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| 1 | Autophagy activation aggravates neuronal injury in the hippocampus of vascular dementia rats显示文摘It remains unclear whether autophagy affects hippocampal neuronal injury in vascular dementia. In the present study, we investigated the effects of autophagy blockade on hippocampal neuronal injury in a rat model of vascular dementia. In model rats, hippocampal CA1 neurons were severely damaged, and expression of the autophagy-related proteins beclin-1, cathepsin B and microtubule-associated protein 1 light chain 3 was elevated compared with that in sham-operated animals. These responses were suppressed in animals that received a single intraperitoneal injection of wortmannin, an autophagy inhibitor, prior to model establishment. The present results confirm that autophagy and autophagy-related proteins are involved in the pathological changes of vascular dementia, and that inhibition of autophagy has neuroprotective effects. | Bin Liu Jing Tang Jinxia Zhang Shiying Li Min Yuan Ruimin Wang | 2014 | Neural Regeneration Research2014，9，13： | 25 |
| 2 | Investigation of quality of life in patients with lung cancer by the EORTC QLQ-C30(V3.0) Chinese version显示文摘Objective To explore quality of life(QOL) and its influencing factors in patients with lung cancer.Methods A QOL questionnaire(European Organization for Research and Treatment of Cancer [EORTC] Quality of Life Questionnaire-Core 30 [QLQ-C30] Chinese version) was used with 138 patients with lung cancer participating in the study. A statistical description of the general characteristics of the patients with lung cancer was performed. The patients' QLQ-C30 scores were compared with the reference value for each dimension. To analyze the influence of QOL in different genders, age groups, and cancer stages, ttests and rank sum tests were used to compare the differences in QOL using a 5% significance level. Results The QLQ-C30 function scores in PF(physical functioning), EF(emotional functioning), SF(social functioning), and GH(global functioning), and symptom scales in NV(nausea and vomiting), DY(dyspnea), SL(insomnia), and FI(financial difficulties) were significantly different(P < 0.05) in comparison to the reference values. Female patients were worse than males(P < 0.05) in EF, NV, and DI(diarrhea). The later the stage of lung cancer, the worse the quality of life became; the functional scales in RF(role functioning), EF, CF, SF, and GH, and symptom scales in PA(pain), AP(appetite), and SL differences were statistically significant(P < 0.05). Conclusion This study aids understanding of the status of the quality of life of Chinese patients with cancer and might be useful for clinical work, theory research, and health policymakers. | Jun Li Xiaoguang Xiao Yao Wei Yang Li Man Zou Shiying Yu Yuan Chen Qian Chu | 2015 | Oncology and Translational Medicine2015，1，3： | 18 |
| 3 | Identification and functional annotation of novel microRNAs in the proximal sciatic nerve after sciatic nerve transection显示文摘The peripheral nervous system is able to regenerate after injury, and regeneration is associated with the expression of many genes and proteins. MicroRNAs are evolutionarily conserved, small, non-coding RNA molecules that regulate gene expression at the level of translation. In this paper, we focus on the identification and functional annotation of novel microRNAs in the proximal sciatic nerve after rat sciatic nerve transection. Using Solexa sequencing, computational analysis, and quantitative reverse transcription PCR verification, we identified 98 novel microRNAs expressed on days 0, 1, 4, 7, and 14 after nerve transection. Furthermore, we predicted the target genes of these microRNAs and analyzed the biological processes in which they were involved. The identified biological processes were consistent with the known time-frame of peripheral nerve injury and repair. Our data provide an important resource for further study of the role and regulation of microRNAs in peripheral nerve injury and regeneration. | LI ShiYing YU Bin WANG YongJun YAO DengBing ZHANG ZhanHu GU XiaoSong | 2011 | Science China(Life Sciences)2011，54，9： | 16 |
