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| 1 | 恶性肿瘤骨转移及骨相关疾病临床诊疗中国专家共识(英文)显示文摘Since 1980s, palliative medicine has been an independent educational project. The development of palliative care in China started in the early 1990s. During the last 18 years, we have seen an increasing allocation of resources to palliative care, the establishment of an academic chair in palliative medicine, and more focused interest and awareness of the need for palliative care in the society at large. So the doctors in China have established principles of treatment on clinical diagnosis and treatment of malignant tumor bone metastases and bone related complications. In order to share our experience with the world, after two years’ preparation, the top-level experts in palliative medicine have written the consensus statement on clinical diagnosis and treatment of malignant tumor bone metastases and bone related complications. The overview includes not only the achievements in the world, but the hands-on experience in clinic, especially the experience in combination of TCM and Western medicine. We hope that the publication of this consensus statement will contribute to the palliative medicine development in this field, thus bring benefits to the majority of patients. | Shiying Yu Zefei Jiang Li Zhang Xiaohui Niu Lvhua Wang Ning Wu Jianhui Ma | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，1： | 15 |
| 2 | Population Pharmacokinetics of High-dose Methotrexate After Intravenous Administration in Chinese Osteosarcoma Patients from a Single Institution显示文摘 | Wei Zhang Qing Zhang Xiaohuang Tian Haitao Zhao Wei LU Jiancun Zhen Xiaohui Niu | 2015 | Chinese Medical Journal2015，，1： | 12 |
| 3 | A comparative study of calcium sulfate artificial bone graft versus allograft in the reconstruction of bone defect after tumor curettage显示文摘 | Yang Yongkun Niu Xiaohui Zhang Qing Hao Lin Ding Yi Xu Hairong | 2014 | Chinese Medical Journal2014，，17： | 11 |
| 4 | Recent Progress in Distributed Optical Fiber Raman Photon Sensors at China Jiliang University显示文摘在在中国 Jiliang 大学(CJLU ) 的完整的分布式的纤维拉曼光子传感器的研究,生产和应用的最近的进步的简短评论被介绍。以便改进测量距离,精确性,空间分辨率,多参数大小的能力,和完整的分布式的纤维传感器系统的智力,一种新一代纤维传感器技术基于光纤维,非线性的散布熔化原则被建议。一系列新一代完整的分布式的纤维传感器被调查并且设计,它由新产生组成极端长的距离散布与一个纤维拉曼放大器综合的光子传感器的完整的分布式的纤维拉曼和瑞利,汽车修正完整的分布式的纤维拉曼光子温度传感器基于拉曼关联双来源,完整的分布式的纤维拉曼光子温度传感器基于编码的脉搏采购原料,完整的分布式的纤维拉曼光子温度传感器 | Zaixuan ZHANG | 2012 | Photonic Sensors2012，2，2： | 8 |
| 5 | The Relationship Between Neuroimmunity and Bipolar Disorder:Mechanism and Translational Application显示文摘Neuroimmune system may be involved in the pathological process of bipolar disorder(BD),but the essential association is not fully understood.Accumulating evidence has shown that BD involves the activation of immune cells and the release of inflammatory substances in the central nerve system(CNS).Meanwhile,neuroimmune responses also interact with other hypothesis of the etiology of BD that are widely recognized,such as neurotransmitter systems,neuroendocrine systems,neurotrophic factors,and oxidative stress.Simultaneously,related genes and immune changes in peripheral blood vary with it.Overall,neuroimmunity may play an important role in the pathogenesis of BD,and the inflammatory cytokines,especially interleukin-6 and tumor necrosis factor-alpha,have potential value for the clinical diagnosis and prognosis of BD,as well as predicting the therapeutic effects of drugs.Large-scale studies are needed to extend the evidence on neuroimmunity in BD,and to examine its clinical value for applications such as early prediction and treatment. | Zhiang Niu Lu Yang Xiaohui Wu Yuncheng Zhu Jun Chen Yiru Fang | 2019 | Neuroscience Bulletin2019，35，4： | 8 |
| 6 | Combined prednisone and levothyroxine improve treatment of severe thrombocytopenia in hepatitis B with compensatory cirrhosis accompanied by subclinical and overt hypothyroidism显示文摘The aim of the present study was to investigate the relationship between hypothyroidism and thrombocytopenia in hepatitis Brelated compensatory liver cirrhosis and to determine whether treatment with levothyroxine and prednisone is superior in a multicenter, open-label, observational study in China. In total, 125 consecutive hepatitis B-related compensated liver cirrhosis patients with severe thrombocytopenia accompanied by hypothyroidism were included. The patients were divided into four groups according to treatment strategy: a control group(n=29), a prednisone group(n=25), a levothyroxine group(n=32) and a prednisone plus levothyroxine