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| 1 | Serum semaphorin 4C as a diagnostic biomarker in breast cancer:A multicenter retrospective study显示文摘Background:To date,there is no approved blood-based biomarker for breast cancer detection.Herein,we aimed to assess semaphorin 4C(SEMA4C),a pivotal protein involved in breast cancer progression,as a serum diagnostic biomarker.Methods:We included 6,213 consecutive inpatients from Tongji Hospital,Qilu Hospital,and Hubei Cancer Hospital.Training cohort and two validation cohorts were introduced for diagnostic exploration and validation.A pan-cancer cohort was used to independently explore the diagnostic potential of SEMA4C among solid tumors.Breast cancer patients who underwent mass excision prior to modified radical mastectomy were also analyzed.We hypothesized that increased pretreatment serum SEMA4C levels,measured using optimized in-house enzymelinked immunosorbent assay kits,could detect breast cancer.The endpoints were diagnostic performance,including area under the receiver operating characteristic curve(AUC),sensitivity,and specificity.Post-surgery pathological diagnosis was the reference standard and breast cancer staging followed the TNM classification.There was no restriction on disease stage for eligibilities.Results:We included 2667 inpatients with breast lesions,2378 patients with other solid tumors,and 1168 healthy participants.Specifically,118 patients with breast cancer were diagnosed with stage 0(5.71%),620 with stage I(30.00%),966 with stage II(46.73%),217 with stage III(10.50%),and 8 with stage IV(0.39%).Patients with breast cancer had significantly higher serum SEMA4C levels than benign breast tumor patients and normal controls(P<0.001).Elevated serum SEMA4C levels had AUC of 0.920(95%confidence interval[CI]:0.900–0.941)and 0.932(95%CI:0.911–0.953)for breast cancer detection in the two validation cohorts.The AUCs for detecting early-stage breast cancer(n=366)and ductal carcinoma in situ(n=85)were 0.931(95%CI:0.916–0.946)and 0.879(95%CI:0.832–0.925),respectively.Serum SEMA4C levels significantly decreased after surgery,and the reduction was more striking after modified radical mastectomy,compared with mass excision(P<0.001).The positive rate of enhanced serum SEMA4C levels was 84.77%for breast cancer and below 20.75%for the other 14 solid tumors.Conclusions:Serum SEMA4C demonstrated promising potential as a candidate biomarker for breast cancer diagnosis.However,validation in prospective settings and by other study groups is warranted. | Ya Wang Long Qiao Jie Yang Xiong Li Yaqi Duan Jiahao Liu Shaoqi Chen Huayi Li Dan Liu Tian Fang Jingjing Ma Xiaoting Li Fei Ye Junxiang Wan Juncheng Wei Qin Xu Ensong Guo Ping Jin Mingfu Wu Lin Zhang Yun Xia Yaqun Wu Jun Shao Yaojun Feng Qing Zhang Zongyuan Yang Gang Chen Qinghua Zhang Xingrui Li Shixuan Wang Junbo Hu Xiaoyun Wang Mona P.Tan Kazuaki Takabe Beihua Kong Qifeng Yang Ding Ma Qinglei Gao | 2021 | Cancer Communications2021，41，12： | 3 |
| 2 | Development of a gaseous and solid-state hybrid system for stationary hydrogen energy storage显示文摘Hydrogen can serve as a carrier to store renewable energy in large scale.However,hydrogen storage still remains a challenge in the current stage.It is difficult to meet the technical requirements applying the conventional storage of compressed gaseous hydrogen in high-pressure tanks or the solid-state storage of hydrogen in suitable materials.In the present work,a gaseous and solid-state(G-S)hybrid hydrogen storage system with a low working pressure below 5 MPa for a 10 kW hydrogen energy storage experiment platform is developed and validated.A Ti-Mn type hydrogen storage alloy with an effective hydrogen capacity of 1.7 wt%was prepared for the G-S hybrid hydrogen storage system.The G-S hybrid hydrogen storage tank has a high volumetric hydrogen storage density of 40.07 kg H_(2)m^(-3) and stores hydrogen under pressure below5 MPa.It can readily release enough hydrogen at a temperature as low as-15C when the FC system is not fully activated and hot water is not available.The energy storage efficiency of this G-S hybrid hydrogen storage system is calculated to be 86.4%-95.9%when it is combined with an FC system.This work provides a method on how to design a G-S hydrogen storage system based on practical demands and demonstrates that the G-S hybrid hydrogen storage is a promising method for stationary hydrogen storage application. | Haizhen Liu Li Xu Yu Han Xin Chen Peng Sheng Shumao Wang Xiantun Huang Xinhua Wang Chenglin Lu Hui Luo Shixuan He Zhiqiang Lan Jin Guo | 2021 | Green Energy & Environment2021，6，4： | 2 |
