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| 1 | Treatment strategy for gastric non-invasive intraepithelial neoplasia diagnosed by endoscopic biopsy显示文摘Treatment strategies,whether as follow-up or'total incisional biopsy'for gastric noninvasive intraepithelial neoplasia diagnosed by examination of an endoscopic forceps biopsy specimen,are controversial due to problems associated with the diagnostic accuracy of endoscopic forceps biopsy and questions about the safety and efficacy of endoscopic treatment.Based on the histological findings of the biopsy specimen,it is difficult to differentiate between reactive or regenerative changes,inflammation and neoplastic changes,intraepithelial and invasive tumors.Therefore,gastric neoplasia diagnosed as noninvasive intraepithelial often develop into invasive carcinoma during follow-up.Recent advances in endoscopic modalities and treatment devices,such as image-enhanced endoscopy and highfrequency generators,may make endoscopic treatment,such as endoscopic submucosal dissection(ESD),a therapeutic option for gastric intraepithelial neoplasia,including low-grade neoplasms.Future studies are required to evaluate whether ESD is a valid strategy for gastric intraepithelial neoplasm with regard to safety and cost effectiveness. | Tsutomu Nishida Shusaku Tsutsui Motohiko Kato Takuya Inoue Shunsuke Yamamoto Yoshito Hayashi Tomofumi Akasaka Takuya Yamada Shinichiro Shinzaki Hideki Iijima Masahiko Tsujii Tetsuo Takehara | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 18 |
| 2 | Choroidal and cutaneous metastasis from gastric adenocarcinoma显示文摘Choroidal or cutaneous metastasis of gastric cancer is rare. Gastrointestinal cancer was found in only 4% in patients with uveal metastasis. Choroidal metastasis from gastric cancer was reported in two cases in earlier literature. The frequency of gastric cancer as a primary lesion was 6% in cutaneous metastasis of men, and cutaneous metastasis occurs in 0.8% of all gastric cancers. We report a patient with gastric adenocarcinoma who presented with visual disorder in his left eye and skin pain on his head as his initial symptoms. These symptoms were diagnosed to be caused by choroidal and cutaneous metastasis of gastric adenocarcinoma. Two cycles of chemotherapy consisted of oral S-1 and intravenous cisplatin (SPIRITS regimen); this was markedly effective to reduce the primary gastric lesion and almost all the metastatic lesions. | Shoichiro Kawai Tsutomu Nishida Yoshito Hayashi Hisao Ezaki Takuya Yamada Shinichiro Shinzaki Masanori Miyazaki Kei Nakai Takayuki Yakushijin Kenji Watabe Hideki Iijima Masahiko Tsujii Kohji Nishida Tetsuo Takehara | 2013 | World Journal of Gastroenterology2013，19，9： | 6 |
| 3 | Esophageal early basaloid squamous carcinoma with unusual narrowband imaging magnified endoscopy findings显示文摘Basaloid squamous carcinoma(BSC)is a rare variant of esophageal cancer.There are very few reports of'early'BSC.Here we report a case of early BSC with unusual findings by narrowband imaging magnified endoscopy(NBI-ME).A 70-year-old man with a middle thoracic esophageal tumor was referred to our hospital.White-light endoscopy revealed a reddish depressed lesion 5 mm in diameter having a subepithelial tumor-like prominence with a gentle rising slope.NBI-ME revealed irregular loop-shaped microvessels coexistent with thick irregularly branched non-looped vessels.Iodine staining revealed a pale brown lesion.We performed endoscopic submucosal dissection for diagnostic treatment.Histologic examination showed the proliferation of basal cell-like hyperchromatic tumor cells in the lamina propria and with slight invasion into the submucosa at a depth of 320μm.The tumor cells formed solid nests and microcystic structures,containing an Alcian blue-positive mucoid matrix.The surface was covered with squamous epithelium without cellular atypia.Thin vessels were observed in the intra-epithelial papilla and thick vessels were observed around the solid nests beneath the epithelium.Based on these findings together,we diagnosed the lesion as BSC.In this case,the NBI-ME findings differed from those of typical squamous cell carcinoma in that both non-invasive cancer-like irregular loop-shaped microvessels coexisted with massively invasive cancerlike thick non-looped vessels.We speculate that the looped and non-looped vessels observed by NBI-ME histologically corresponded to thin vessels in the intraepithelial papilla and thick vessels around the tumor nests,respectively.These NBI-ME findings might be a feature of early esophageal BSC. | Yugo Kai Motohiko Kato Yoshito Hayashi Tomofumi Akasaka Shinichiro Shinzaki Tsutomu Nishida Masahiko Tsujii Eiichi Morii Tetsuo Takehara | 2014 | World Journal of Gastroenterology2014，20，35： | 4 |