group(n=39). Severe thrombocytopenia was more prevalent in hepatitis B-associated compensatory liver cirrhosis patients with hypothyroidism than in euthyroid patients(29.6% vs. 14.7%, P<0.05). Combination treatment with prednisone and levothyroxine decreased the risk of bleeding and improved platelet recovery compared to control treatment and treatment with either prednisone or levothyroxine alone. The platelet count before therapy, serum thyroid stimulating hormone and combination treatment with prednisone and levothyroxine were associated with bleeding events. Therefore, the present study suggests that hypothyroidism is associated with severe thrombocytopenia in hepatitis B-associated compensatory liver cirrhosis. Treatment with prednisone plus levothyroxine may present a novel approach in these patients. | Jing Xue Ru Feng Haixia Fu Qian Jiang Hao Jiang Jing Lu Hui Liu Jingwen Wang Ting Niu Xin Wang YANDi Xie Hao Wang Lanping Xu Kaiyan Liu Xiaojun Huang Xiaohui Zhang | 2018 | Science China(Life Sciences)2018，61，8： | 8 |
| 7 | Perioperative rh-endostatin with chemotherapy improves the survival of conventional osteosarcoma patients: a prospective non-randomized controlled study显示文摘Objective: Anti-angiogenic drugs are an emerging treatment option against malignant tumors. The aim of this study was to determine whether the addition of perioperative rh-endostatin to chemotherapy could improve the probability of distant metastasis-free survival(DMFS) and overall survival(OS) in patients newly diagnosed with non-metastatic conventional osteosarcoma.Methods: This was a controlled non-randomized clinical study that included 388 patients without clinically detectable metastatic disease enrolled from January 2008 to April 2012. The control treatment group had 272 patients; 180 were male and 92, female,with a median age of 17 years. The treatment group had 58 patients; 36 were male and 22, female, with a median age of 16 years.The control group received preoperative chemotherapy followed by surgery and postoperative chemotherapy. The treatment group received 4 cycles of rh-endostatin perioperatively in addition to chemotherapy as per the control group. Patients were followed up from 6-101 months with a median follow-up period of 50.2 months.Results: The 5-year DMFS of the control group(61%) was significantly lower than that of the rh-endostatin group(79%)(P = 0.013). The 5-year OS of the control group(74%) was significantly lower than that of the rh-endostatin treatment group(87%)(P = 0.029). No difference in adverse drug reactions was found between these 2 groups.Conclusions: The addition of perioperative rh-endostatin to chemotherapy could significantly improve the DMFS and OS of patients with non-metastatic osteosarcoma. | Hairong Xu Zhen Huang Yuan Li Qing Zhang Lin Hao Xiaohui Niu | 2019 | Cancer Biology & Medicine2019，16，1： | 5 |
| 8 | Chinese expert consensus on the management of chimeric antigen receptor T cell therapy-associated coagulopathy显示文摘Chimeric antigen receptor T-cell(CAR-T)therapy has greatly improved the disease remission rate and long-term survival rate of patients with relapsed/refractory hematological malignancies.[1-3]Currently,several commercial CAR-T products are available in the market and numerous CAR-T clinical trials have been conducted.Attention should be paid to the safety of CAR-T therapy.The main adverse effects of CAR-T therapy are cytokine release syndrome(CRS)and immune effector cell-associated neurotoxicity syndrome(ICANS).[4] | Heng Mei Fangping Chen Yue Han Ming Hou He Huang Xiaojun Huang Yuhua Li Aibin Liang Qifa Liu Ting Niu Jun Peng Wenbin Qian Yongping Song Jianxiang Wang Ying Wang Depei Wu Kailin Xu Linhua Yang Renchi Yang Lei Zhang Liansheng Zhang Xi Zhang Xiaohui Zhang Weili Zhao Weidong Han Yu Hu | 2022 | Chinese Medical Journal2022，，14： | 4 |
| 9 | Hypothalamic-Pituitary-End-Organ Axes:Hormone Function in Female Patients with Major Depressive Disorder显示文摘Classic hypothalamic-pituitary-end-organ feedback loops–the hypothalamic-pituitary-adrenal axis(HPAA),hypothalamic-pituitary-thyroidal axis(HPTA),and hypothalamic-pituitary-gonadal axis(HPGA)–are associated with the neuroendocrine and immune systems in major depressive disorder(MDD).Female patients with MDD present with evident neuroendocrine and immunological changes.Glucocorticoid,thyroid hormone,and reproductive steroid levels fluctuate with menstrual cycles,which might lead to glucocorticoid receptor resistance,impairment of triiodothyronine conversion,and sex hormone secretion disorders.In this review,we summarize the independent and interactive functions of these three axes in female MDD patients.The similar molecular structure of steroids implies an interrelationship between the hypothalamic-pituitary-end-organ axes and the competitive inhibitory effects at the receptor level,especially when considering the HPAA and HPGA. | Yuncheng Zhu Xiaohui Wu Rubai Zhou Oliver Sie Zhiang Niu Fang Wang Yiru Fang | 2021 | Neuroscience Bulletin2021，37，8： | 3 |
