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| 1 | Usefulness of anti-ulcer drugs for the prevention and treatment of peptic ulcers induced by low doses of aspirin显示文摘AIM:To investigate the usefulness of anti-ulcer drugs for the prevention and treatment of low-dose aspirin- induced peptic ulcer. METHODS:Upper gastrointestinal endoscopy was performed in 68 patients receiving daily low-dose aspirin(81 or 100 mg/day).The endoscopic findings were classified according to the Lanza score,and the scores were compared between groups categorized according to the concomitant use of anti-ulcer drugs and the types of drugs used.In another study,31 hemorrhagic peptic ulcer patients who had been receiving low-dose aspirin were enrolled.The patients were randomly classified into the proton pump inhibitor (PPI)-treated group and the H2 receptor antagonist (H2RA)-treated group.The administration of low-dose aspirin was continued concomitantly,and endoscopic examinations were performed 8 wk later. RESULTS:The Lanza scores(mean±SD)of the gastro-mucosal lesions were 1.0±1.9 and 1.9±2.3 in 8 and 16 patients receiving prevention therapy with a PPI and an H2RA,respectively.Both scores were significantly smaller than the scores in 34 patients who were not receiving prevention therapy(4.7±1.0)and in 10 patients receiving cytoprotective anti-ulcer drugs (4.3±1.6).In the prospective study,18 and 13 patients received a PPI and an H2RA,respectively.Endoscopic examinations revealed that the tissue in the region of the gastro-mucosal lesions had reverted to normal in all patients in the PPI-treated group and in 12 patients (92%)in the H2RA-treated group;no significant differences were observed between the groups. CONCLUSION:H2RA therapy was effective for both the prevention and treatment of low-dose aspirin- induced peptic ulcer,similar to the effects of PPIs, while cytoprotective anti-ulcer drugs were ineffective in preventing ulceration. | Sayaka Nakashima Shinichi Ota Shin Arai Kiyoko Yoshino Mie Inao Keiko Ishikawa Nobuaki Nakayama Yukinori Imai Sumiko Nagoshi Satoshi Mochida | 2009 | World Journal of Gastroenterology2009，15，6： | 11 |
| 2 | Embolization of Acute Nonvariceal Upper Gastrointestinal Hemorrhage Resistant to Endoscopic Treatment: Results and Predictors of Recurrent Bleeding显示文摘 | Romaric Loffroy Pramod Rao Shinichi Ota Ming Lin Byung-Kook Kwak Jean-Fran?ois Geschwind | 2010 | CardioVascular and Interventional Radiology2010，，6： | 1 |
| 3 | Gastric Small Cell Carcinoma Successfully Treated by Surgery and Postoperative Chemotherapy Consisting of Cisplatin and S-1: Report of a Case显示文摘 | Naohiko Koide Akira Suzuki Hiroyasu Saito Toshiyuki Sato Maki Murakami Hiroyoshi Ota Shinichi Miyagawa | 2007 | Surgery Today2007，，11： | 1 |
| 4 | A case of primary gastric choriocarcinoma and a review of the Japanese literature显示文摘 | Yasuo Imai Takao Kawabe Morio Takahashi Masayuki Matsumura Yutaka Komatsu Eiji Hamada Yasuo Niwa Masahiro Kurita Shuichiro Shiina Tadahito Shimada Shinichi Ota Yasushi Shiratori Akira Terano Masao Omata | 1994 | Journal of Gastroenterology1994，，5： | 1 |
| 5 | A case of primary gastric choriocarcinoma and a review of the Japanese literature显示文摘 | Yasuo Imai Takao Kawabe Morio Takahashi Masayuki Matsumura Yutaka Komatsu Eiji Hamada Yasuo Niwa Masahiro Kurita Shuichiro Shiina Tadahito Shimada Shinichi Ota Yasushi Shiratori Akira Terano Masao Omata | 1994 | Journal of Gastroenterology1994，，5： | 1 |
| 6 | Expression of major histopatibility class II antigen in endometriotic tissue in patients with endometriosis and endonomyosis显示文摘 | Hirotaka Ota Shinichi Igarashi | 1993 | Fertility and Sterility1993，60，5： | 1 |
| 7 | A case of primary gastric choriocarcinoma and a review of the Japanese literature显示文摘 | Yasuo Imai Takao Kawabe Morio Takahashi Masayuki Matsumura Yutaka Komatsu Eiji Hamada Yasuo Niwa Masahiro Kurita Shuichiro Shiina Tadahito Shimada Shinichi Ota Yasushi Shiratori Akira Terano Masao Omata | 1994 | Journal of Gastroenterology1994，，5： | 1 |
| 8 | Case-control study on the association of upper gastrointestinal bleeding and nonsteroidal anti-inflammatory drugs in Japan显示文摘 | Choitsu Sakamoto Kentaro Sugano Shinichi Ota Nobuhiro Sakaki Shin’ichi Takahashi Yukio Yoshida Taku Tsukui Hiroyuki Osawa Yukihiro Sakurai Junji Yoshino Yuji Mizokami Tetsuya Mine Tetsuo Arakawa Hajime Kuwayama Katsunori Saigenji Koji Yakabi Tsutomu Chiba | 2006 | European Journal of Clinical Pharmacology2006，，9： | 1 |
| 9 | Endoscopic Mucosal Resection: An Improved Diagnostic Procedure for Early Gastroesophageal Epithelial Neoplasms显示文摘 | Mindy J Hull Mari Mino-Kenudson Norman S Nishioka Shinichi Ban Alireza Sepehr William Puricelli Laura Nakatsuka Shinichi Ota Michio Shimizu William R Brugge Gregory Y Lauwers | 2006 | The American Journal of Surgical Pathology2006，，： | 1 |
| 10 | 结肠直肠癌和非甾类消炎药(英文)显示文摘Non-steroidal anti-inflammatory drugs ( NSAIDs) can prevent or reduce the occurrence of colorectal cancers . Anti-carcinogenic properties of NSAIDs have been demonstrated in epidemiological studies of humans and experimental animals. In addition, clinical studies of familial adenomatous polyposis and sporadic adenomas have demonstrated that NSAIDs induce regression of colorectal adenomas and prevent formation of these tumors. NSAIDs thus induce early disruption of the adenoma-carcinoma sequence and may mainly suppress subsequent cancer formation at adenoma stage. The mechanism of the anti-carcinogenic effect of these drugs is not known, but results of most studies support that cyclooxygenase-2 (an inducible isoform of prostaglandin synthetase, COX-2) is a major target of NSAIDs in this effect. Recent immunohistochemical studies have revealed that COX-2 is expressed not in tumor cells but in interstitial cells of colonic adenomas. Accordingly, NSAIDs may exhibit anti-carcinogenic property through the | OTA Shinichi, BAMBA Hiromi, KATO Akira (Third Department of Internal Medicine, Saitama Medical School, 38 Morohongo, Moroyama-cho, Iruma-gun, Saitama 350 - 0495, Japan First Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, Saitama, Japan) | 2000 | Acta Pharmacologica Sinica2000，21，5： | 0 |
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