| 4 | 恶性肿瘤骨转移及骨相关疾病临床诊疗中国专家共识(英文)显示文摘Since 1980s, palliative medicine has been an independent educational project. The development of palliative care in China started in the early 1990s. During the last 18 years, we have seen an increasing allocation of resources to palliative care, the establishment of an academic chair in palliative medicine, and more focused interest and awareness of the need for palliative care in the society at large. So the doctors in China have established principles of treatment on clinical diagnosis and treatment of malignant tumor bone metastases and bone related complications. In order to share our experience with the world, after two years’ preparation, the top-level experts in palliative medicine have written the consensus statement on clinical diagnosis and treatment of malignant tumor bone metastases and bone related complications. The overview includes not only the achievements in the world, but the hands-on experience in clinic, especially the experience in combination of TCM and Western medicine. We hope that the publication of this consensus statement will contribute to the palliative medicine development in this field, thus bring benefits to the majority of patients. | Shiying Yu Zefei Jiang Li Zhang Xiaohui Niu Lvhua Wang Ning Wu Jianhui Ma | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，1： | 15 |
| 5 | Microstructural evolution and FCC twinning behavior during hot deformation of high temperature titanium alloy Ti65显示文摘Although the development of titanium alloys with working temperatures above 600?C faces enormous difficulties and challenges,the related research has not stopped.In the present work,detailed analyses on microstructure evolution and hot deformation behavior of a new temperature resistant 650?C titanium alloy Ti65 were investigated from micrometer scale to nanometer scale.The results revealed that lamellarαgrains gradually fragmentized and spheroidized during theα+βphase region compression and the orientation of the c-axis ofαgrains gradually aligned to radial directions,forming two high Schmid factors(SFs)value texture eventually with the increase of strain to 0.7.Moreover,there were some strengthening characters in theα+βphase region such as lenticularαsand nano silicide(TiZr)6 Si3.In theβphase region,fine equiaxed dynamic recrystallized(DRX)βgrains were formed.Besides,the variant selection ofαm′artensite followed Burgers orientation relationship during the compression process.The main deformation mechanisms of theα+βphase region were dislocation slip and orientation dependent spheroidization.Whereas,the deformation process in theβphase region was controlled byβgrain DRX.Interestingly,many nano scale FCC twins were generated at the interface ofαl′ath during deforming in theβphase region,which was firstly observed in Ti65 alloy. | Zhixin Zhang Jiangkun Fan Bin Tang Hongchao Kou Jian Wang Xin Wang Shiying Wang Qingjiang Wang Zhiyong Chen Jinshan Li | 2020 | Journal of Materials Science & Technology2020，47，14： | 10 |
| 6 | Non-Resonant Structure Design of Catenary Transformer in Ultrasonic Gear Honing显示文摘To solve the design problem of transformer composed of non-resonant structure in ultrasonic gear-honing, force coupling conditions for moderately thick annular plate (MTAP) and catenary horn are proposed, and the frequency equations of the transformer, which consist of an MTAP and a catenary horn, are derived based on Mindlin's theory. The design parameters of the transformer were obtained by solving the frequency equations with the help of MATLAB, and its mode and frequency were deduced by the modal analysis of finite element method (FEM), which are consistent with the theoretical design demands. The transformer design can be extended from system with thin annular plate to that with MTAP as the theoretical method by the simulation analysis of various ratios of the thickness to radius. | LI Xiangpeng ZHANG Chunhui WANG Shiying | 2012 | Wuhan University Journal of Natural Sciences2012，17，1： | 8 |