| 3 | Two-dimensional vanadium carbide for simultaneously tailoring the hydrogen sorption thermodynamics and kinetics of magnesium hydride显示文摘Magnesium hydride(MgH_(2))is a potential material for solid-state hydrogen storage.However,the thermodynamic and kinetic properties are far from practical application in the current stage.In this work,two-dimensional vanadium carbide(V_(2)C)MXene with layer thickness of 50−100 nm was fist synthesized by selectively HF-etching the Al layers from V_(2)AlC MAX phase and then introduced into MgH_(2) to improve the hydrogen sorption performances of MgH_(2).The onset hydrogen desorption temperature of MgH_(2) with V_(2)C addition is significantly reduced from 318℃ for pure MgH_(2) to 190℃,with a 128℃ reduction of the onset temperature.The MgH_(2)+10 wt%V_(2)C composite can release 6.4 wt%of H_(2) within 10 min at 300℃ and does not loss any capacity for up to 10 cycles.The activation energy for the hydrogen desorption reaction of MgH_(2) with V_(2)C addition was calculated to be 112 kJ mol^(−1) H_(2) by Arrhenius’s equation and 87.6 kJ mol^(−1) H_(2) by Kissinger’s equation.The hydrogen desorption reaction enthalpy of MgH_(2)+10 wt%V_(2)C was estimated by van’t Hoff equation to be 73.6 kJ mol^(−1) H_(2),which is slightly lower than that of the pure MgH_(2)(77.9 kJ mol^(−1) H_(2)).Microstructure studies by XPS,TEM,and SEM showed that V_(2)C acts as an efficient catalyst for the hydrogen desorption reaction of MgH_(2).The first-principles density functional theory(DFT)calculations demonstrated that the bond length of Mg−H can be reduced from 1.71A for pure MgH_(2) to 2.14A for MgH_(2) with V_(2)C addition,which contributes to the destabilization of MgH_(2).This work provides a method to significantly and simultaneously tailor the hydrogen sorption thermodynamics and kinetics of MgH_(2) by two-dimensional MXene materials. | Chenglin Lu Haizhen Liu Li Xu Hui Luo Shixuan He Xingqing Duan Xiantun Huang Xinhua Wang Zhiqiang Lan Jin Guo | 2022 | Journal of Magnesium and Alloys2022，10，4： | 2 |
| 4 | The reservoir characteristics research of Devonian Jinbaoshi Formation,Northwest Sichuan Basin,SW China显示文摘A great breakthrough was achieved on the Middle Devonian's oil-gas exploration in the Longmenshan area in northwestern Sichuan.However,only the Guanwushan Formation was researched in detail.The underlying formation-Jinbaoshi Formation as a set of the potential well reservoir and its reservoir characteristics have not been discussed.Based on the section's fine description,thin section analysis,and core borehole logging,combined with petrophysical analysis,the reservoir characteristics,controlling factors,and evolution process of the Jinbaoshi Formation reservoir in the Longmenshan area are deeply studied in this paper.The results showed that the Jinbaoshi Formation has developed a set of sand-shale interbedding deposit of terrigenous clastic and carbonate rocks.The reservoir lithology is mainly quartz sandstone and calcareous quartz sandstone.The quartz sandstone reservoir has good physical properties,but the calcareous quartz sandstone has the characteristics of strong heterogeneity,low porosity,and permeability.Residual intergranular pores are mainly developed in the reservoir space.And the development of intercrystalline pores and intergranular dissolved pores can also be seen,but the development frequency is low,and the scale is small.Among them,the Devonian Jinbaoshi Formation quartz sandstone's average porosity is about 8%,and the highest is 18.43%.The main diagenesis types of the Jinbaoshi Formation are compaction,recrystalization,and dissolution.Compaction is the main reason for the destruction of original pores,and dissolution is the main driving force for later porosity and permeability improvement.Rock fragments,calcareous silty clasts,and bioclastic grains are the main dissolution objects.The formation of intergranular dissolved pores significantly improves the physical properties of the reservoir.Therefore,the reservoir development of the Jinbaoshi Formation is mainly controlled both by favourable sedimentary facies and diagenesis.Quartz sandstone and calcareous sandstone of the Jinbaoshi Formation were controlled by early sedimentary facies in the syngenetic rock stage and developed more early intergranular pores;in the early diagenesis stage,compaction-pressure solution and cementation resulted in residual intergranular pores.In the middle-late diagenesis stage,the calcareous cement is dissolved,and more pores were formed. | Shixuan Zhang Xiucheng Tan Hao Tang Cheng Huang Zhimin Jin Minglong Li Yuwei Shen | 2022 | Petroleum2022，8，3： | 1 |