| 10 | NiO nanoparticle-decorated SnO_(2)nanosheets for ethanol sensing with enhanced moisture resistance显示文摘In a high relative humidity(RH)environment,it is challenging for ethanol sensors to maintain a high response and excellent selectivity.Herein,tetragonal rutile SnO_(2)nanosheets decorated with NiO nanoparticles were synthesized by a two-step hydrothermal process.The NiO-decorated SnO_(2)nanosheet-based sensors displayed a significantly improved sensitivity and excellent selectivity to ethanol gas.For example,the 3 mol%NiO-decorated SnO_(2)(SnO_(2)-3Ni)sensor reached its highest response(153 at 100 ppm)at an operating temperature of 260℃.Moreover,the SnO_(2)-3Ni sensor had substantially improved moisture resistance.The excellent properties of the sensors can be attributed to the uniform dispersion of the NiO nanoparticles on the surface of the SnO_(2)nanosheets and the formation of NiO-SnO_(2)p–n heterojunctions.Considering the long-term stability and reproducibility of these sensors,our study suggests that the NiO nanoparticle-decorated SnO_(2)nanosheets are a promising material for highly efficient detection of ethanol. | Gaoqiang Niu Changhui Zhao Huimin Gong Zhitao Yang Xiaohui Leng Fei Wang | 2019 | Microsystems & Nanoengineering2019，5，1： | 3 |
| 11 | The Silurian A-Type Granites in Northeastern Guangxi,South China Block:New Evidence of Transition from Compression to Post-orogenic Extension of the Kwangsian Orogen显示文摘Objective More and more evidence suggests that the Kwangsian orogen is probably an intraplate orogen,which is one of the few examples of intraplate orogenesis worldwide.However,the initiation time,size and scope of the Kwangsian orogeny have not been determined yet.This study analyzed the Silurian A-type granites in | JIA Xiaohui WANG Xiaodi TANG Gongjian YANG Wenqiang NIU Zhijun | 2016 | Acta Geologica Sinica(English Edition)2016，90，5： | 3 |
| 12 | Robust Recommendation Algorithm Based on Kernel Principal Component Analysis and Fuzzy C-means Clustering显示文摘面临先令攻击,存在建议算法有更低的坚韧性。就这个问题而言,我们在场一个柔韧的建议算法基于聚类的核主管部件分析和模糊 c 工具。第一,我们使用核主管部件分析方法减少原来的等级矩阵的维数,它能提取用户和项目的有效特征。根据在攻击侧面之间的减少尺寸的等级矩阵和高关联特征,然后,我们使用聚类方法聚类用户概况的模糊 c 工具,它能认识到真侧面和攻击侧面的有效分离。最后,我们基于攻击察觉结果构造指示物功能到攻击的影响在建议上介绍的减少,并且把它合并到矩阵因式分解技术设计相应柔韧的建议算法。实验结果显示建议算法比在建议精确性和坚韧性的存在方法优异。 | YI Huawei NIU Zaiseng ZHANG Fuzhi LI Xiaohui WANG Yajun | 2018 | Wuhan University Journal of Natural Sciences2018，23，2： | 2 |
| 13 | Massive allograft replacement in management of bone tumors显示文摘Objective:To evaluate the functional outcome and complications of allograft replacement in management of bone tumors. Methods:Between March 1992 and September 2002,164 patients underwent bone tumor resection and massive allograft reconstruction of bone defects. The length of the resected part ranged from 5-35 cm. The resections were classified as marginal or wide resections of the tumor on the basis of the Musculoskeletal Tumor Society staging system. Fresh-frozen allografts were employed as osteoarticular grafts(n = 95),hemi-condylar(n = 15),massive(n = 23),allograft-prosthesis composite(n = 12),intercalary grafts(n = 15) or hemi-pelvic grafts(n = 4). Most of the lesions were osteosarcoma and giant cell tumor of bone and located in proximal and distal femur,proximal tibia and humerus. Results:At a median follow-up of 47 months(range,12 to 168 months) after the operation,154 of the patients in the study were free of disease and 10 died of disease. Twenty-one(12.8%) patients had local recurrence and 38(23.2%) nonunion. Late complications included 11(6.7%) fractures of the allograft and 18(11.0%) infections of the graft. Instability of the joint in the form of subluxation was noted in 13(7.9%) patients. Ten extremities were amputated due to local recurrence or severe infection. Conclusion:Allografts can be used for reconstruction of bony defects after tumor resection. Allograft has nearly similar shape,strength,osteo-inductivity and osteo-conductivity with host bone. Allograft implantation is a high complication reconstruction method,and the risk of recurrence increases when less surgical margin achieves. | Xiaohui Niu Lin Hao Qing Zhang Yi Ding | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，3： | 2 |
