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| 1 | Study on Pharmacological Effects of Calycosin in Astragali Radix显示文摘Calycosin is an important isoflavone compound in traditional Chinese medicine Astragali Radix.It not only has remarkable anti-oxidation,anti-inflammatory and anti-tumor functions,but also has the characteristics of small adverse reactions and low toxicity,so it has attracted wide attention of scholars and researchers.This paper reviewed the pharmacological effects and mechanisms of calycosin in recent years,in the hope of providing a theoretical basis for its clinical application. | Yu ZHANG Tong ZHANG Shinong WANG Yannan LI Hui XUE Wenbo ZUO Chenghao JIN | 2020 | Medicinal Plant2020，11，2： | 3 |
| 2 | EXPERT SYSTEM FOR SINTER CHEMICAL COMPOSITION CONTROL BASED ON ADAPTIVE PREDICTION显示文摘In order to stabilize the sinter chemical composition,the expert system for composition control based on adaptive prediction has been developed on the basis of modern control theory and artificial intelligence.It has been verified by using real data at No.3 Sintering Plant of Anshan Iron and Steel Co.,and satisfactory results have been obtained. | Fan Xiaohui Wang Haidong Chen Jin Huang Tianzheng Yang Shinong Wang Yueli Zheng Tianzhong | 1996 | Transactions of Nonferrous Metals Society of China1996，6，1： | 1 |
| 3 | Connective tissue growth factor in tubulointerstitial injury of diabetic nephropathy 显示文摘 | WANG Shinong DENICHILO M BRUBAKER C | 2001 | Kidney Int2001，60，1： | 1 |
| 4 | Enhanced Multi-phosphopeptide Enrichment and Nano LC-ESI-qTOF-MS Detection Strategy Using Click OEG-CD Matrix显示文摘 | ZHAO Yanyan WANG Liheng GUO Zhimou CHI Xiaofei MA Xiaochi QI Yan FANG Shinong LI Xiuling LIANG Xinmiao | 2015 | Chemical Research in Chinese Universities2015，31，1： | 1 |
| 5 | Growth factor ultrafiltration in experimental diabetic nephropathy contributes to interstitial fibrosis显示文摘 | Raimund Hirschberg | 2000 | Am plysiol (Renalphysiol)2000，278，： | 1 |
| 6 | Advances in Research on Anti-cancer Mechanism of 18β Glycyrrhetinic Acid显示文摘Glycyrrhiza uralensis Fisch has been used to treat the symptoms of organ fever, food poisoning, typhoid fever, sore throat, cough due to lung heat, children's diseases and so on since the ancient times. It is a solid Chinese herbal medicine which is good for the health. In recent years, it has been found that licorice extract also has excellent anti-cancer effect. The 18β glycyrrhetinic acid, obtained by hydrolysis of precursor glycyrrhizic acid, is a relatively efficient anti-cancer ingredient. 18β glycyrrhetinic acid can exert anti-cancer effects by inhibiting cancer cell proliferation, inducing apoptosis of cancer cells, inhibiting invasion and metastasis of cancer cells, preventing oxidation, inhibiting neovascularization, inhibiting lymphangiogenesis, and regulating hormone secretion. This paper reviewed the advances in research of the anticancer mechanism of 18β glycyrrhetinic acid, to provide a theoretical basis for future research. | Shinong WANG Yu ZHANG Tong ZHANG Jiaru WANG Wanting XU Yi ZHANG Yinghua LUO Chenghao JIN | 2019 | Medicinal Plant2019，10，1： | 1 |
| 7 | Imatinib mesylate blocks a non-Smad TGF-β pathway and reduces renal fibrogenesis in vivo显示文摘 | Shinong Wang Mark C Wilked Edward B Leof | 2005 | The FASEB Journal2005，，19： | 1 |
| 8 | Fluorescence Spectra Characters of Gold Nanorods 显示文摘 | Zhu Jian Wang Yongchang Yan Shinong | 2004 | Chin Phys Lett2004，21，3： | 1 |
