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| 1 | 恶性肿瘤骨转移及骨相关疾病临床诊疗中国专家共识(英文)显示文摘Since 1980s, palliative medicine has been an independent educational project. The development of palliative care in China started in the early 1990s. During the last 18 years, we have seen an increasing allocation of resources to palliative care, the establishment of an academic chair in palliative medicine, and more focused interest and awareness of the need for palliative care in the society at large. So the doctors in China have established principles of treatment on clinical diagnosis and treatment of malignant tumor bone metastases and bone related complications. In order to share our experience with the world, after two years’ preparation, the top-level experts in palliative medicine have written the consensus statement on clinical diagnosis and treatment of malignant tumor bone metastases and bone related complications. The overview includes not only the achievements in the world, but the hands-on experience in clinic, especially the experience in combination of TCM and Western medicine. We hope that the publication of this consensus statement will contribute to the palliative medicine development in this field, thus bring benefits to the majority of patients. | Shiying Yu Zefei Jiang Li Zhang Xiaohui Niu Lvhua Wang Ning Wu Jianhui Ma | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，1： | 15 |
| 2 | ITS2 barcoding DNA region combined with high resolution melting(HRM) analysis of Hyoscyami Semen, the mature seed of Hyoscyamus niger显示文摘Hyoscyami Semen, the mature dried seed of Hyoscyamus niger L., has long been used as a traditional Chinese medicine to treat human diseases. Hyoscyami Semen is found in local markets in China. In markets, sellers and buyers commonly inadvertently mix the seeds of H. niger with the seeds of related species such as Hygrophila salicifolia(Vahl) Nees, Astragalus complanatus R. Br., Cuscuta australis R. Br., Cuscuta chinensis Lam., and Impatiens balsamina L. because of their similar morphologies or similar names. Thus, developing a reliable method for discriminating H. niger seeds from its adulterants is necessary to reduce confusion and ensure the safe use of Hyoscyami Semen. The present study was designed to evaluate the efficiency of high-resolution melting analysis combined with DNA barcoding(Bar-HRM) with internal transcribed spacer 2 to discriminate H. niger. Our results show that Bar-HRM successfully identified the adulterants and detected the proportion of H. niger DNA extract within an admixture. In particular, HRM detected H. niger DNA extract in A. complanatus DNA extract at concentrations as low as 1%. In conclusion, the Bar-HRM method developed in the present study for authenticating H. niger is rapid and cost-effective. It can be used in the future to guarantee the purity of Hyoscyami Semen for the clinical use. | XIONG Chao HU Zhi-Gang TU Yuan LIU He-Gang WANG Ping ZHAO Ming-Ming SHIi Yu-Hua WU Lan SUN Wei CHEN Shi-Lin | 2016 | Chinese Journal of Natural Medicines2016，14，12： | 5 |
| 3 | Regulation of pathological BBB restoration via nanostructured ROS-responsive glycolipid-like copolymer entrapping siVEGF for glioblastoma targeted therapeutics显示文摘Glioblastoma(GBM)is one of the malignant brain tumors with high mortality and no curative treatments.Abnormally elevated vascular endothelial growth factor(VEGF)in GBM seriously disrupts the blood brain barrier(BBB)with an increased permeability,resulting in poor outcome and prognosis.RNAi interference has shown strong potential to inhibit VEGF expression,thus it is necessary to development an effective and safe gene delivery system possessing the ability to cross the BBB and target GBM cells.This study aims to explore the anti-GBM effect of angiopep-2(Ap)peptide modified reactive oxygen species(ROS)cleavable thioketal(TK)linked glycolipid-like nanocarrier(CSTKSA)delivering anti-VEGF siRNA(R),termed as Ap-CSTKSA/R complexes.Ap functionalized modification produced an enhanced cellular uptake and a stronger bio-distribution of Ap-CSTKSA/R complexes in U87 MG cells and brain tumor tissues,respectively.Ap-CSTKSA/R complexes exhibited great superiority in GBM growth inhibition and finally translated into the longest survival period mainly via receptor-mediated targeting delivery,VEGF gene silencing accompanied with remarkable angiogenesis inhibition,and suppressed expression of caveolin-1 which is involved in BBB functional regulation in the occurrence and treatment of GBM.The study indicated that Ap functionalization on ROS-responsive glycolipid-like copolymer exhibits a promising and effective gene delivery platform for GBM targeted treatment. | Lijuan Wen Yu Peng Kai Wang Zhihua Huang Shiying He Ruiwen Xiong Longping Wu Fengtian Zhang Fuqiang Hu | 2022 | Nano Research2022，15，2： | 2 |