| 14 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://links.lww.com7CM9/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 15 | Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-[beta]-like signaling pathway显示文摘 | Ding Lihua Wang Zhaoyun Yan Jinghua Yang Xiao Liu Aijun Qiu Weiyi Zhu Jianhua Han Juqiang Zhang Hao Lin Jing Cheng Long Qin Xi Niu Chang Yuan Bin Wang Xiaohui Zhu Cui Zhou Yan Li Jiezhi Song Haifeng Huang Cuifen Ye Qinong | 2009 | Journal of Clinical Investigation2009，，2： | 1 |
| 16 | Giant cell tumor of the extremity: retrospective analysis of 621 chinese patients from one institution显示文摘 | Xiaohui Niu Qing Zhang Lin Hau | 2012 | J Bone Joint Surg Am2012，94，： | 1 |
| 17 | Synergistic antitumor efficacy by combining adriamycin with recombinanthuman endostatin in an osteosarcoma model显示文摘 | Hairong Xu Xiaohui Niu Qing Zhang Lin Hao Yi Ding Weifeng Liu Lu Yao | 2011 | Oncology Letters2011，，5： | 1 |
| 18 | Offlattice Model in the Prediction of Protein 3D Structure显示文摘3-dimension HPNX offlattice model is developed from the 2-dimension HP offlattice model. In the HP model, 20 types of amino acid monomers are divided into two classes, H (non-polar monomer) and P (polar monomer). In the HPNX model, polar monomers are split into positively charged (P), negatively charged (N) and neutral (X) monomers. A new evolutionary algorithm is applied to study long chains of the HPNX offlattice protein model. This method successfully predict the structures of several proteins in the 3-dimension space that are similar to the structures gotten by X-Ray Crystallography and NMR and published in the PDB(Protein Data Bank). | SHI Feng LI Nana NIU Xiaohui | 2007 | Wuhan University Journal of Natural Sciences2007，12，2： | 1 |
| 19 | Vojta and Bobath combined treatment for high risk infants with brain damage at early period显示文摘BACKGROUND: In the process of early screening and interventions to high risk infants with brain damage, the occasion and choosing methods of interventions and the combined application of different interventions are still at the exploratory phase. OBJECTIVE: To observe the efficacy of early intervention using Vojta and Bobath combined treatment in high risk infants with brain damage, and investigate the effect of early rehabilitation on the prognosis. DESIGN: A randomized controlled comparative observation. SETTING: Daqing Oil Field General Hospital of Heilongjiang Province. PARTICIPANTS: Eighty-four high risk infants younger than 1 year were selected from the Department of Pediatrics, Daqing Oil Field General Hospital of Heilongjiang Province from October 2005 to October 2006, including 52 boys (62%) and 32 girls (38%). The treatment started at the age of 0–3 months in 11 cases (13%), 4–6 months in 28 cases (33%), 7–9 months in 35 cases (42%), and 10–12 months in 10 cases (12%). Infants with at least two of the followings were enrolled, including 7 Vojta abnormal postural reflexes, slow or disorder of motor development, increase of muscular tension, postural abnormality, primary reflection residual and CT/MRI abnormalities. Informed consents were obtained from their guardians. The 84 infants were randomly divided into treatment group (n =42) and control group (n =42). METHODS: All the children were intravenously injected with cerebroprotein hydrolysate injection or cattle encephalon glycoside and ignotin injection, 10 times as a course for 2–5 courses; Besides, the infants in the treatment group also received early rehabilitative training of Vojta and Bobath combined treatment, once a day, 40 minutes per time, 5 times a week followed by a 2-day rest, 1 month as a course, and totally 2–5 courses. The Vojta method was to facilitate the automatic regulation by reflexlocomotion. Bobath method was to inhibit abnormal posture but facilitate the normal one, thus it is also called neurodevelopmental therapy realized by reflex inhibition and facilitation. The rehabilitation was evaluated clinically using Gesell Development Schedules (GDS) after the courses when the infants were 1 year old. GDS included five aspects of adaptive behavior, gross motor, refine motor, speech, individual-social behavior. The developmental quotient (DQ) could be calculated according to their development. DQ=developmental age/actual age×100, < 