| 7 | Bevacizumab plus capecitabine and cisplatin in Chinese patients with inoperable locally advanced or metastatic gastric or gastroesophageal junction cancer: randomized, double-blind, phase III study (AVATAR study)显示文摘 | Lin Shen Jin Li Jianming Xu Hongming Pan Guanghai Dai Shukui Qin Liwei Wang Jinwan Wang Zhenzhou Yang Yongqian Shu Ruihua Xu Lei Chen Yunpeng Liu Shiying Yu Lilian Bu Yongzhe Piao | 2015 | Gastric Cancer2015，，1： | 7 |
| 8 | Reliability analysis of Lan Chengyu corroded pipeline with associated defects显示文摘Traditional reliability evaluation method for corroded pipeline exists the problem of not considering the associated defects.We therefore propose a new calculation method considering the associated defects.In this paper,the traditional and new methods are respectively used to calculate and contrastively analyze the failure probability of corroded pipeline;we then perform the research of residual life prediction for the corroded pipeline,followed by the sensitivity calculation of all random evaluation parameters.And then the Monte Carlo method(MCS)is applied to verify the rationality of the new method.The research results show that:the method considering associated defect is more objective,and truly react corroded pipeline's dynamic reliability changes;obtain new method to predict residual life of corroded pipeline;corrosion depth,radial corrosion rate have a significant impact on reliability of corroded pipeline considering associated defects.The calculation results of the method are more accurate,more time-saving. | Qin Li Chunmei Sun Zhiqiang Huang Xiang Xiao Haiping Thang Shiying Zhao | 2015 | Petroleum2015，1，3： | 6 |
| 9 | Robust L_2-L_∞ control for uncertain singular systems with time-varying delay显示文摘We study the problem of L2-L1 control for a class of uncertain singular systems with time-delay and norm-bounded parameter uncertainties in this paper. A new delay-dependent robust stability criterion is obtained in terms of linear matrix inequalities (LMIs). Based on this criterion, a state feedback controller is designed to guarantee that the closed-loop system is regular, impulse free and stable with a prescribed L2-L1 performance satisfied for all admissible parameter uncertainties. A simulation example is included to illustrate the effectiveness of the proposed method. | Lin Li Yingmin Jia Junping Du Shiying Yuan | 2008 | Progress in Natural Science:Materials International2008，18，8： | 5 |
| 10 | Microstructure and mechanical properties of CoCrNi-Mo medium entropy alloys:Experiments and first-principle calculations显示文摘The effect of Mo additions on the microstructures and mechanical properties of CoCrNi alloys was investigated,meanwhile,ab initio calculations are performed to quantitatively evaluate the lattice distortion and stacking fault energy(SFE).The yield strength,ultimate tensile strength,and elongation of(CoCrNi)_(97)Mo_(3)alloy are 475 MPa,983 MPa and 69%,respectively.The yield strength is increased by~30%and high ductility is maintained,in comparison with CoCrNi alloy.Besides the nano-twins and dislocations,the higher density of stacking faults is induced during the tensile deformation for(CoCrNi)_(97)Mo_(3)alloy.Ab initio calculation results indicate the mean square atomic displacement(MSAD)and SFE value of(CoCrNi)_(97)Mo_(3)alloy is 42.6 pm^(2)and-40.4 mJ/m^(2)at 0 K,respectively.The relationship between mechanical properties and MSAD,SFE for various multiple principal element alloys is discussed. | Ruobin Chang Wei Fang Jiaohui Yan Haoyang Yu Xi Bai Jia Li Shiying Wang Shijian Zheng Fuxing Yin | 2021 | Journal of Materials Science & Technology2021，，3： | 5 |
| 11 | Biodegradation behavior of magnesium and ZK60 alloy in artificial urine and rat models显示文摘In this work, the biodegradable and histocompatibility properties of pure Mg and ZK60 alloy wereinvestigated as new temporary implants for urinary applications. The corrosion mechanism in artificialurine was proposed using electrochemical impedance spectroscopy and potentiodynamic polarizationtests. The corrosion potential of pure magnesium and ZK60 alloy were -1820 and -1561 mV, respectively,and the corrosion current densities were 59.66 ± 6.41 and 41.94 ± 0.53 μA cm^-2, respectively. Thein vitro degradation rates for pure Mg and ZK60 alloy in