| 9 | Endoscopically controlled surgery with open hemilaminectomy for the treatment of intradural extramedullary tumors:an operative technique and short-term outcomes of 20 consecutive cases显示文摘Background:To present a surgical technique for the treatment of intradural extramedullary(IDEM)tumors by using endoscopically controlled surgery with open hemilaminectomy technique.Methods:In this study,20 patients with 22 IDEM tumors were enrolled.An endoscopically controlled surgery with open hemilaminectomy was employed to remove the tumors.Data related to clinical symptoms and medical images before and after surgery were collected for perioperative evaluation and follow-up analysis.Results:All the tumors in 20 patients were well removed.The clinical symptoms were significantly reduced in all the patients as well.The short-term follow-up data showed that there was no tumor recurrence or spinal deformity.Conclusion:The endoscopically controlled surgery with open hemilaminectomy technique provided favorable exposure and satisfactory resection to the IDEM tumors.It may be an effective surgical method for treating IDEM tumors.Larger samples and longer follow-up data are needed to verify its long-term effectiveness. | Xiaorong Yan Huiqing Wang Cai Li Yuanxiang Lin Lin Lin Shinong Zhu Chenyang Wang Zhangya Lin Changzhen Jiang Dezhi Kang | 2021 | Chinese Neurosurgical Journal2021，7，2： | 0 |
| 10 | 3.0-T magnetic resonance imaging in children with brachial plexus birth injury显示文摘Brachial plexus birth injuries in children are usually diagnosed using 1.5-T magnetic resonance imaging,while the application of high-field magnetic resonance imaging is rarely reported.Therefore,a retrospective comparison of 18 cases of children with brachial plexus injury was performed to investigate the characteristics of 3.0-T magnetic resonance imaging and intraoperative observations.Magnetic resonance examinations in 18 cases of children showed that pseudo-meningocele sensitivity,specificity,accuracy,and positivity rates were 83.3%,79.6%,81.1%,and 40.0%,respectively.As for the neuroma and fibrous scar encapsulation,the sensitivity,specificity,accuracy,and positivity rates were 92.9%,50.0%,83.3%,and 77.8%,respectively.These results confirm that 3.0-T high-field magnetic resonance imaging can clearly reveal abnormal changes in brachial plexus injury,in which pseudo-meningocele,fibrous scar encapsulation,and neuroma are the characteristic changes of obstetric brachial plexus preganglionic and postganglionic nerve injury. | Shinong Pan Lijie Tian Wei Liao Feng Tian Jian Mao Fei Wang Rongjie Bai Qi Li ZhianChen Qiyong Guo | 2011 | Neural Regeneration Research2011，6，6： | 0 |
| 11 | Study on Anti-tumor Activity and Mechanism of Isoorientin显示文摘Isoorientin can play an anti-tumor effect through interfering with tumor cell proliferation, inducing tumor cell apoptosis, regulating reactive oxygen species level, inducing tumor cell autophagy, blocking tumor cell infiltration and metastasis, inhibiting tumor neovascularization and other pathways. This paper reviews the research progress of anti-tumor activity and mechanism of isoorientin in recent years. | Tong ZHANG Yu ZHANG Shinong WANG Jiaru WANG Yinghua LUO Chenghao JIN | 2019 | Medicinal Plant2019，10，1： | 0 |
| 12 | Research Progress on the Biological Activity of Pectolinarigenin显示文摘Pectolinarigenin is a kind of flavonoid,which is an active ingredient in Eupatorium odoratum.Some studies have confirmed that pectolinarigenin has many biological activities,including anti-oxidation,anti-allergy,anti-inflammation,anti-tumor and so on.In this paper,the biological activity and related mechanism of pectolinarigenin were summarized in order to provide theoretical basis and reference for the further development and utilization of pectolinarigenin. | Wenbo ZUO Shumei LI Yannan LI Hui XUE Yu ZHANG Tong ZHANG Shinong WANG Chenghao JIN | 2020 | Medicinal Plant2020，11，3： | 0 |
| 13 | Advance in Research on Anti-tumor Pharmacological Mechanism of Cryptotanshinone显示文摘Cryptotanshinone is a natural active ingredient extracted from traditional Chinese medicine Radix Salviae Miltiorrhizae.It has a variety of pharmacological effects,in addition to preventing and treating ischemic diseases,coronary artery disease Alzheimer's disease and fighting tumors.The anti-tumor effects are exerted through inhibiting tumor cell proliferation,inducing tumor cell apoptosis,inhibiting tumor metastasis and invasion,inhibiting angiogenesis and regulating reactive oxygen species levels.The studies on the anti-tumor activity and action mechanism of cryptotanshinone in recent years are reviewed in this article. | Jiaru WANG Lingqi MENG Yi ZHANG Hao WANG Wanting XU Yang LIU Yu ZHANG Tong ZHANG Shinong WANG Yuqing ZHAI Yinghua LUO Chenghao JIN | 2018 | Medicinal Plant2018，9，6： | 0 |