| 4 | Lew oxygen extraction despite high oxygen delivery causes low oxygen consumption in patients with burns recovering slowly from operative hypothermia显示文摘 | Ohnishi M Tasakl O | 1995 | Surgery1995，118，1： | 1 |
| 5 | Atypical duodenal ulcer and in vagination caused by a large pedunculated duodenal Brunner's gland hamartoma显示文摘 | Nakabori T Shinzaki S Yamada T | 2014 | Gastroin test Endosc2014，79，4： | 1 |
| 6 | Effects of the omega-6: omega-3 fatty acid ratio of fat emulsions on the fatty acid composition in cell membranes and the anti-inflammatory action 显示文摘 | Hagi A Nakayama M Shinzaki W | 2010 | JPEN J Parenter Enteral Nutr2010，34，3： | 1 |
| 7 | Fucosylated haptoglobin is a novel type of cancer biomarker linked to the prognosis atter an oper- ation in colorectal cancer显示文摘 | Takeda Y Shinzaki S Okudo K | 2012 | Cancer2012，118，12： | 1 |
| 8 | Effects of the ome- ga-6:omega-3 fatty acid ratio of fat emulsions on the fatty acid composition in cell membranes and the anti-inflammatory ac- tion 显示文摘 | Hagi A Nakayama M Shinzaki W | 2010 | J Parenter Enteral Nutr2010，34，3： | 1 |
| 9 | CO2 response of cyclic electron flow around PSI(CEF-PSI)in tobacco leaves-relative electron fluxes through PSI and PSII determine the magnitude of non-photochemical quenching(NPQ)of Chl fluorescence显示文摘 | Miyake C Miyata M Shinzaki Y | 2005 | Plant Cell and Physiology2005，46，4： | 1 |
| 10 | Overexpression of α1,6-fucosyltransferase in hepatoma enhances expressionof Golgi phosphoprotein 2 in a fucosylation-independent manner显示文摘 | Sayuri Kawamoto Kenta Moriwaki Tsutomu Nakagawa Mika Terao Shinichiro Shinzaki Naoko Yamane-Ohnuki Mitsuo Satoh Anand Mehta Timothy Block Eiji Miyoshi | 2011 | International Journal of Oncology2011，，1： | 1 |
| 11 | The preferential expression of CD7 and CD34 in myeloid blast crisis in chronic myeloid leukemia 显示文摘 | Kosugi N Tojo A Shinzaki H | 2000 | Blood2000，95，： | 1 |
| 12 | Effects of the ω-6: ω-3 fatty acid ratio of fat emulsions on the fatty acid compo- sition in cell membranes and the anti-inflammatory action 显示文摘 | Hagi A Nakayama M Shinzaki W | 2010 | Journal of Parenteral and Enteral Nutrition2010，34，3： | 1 |
| 13 | Vitamin K deficiency leads to exacerbation of murine dextran sulfate sodium-induced colitis显示文摘 | Shiraishi E Iijima H Shinzaki S | 2016 | J Gastroenterol2016，51，4： | 1 |
| 14 | GDP-mannose-4,6-dehydrat ase(GMDS)deficiency renders colon cancer cells resistant to tumor necrosis factor-related apoptosis-inducing lig and(TRAIL)receptor-and CD95-mediated apoptosis by inhibi ring complex II formation显示文摘 | Moriwaki K Shinzaki S Miyoshi E | 2011 | Biol Chem2011，286，50： | 1 |
| 15 | Biometric authentication technology 显示文摘 | MORI M SHINZAKI T SASAKI S | 2003 | Fujitsu2003，07，： | 1 |
| 16 | Evaluation of Endoscopic Ultrasound Image Quality Is Necessary in Endosonographic Assessment of Early Gastric Cancer Invasion Depth显示文摘 | Shunsuke Yamamoto Tsutomu Nishida Motohiko Kato Takuya Inoue Yoshito Hayashi Jumpei Kondo Tomofumi Akasaka Takuya Yamada Shinichiro Shinzaki Hideki Iijima Masahiko Tsujii Tetsuo Takehara Salem Omar | 2012 | <journal-title>Gastroenterology Research and Practice2012，，： | 1 |
| 17 | The preferential expression of CD7 and CD34 in myeloid blast crisis in chronic myeloid leukemia显示文摘 | Kosugi N Tojo A Shinzaki H | 2000 | Blood2000，95，： | 1 |
| 18 | Plasma tissue factor pathway inhibitor levels in patients with acute pancreatitis显示文摘 | Takeo Yasuda Takashi Ueda Keiko Kamei Wataru Shinzaki Hidehiro Sawa Makoto Shinzeki Yonson Ku Yoshifumi Takeyama | 2009 | Journal of Gastroenterology2009，，10： | 1 |
| 19 | CO2 response of cyclic electron flow around PSⅠ (CEF-PSⅠ) in tobacco leaves-relative electron fluxes through PSⅠ and PSⅡ determine the magnitude of non-photochemical quenching (NPQ) of chl fluorescence显示文摘 | Miyake C Miyata M Shinzaki Y Tomizawa K | 2005 | Plant Cell Physiol2005，46，4： | 1 |
| 20 | Clinical application of a lectin-antibody ELISA to measure fucosylated haptoglobin in sera of patients with pancreatic cancer显示文摘 | Hitoshi Matsumoto Shinichiro Shinzaki Megumi Narisada Sayuri Kawamoto Kana Kuwamoto Kenta Moriwaki Futoshi Kanke Shinji Satomura Takashi Kumada Eiji Miyoshi | 2010 | Clinical Chemistry and Laboratory Medicine2010，，4： | 1 |
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