artificial urine were 0.382 and 1.023 mm/y,respectively, determined from immersion tests. The ZK60 alloy degraded faster than the pure Mg in bothartificial urine and in rat bladders (the implants of both samples are ø 3 mm × 5 mm). Histocompatibilityevaluations showed good histocompatibility for the pure Mg and ZK60 alloy during the 3 weeks postimplantationin rat bladders, and no harm was observed in the bladder, liver and kidney tissues. Theresults provide key information on the degradation properties and corrosion mechanism of pure Mg andZK60 alloy in the urinary system. | Shiying Zhang Yanze Bi Jianye Li Zhenguo Wang Jingmin Yan Jiawang Song Haibo Sheng Heqing Guo Yan Li | 2017 | Bioactive Materials2017，2，2： | 4 |
| 12 | Noncoding RNAs and Their Potential Therapeutic Applications in Tissue Engineering显示文摘Tissue engineering is a relatively new but rapidly developing field in the medical sciences. Noncoding RNAs(ncRNAs) are functional RNA molecules without a protein-coding function; they can regulate cellular behavior and change the biological milieu of the tissue. The application of ncRNAs in tissue engineering is starting to attract increasing attention as a means of resolving a large number of unmet healthcare needs, although ncRNA-based approaches have not yet entered clinical practice. In-depth research on the regulation and delivery of ncRNAs may improve their application in tissue engineering.The aim of this review is: to outline essential ncRNAs that are related to tissue engineering for the repair and regeneration of nerve, skin, liver, vascular system, and muscle tissue; to discuss their regulation and delivery; and to anticipate their potential therapeutic applications. | Shiying Li Tianmei Qian Xinghui Wang Jie Liu Xiaosong Gu | 2017 | Engineering2017，3，1： | 4 |
| 13 | Influence of cosmic radiation on lymphocyte micronucleus,serum lipid peroxide and antioxidation capacity in aircrew members显示文摘This study looks into the influence of cosmic radiation at high altitudes on human bodies. Results reveal that the cytokinesis-block micronuclei (CBMN) and conventional cultured micronuclei in peripheral blood lymphocytes, serum levels of lipid peroxide, superoxide dismutase, and the total antioxidation capacity by chemical colorimetry all increased significantly in aircrew members. There exists a linear relationship between the CBMN and the average annual effective doses of radiation received or the average annual flying hours. With both of them, a trend shows that the serum lipid peroxide levels increase as well. Either the lipid peroxide or CBMN can sensitively reflect the recent changes in flight load. These findings indicate that cosmic radiation impairs the stability of chromosomes and genome, and induces lipid oxidative damage in aircrews; Lymphocyte CBMN and serum lipid peroxide can be used as monitoring indicators in the cosmic radiation protection for aircrew members. | CHEN Weiru FENG Yingjin LIU Jiangkuang ZHANG Haili GUO Ying ZHANG Yan DUAN Shiying PENG Xintao SUN Tianping JIA Baoshan ZHAO Junxian LI Hua | 2002 | Chinese Science Bulletin2002，47，8： | 3 |
| 14 | Exploring facile strategies for high-oxidation-state metal nitride synthesis: carbonate-assisted one-step synthesis of Ta_3N_5 films for solar water splitting显示文摘Metal nitrides are widely studied due to their outstanding physical properties, including high hardness,high thermal and chemical stability, low electrical resistivity etc. Generally, metal nitrides can be obtained from the direct reaction of metal and ammonia/nitrogen. However, some of the metal nitrides,such as Ta_3N_5, cannot be synthesized by direct nitridation of metals. To achieve Ta_3N_5, high-oxidationstate Ta precursors like Ta_2O_5, NaTaO_3, TaS_3, K_6Ta_(10.8)O_(30), Ta(N(CH_3)_2)_5 and TaCl_5 have to be employed,which is a time-consuming and laborious process with the possibility of introducing undesirable impurities. Here taking Ta_3N_5 as an example, a facile carbonate-assisted one-step nitridation method is proposed, which enables the direct synthesis of high-oxidation-state metal nitride films from metal precursors under ammonia flow. The mechanism of the