory neurons, transport into brain tissues, and intra-brain diffusion), a low molecular weight protamine(LMWP) cell-penetrating peptide was utilized to facilitate nose-to-brain transport. Cell-penetrating peptides(CPP)have been widely used to mediate macromolecular delivery through many kinds of biobarriers. Our results show that conjugates of LMWP–proteins are able to effectively penetrate into the brain after intranasal administration.The CPP-based intranasal method highlights a promising solution for protein therapy of brain diseases. | Tingting Lin Ergang Liu Huining He Meong Cheol Shin Cheol Moon Victor C.Yang Yongzhuo Huang | 2016 | Acta Pharmaceutica Sinica B2016,6,4: | 4 |
| 4 | Significance and strategies in developing delivery systems for bio-macromolecular drugs显示文摘 | Huining HE Qiuling LIANG Meong Cheoi SHIN Kyuri LEE Junbo GONG Junxiao YE Quan LIU Jingkang WANG Victor YANG | 2013 | Frontiers of Chemical Science and Engineering2013,7,4: | 2 |
| 5 | A case of hepatic sclerosed hemangioma mimicking cholangiocellular carcinoma显示文摘 | Park SM Shin SM Seo HE | 2009 | Korean J Gastroenterol2009,54,6: | 1 |
| 6 | Enhanced apoptotic effect ofcombined modality of 9 -hydroxypheophorbide alpha-mediatedphotodynamic therapy and carboplatin on AMC-HN-3 human headand neck cancer cells显示文摘 | He P Ahn JC Shin JI | 2009 | Oncol Rep2009,21,2: | 1 |
| 7 | Robust, secure, andcost-effective design for Cyber-Physical Systems显示文摘 | Dong Hoon Shin He Shibo Zhang Junshan | 2014 | IntelligentSystems IEEE2014,29,1: | 1 |
| 8 | PKotoactivation of 9-hydroxypheophorbide alpha triggers apoptosis through the reactiveoxygen species-mediated mitochondrial pathway and endoplasmicreticulum stress in AMC-HN-3 laryngeal cancer cells 显示文摘 | He P Ahn JC Shin JI | 2010 | Int JOncol2010,36,4: | 1 |
| 9 | Perioperative stroke in the brain and spinal cord following an induced hypotension 显示文摘 | KIM JS KO SB SHIN HE | 2003 | Yonsei Med J2003,44,1: | 1 |
| 10 | Bone formation on the apa- tite-coated zirconia porous scaffolds within a rabbit calvarial de-feet显示文摘 | Kim HW Shin SY Kim HE | 2008 | J Biomater Appl2008,22,6: | 1 |
| 11 | Calcium Sulfate Hemihydrate Powders with a Controlled Morphology for Use as Bone Cement显示文摘 | Wang P Lee EJ Park CS Yoon BH Shin DS Kim HE | 2008 | Am Ceram Soc2008,91,6: | 1 |
| 12 | The flavonoid quercetin inhibits dimethylnltrosamine-indueed liver damage in rats显示文摘 | Lee ES Lee HE Shin JY | 2003 | J Pharm Pharmaeol2003,55,8: | 1 |
| 13 | Association between cerebrospinal fluid S100B protein and neuronal damage in patients with central nervous system infections显示文摘 | Park JW Suh GI Shin HE | 2013 | Yonsei Med J2013,54,3: | 1 |
| 14 | Computer simulation of 2D grain growth using a cellular automata model based on the lowest energy principle显示文摘 | HE Yi-zhu DING Han-lin LIU Liu-fa KEESAM Shin | 2006 | Mater Sci Eng A2006,429,: | 1 |
| 15 | Association between ce- rebrospinal fluid S100B protein and neuronal damage in patients with central nervous system infections显示文摘 | Park JW Suh GI Shin HE | 2013 | Yonsei Med2013,54,3: | 1 |
| 16 | Enhanced apoptotic effect of com- bined modality of 9-hydroxypheophorbide alpha-mediated photody- namic therapy and carboplatin on AMC-HN-3 human head and neck cancer cells显示文摘 | He P Ahn JC Shin JI | 2009 | Oncol Rep2009,21,2: | 1 |
| 17 | Clinical impact of renal biopsy on outcomes in elderly patients with nephrotic syndrome 显示文摘 | Yoon HE Shin MJ Kim YS | 2011 | Nephro Clin Pract2011,117,1: | 1 |
| 18 | Photoaetivation of 9-hyctroxypheo- phorbide alpha triggers apoptosis through the reactive oxygen spe- cies-mediated mitochondilal pathway and endoplasmie reticulum stress in AMC-HN-3 laryngeal cancer cells 显示文摘 | He P Ahn JC Shin JI | 2010 | Int J Oncol2010,36,4: | 1 |
| 19 | p53 loss increases the osteogenic differentiation of bone marrow stromal cells显示文摘 | He Y de Castro LF Shin MH | 2015 | Stem Cells2015,33,4: | 1 |
| 20 | Total and interalrial epicardial adipose tissues are independently associated with left atrial remodeling in patients with alrial fibrillation显示文摘 | Shin SY Yong HS Lim HE | 2011 | J Cardiovasc Elec Irophysiol2011,22,6: | 1 |