85 points was taken as abnormal; The higher the DQ value, the better the development. ② Evaluation of efficacy: Cured: Developmental order reached normal or generally normal, abnormal posture disappeared, muscular tension ameliorated, symmetric limbs' motor function, free movement, normal intelligence, powerful reaction, and clear speech. Significant effect: Developmental order tended to normal, abnormal posture disappeared incompletely, muscular tension ameliorated incompletely, transient pause in the flexion and extension of limbs, good reaction, and improved intelligence. Effective: Developmental order improved to a certain degree, muscular tension ameliorated, limbs' motor function and posture improved as compared with before treatment, but still under control, intelligence improved a little. Invalid: No obvious changes before and after treatment. Total significant effective rate=(cured cases+cases of significant effect)/total cases ×100%. ③ The enumeration data and measurement data were compared with chi-square test and t test respectively. MAIN OUTCOME MEASURES: Clinical efficacy and GDS results at 1 year old in both groups. RESUTLS: All the 84 infants were involved in the analysis of results. ① Efficacy: The total significant effective rate in the treatment group was higher than that in the control group (93%, 74%, χ2=4.2, P < 0.05). ② Results of GDS evaluation: The DQ values of individual intercourse and social adaptation in the treatment group (93.57±11.23, 95.13±9.32) were higher than those in the control group (88.27±10.18, 90.10±10.67, t =2.267, 2.301, P < 0.05); The DQ values of gross motor, fine motor and speech in the treatment group (90.78±10.20, 98.63±9.23, 93.69±11.31) were higher than those in the control group(84.32±11.33, 87.80±8.61, 85.52±10.61, t =2.746, 5.560, 2.746, P < 0.01). The interventional effects on each functional area were significant, especially the gross motor, fine motor and speech. CONCLUSION: The Vojta and Bobath combined treatment on the basis of drug therapy can improve the general developments of abilities in motor, intelligence, social intercourse, social adaptation and speech of high risk infants with brain damage, also can improve the curative efficacy. | Chunyan Wu Xiaohui Peng Xuesong Li Qingling Niu Hong Guo Huitao Huang | 2007 | Neural Regeneration Research2007，2，2： | 1 |
| 20 | Early Diagnosis of Bipolar Disorder Coming Soon:Application of an Oxidative Stress Injury Biomarker(BIOS)Model显示文摘Early distinction of bipolar disorder(BD)from major depressive disorder(MDD)is difficult since no tools are available to estimate the risk of BD.In this study,we aimed to develop and validate a model of oxidative stress injury for predicting BD.Data were collected from 1252 BD and 1359 MDD patients,including 64 MDD patients identified as converting to BD from 2009 through 2018.30 variables from a randomly-selected subsample of 1827(70%)patients were used to develop the model,including age,sex,oxidative stress markers(uric acid,bilirubin,albumin,and prealbumin),sex hormones,cytokines,thyroid and liver function,and glycolipid metabolism.Univariate analyses and the Least Absolute Shrinkage and Selection Operator were applied for data dimension reduction and variable selection.Multivariable logistic regression was used to construct a model for predicting bipolar disorder by oxidative stress biomarkers(BIOS)on a nomogram.Internal validation was assessed in the remaining 784 patients(30%),and independent external validation was done with data from 3797 matched patients from five other hospitals in China.10 predictors,mainly oxidative stress markers,were shown on the nomogram.The BIOS model showed good discrimination in the training sample,with an AUC of 75.1%(95%CI:72.9%–77.3%),sensitivity of 0.66,and specificity of 0.73.The discrimination was good both in internal validation(AUC 72.1%,68.6%–75.6%)and external validation(AUC 65.7%,63.9%–67.5%).In this study,we developed a nomogram centered on oxidative stress injury,which could help in the individualized prediction of BD.For better real-world practice,a set of measurements,especially on oxidative stress markers,should be emphasized using big data in psychiatry. | Zhiang Niu Xiaohui Wu Yuncheng Zhu Lu Yang Yifan Shi Yun Wang Hong Qiu Wenjie Gu Yina Wu Xiangyun Long Zheng Lu Shaohua Hu Zhijian Yao Haichen Yang Tiebang Liu Yong Xia Zhiyu Chen Jun Chen Yiru Fang | 2022 | Neuroscience Bulletin2022，38，9： | 1 |
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