nitridation process has been studied, which carbon dioxide released from carbonates decomposition reacts with metallic Ta and assists the one-step conversion of metallic Ta to Ta_3N_5. The as-prepared Ta_3N_5 film, after modified with NiFe layered double hydroxide, exhibits promising water splitting performance and stability. This method avoids the preoxidation process of metal precursors in high-oxidation-state metal nitride synthesis, and may facilitate the direct fabrication of other important metal nitrides besides Ta_3N_5. | Tao Fang Huiting Huang Jianyong Feng Yingfei Hu Yongsheng Guo Shiying Zhang Zhaosheng Li Zhigang Zou | 2018 | Science Bulletin2018，63，21： | 3 |
| 15 | Excretion of manure-borne estrogens and androgens and their potential risk estimation in the Yangtze River Basin显示文摘The Yangtze River is the longest river in China, and the river basin spans one fifth of the area of the whole country. Based on statistical data, the excretion of manure-borne steroid hormones, including steroid estrogens(SEs) and steroid androgens(SAs), in 10 provinces of China within the region has been estimated. The potential environmental and ecological risk of manure-borne steroid estrogens to the surface water in this region was also assessed. The manure-borne SE and SA excretions in the 10 provinces and municipalities vary in the order: Sichuan > Hunan > Hubei > Yunnan > Jiangsu > Anhui > Jiangxi >Chongqing > Qinghai > Shanghai. The highest increase of manure-borne SEs(1434.3 kg)and SAs(408.5 kg) was found in Hunan and Hubei provinces, respectively, and the total excretion in 2013 was 65% more than 15 years earlier in these two provinces. However, the emissions in Anhui and Shanghai decreased in this 15 year period of time. Swine urine,chicken feces, cattle urine, and laying hen feces were considered the dominant sources of manure-borne E1, βE2, αE2, and SAs, respectively. Although Jiangsu province did not have the largest excretion of manure-borne SEs, it had the highest level of predicted17β-estradiol equivalency(EEQs) value of 16.65 ng/L in surface water because of the limited surface water resources. According to the lowest observable effect level of 10 ng/L for17β-estradiol, the manure-borne SEs in Jiangsu province might potentially pose ecological risk to its wild aquatic organisms. | Yanxia Li Shiying Gao Shufang Liu Bei Liu Xuelian Zhang Min Gao Linjie Cheng Boyang Hu | 2015 | Journal of Environmental Sciences2015，27，11： | 2 |
| 16 | Involvement of the Wnt signaling pathway and cell apoptosis in the rat hippocampus following cerebral ischemia/reperfusion injury显示文摘We investigated the role of the Wnt signaling pathway in cerebral ischemia/reperfusion injury by examining β-catenin and glycogen synthase kinase-3β protein expression in the rat hippocampal CA1 region following acute cerebral ischemia/reperfusion. Our results demonstrate that cell apoptosis increases in the CA1 region following ischemia/reperfusion. In addition, β-catenin and glycogen synthase kinase-3β protein expression gradually increases, peaking at 48 hours following reperfusion. Dickkopf-1 administration, after cerebral ischemia/reperfusion injury, results in decreased cell apoptosis, and β-catenin and glycogen synthase kinase-3β expression, in the CA1 region. This suggests that β-catenin and glycogen synthase kinase-3β, both components of the Wnt signaling pathway, participate in cell apoptosis following cerebral ischemia/reperfusion injury. | Bin Liu Jing Tang Shiying Li Yuqin Zhang Yan Li Xiaoliu Dong | 2013 | Neural Regeneration Research2013，8，1： | 2 |
| 17 | Screening, Characterization and Evaluation of Mangiferin Polymorphs显示文摘Mangiferin is a compound with many pharmacological activities and exists in many natural products.Anhydrous and hydrate of mangiferin have been reported separately in two literatures,but the polymorphism of this compound has not been realized until this paper.In this study,polymorph screening of mangiferin has been carried out and five forms have been obtained including three new forms never reported.Several solid state characterization methods,such as powder X-ray diffraction,differential scanning calorimetry and thermogravimetry,are used to identify and characterize all of mangiferin forms.The comparison of the crystallographic data and hirshfeld surface analysis were first reported for mangiferin anhydrous and hydrate.Furthermore,the studies on stability,transformation and solubility have been undertaken,the results prompt that form V can be used as the dominant polymorph for the development of innovative pharmaceuticals. | Shiying Yang Qi Zhou Baoxi Zhang Li Zhang Dezhi Yang Haiguang Yang Guanhua Du Yang Lu | 2020 | Natural Products and Bioprospecting2020，10，4： | 2 |