| 4 | Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China显示文摘 | Baoli Cheng Guohao Xie ShangLong Yao Xinmin Wu Qulian Guo Miaoning Gu Qiang Fang Qiuping Xu Dongxin Wang Yuhong Jin ShiYing Yuan Junlu Wang Zhaohui Du Yunbo Sun XiangMing Fang | 2007 | Critical Care Medicine2007，，11： | 2 |
| 5 | Frameless stereotactic aspiration and thrombolysis of moderate thalamic hemorrhage显示文摘To the editor:Frameless stereotactic aspiration and thrombolysis (FSAT) is appropriate for treating deep-seated brain hematoma such as thalamic haemorrhage (TH).1 We performed FSAT to determine the efficacy and safety of this method for treating moderate TH (hematoma volume of 10-30 ml). From December 2006 to November 2011,a total of 75 consecutive moderate TH patients were enrolled in this study.These patients were non-randomly assigned to two groups,the FSAT group and the conservative group,according to the preference of physicians or patients.The study protocol was approved by the Medical Ethics Committee of the Third Affiliated Hospital of Soochow University.The final analysis included 27 patients in the FSAT group and 48 patients in conservative group. | Lian Xuegan Huang Hongwei Wu Jian Wei Ning Zhou Jianzhong Sheng Shiying He Xiaozhou | 2014 | Chinese Medical Journal2014，，12： | 2 |
| 6 | Evaluation of CMPAS precipitation products over Sichuan,China显示文摘高质量和高分辨率的降水产品在天气预报,数值模式模拟和气象防灾减灾方面起着重要的作用.本文利用四川地区高密度的地面降水传感器观测数据,比较CMPAS四种不同时空尺度的降水实况分析产品,评估CMPAS的融合准确性与在四川地区的适用性.研究表明:四种CMPAS降水产品都在四川盆地内精度较高,攀西地区和川西高原次之.随着降水量的增加,产品的误差也随之增加.CMPAS在夏秋两季对降水量高估,在春冬两季对降水量低估.总而言之,CMPAS在四川盆地内与观测数据的融合准确性较高.由于高原地区气象观测站点数量不足且观测数据受复杂地形和气候条件影响较大,CMPAS在高原地区的适用性检验仍需进一步研究. | Shiying Li Xiaolong Huang Wei Wu Bing Du Yuhe Jiang | 2022 | Atmospheric and Oceanic Science Letters2022，15，2： | 2 |
| 7 | Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology:Implications for Alzheimer's disease therapy显示文摘Alzheimer's disease(AD),characterized by the accumulation of protein aggregates including phosphorylated Tau aggregates,is the most common neurodegenerative disorder with limited therapeutic agents.Autophagy plays a critical role in the degradation of phosphorylated Tau aggregates,and transcription factor EB(TFEB)is a master regulator of autophagy and lysosomal biogenesis.Thus,small-molecule autophagy enhancers targeting TFEB hold promise for AD therapy.Here,we found that celastrol,an active ingredient isolated from the root extracts of Tripterygium wilfordii(Lei Gong Teng in Chinese)enhanced TFEB-mediated autophagy and lysosomal biogenesis in vitro and in mouse brains.Importantly,celastrol reduced phosphorylated Tau aggregates and attenuated memory dysfunction and cognitive deficits in P301S Tau and 3xTg mice,two commonly used AD animal models.Mechanistical studies suggest that TFEB-mediated autophagy-lysosomal pathway is responsible for phosphorylated Tau degradation in response to celastrol.Overall,our findings indicate that Celastrol is a novel TFEB activator that promotes the degradation of phosphorylated Tau aggregates and improves memory in AD animal models.Therefore,Celastrol shows potential as a novel agent for the treatment and/or prevention of AD and other tauopathies. | Chuanbin Yang Chengfu Su Ashok Iyaswamy Senthil Kumar Krishnamoorthi Zhou Zhu Sichang Yang Benjamin Chunkit Tong Jia Liu Sravan G.Sreenivasmurthy Xinjie Guan Yuxuan Kan Aston Jiaxi Wu Alexis Shiying Huang Jieqiong Tan Kingho Cheung Juxian Song Min Li | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 2 |
| 8 | Use of a high thoracic epidural analgesia for treatment of end-stage congestive heart failure secondary to coronary artery disease显示文摘 | Wu Shuang Fu Shiying Liu Fengqi Qu Renhai Wang Lanfeng Li Zhuqin Wang Xu | 2007 | International Journal of Cardiology2007，，2： | 1 |
