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| 1 | The mechanisms of sorafenib resistance in hepatocellular carcinoma:theoretical basis and therapeutic aspects显示文摘Sorafenib is a multikinase inhibitor capable of facilitating apoptosis,mitigating angiogenesis and suppressing tumor cell proliferation.In late-stage hepatocellular carcinoma(HCC),sorafenib is currently an effective first-line therapy.Unfortunately,the development of drug resistance to sorafenib is becoming increasingly common.This study aims to identify factors contributing to resistance and ways to mitigate resistance.Recent studies have shown that epigenetics,transport processes,regulated cell death,and the tumor microenvironment are involved in the development of sorafenib resistance in HCC and subsequent HCC progression.This study summarizes discoveries achieved recently in terms of the principles of sorafenib resistance and outlines approaches suitable for improving therapeutic outcomes for HCC patients. | Weiwei Tang Ziyi Chen Wenling Zhang Ye Cheng Betty Zhang Fan Wu Qian Wang Shouju Wang Dawei Rong F.P.Reiter E.N.De Toni Xuehao Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 19 |
| 2 | Hollow iron oxide nanoparticles as multidrug resistant drug delivery and imaging vehicles显示文摘磁性的 nanoparticles 对很多个癌症房间被用作药交货车辆。大多数这些 theranostic 明确的表达使用了为两磁性的回声成像(MRI ) 和癌症治疗作为 nano 搬运人明确的表达与 chemotherapeutics 装载的稳固的氧化铁 nanoparticles (SIONP ) 。在这研究,我们使用了 dopamine-plus-human 浆液白朊(HSA ) 方法在 nano 搬运人的空多孔的结构以内修改空氧化铁 nanoparticles (HIONP ) 和 encapsuated doxorubicin (纪录影片) 。新交货系统能用一样的涂层策略比一样的核心尺寸的稳固的氧化铁 nanoparticles 装载更多的药。HIONPs 纪录影片明确的表达也有 pH 依赖的药版本行为。与免费纪录影片相比, HIONPs 纪录影片有效地是更多由 multidrug 的 uptaken 抵抗 OVCAR8-ADR 房间并且因而在杀死药的更多的有势力抵抗癌症房间。MRI 幽灵和房间研究也证明 HIONPs 纪录影片能减少当充当药交货车辆时, T 2 MRI 信号紧张和罐头被用作一个 MRI 对比代理人。第一次, chemo 药运输的双申请和用 HIONPs 纪录影片明确的表达的先生成像对纪录影片敏感、纪录影片抵抗的癌症房间被完成。 | Ruijun Xing Ashwinkumar A. Bhirde Shouju Wang Xiaolian Sun Gang Liu Yanglong Hou Xiaoyuan Chen | 2013 | Nano Research2013，6，1： | 11 |
| 3 | Identification of vibration loads on hydro generator by using hybrid genetic algorithm显示文摘颤动动态特征是在建模和大水疗院发电机的机械分析的一个主要问题。一个算法为识别颤动被开发借助于混合基因算法的动态特征。从一个水疗院发电机的测量动态回答,一个适当评价算法被需要识别装载参数,包括颤动的主要频率和振幅力量。以便以一种有效、柔韧的方式识别参数,一个优化方法被建议那把基因算法与退火模仿和优秀人材策略相结合。混合基因算法然后被用来处理参数鉴定,建议优化方法的有效性被它的比较与实际观察数据在证实的一个提出病的问题。 | Shouju Li Yingxi Liu | 2006 | Acta Mechanica Sinica2006，22，6： | 6 |
| 4 | Study on Closed-set Speaker Identification Based on Biomimetic Pattern Recognition显示文摘 | WU Lili WANG Shoujue | 2009 | Chinese Journal of Electronics2009，18，2： | 4 |
| 5 | Blind Image Restoration Based on the Theory of High-Dimensional Space Geometry显示文摘 | WANG Shoujue CAO Yu HUANG Yi | 2007 | Chinese Journal of Electronics2007，16，2： | 2 |
| 6 | A Neural Network Constructing Method Based on Many Kinds of Neurons Model显示文摘 | WANG Xianbao CAO Wenming FENG Hao WANG Shoujue | 2005 | 通讯和计算机(中英文版)2005，2，1： | 2 |
| 7 | Mathematical Symbols and Computing Methods in High Dimensional Biomimetic Informatics and Their Applications显示文摘 | WANG Shoujue LIU Xingxing | 2008 | Chinese Journal of Electronics2008，17，1： | 1 |