| 5 | Genesis and characteristics of the dolomite reservoirs in Middle Devonian Guanwushan Formation, Northwest Sichuan Basin, SW China显示文摘A great breakthrough has been made on oil-gas exploration of the Middle Devonian Guanwushan Formation in Northwest Sichuan Basin.The further exploration shows that the dolomite reservoir is complicated with insufficient investigation.Taking the Middle Devonian Guanwushan Formation as an example,systematic study has been carried out on its reservoir character,mechanism and genesis of dolostone.The field and core data suggest that reservoir types of Guanwushan Formation consist of crystalline dolomite,breccia dolomite and reef dolomite,and reservoir space is characterized by intercrystal(dissolution)pores,residual pores among breccias,intragranular dissolution pores,pockets as well as fractures.Besides,pore structure is of good configuration,showing medium-low porosity and moderate permeability,with average porosity and permeability of 2.23%and 0.44mD respectively,which suggesting fracture-pore and fracture-cavity reservoir.Combined with the previous research,it is suggested that the reservoir of Guanwushan Formation was controlled by facies,dolomitization and two-step karstification,with reef-shoal facies being material base for reservoir development,early dolomitization being key factor for reservoir space preservation,polyphase karstification being foundation for reservoir development and tectogenesis finally finalizing the reservoir. | Ya Zhang Bing Luo Cong Chen Minglong Li Zhimin Jin Shixuan Zhang Yuwei Shen | 2020 | Petroleum2020，6，2： | 1 |
| 6 | Three-Dimensional N-Doped Carbon Nanotube/Graphene Composite Aerogel Anode to Develop High-Power Microbial Fuel Cell显示文摘Optimizing the structure of electrode materials is one of the most effective strategies for designing high-power microbial fuel cells(MFCs).However,electrode materials currently suffer from a series of shortcomings that limit the output of MFCs,such as high intrinsic resistance,poor electrolyte wettability,and low microbial load capacity.Here,a three-dimensional(3D)nitrogen-doped multiwalled carbon nanotube/graphene(N-MWCNT/GA)composite aerogel is synthesized as the anode for MFCs.Comparing nitrogen-doped GA,MWCNT/GA,and N-MWCNT/GA,the macroporous hydrophilic N-MWCNT/GA electrode with an average pore size of 4.24μm enables high-density loading of the microbes and facilitates extracellular electron transfer with low intrinsic resistance.Consequently,the hydrophilic surface of N-MWCNT can generate high charge mobility,enabling a high-power output performance of the MFC.In consequence,the MFC system based on N-MWCNT/GA anode exhibits a peak power density and output voltage of 2977.8 mW m^(−2)and 0.654 V,which are 1.83 times and 16.3%higher than those obtained with MWCNT/GA,respectively.These results demonstrate that 3D N-MWCNT/GA anodes can be developed for high-power MFCs in different environments by optimizing their chemical and microstructures. | Shixuan Jin Yiyu Feng Jichao Jia Fulai Zhao Zijie Wu Peng Long Feng Li Huitao Yu Chi Yang Qijing Liu Baocai Zhang Hao Song Wei Feng | 2023 | Energy & Environmental Materials2023，6，3： | 0 |
| 7 | The composite phenotype analysis identifies potential concerted responses of physiological systems to high altitude exposure显示文摘Environmental stresses,such as temperature,disease and altitude could induce systematic changes of biological systems which manifests as concerted responses across multiple systems within a certain period of time[1].High altitude acclimatization(HAA)refers to a series of adaptive physiological responses to hypoxic stress. | Yi Li Meng Hao Zixin Hu Yanyun Ma Kun Wang Xiaoyu Liu Xianhong Yin Menghan Zhang Yi Wang Meng Liang Yuan Guo Lei Bao Shixuan Zhang Shiguan Le Chenyuan Wu Dayan Sun Yang Wei Fei Wu Rui Zhang Lingxian Zhu Hui Zhang Shuai jang Xingdong Chen Xiaofeng Wang Yao Zhang Longli Kang Wenyuan Duan Bin Qiao Jiucun Wang Li Jin | 2023 | National Science Review2023，10，5： | 0 |