| 9 | In_(2)O_(3-)x(OH)y/Bi_(2)MoO_(6) S-scheme heterojunction for enhanced photocatalytic performance显示文摘Surface heterojunction engineering has been extensively studied to promote efficient charge separation in semiconductor materials.Designing an effective heterojunction system to optimize the separation and transport of photo-induced charges is an appealing strategy to enhance the photocatalytic efficiency.In this work,In_(2)O_(3)-x(OH)y in situ decorated Bi_(2)MoO_(6) two-dimensional step-scheme heterojunctions were synthesized through a controlled dehydroxylation process of indium-based precursors.The charge transfer mechanism of this step-scheme heterojunctions was confirmed by the characterization of electron structures,reactive species,photoelectric properties and DFT theoretical calculation.The band bending and the internal electric field caused by the charge transfer upon hybridization can effectively promote the separation of charges and present the optimal redox capacity.In addition,surface residual hydroxyl groups can regulate the surface energy state and optimize the interfacial charge transfer kinetics of the prepared step-scheme heterojunction.Eventually,the step-scheme heterojunction exhibits superior performance in photocatalytic reduction of hexavalent chromium and degradation of organic pollutants under visible light irradiation.This work provides an innovative perspective to construct photocatalyst with superior activity. | Zhongfu Li Zhaohui Wu Rongan He Long Wan Shiying Zhang | 2020 | Journal of Materials Science & Technology2020，56，21： | 1 |
| 10 | Preparation and characterization of seriein powder extracted from silk industry wastewater显示文摘 | Wu Jinhong Wang Zhang Xu Shiying | 2007 | Food Chemistry2007，103，4： | 1 |
| 11 | Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China显示文摘 | Baoli Cheng Guohao Xie ShangLong Yao Xinmin Wu Qulian Guo Miaoning Gu Qiang Fang Qiuping Xu Dongxin Wang Yuhong Jin ShiYing Yuan Junlu Wang Zhaohui Du Yunbo Sun XiangMing Fang | 2007 | Critical Care Medicine2007，，11： | 1 |
| 12 | Dipeptidyl Peptidase‐4 Inhibitors and Cardiovascular Outcomes: Meta‐Analysis of Randomized Clinical Trials with 55,141 Participants显示文摘 | Shiying Wu Ingrid Hopper Marina Skiba Henry Krum | 2014 | Cardiovasc Ther2014，，4： | 1 |
| 13 | Neighborhood Conditions for Graphs to be Super Restricted Edge Connected 显示文摘 | Wang Shiying Li Jing Wu Lihong | 2010 | Networks2010，56，1： | 1 |
| 14 | The Inhibitory Effects of Rh- cndostatin (YI-I-16) in Combination with Radiotherapy on LungAdenocarcinoma A549 in Mice and the Underlying Mechanisms 显示文摘 | Huita WU Jie DENG Shiying YU | 2010 | J Huazhong Univ Sci Techno2010，30，1： | 1 |
| 15 | Oxygen isotope composition of seawatersin the Huanghai (Yellow) Sea and Bohai Sea显示文摘 | Wu Shiying | 1990 | Sci-ence in China (Series B)1990，7，： | 1 |
| 16 | Dipeptidyl Peptidase‐4 Inhibitors and Cardiovascular Outcomes: Meta‐Analysis of Randomized Clinical Trials with 55,141 Participants显示文摘 | Shiying Wu Ingrid Hopper Marina Skiba Henry Krum | 2014 | Cardiovasc Ther2014，，4： | 1 |
| 17 | Engineering Sodium Metal Anode with Sodiophilic Bismuthide Penetration for Dendrite-Free and High-Rate Sodium-Ion Battery显示文摘Sodium(Na)metal batteries with a high volumetric energy density that can be operated at high rates are highly desirable.However,an uneven Na-ion migration in bulk Na anodes leads to localized deposition/dissolution of sodium during high-rate plating/stripping behaviors,followed by severe dendrite growth and loose stacking.Herein,we engineer the Na hybrid anode with sodiophilic Na_(3)Bi-penetration to develop the abundant phase-boundary ionic transport channels.Compared to intrinsic Na,the reduced adsorption energy and ion-diffusion barrier on Na_(3)Bi ensure even Na^(+)nucleation and rapid Na^(+)migration within the hybrid electrode,leading to uniform deposition and dissolution at high current densities.Furthermore,the bismuthide enables compact Na deposition within the sodiophilic framework during cycling,thus favoring a high volumetric capacity.Consequently,the obtained anode was endowed with a high current density(up to 5 mA∙cm^(−2)),high areal capacity(up to 5 mA∙h∙cm^(−2)),and long-term cycling stability(up to 2800 h at 2 mA∙cm^(−2)). | Wanyu Zhao Min Guo Zhijun Zuo Xiaoli Zhao Huanglin Dou Yijie Zhang Shiying Li Zichen Wu Yayun Shi Zifeng Ma Xiaowei Yang | 2022 | Engineering2022，8，4： | 0 |