| 18 | Anti-inflammatory Effects and Mechanisms of Rhein, an Anthraquinone Compound, and Its Applications in Treating Arthritis: A Review显示文摘Inflammation is a defensive response of living tissues to damaging agents,which exists in two forms,acute inflammation and chronic inflammation,and chronic inflammation is closely related to arthritis.Currently,the commonly prescribed anti-inflammatory medications are greatly limited by high incidence of gastrointestinal erosions in the clinical applications.Rhein,a bioactive constituent of anthraquinone,exhibits excellent anti-inflammatory activities and therapeutic effects on arthritis with less gastrointestinal damages.Although there are numbers of studies on anti-inflammatory effects and mechanisms of rhein in the last few decades,to the best of our knowledge,only a few review articles pay attention to the interactive relationships of rhein on multiple inflammatory signaling pathways and cellular processes from a comprehensive perspective.Herein,we summarized anti-inflammatory effects and mechanisms of rhein and its practical applications in the treatment of arthritis,thereby providing a reference for its basic researches and clinical applications. | Hongjuan Wang Dezhi Yang Li Li Shiying Yang Guanhua Du Yang Lu | 2020 | Natural Products and Bioprospecting2020，10，6： | 2 |
| 19 | Evaluation of CMPAS precipitation products over Sichuan,China显示文摘高质量和高分辨率的降水产品在天气预报,数值模式模拟和气象防灾减灾方面起着重要的作用.本文利用四川地区高密度的地面降水传感器观测数据,比较CMPAS四种不同时空尺度的降水实况分析产品,评估CMPAS的融合准确性与在四川地区的适用性.研究表明:四种CMPAS降水产品都在四川盆地内精度较高,攀西地区和川西高原次之.随着降水量的增加,产品的误差也随之增加.CMPAS在夏秋两季对降水量高估,在春冬两季对降水量低估.总而言之,CMPAS在四川盆地内与观测数据的融合准确性较高.由于高原地区气象观测站点数量不足且观测数据受复杂地形和气候条件影响较大,CMPAS在高原地区的适用性检验仍需进一步研究. | Shiying Li Xiaolong Huang Wei Wu Bing Du Yuhe Jiang | 2022 | Atmospheric and Oceanic Science Letters2022，15，2： | 2 |
| 20 | Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology:Implications for Alzheimer's disease therapy显示文摘Alzheimer's disease(AD),characterized by the accumulation of protein aggregates including phosphorylated Tau aggregates,is the most common neurodegenerative disorder with limited therapeutic agents.Autophagy plays a critical role in the degradation of phosphorylated Tau aggregates,and transcription factor EB(TFEB)is a master regulator of autophagy and lysosomal biogenesis.Thus,small-molecule autophagy enhancers targeting TFEB hold promise for AD therapy.Here,we found that celastrol,an active ingredient isolated from the root extracts of Tripterygium wilfordii(Lei Gong Teng in Chinese)enhanced TFEB-mediated autophagy and lysosomal biogenesis in vitro and in mouse brains.Importantly,celastrol reduced phosphorylated Tau aggregates and attenuated memory dysfunction and cognitive deficits in P301S Tau and 3xTg mice,two commonly used AD animal models.Mechanistical studies suggest that TFEB-mediated autophagy-lysosomal pathway is responsible for phosphorylated Tau degradation in response to celastrol.Overall,our findings indicate that Celastrol is a novel TFEB activator that promotes the degradation of phosphorylated Tau aggregates and improves memory in AD animal models.Therefore,Celastrol shows potential as a novel agent for the treatment and/or prevention of AD and other tauopathies. | Chuanbin Yang Chengfu Su Ashok Iyaswamy Senthil Kumar Krishnamoorthi Zhou Zhu Sichang Yang Benjamin Chunkit Tong Jia Liu Sravan G.Sreenivasmurthy Xinjie Guan Yuxuan Kan Aston Jiaxi Wu Alexis Shiying Huang Jieqiong Tan Kingho Cheung Juxian Song Min Li | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 2 |
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