| 8 | ecent progress in the theoretical design of two-dimensional ferroelectric显示文摘Two-dimensional(2D)ferroelectrics(FEs),which maintain stable electric polarization in ultrathin films,are a promising class of materials for the development of various miniature functional devices.In recent years,several 2D FEs with unique properties have been successfully fabricated through experiments.They have been found to exhibit some unique properties either by themselves or when they are coupled with other functional materials(e.g.,ferromagnetic materials,materials with 5 d electrons,etc.).As a result,several new types of 2D FE functional devices have been developed,exhibiting excellent performance.As a type of newly discovered 2D functional material,the number of 2D FEs and the exploration of their properties are still limited and this calls for further theoretical predictions.This review summarizes recent progress in the theoretical predictions of 2D FE materials and provides strategies for the rational design of 2D FE materials.The aim of this review is to provide guidelines for the design of 2D FE materials and related functional devices. | Xin Jin Yu-Yang Zhang Shixuan Du | 2023 | Fundamental Research2023，3，3： | 0 |
| 9 | Intrinsically scale-free ferroelectricity in two-dimensional M_(2)X_(2)Y_(6)显示文摘Discovery of novel two-dimensional(2D)ferroelectric materials and understanding the mechanism are of vital importance for the design of nanoscale ferroelectric devices.Herein,we report the distinct geometric evolution mechanism of the newly reported M_(2)Ge_(2)Y_(6)monolayers and find out a large group of 2D ferroelectric candidates based on this mechanism.The origination of the ferroelectricity of M_(2)Ge_(2)Y_(6)is the vertical displacement of Ge-dimer in the same direction driven by a soft phonon mode of the centrosymmetric configuration.Interestingly,we find another centrosymmetric configuration which is dynamically stable but higher in energy comparing with the ferroelectric phase.The metastable centrosymmetric phase of M_(2)Ge_(2)Y_(6)monolayers allows a new two-step ferroelectric switching path and may induce novel domain behaviors.Moreover,the ferroelectric M_(2)Ge_(2)Y_(6)monolayers exhibit independently switchable dipoles and maintain their ferroelectricity after contacting with graphene electrodes,indicating their high application potentials in high-density storage.Furthermore,16 ferroelectric(FE)M_(2)Ge_(2)Y_(6)and 65 potential FE M2Sn2Y6 monolayers are identified through high-throughput calculations.Our findings provide a new strategy for future discovery of novel 2D ferroelectric materials and also platforms for experimental design of related functional devices. | Xin Jin Lei Tao Yu-Yang Zhang Jinbo Pan Shixuan Du | 2022 | Nano Research2022，15，4： | 0 |
| 10 | Nonvolatile electrical control of spin polarization in the 2D bipolar magnetic semiconductor VSeF显示文摘Nonvolatile electrical control of spin polarization in two-dimensional(2D)magnetic semiconductors is greatly appealing toward future low-dissipation spintronic nanodevices.Here,we report a 2D material VSeF,which is an intrinsic bipolar magnetic semiconductor(BMS)featured with opposite spin-polarized valence and conduction band edges.We then propose a general nonvolatile strategy to manipulate both spin-polarized orientations in BMS materials by introducing a ferroelectric gate with proper band alignment.The spin-up/spin-down polarization of VSeF is successfully controlled by the electric dipole of ferroelectric bilayer Al_(2)Se_(3),verifying the feasibility of the design strategy.The interfacial doping effect from ferroelectric gate also plays a role in enhancing the Curie temperature of the VSeF layer.Two types of spin field effect transistors,namely multiferroic memory and spin filter,are further achieved in VSeF/Al_(2)Se_(3) and VSeF/Al_(2)Se_(3)/Al_(2)Se_(3) multiferroic heterostructures,respectively.This work will stimulate the application of 2D BMS materials in future spintronic nanodevices. | Yuhui Li Jun Deng Yan-Fang Zhang Xin Jin Wen-Han Dong Jia-Tao Sun Jinbo Pan Shixuan Du | 2023 | npj Computational Materials2023，，1： | 0 |
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