| 18 | Real time observation of the photocleavage of single DNA molecules显示文摘A method for real time observation of photo-cleavage of stretched λDNA at single molecular level by a fluorescent microscope coupled with CCD is developed. DNA molecules stained with YOYO-1 are stretched by the mo-lecular combing technique and fixed on a modified slide. Then the process of photocleavage and relaxation of DNA under radiation of blue light is observed. We speculate that the conformation change of stretched DNA and the effect of water are likely to facilitate the effect of YOYO photocleav-age DNA molecules. The photocleavage effect of YOYO for stretched DNA may be useful to study DNA elasticity, cancer research as well as the interaction between DNA and dyes. | LI Bin , HU Jun , WANG Ying, WU Shiying, HUANG Yibo & LI Minqian Shanghai Institute of Nuclear Research,Chinese Academy of Sciences, Shanghai 201800,China | 2003 | Chinese Science Bulletin2003，48，7： | 0 |
| 19 | One-pot synthesis of array-like sulfur-doped carbon nitride with covalently crosslinked ultrathin MoS cocatalyst for drastically enhanced photocatalytic hydrogen evolution显示文摘Constructing noble-metal-free loaded catalyst with high-efficiency photocatalytic activity by a simple and scalable method is of profound significance for fundamental research and practical application.Herein,a simple one-pot method was used to synthesize novel samples of array-like sulfur-doped graphitic carbon nitride(SCN)nanosheets with ultrathin MoS2 loading(MS/SCN-x%).The ultrathin MoS2 cocatalyst was evenly distributed on the surface of SCN and was linked to the main catalyst by covalent chemical bonds.Benefited from the multiple advantages of the array-like porous nanosheets structure with rich exposed surface,covalent cross-linking structure,and enhanced visible light absorption,the MS/SCN-2.5%composites drastically improve hydrogen evolution performance,which is superior to original MoS2 nanosheet modified by two-step mixing method,and also rivals with Pt/SCN.The designing strategy of photocatalyst modified by noble-metal-free cocatalyst with covalent bond structure provides fascinating insights into enhanced photocatalytic hydrogen evolution. | Shumin Zhang Hu Dong Changsheng An Zhongfu Li Difa Xu Kaiqiang Xu Zhaohui Wu Jie Shen Xiaohua Chen Shiying Zhang | 2021 | Journal of Materials Science & Technology2021，，16： | 0 |
| 20 | Different physiopsychological changes between AMS-susceptible and AMS-resistant pre-selected Antarctic expeditioners in Tibet显示文摘Through dynamically monitoring changes of acute mountain sickness(AMS)occurrences,cardiopulmonary function and mood states from Shanghai(4 m)to Lhasa(3650 m)and Yambajan(4300 m),Tibet,we obtained physiopsychological data of the 37th Chinese Antarctic pre-selected expeditioners for Kunlun Station.Through analyzing different physiopsychological changes between AMS-susceptible(AMS-S)and AMS-resistant(AMS-R)expeditioners,we would explore indicators to screen hypoxia-susceptible expeditioners.According to AMS occurrences evaluated by Lake Louise Score(LLS)in Yambajan,we divided the expeditioners(n=24,31.92±5.76 a)into AMS-S and AMS-R groups.Using a series of medical instrumentsand questionnaires,we monitored their cardiopulmonary function and mood states,and analyzed the differences of physiopsychological parameters between AMS-S and AMS-R groups.Compared with Shanghai,when expeditioners arrived in Yambajan,in both AMS-S and AMS-R groups,oxygen saturation(SpO2)significantly decreased,and blood pressure significantly increased(P<0.05).As for electrocardiogram(ECG),interval from the beginning to the end of QRS complex wave(QRS),interval from the beginning of QRS complex wave to the end of T wave(QT),interval between 2 adjacent P waves(PP)and interval between 2 adjacent R waves(RR)significantly decreased,heart rate(HR)and HR-corrected QT interval(QTc)significantly increased(P<0.05).Cardiac contractility and pumping function significantly decreased,systemic vascular resistance significantly increased(P<0.05).Pulmonary airway patency significantly increased(P<0.05).Compared with AMS-R group,AMS-S group showed significantly lower SpO2 and higher stroke volume variation(SVV)in Shanghai,however,significantly lower maximal expiratory flow at 75%of forced vital capacity(MEF75),higher levels of anxiety,fatigue and confusion in Yambajan(P<0.05).In conclusion,when expeditioners arrived at 4300 m,their cardiopulmonary function and mood states changed significantly.SpO2,SVV,MEF75,anxiety,fatigue and confusion maybe could be used as clues for screening hypoxia-susceptible individuals. | WU Xiaopei LIU Shiying WANG Xi WANG Jianan QIN Pengrui XU Chengli | 2021 | Advances in Polar Science2021，32，3： | 0 |
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