| 14 | Apoptotic Effect of Cryptotanshinone on Human Melanoma A375 Cells显示文摘[Objectives] The aim was to investigate the effect of cryptotanshinone on apoptosis of human melanoma A375 cells and its related mechanism of mitochondrial pathway.[Methods]The cytotoxic effect of cryptotanshinone on apoptosis of human melanoma A375 cells was detected by MTT colorimetry.The apoptosis of melanoma A375 cells was detected with Annexin V-FITC/PI and observed by fluorescence inverted microscope.The expression of apoptosis-related proteins was detected by Western blotting.[Results]The viability of the A375 cells decreased with the increase of drug concentration.The fluorescence intensity of the cells increased with the treatment time.The expression of pro-apoptotic protein caspase-3 gradually increased,while the expression of apoptosis-inhibiting proteins p-AKT and Bcl-2 gradually reduced.[Conclusions]Cryptotanshinone induces apoptosis of human melanoma A375 cells via AKT signaling pathway,thus exerting a good cytotoxic effect on A375 cells. | Jinqian LI Jiaru WANG Lingqi MENG Yi ZHANG Hao WANG Wanting XU Yang LIU Yu ZHANG Shinong WANG Yuqing ZHAI Yinghua LUO Chenghao JIN | 2018 | Medicinal Plant2018，9，6： | 0 |
| 15 | Pro-apoptotic Effects of OSNQ on Human Colon Cancer SW480 Cells显示文摘[Objectives] The aim was to elucidate the pro-apoptosis mechanism of naphthoquinone derivative 2-octyl sulfoxide-1,4-naphthoquinone(OSNQ) on human colon cancer SW480 cells.[Methods]The cytotoxic effect of OSNQ on colon cancer SW480 cells was detected by MTT colorimetry.The pro-apoptotic effect of OSNQ on human colon cancer SW480 cells was detected by Annexin V-FITC/PI double staining.The changes in expression of apoptosis-related proteins were detected by Western blot.[Results]The results of MTT assay showed that OSNQ had a significant cytotoxic effect on colon cancer SW480 cells.The results of Western blot showed that OSNQ induced the apoptosis in colon cancer SW480 cells through promoting the expression of pro-apoptotic caspase-3 and inhibiting the expression of apoptosis-inhibiting protein Bcl-2.[Conclusions] OSNQ has a significant cytotoxic effect on colon cancer SW480 cells,and it induces the apoptosis of colon cancer SW480 cells by AKT signaling pathway. | Yu ZHANG Jiaru WANG Yuchao FENG Yi ZHANG Wanting XU Tong ZHANG Shinong WANG Hui XUE Cheng LU Wenzhong WANG Meng NI Hongxing WANG Yinghua LUO Chenghao JIN | 2018 | Medicinal Plant2018，9，6： | 0 |
| 16 | Research Progress on Biological Activity of Cytisine显示文摘Cytisine(Cyt) is a kind of quinolizidine alkaloids mainly existing in seeds of plants from Laburnum of Leguminosae sp. In recent years, various biological activities of Cyt have been explored gradually, and it has the effects of quitting smoking, promoting breathing, analgesia, and anti-cancer. At anti-cancer aspect, Cyt could induce apoptosis of cancer cells, and has been widely applied to inhibit proliferation of multiple tumor cells. At quitting smoking aspect, Cyt could be taken as selective local agonist to decline smokers' dependence on nicotine, and it is expected to be widely used in quitting smoking. At analgesia aspect, Cyt could regulate reflective exciting breathing and has been widely used in anesthesia of patients in clinical operation. In this paper, through consulting and verifying a large number of documents, biological activities of Cyt and its related action mechanisms are summarized, to provide theoretic basis for the development and utilization of Cyt. | Hongxing WANG Hui XUE Tong ZHANG Shinong WANG Yinghua LUO Chenghao JIN | 2019 | Medicinal Plant2019，10，2： | 0 |
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