| 8 | Model reference control for bulkhead pressure of EPB shield in tunneling显示文摘 | Zichang Shangguan Shouju Li | 2010 | Journal of Convergence Information Technology2010，5，1： | 1 |
| 9 | A new filtering algorithm based on extremum and median val- ue显示文摘 | Xing Cangju Wmlg Shoujue Deng Haojiang | 2001 | Journal of Image and Graphics2001，6，6： | 1 |
| 10 | Self-organization based DSS framework 显示文摘 | Zhang Lei Ren Shouju Liu Zuzhao | 2000 | IEEE International Conference2000，1，60： | 1 |
| 11 | A New Generation of Decision Support System for Advanced Manufacturing Enterprises显示文摘 | Shouju Ren | 1997 | Journal of Intelligent Manufacturing1997，8，5： | 1 |
| 12 | A New Filtering Algorithm Based on Extremum and Median Value显示文摘 | Xing Cangiu Wang Shoujue Deng Haojiang | 2001 | Journal of Image and Graphics2001，6，6： | 1 |
| 13 | A Cancer Recognition Method Based on DNA Microarray显示文摘 | SU Qian AN Dong ZHAI Yafeng WANG KU WANG Shoujue | 2009 | Chinese Journal of Electronics2009，18，3： | 1 |
| 14 | A new development on ANN in China -biomimetic pattern recognition and multi weight vector neurons显示文摘 | WANG Shoujue | 2003 | RSFDGrC2003，，： | 1 |
| 15 | Application of geometrical learning for similarity index about clustering DNA microarray data显示文摘 | CAO Wenming WANG Shoujue | 2005 | LECTURE NOTES IN ARTIFICIAL INTELLIGENCE2005，，3642： | 1 |
| 16 | Supply Chain based Self-Organization Modeling of Decision Support System in Virtual Enterprise显示文摘 | Ren Shouju | 1999 | Transactions of Tsinghua University1999，，7： | 1 |
| 17 | A New Generation of Decision Support Systems for Advanced Manufacturing Enterprises显示文摘 | Shouju Ren | 1997 | Journal of Intelligent Manufacturing1997，8，5： | 1 |
| 18 | A New Filtering Algorithm Based on Extremum and Median Value显示文摘 | Xing Cangju Wang Shoujue Dang Haojiang | 2001 | Journal of Image and Graphics2001，6，6： | 1 |
| 19 | Results from in-situ monitoring of displacement,bolt load,and disturbed zone of a powerhouse cavern during excavation process显示文摘 | LI Shouju YU He LIU Yingxi | 2008 | International Journal of Rock Mechanics & Mining Sciences2008，45，8： | 1 |
| 20 | A Point-to-Point Tracking Algorithm Based on the Theory of Floating Pixels显示文摘Based on the theory of floating pixels, a point-to-point tracking algorithm based on local features is presented. A novel texture-based feature set is proposed in a form of high dimensional vector which describes each single point. Point-to-point matching is applied in a way of vector operation at multiple scales. Each match is verified by variance analysis, and unreliable matches are corrected with candidates available. Experimental results demonstrate that this algorithm maintains strong robustness when target-appearance is varying and environment is complex. | WANG Shoujue JIANG Yuwen TAN Leyi | 2016 | Chinese Journal of Electronics2016，25，1： | 1 |
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